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6797708 Inhibitors of cytosolic phospholipase A2  
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
6797504 Inhibitors of serine protease activity of matriptase or MTSP1  
The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of...
6794406 Indole derivatives  
The invention relates to new indole derivatives, processes for their preparation, and their use in medicaments.
6787561 Benzimidazole compounds  
A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of an orally available medicament for preventive and/or...
6787556 Benzoic acid derivatives for the treatment of diabetes mellitus  
The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR)...
6777436 Intraocular tension lowering compositions for topical administration  
An intraocular tension lowering composition for topical administration is disclosed which comprises an effective amount of an (i) angiotensin II antagonist, (ii) a boric aid and (iii) an...
6756399 Use of lipoxygenase inhibitors and PPAR ligands as anti-cancer therapeutic and intervention agents  
The present invention provides a method for treating and preventing an epithelial cell-derived cancer in a subject in need thereof, comprising administering to the subject an amount of a...
6743817 Substituted fused pyrroleimines and pyrazoleimines  
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists,...
6734206 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure  
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
6723742 Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators  
The use is described of 3,5-diphenyl-1,2,4-triazoles of the formula I in which R1-R5 are as defined in the description. The compounds have useful pharmaceutical properties and are particularly...
6723753 Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity  
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
6716875 Synergistic therapeutic compositions of ACE and renin inhibitors and methods  
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
6716605 Indole derivatives having an antiviral activity  
A compound of the formula: whereinR1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like,R2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the like,R3,...
6713507 Ether compounds and compositions for cholesterol management and related uses  
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
6706735 2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
6706744 Glucagon antagonists/inverse agonists  
Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for...
6706749 Substituted phenyl derivatives, their preparation and use  
The present invention discloses compounds having formula (I) wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.
6703422 Sulfide and disulfide compounds and compositions for cholesterol management and related uses  
The present invention relates to novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular...
6699904 PPAR agonists  
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol...
6699894 Methods for treatment of inflammatory bowel disease  
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of inflammatory bowel disease.
6689773 Uracil substituted phenyl sulfamoyl carboxamides  
Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, whereA=oxygen or sulfur;X1=H, halogen, C1-C4-alkyl;X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl;X3=H, CN,...
6686383 Prophylactic or therapeutic drug for renal diseases  
This invention relates to methods for the prophylaxis or treatment of diabetic nephropathy comprising, administering as an active ingredient, a compound, or salt thereof, of formula (I) wherein R1...
6673780 Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses  
The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing...
6660742 Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins  
The present invention relates to novel achiral seco-analogues of DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II, III, IV...
6653306 Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy  
A combination comprising therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is...
6649643 Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase  
Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism,...
6649641 Glucagon antagonists/inverse agonists  
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
6630468 Disubstituted pyrazolines and triazolines as factor Xa inhibitors  
The present application describes disubstituted pyrazolines and triazolines of formulae I and II: or pharmaceutically acceptable salt forms thereof, wherein one of M1 and M2 maybe N and D may be a...
6613760 Indole derivatives and their use as MCP-1 receptor antagonists  
The present invention relates to certain novel compounds, including their production, their formulation as pharmaceutical compositions, and their therapeutic uses. In particular, the invention...
6610719 Use of prostaglandin (PGE2) receptor a (EP4) selective agonists for the treatment of acute and chronic renal failure  
This invention is directed to methods and compositions of treating acute or chronic renal failure or dysfunction, or conditions caused thereby, comprising administering prostaglandin agonists,...
6605641 20-HETE antagonists and agonists  
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of...
6602895 Inhibitors of factor Xa with a neutral P1 specificity group  
The present application describes inhibitors of factor Xa with a neutral P1 specificity group of formula I: or pharmaceutically acceptable salt forms thereof, wherein R and E may be groups such as...
6596716 2-propane-sulphonamide derivatives  
The present invention relates to the potentiation of glutamate receptor function using certain 2-propane-sulphonamide derivatives. It also relates to novel 2-propane-sulphonamide derivatives, to...
6593355 Benzimidazoles with antithrombotic activity  
Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonyl methylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimida zol...
6589970 6-(aryl-amido or aryl-amidomethyl)-naphthalen-2-yloxy-acidic derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)  
This invention provides novel compounds, pharmaceutical compositions and methods of treating thrombotic disorders in mammals, the compounds having the formula: Wherein: Ar is phenyl, naphthyl,...
6583164 Antimycotic drug composition  
The composition of the present invention comprises a quaternized nitrogen-containing imidazole-1-yl or 1,2,4-triazole-1-yl compound wherein one of the nitrogen atoms constituting the azole ring is...
6576632 Biaryl compounds useful as anticancer agents  
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as...
6569888 Anti-inflammatory indole derivatives  
Compounds of formula (I) or a pharmaceutically acceptable salt, in vivo hydrolysable ester, or an N—C1-6alkyl or N,N-di-(C1-6alkyl)amide thereof, where X is CH2 or SO2; R1 is an aryl optionally...
6555576 Method for treating exercise induced asthma  
Methods of treating exercise-induced asthma using a PDE-4 inhibitor are disclosed.
6552051 Energetic nitramine-linked azoles and related compounds as oxidizers, initiators and gas generators  
Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be...
6545031 Endothelin receptor antagonists  
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists as described.
6538029 Methods for treatment of renal cell carcinoma  
A method of treating renal cell carcinoma in a mammal with that disease comprising administering to the mammal a physiologically effective amount of an inhibitor of PDE10.
6525073 Prevention or treatment of insomnia with a neurokinin-1 receptor antagonist  
A tachykinin antagonist is useful, alone or in conjunction with other agents, for altering circadian rhythmicity and alleviating circadian rhythm disorders and for enhancing and improving the...
6525099 N-substituted sulfonamide derivatives  
The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
6521650 Amines as pharmaceutical agents  
Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders,...
6518292 Heterocyclic aromatic compounds usefuls as growth hormone secretagogues  
Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and...
6518289 1-substituted-1-aminomethyl-cycloalkane derivatives (&equals gabapentin analogues), their preparation and their use in the treatment of neurological disorders  
Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide,...
6511670 (poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof  
Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1—Y—CH2—C≡C—CH2—S—CH2—R2 (I)and are useful for the treatment of a wide variety of disease...
6509353 Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors  
Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
6506738 Benzimidazolone antiviral agents  
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the...