Matches 401 - 450 out of 725 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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5466704 N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists  
Compounds are disclosed having the formula ##STR1## These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
5464854 Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.  
The method of treatment moderating, blocking and/or eliminating premenstrual syndrome embodies the intermittent administering of an AT1 antagonist to a female having menstrual cycles characterized...
5462954 Substituted phenyl phenol leukotriene antagonists  
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and...
5462963 Chelator compositions comprising α-diamine compounds  
The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising...
5461049 Amide tetrazole ACAT inhibitors  
Amide tetrazoles of the formula ##STR1## wherein aryl includes phenyl and naphthyl, unsubstituted or substituted, X is O, N--R 5 , or --NR 3 R 4 , where R 2 , R 4 , and R 5 include alkyl...
5459148 Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease  
Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R 1 is alkyl, alkenyl, cycloalkyl or a group of formula R 4 --Y--R 5 --, where: R 4 is...
5459134 (Fused) benz (thio) amides  
A novel (fused) benz(thio)amide of the general formula: ##STR1## or a non-toxic salt thereof, wherein R 4 represents: (i) when B represents a closed ring, a group of the general formula: ##STR2##...
5457114 Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants  
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
5455222 1-substituted-5-thiomethylthiocyanato-1H-tetrazoles, compositions containing them and their use as antimicrobial and marine antifouling agents  
Disclosed are substituted-5-thiomethylthiocyanato-1H-tetrazole compounds corresponding to the formula ##STR1## wherein R represents a C 1 -C 6 straight or branched chain alkyl radical, a C 3 -C...
5451597 Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists  
A class of N-substituted (α-imidazolyltoluyl)pyrrole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
5449682 Angiotensin II antagonists incorporating a substituted benzyl element  
Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are...
5444081 Substituted histidines having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5444080 Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5436260 Angiotensin II receptor antagonists  
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Intermediates...
5434167 Imidazolines N-substituted by a biphenylmethyl group, their medical use and the pharmaceutical compositions therefor  
The invention relates to compounds of the formula ##STR1## in which X and R 1 -R 5 are defined in the specification and their salts where appropriate, all of which are useful as angiotensin II...
5430047 Neurotensin antagonists  
Neurotensin antagonists are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful...
5426114 ω-[2-(tetrazolylalkyl)cyclohexyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors  
The present invention pertains to antagonists of excitatory amino acid receptors, their method or preparation as well as compositions pertaining to them, which have the general formula: ##STR1##...
5426105 Conformationally restricted angiotensin II antagonists  
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest...
5426113 Method of preventing ulcer formation caused by nonsteroidal antiinflammatory drugs employing tetrazol-benzothiophene carboxamide compounds  
Tetrazol-benzothiophenes carboxamides or a pharmaceutically acceptable salt thereof are useful in preventing ulcer formation caused by nonsteroidal antiinflammatory drugs in mammals.
5414008 Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives  
Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The...
5409947 Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds  
New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R 1 represents H or isopropyl...
RE34918 Azaazulene compounds which are useful as antiallergic and antiinflammatory agents  
An azaazulene derivative having the general formula (I): ##STR1## wherein R 1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond...
5407951 Sulphonamidocycloalkane compounds, pharmaceutical compositions containing them, and methods of use thereof  
The present invention provides sulphonamides of the general formula: ##STR1## wherein R 1 and R 2 , which can be the same or different, are hydrogen or halogen atoms or C 1 -C 6 -alkyl,...
5401764 Benzimidazole derivative compositions and medical use thereof  
1-Acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzi midazole-7-car boxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity and...
5395840 Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives  
Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides. The compounds can be employed...
5393768 Leukotriene antagonists  
This invention provides novel benzene derivatives which are leukotriene antagonists, formulations of those derivatives, intermediates for preparing the derivatives, and a method of using those...
5393767 Insect control with substituted triazole and tetrazole compounds  
Insects, especially sucking insects, such as brown planthoppers, and phytophageous mites, such as two-spotted spider mites, are controlled by applying an triazole or tetrazole compound substituted...
5393762 Pharmaceutical agents for treatment of emesis  
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives...
5389634 Imidazole derivatives having angiotensin II receptor antagonistic activity  
Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5389641 Fused heterocyclic compounds, having angiotensin II antagonistic activity  
Fused heterocyclic compounds of the formula (I): ##STR1## wherein R 1 is an optionally substituted hydrocarbon residue which may be attached through a hetero atom; R 2 is a group capable of...
5389663 1-(1h-1,2,4-triazole-yl)-2-propanol compounds  
An azole compound represented by the formula (I): ##STR1## wherein X is a nitrogen atom; Ar is a phenyl group substituted by halogen or a halogenated C 1 -4 alkyl group; R 1 and R 2 independently...
5389661 Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties  
This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of...
5389659 C-linked pyrazole derivatives  
The invention provides compounds of the general formula (I): ##STR1## or a physiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof. The compounds may be used...
5380739 Substituted indole derivatives  
Compounds of the Formula (I), (II), or (III): ##STR1## wherein the variables are as defined in the specification and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological...
5376666 Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl  
Novel heterocycle substituted azocycloalkane benzylimidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
5374638 Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma  
Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as...
5374615 Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives  
Novel compounds are disclosed having the formula ##STR1## wherein X, R 1 , R 2 , R 3 , R 4 , and R 5 are substituents. These compounds inhibit the action of angiotensin II and are useful,...
5371100 Optically active tetrazole compounds, and fungicidal compositions thereof  
An optically active azole compound of the formula (I): ##STR1## wherein R 1 and R 2 are independently a hydrogen atom, a halogen atom, a haloalkyl group, a haloalkoxy group or an optionally...
5364876 Omega-[2-(alkyl)phenyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors  
The present invention pertains to antagonists of excitatory amino acid receptors, their method of preparation as well as compositions pertaining to them, which have the general formula: ##STR1##...
5362744 Tetrazole-substituted urea acat inhibitors  
Novel ACAT inhibitors useful in the treatment of atherosclerosis which are tetrazole-substituted ureas,
5356919 Leukotriene B.sub.4 synthesis inhibitors  
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CHCH--, or --CHN--; wherein R 1 is --CO 2 R 2 or...
5352690 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists  
This invention provides 1,2,4-trioxygenated benzene derivatives which are leukotriene B 4 antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment...
5350751 Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure  
The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR 2 , R 1 and R 2 are as defined in the description, L is an alkylene...
5340826 Pharmaceutical agents for treatment of urinary incontinence  
The present invention relates to a method of treating or preventing urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane...
5338756 Benzimidazole compounds  
Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5338740 Angiotensin II receptor antagonists  
The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Het wherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR 1 R 2 --CO--Y--NR 3 --CHR 4 --CR 5 --CH 2 --(CR 6 R 7 ) r --Z--Het I in which R 1 to R 7 , W, X, Y, Z, r and Het...
5328919 Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof  
Pivaloyloxymethyl2-ethoxy-1-[['-(1H-tetrazol-5-yl)biphenyl-4 -yl]methyl]benz imidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity...
5318981 Cholecystokinin antagonists useful in the treatment of panic attacks  
Unnatural dipeptoids of α-substituted Try-Phe derivatives are useful as agents in the treatment of panic disorders. These dipeptoids are Cholecystokinin-B Receptor (CCK B ) antagonists having...
5318980 Sulphonylbenzyl-substituted imidazoles  
Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary...
Matches 401 - 450 out of 725 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >