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6495580 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases  
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with...
6479518 Zwitterionic tachykinin receptor antagonists  
The present invention is directed to certain novel compounds represented by structural formula I: or a pharmaceutically acceptable salt thereof, wherein R3, R5, R6, R7, R8, R11, R12, R13, Q, W, X,...
6479493 Methods for treatment of type I diabetes  
Substituted condensation products of -benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of type I diabetes.
6465502 Additional therapeutic use  
The invention relates to the use of an AT1 receptor antagonist or or an AT2 receptor modulator, respectively, or a pharmaceutically acceptable salt thereof, for producing a pharmaceutical...
6465503 Selective urokinase inhibitors  
The present invention provides novel compounds of Formula I: its prodrug forms, or pharmaceutically acceptable salts thereof. The compounds of this invention are inhibitors of uPA, and have...
6462061 Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for treatment of dry eye  
Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.
6451833 N-substituted (α-imidazolyl-toluyl)pyrrole compounds for treatment of circulatory disorders  
A class of N-substituted (α-imidazolyl-toluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
6448280 Angiotensin II antagonists against disorders associated with impaired neuronal conduction velocity, especially diabetic neuropathy  
This invention relates to the use of angiotensin II antagonists in treating or preventing the development of disease conditions associated with impaired neuronal conduction velocity, such as...
6441015 Tetrazole compounds as thyroid receptor ligands  
The present invention relates to tetrazole compounds of Formula I, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, and pharmaceutically acceptable salts of the prodrugs. The...
6436974 Amino heterocycles useful as pharmaceutical agents  
The instant invention is a novel series of amino heterocycles useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression,...
6436965 PDE IV inhibiting amides, compositions and methods of treatment  
Compounds represented by formula I: as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by...
6436971 Use of PDE 4-specific inhibitors to reduce the severity of a bacterial infection after a respiratory viral infection  
This invention relates to a method for the prophylaxis of or reducing the severity of post-viral bacterial infection by administering a PDE 4-specific inhibitor prior to or during the course of a...
6426359 Prevention and treatment of skeletal disorder with EP2 receptor subtype selective prostaglandin E2 agonists  
This invention relates to the use of EP2 receptor subtype selective prostaglandin E2 agonists to augment bone mass including the prevention and treatment of skeletal disorders in mammals,...
6420405 Pharmaceutical composition for angiotensin II-mediated diseases  
This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula wherein R1 is H...
6420401 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives  
Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
6413996 Diaminocyclobutene-3,4-dione derivatives, their preparation and use  
The invention relates to compounds having the formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), X represents a group having the structural formula (II), and Y...
6410542 Aminotetrazole derivatives useful as nitric oxide synthase inhibitors  
The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
6399641 2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists  
The present invention is a series of 2H-tetrazole-5-yl-amide derivatives showing activity as ligands of metabotropic glutamate receptors.
6395728 Method of treatment and pharmaceutical composition  
The invention relates to a method for the treatment or prevention of a condition or disease selected from the group consisting of hypertension, (acute and chronic) congestive heart failure, left...
6376524 Triphenyl compounds as interleukin-4 antagonists  
Triphenyl compounds of the formulae I, II, and VI: methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are compounds are interleukin-4...
6369108 Method for treating COPD  
A method for treating COPD is disclosed comprising administering compounds of Formula (I) wherein the terms R1, R3, X, X2 and Z are herein defined.
6352985 Benzimidazole compounds  
A benzimidazole compound represented by the formula (I): wherein R3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
6353012 15-Hydroxyeicosatetraenoic acid-related compounds and methods of use  
HETE derivatives and methods of their use for treating dry eye are disclosed.
6342247 Pharmaceutical compositions containing irbesartan  
Pharmaceutical compositions containing irbesartan, alone or in combination with a diuretic, providing tablets with a high relative amount of active agent and excellent wetting and disintegration...
6339100 Methods for inhibiting mastocytosis  
A method of preventing or treating in a subject mastocytosis which comprises administering to the subject a therapeutically effective amount of a compound having the structure: or a...
6337340 Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders  
This invention relates to novel compositions and uses of carboxylic acid or isostere of a heterocyclic ring compound having two or more heteroatoms within the heterocyclic ring and wherein the...
6329401 Enhancement of sleep with a tachykinin antagonist  
A tachykinin antagonist is useful, alone or in conjunction with other agents, for altering circadian rhythmicity and alleviating circadian rhythm disorders and for enhancing and improving the...
6323230 Use of nitrogen heterocyclic aromatic derivatives in the topical treatment of the epithelial tissues diseases  
Derivatives of general chemical formula L(I) and (IV) ##STR1##are used in the topical treatment of diseases of the epithelial tissues, like psoriasis (epidermis) and ulcerative colitis L(lower...
6319933 Azole derivatives  
The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), ##STR1##and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the...
6319939 Retinoic acid mimetic anlides  
The present invention is concerned with compounds of formula ##STR1##the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X...
6306887 Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases  
Compounds of Formula (1.0.0): ##STR1##are described wherein A is for example aryl, heteroaryl or heterocyclyl, Y is preferably --C(O)--; B is independently selected from a group of moieties, the...
6300356 Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist  
Angiotensin II receptor antagonists are useful for decreasing QT dispersion or inhibiting the progression of QT prolongation in patients. Also disclosed is a method for monitoring the reduction in...
6291530 Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity  
##STR1##Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di cabocyclic or heterocyclic aryl)-lower alkyl; R1 is hydrogen or lower alkyl; R2 and R3 are hydrogen, lower...
6284784 Substituted 2-pyrrolidinone activators of PKC  
Compounds of formula I: ##STR1##wherein R1 and R2 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are PKC activators and are useful for treating...
6277880 Chemical compounds  
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active...
6274604 Alteration of circadian rhythmicity with a tachykinin antagonist  
A tachykinin antagonist is useful, alone or in conjunction with other agents, for altering circadian rhythmicity and alleviating circadian rhythm disorders and for enhancing and improving the...
6268391 Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases  
Compounds of general formula (I) wherein: R1 is H or optionally joined with R2 to form a fused ring selected from the group consisting of five to ten membered aryl, heteroaryl or heterocyclyl...
6265423 Aromatic polycyclic retinoid-type derivatives, method for preparing same, and use thereof for making pharmaceutical and cosmetic compositions  
Novel aromatic polycyclic retinoid-type derivatives of general formula (I), ##STR1##wherein groupings R3 and R4 attached to the double bond between carbons 11 and 12 are cis groupings, and...
6248729 Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination  
A method is provided for preventing a cerebral infarction by administering to a patient a combination of an ADP-receptor blocking antiplatelet drug, such as clopidogrel, in combination with an...
6239175 Carbamoyloxy derivatives of mutiline and their use as antibacterials  
Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is...
6225329 Modulators of protein tyrosine phosphatases (PTPases)  
The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are...
6211217 Method for reducing pericardial fibrosis and adhesion formation  
Disclosed are methods of reducing fibrosis and adhesion formation in a surgical patient wherein the AT1 receptor antagonist, the compound...
6201002 Method for reducing mortality with an angiotensin II antagonist  
Angiotensin II receptor antagonists are useful in reducing and preventing mortality and sudden cardiac death in symptomatic heart failure patients. Losartan potassium has been shown to reduce...
6194432 Prevention and treatment of migraine, cluster and other recurrent headaches using leukotriene antagonist drugs  
A method is disclosed for using leukotriene (LT) antagonist drugs to prevent and treat recurrent primary headaches, which includes migraine headaches and cluster headaches. LT antagonist drugs...
6191156 Compositions and methods for treating bladder dysfunction  
A method for treating patients having bladder dysfunction is described. The method involves the step of treating a patient with a renin-angiotensin system inhibitor. Preferably the inhibitor is an...
6174910 AT1 receptor antagonist for the stimulation of apoptosis  
The invention provides the use of an AT1 receptor antagonist, or a pharmaceutical salt thereof, for producing a pharmaceutical preparation for the stimulation of apoptosis and for the treatment of...
6174883 3-substituted-2-oxindoles derivatives  
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1##and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H2 synthase,...
6166004 Combinations of HIV protease inhibitors with reverse transcriptase inhibitors  
There are described compounds of formula I*, ##STR1## wherein R1 is lower alkoxycarbonyl, R2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R3 is phenyl that is unsubstituted...
6156774 Beta-thiopropionyl-amino acid derivatives and their use as beta-lactamase inhibitors  
PCT No. PCT/EP97/05709 Sec. 371 Date Apr. 7, 1999 Sec. 102(e) Date Apr. 7, 1999 PCT Filed Oct. 10, 1997 PCT Pub. No. WO98/17639 PCT Pub. Date Apr. 30, 1998Mercapto amino acid derivatives of...
6150412 Catechol derivatives  
The invention relates to compounds of formula (I) ##STR1## wherein R1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R2 is --A--R4, wherein A is a branched or...