Matches 151 - 200 out of 253 < 1 2 3 4 5 6 >
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5177096 Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5175184 Benzothiophene derivatives and antihyperuricemia thereof  
A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or...
5166212 Certain n-substituted butyramide derivatives  
Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and...
5164381 Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same  
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
5158950 1,3-dithiol-2-ylidene derivatives and process for the preparation thereof  
2-(1,3-Dithiol-2-ylidene)-2-[N-(substituted) carbamoly] acetate esters and salts thereof, having potent therapeutic or prophylactic effect for hepatic disorder, are provided. Processes for their...
5153197 Treatment of hypertension with angiotensin II blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5149717 Alkanophenones useful for treating allergies  
Substituted alkanophenones of general formula ##STR1## in which R 1 is unsubstituted or fluorinated lower alkyl, R 2 is hydrogen, or unsubstituted or fluorinated lower alkyl or lower alkenyl, X...
5147885 N-amino bicyclic compounds  
N-amino hexahydrocyclopenta imidazole-2(1H)-one derivatives useful for treating or preventing thrombo-embolic disorders and ocular diseases characterized by increased ocular pressure.
5128346 Derivatives of D-glutamic acid and D-aspartic acid  
A compound of the formula: ##STR1## wherein R 1 and R 2 are substituents; R 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is...
5110821 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents  
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms; R 1 and R 2 are hydrogen, halogen,...
5110825 Benzofuran derivative  
The compounds of the present invention inhibit HMG-CoA reductase, subsequently suppress the synthesis of cholesterol; and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia,...
5093346 Substituted 1,2,4-triazole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5073566 Angiotensin II antagonist 1,3-imidazoles and use thereas  
This invention provides novel phenyl and heterocyclic derivatives, their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.
5070098 Substituted pyrazoline derivatives, pesticidal compositions and use  
This invention relates to novel substituted pyrazoline derivatives of the general formula ##STR1## processes for their preparation and their use as pesticides.
5047412 Alkene derivatives  
The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes...
5015651 Treatment of hypertension with 1,2,4-angiotensin II antagonists  
Substituted pyrroles, pyrazoles and traizoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5004750 Benzofuran and benzothoiphene derivatives, of tetrazole and anti-hyperuricemia use thereof  
A new series of benzofuran and benzothiophene derivatives are disclosed. These compounds have a structure which can be obtained by substituting the third position of 2-lower alkyl-benzofuran or...
4985451 Elaiophylin derivatives, the use thereof as pharmaceuticals, and pharmaceuticals containing them  
The invention relates to elaiophylin derivatives of the formula I, II and III ##STR1## in which the substituents R(1), R(2), R(3) and R(3)' have the specified meanings. The compounds have...
4980349 Sulphonamides derived from diarylmethanes, the processes for preparing them and pharmaceutical compositions containing them  
The invention relates to new compounds corresponding to formula I: ##STR1## in which: W represents C=O, CH 2 or CHOH, Z represents ##STR2## R 1 and R 2 represent especially Cl or F, R, R' and...
4977174 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease  
7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula ##STR1## wherein m is 0, 1, 2, 3 or...
4962117 Heterazole dialkanoic acids  
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and...
4959387 Mycophenolic acid derivatives in the treatment of rheumatoid arthritis  
A method of treating rheumatoid arthritis which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR1## and...
4954518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient  
This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the...
4933351 Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis  
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus...
4863923 Method of inhibiting superoxide release  
A method of inhibiting superoxide release and reducing tissue damage following an inflammatory or ischemic event employing benzothiophenes, benzofurans, and naphthalenes is disclosed.
4847277 Compound and treatment of obstructive airways disease therewith  
There is described the calcium salt of 10-propyl-2,8-bis(1H-tetrazol-5-yl)-4H,6H-benzo(1,2-b;5,4-b' )dipyran-4,6- dione and processes for its preparation. Also described are pharmaceutical...
4824858 1,3-Dioxolane-5-yl-hexenoic acid derivatives  
The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes...
4808597 Method for inhibiting the degradation of cartilage  
Certain carboxylic acids of the formula ##STR1## and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular...
4783473 Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use  
Geminally-substituted cyclic ether carboxylic acids or derivatives thereof are provided which have the structure ##STR1## wherein Z is aryl, which may be optionally substituted with one or more of...
4775679 Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4766120 Tetrazole derivatives, having a further unsaturated heterocyclic ring anti-ulcer composition containing the same and method for treating ulcers  
Tetrazole derivatives of the formula: ##STR1## wherein R 1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R 2 is hydroxy, a lower...
4749715 7-oxabicycloheptane substituted amino prostaglandin analogs  
7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## wherein n is 1 to 5; R 1 is CO 2 H, CO 2 lower alkyl or ##STR2## and R 2 is...
4740517 Antidiabetic spiro-3-heteroazolidines  
A spiro-3-heteroazolidine compound and agents comprising that compound which have special utility as an antidiabetic composition and as a substance to inhibit aldose reductase enzyme activity.
4738978 Bisthioamide-7-oxabicycloheptane prostaglandin analogs  
Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; R is CO 2 H, CO 2 lower...
4735962 7-thiabicycloheptane substituted diamide and its congener prostaglandin analogs  
7-Thiabicycloheptane substituted diamide and congener prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 1 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1...
4734424 Bicycloheptane substituted diamide and its congener prostaglandin analogs  
Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; Q is...
4734425 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs  
7-Oxabicycloheptane substituted hydroxamic acid prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CHCH-- or --CH 2 -CH 2 --; n is 1 to 5; R is CO 2 H,...
4734426 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs  
5,6-Epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; R is CO 2 ...
4713393 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4703053 Benzothiophenes and benzofurans and antiallergic use thereof  
Novel benzothiophene and benzofuran derivatives having antiallergic activity are described as well as a method of manufacture, pharmaceutical compositions, and methods of use therefor. The...
4696922 5-azolylacetoxymilbemycins as ecto- and endoparasites  
The present invention relates to milbemycin derivatives of the formula I ##STR1## wherein X is hydrogen or β-halogen, R is methyl, ethyl, isopropyl or sec-butyl and Az is a 5 membered heterocyclic...
4675320 Aminoalkyl and aminoalkoxy derivatives of 2-nitro-3-phenylbenzofuran  
Antimicrobial 2-nitro-3-phenylbenzofurans wherein the benzo or the 3-phenyl portion of the molecule is bonded to an alkylene or an oxyalkylene group which is in turn bonded to a basic nitrogen atom...
4670452 Dioxo dibenzopyrans and anti-allergic use thereof  
There are provided benzopyrans of formula I ##STR1## wherein R 6 and R 7 together form the chain --CHOCH(A 1 E 1 )--O-- in which --O-- is attached to R 7 , R 5 represents hydrogen, R 8...
4670453 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease  
7-Oxabicycloheptane substituted amidocarbamoyl prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; R...
4665084 Condensed benzopyrone derivatives  
The present invention relates to new condensed benzopyrone derivatives having a 5-tetrazolyl substituent thereon, and to pharmaceutical compositions containing them. The compounds are useful in the...
4663337 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease  
7-Oxabicycloheptane substituted amides are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; R is CO 2 H, CO 2 alkyl, CO 2 ...
4661506 7-oxabicycloheptane substituted ox prostaglandin analogs  
7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R 1 is lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is...
4656185 7-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs  
7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; R...
4654355 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs  
7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 CH 2 --; n is 1 to 5; Q...
4654357 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs  
7-Oxabicycloheptane substituted sulfonamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CHCH-- or --CH 2 --CH 2 --; n is 1 to 5; Q is...
Matches 151 - 200 out of 253 < 1 2 3 4 5 6 >