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7601747 |
One-pot process for making di-functional di-tetrazole diols to produce tetrazole based polymers
A one-pot process for making energetic cast cured binders making di-tetrazoles to produce di-functional di-tetrazole diols for making tetrazole base polymers. Embodiments of the present invention...
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7576112 |
Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
A compound having a structure
and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7547685 |
Therapeutic substituted pyrrolidone compounds
Compounds comprising
or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7414071 |
Methods of treatment with selective EP4 receptor agonists
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the...
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7361672 |
Heteroarylacetamide inhibitors of factor Xa
The invention is concerned with novel heteroarylacetamides of formula (I)
R d —C(O)—N(R e )—R c —CH 2 —C(O)—N(R a )(R b ) ...
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7314885 |
Pyrrole compounds useful as kinase inhibitors
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for...
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7309721 |
Aminoalkylphosphonates and related compounds as Edg receptor agonists
The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
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7291639 |
Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
This invention provides methods of inhibiting plasminogen activator inhibitor-1 (PAI-1) in a mammal, utilizing compounds of the formula:
wherein: A is C or N; B is O, S, N, or CH═CH;
...
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7291623 |
Compounds that interact with kinases
A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose...
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7271187 |
Compositions and methods for promoting tissue regeneration
The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7196089 |
EP4 receptor antagonists
Compounds of formula (I):
wherein: R 2 is H or an optionally substituted C 1-4 alkyl group; Y is either —(CH 2 ) n —X—, where n is 1 or 2 and X is O, S, S(═O), S(═O) 2 , or NR N1 ,...
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7163954 |
Substituted naphthyl benzothiophene acids
The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them.
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7148248 |
Method of treating or inhibiting the development of brain inflammation and sepsis
A leukotriene C4 and D4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7109223 |
Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which...
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7087553 |
Soil fumigant, herbicide, larvacide, ovacide and fungicide
A treatment for eliminating unwanted organisms in agriculture, the treatment comprising a first component comprising allyl isothiocyanate emulsified in water, and a second component comprising a...
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6972298 |
Method of treating or inhibiting neutrophil chemotaxis by administering a MEK inhibitor
The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by...
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6951869 |
Use of leukotriene receptor antagonist for treatment of scarring
A method of preventing or treating either scarring or capsular contractures in subjects in need of such treatment comprising the administration of leukotriene receptor antagonists to said subject...
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6916831 |
Flavone acetic acid analogs and methods of use thereof
Compounds are described having a structure according to Formula I or Formula II:
wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O...
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6906085 |
Tetrahydropyran derivatives as neurokinin receptor antagonists
The present invention relates compounds of the formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 represent a variety of substituents; and pharmaceutically acceptable salts...
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6900234 |
Synergistic therapeutic compositions and methods
Compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, synergistic compositions comprising...
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6890928 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
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6723742 |
Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R 1 -R 5 are as defined in the description. The compounds have useful pharmaceutical properties and are...
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6716875 |
Synergistic therapeutic compositions of ACE and renin inhibitors and methods
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
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6699894 |
Methods for treatment of inflammatory bowel disease
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of inflammatory bowel disease.
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6699860 |
Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists
This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
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6689794 |
Aromatic sulfone hydroxamates and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
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6680319 |
Isoxazolecarboxamide derivatives
The invention relates to novel N-(substituted phenyl)-N′-[ω-(3-substituted phenyl-4-isoxazolecarbonylamino)alkyl]piperazines, their N-oxides, and pharmaceutically acceptable salts thereof. The...
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6620826 |
Endothelin receptor antagonists
Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
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6605641 |
20-HETE antagonists and agonists
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of...
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6599925 |
Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
This invention provides compounds which act as inhibitors of plasminogen activator inhibitor-1 (PAI-1) of the formula: wherein: R, R 1 , R 2 , and R 3 are H, alkyl, cycloalkyl, —CH 2...
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6589970 |
6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
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6555559 |
5,6,7-trinor-4,8-inter-m-phenylene PGI2, derivative and drugs containing the same
The present invention provides novel PGI 2 derivatives and an anti Helicobacter agent, a platelet function potentiating agent or a cervical ripening agent containing any of the derivatives.
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6486188 |
Method of treatment for cardiovascular complications
The present invention relates to the use of an angiotensin II type 1 receptor antagonist in the manufacture of a medicament for the prophylactic and/or therapeutic treatment of cardiovascular...
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6479527 |
Bicyclic pyrrole derivatives as MCP-1 inhibitors
A pharmaceutical composition comprising a compound of formula (I): or a pharmaceutically acceptable salt, ester or amide thereof, which is an inhibitor of monocyte chemoattractant protein-1 and...
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6448280 |
Angiotensin II antagonists against disorders associated with impaired neuronal conduction velocity, especially diabetic neuropathy
This invention relates to the use of angiotensin II antagonists in treating or preventing the development of disease conditions associated with impaired neuronal conduction velocity, such as...
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6441015 |
Tetrazole compounds as thyroid receptor ligands
The present invention relates to tetrazole compounds of Formula I, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, and pharmaceutically acceptable salts of the prodrugs. ...
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6420401 |
1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
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6410582 |
Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az...
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6399641 |
2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists
The present invention is a series of 2H-tetrazole-5-yl-amide derivatives showing activity as ligands of metabotropic glutamate receptors.
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6391902 |
Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
Compounds of the Formulae (I) and (II): wherein R 1 , R 2 , R 3 , X, Y and Z are as defined in the specification which compounds are useful in the treatment of disorders associated with smooth...
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6387894 |
Use of CRF antagonists and renin-angiotensin system inhibitors
The present invention relates to compositions and methods of achieving a therapeutic effect including, but not limited to, the treatment of congestive heart failure or hypertension in an animal,...
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6369084 |
Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester...
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6352985 |
Benzimidazole compounds
A benzimidazole compound represented by the formula (I): wherein R 3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
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6300356 |
Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
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6274609 |
Aqueous liquid pharmaceutical composition containing as main component benzopyran derivative
In order to promote solubilization or suspension of 4-oxo-8-[4-(4-phenylbutoxy)benzoylamino]-2-(tetrazol-5-yl)-4
H-1-benzopyran or its hydrate (pranlukast) in water, at least one component selected...
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