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6274609 |
Aqueous liquid pharmaceutical composition containing as main component benzopyran derivative
In order to promote solubilization or suspension of 4-oxo-8-[4-(4-phenylbutoxy)benzoylamino]-2-(tetrazol-5-yl)-4
H-1-benzopyran or its hydrate (pranlukast) in water, at least one component selected...
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6262103 |
Thienycyclohexanone derivatives as ligands of the GABAA α5 receptor subtype
A pharamceutical composition comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A is C 1 -6 alkyl, C 2 -6 alkenyl, C 2 -6 -alkynyl, C 3 -6 -cycloalkyl, arylC...
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6218414 |
Use of an angiotensin II antagonist and a benzofuran derivative in the treatment of cardiovascular complaints
The invention relates to the use of an angiotensin II antagonist and a benzofuran derivative with antiarrhythmic activity in the treatment of cardiovascular complaints, in particular in the...
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6201002 |
Method for reducing mortality with an angiotensin II antagonist
Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce...
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6174910 |
AT1 receptor antagonist for the stimulation of apoptosis
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6143774 |
Imidazole n-benzyldioxol derivatives, method for preparing same, resulting intermediates, pharmaceutical compositions and use of said derivatives as endothelin antagonists
The invention relates to the new products of formula (I): ##STR1## in which: R 1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms, R 2 ; R 3 both...
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6143776 |
Tosylproline analogs as thymidylate synthase inhibitors
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
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6143732 |
Sesquiterpene derivatives
The Sesquiterpene derivatives are useful as antivirus agents, which are shown by the formula: ##STR1## wherein R 1 is hydrogen or halogen; and R 2 is hydrogen, halogen, --OR 7 (wherein R 7 is...
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6110962 |
11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure ##STR1## wherein A is hydrogen, halogen, or OH; B and D are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon...
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6110963 |
Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
This invention provides compounds of Formula I having the structure ##STR1## wherein A is C or N; B is O, S, N, or CHCH; E is ##STR2## or --X--D; D is ##STR3## or alkyl of 1-12 carbon...
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6096740 |
Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+)...
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6096773 |
Compounds that inhibit the binding of integrins to their receptors
A method for the inhibition of the binding of α 4 β 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding;...
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6080772 |
Thiazole compounds and methods of modulating signal transduction
The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or...
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6051586 |
Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
This invention related to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
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6034114 |
Medicament
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of left ventricular hypertrophy regression.
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6028092 |
Salts of N-(4-Oxo-2-(1H-tetrazoyl-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)b enzamide
This invention relates to novel formulations of salts of certain benzopyran compounds, to compositions containing them and their use in the treatment of certain disorders.
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6020355 |
Pesticidal tetrazole derivatives
Tetrazole derivatives of the formula wherein R is a substituted or unsubstituted phenyl group, heterocyclic group, or benzo-fused heterocyclic group, which exhibit activity as insecticides and...
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6013644 |
Spiro-substituted azacycles as modulators of chemokine receptor activity
The present invention is directed spiro-substituted azacycles of formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , k, l and m are defined herein) which are useful as modulators of chemokine...
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6004988 |
Carboxylic acid derivatives, their preparation and their use
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
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6001867 |
1-aryl-dibenzothiophenes
This invention provides compounds of Formula I having the structure ##STR1## wherein: B and D are each, independently, hydrogen, halogen, --CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12...
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5990142 |
Benzopyran derivatives having leukotriene-antagonistic action
The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a...
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5981438 |
1-phenyl-5-anilinotetrazoles
The present invention relates to novel 1-Phenyl-5-anilinotetrazoles of the formula (I): ##STR1## wherein, R 1 , R 2 , R 3 , R 4 , m and n have the meaning provided in the specification, precesses...
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5977169 |
Substituted tetronic acids useful for treating HIV and other retroviruses
This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the...
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5968959 |
Method for the prevention and treatment of stunned myocardium
A method for the prevention and treatment of stunning of the heart subsequent to ischemia-reperfusion is described. The method comprises administering a therapeutically effective amount of a...
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5962491 |
Benzimidazole derivatives and use thereof
Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R 1 is hydrogen or an optionally...
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5955487 |
N-acyl-N-heterocyclylalkyamino acids compositions and method of use
The invention relates to N-acyl-N-heterocyclylalkylamino acids of the formula ##STR1## R 1 is C 1 -C 7 alkyl that is unsubstituted or substituted by halogen or by hydroxy, or is C 2 -C 7 ...
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5955492 |
Carboxylic acid indole inhibitors of chemokines
This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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5939447 |
Substituted benzopyrans
This invention covers certain hydroxy-substituted benzopyrans which are useful for treating asthma and other diseases involving leukotriene-related disease states.
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5935973 |
Heterocyclcarboxamide derivatives and their use as therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R 1 is an optional substituent; U is an alkylene...
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5925664 |
Method for treating ocular hypertension and glaucoma
A method of treating ocular hypertension and/or glaucoma in a mammal by locally administering to the eyes of a mammal a composition comprising an effective amount of a compound of the formula...
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5922744 |
Ethane-1-2-diamine derivatives and tachykinin antagonists
The present invention provides a compound of formula: ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a and R 6b are defined herein or a pharmaceutically acceptable salt thereof, a process...
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5922747 |
Indole derivatives as steroid 5α-reductase inhibitors
A method of treatment of a human to inhibit a steroid 5α-reductase, particularly a testosterone 5α-reductase, which comprises treating said human with an effective amount of a compound of the...
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5889020 |
Treatment of normotensive glaucoma with angiotensin II antagonists
The present invention relates to the use of angiotensin antagonist or a pharmaceutically acceptable salt thereof for the treatment of normal tension glaucoma, wherein said angiotensin antagonist...
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5869474 |
Low dosage treatment for cocaine craving and withdrawal
Ketoconazole is used for treating cocaine addiction. Mammals, including humans, that are chronically addicted to cocaine are treated with ketoconazole to decrease self-administration of the drug.
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5861380 |
Serine protease inhibitors-keto and di-keto containing ring systems
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
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5837702 |
4-arylamino-benzopyran and related compounds
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH 2 --, --C(O)--, --O--, --S-- or --N(R 8 )-- where R 8 is hydrogen,...
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5830909 |
Angiotensin (AII) antagonists as inhibitors of the growth of adipose tissue
The invention is a method of using Angiotensin (AII) Antagonists as inhibitors of the growth of adipose tissue, reducing adipocyte growth and body weight gain.
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5824696 |
Medicaments
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of chronic inflammatory disease states.
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5767139 |
Indoles which have steroid 5-α reductase inhibitory activity
The present invention provides compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, together with pharmaceutically compositions containing, uses of, processes for...
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5763447 |
Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises...
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5750558 |
Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis
Described herein are compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein L is selected from the group consisting of ##STR2## R 2 is selected from (a)...
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5750551 |
Treatment for viral diseases
An angiotensin II antagonist compound is administered to mammals with viral disease. This administration ameliorates virus-associated cell injuries, producing therapeutic effects in viral diseases....
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5739164 |
Pharmaceutical compounds for the treatment of CNS diseases
Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is...
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5726195 |
Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1- 5- 4- (5-nitro-2-thienyl)ethynyl!ph...
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5719182 |
Endothelin receptor anatagonists
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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5710153 |
Tetrazole compound
A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1β converting enzyme (ICE).
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5703108 |
Bone deposition by certain prostaglandin agonists
Methods for the treatment of bone disorders utilizing certain prostaglandin agonists/antagonists.
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5693619 |
Method of using renin inhibiting N-(2-amino-2-oxoethyl) butanediamide derivatives
Disclosed herein is a method of using compounds of the formula: A-N(R 1 )C(O)CH 2 CHR 2 C(O)-B wherein A is R 3 R 4 NC(O)CH 2 when, for example, R 3 is hydrogen or alkyl and R 4 is...
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5686478 |
Endothelin antagonists
Novel derivatives of the general structural Formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary...
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5677324 |
Benzopyranes as potassium channel openers
The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein the dashed line represents an optional covalent bond; X is O, NH, S or a direct...
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