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7091231 12-Aryl prostaglandin analogs  
Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted phenyl,...
7087631 Aryltetrazole compounds, and compositions thereof  
The present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a 5-Aryltetrazole Compound, and methods for treating an inflammation disease, a...
7081467 C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals  
The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical...
7078423 5-Aryltetrazole compounds, compositions thereof, and uses therefor  
The present invention relates to 5-Aryltetrazole compounds, compositions comprising a 5-Aryltetrazole compound, and methods for treating an inflammation disease, a reperfusion disease,...
7074814 3-substituted indoles and derivatives thereof as therapeutic agents  
The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful...
7067546 Crystal and process for producing the same  
A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the...
7064141 Method for preventing, treating or inhibiting development of simple retinopathy and preproliferative retinopathy  
To provide a pharmaceutical composition for preventing, treating or development-inhibiting simple retinopathy or preproliferative retinopathy, comprising a compound having angiotensin II...
7060718 Arylsulfonanilide ureas  
The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as...
7053071 Induction of apoptosis in cancer cells  
The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
7045540 Selective estrogen receptor modulators  
The present invention provides, inter alia, triphenylethylene derivatives, such as, 5-{2-[4-(1,2-Diphenyl-but-1-enyl)-phenyl]-vinyl}-1H-tetrazol e, as selective estrogen receptor modulators. Also...
7034034 Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives  
Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo...
7026344 Treating sickle cell disease  
Sickle cell disease is treated by administering a 5-lipoxygenase inhibitor.
7022726 ω-cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists  
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
7022727 Crystalline drug form  
The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluro namide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H -purine-2-carboxamid...
7019033 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives  
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or...
7018986 Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption  
The invention provides methods of using beta glucans to treat conditions associated with bone loss or low bone density as well as methods for promoting bone growth in situations where enhanced...
7008959 Form of irbesartan, processes for obtaining the said and pharmaceutical compositions containing it  
The invention relates to a novel crystalline form of irbesartan to pharmaceutical compositions containing it, to processes for preparing it, and to a method for treating cardiovascular diseases...
7005442 8-azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents  
The present invention provides a compound represented by the general formula I; wherein A, Ar, X, Z, n, x, y, R and R3 are as defined in the specification.
7001918 7-pyrrolyl tetracycline compounds and methods of use thereof  
A compound of Formula (I): wherein variables R, R1, R2, R3 and A are as defined in the
7001901 Tetrazolylpropionamides as inhibitors of Aβ protein production  
This invention relates to novel tetrazolyl-propionamides in which the amide group comprises an aminoazepinone, and related structures, of Formula (I): or pharmaceutically acceptable salt or...
6995182 1-sulfonyl pyrrolidine derivatives  
The present invention is a series of compounds that are derivatives of 1-sulfonyl-pyrrolidine and that demonstrate affinity towards metabotropic glutamate receptors. The invention further relates...
6987112 Organic compound having cyano group and insecticides/miticides  
The present invention is directed to compounds represented by Formula (1); wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions...
6984633 Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone  
A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor...
6984651 Piperidine amides as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
6982264 Substituted alcohols useful in treatment of Alzheimer's disease  
The invention relates to substituted alcohol compounds of the formula (I): wherein X, R1, R2, R3, RN, R20 and RC are defined herein. The compounds are useful in the treatment or prevention of...
6967196 Sulfonamide compounds and uses thereof  
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
6962936 Triazole-derived kinase inhibitors and uses thereof  
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where Ht, R2, T, and m are as described in the specification. The compounds are useful for treating...
6951874 Compounds  
The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions...
6951878 Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)  
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein...
6949575 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives  
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is...
6949546 N-ureidoheterocycloalkyl-piperidines as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
6946492 Use of C2-substituted indan-1-one systems for preparing medicaments for the treatment of obesity  
Embodiments of the invention relate to methods of reducing weight in mammals and for the prophylaxis or treatment of obesity comprising administration of C2-substituted indan-1-one systems and...
6946474 Nitrogen-containing compounds and their use as glycine transport inhibitors  
The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such...
6927217 HIV protease inhibitors  
The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the...
6919343 N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives  
N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and...
6911463 3-substituted oxindole β-3 agonists  
The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and,...
6903086 Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists  
This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2, and A and...
6900234 Synergistic therapeutic compositions and methods  
Compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, synergistic compositions...
6881727 Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same  
Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
6878703 Pharmaceutical composition  
A pharmaceutical composition comprises an angiotensin II receptor antagonist selected from among compounds having the following formula (I), a pharmacologically acceptable salt thereof, a...
6869970 Crystalline salt forms of valsartan  
The invention relates to new forms of salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical...
6858634 Controlled release formulations and methods for their production and use  
Controlled release formulations for pesticides and herbicides contain an active ingredient, a matrix polymer and a matrix polymer plasticizer which is present in an amount sufficient to provide a...
6858636 1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders  
A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
6852743 Preventives for the recurrence of cerebrovascular failure and agents for ameliorating troubles following cerebrovascular failure and inhibiting progress thereof  
There is provided an agent for preventing the recurrence of cerebrovascular disorder and an agent for ameliorating troubles following cerebrovascular disorder and inhibiting the progress thereof...
6849618 Uracil substituted phenyl sulfamoly carboxamides  
Novel uracil substituted phenyl sulfamoyl carboxamides I and salts thereof, where A=oxygen or sulfur;X1=H, halogen, C1-C4-alkyl;X2=H, CN, CS—NH2, halogen, C1-C4-alkyl, C1-C4-haloalkyl;X3=H, CN,...
6849626 Aza-amino acid derivatives (factor Xa inhibitors 15)  
The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formula I can be employed as pharmaceutical...
6846839 Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis  
The present invention relates to methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis. More specifically, this invention relates to methods for...
6841563 Aryloxy propanolamines for improving livestock production  
Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group. R4...
6821960 Glucagon antagonists/inverse agonists  
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
6812237 N-substituted peptidyl nitriles as cysteine cathepsin inhibitors  
Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower...