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7452874 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
7439261 Process for the preparation of valsartan and intermediates thereof  
A novel process for the preparation of valsartan and novel intermediates useful in the preparation thereof.
7414068 Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them  
The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The...
7414071 Methods of treatment with selective EP4 receptor agonists  
The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the...
7378433 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
7365085 Compounds and methods  
Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as...
7361672 Heteroarylacetamide inhibitors of factor Xa  
The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) (I) wherein Ra to Re are as defined in the description and in the claims, as well as...
7351729 JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers  
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective...
7351730 Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)  
This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8, perfluoroalkyl, alkoxy,...
7348322 Glucocorticoid receptor modulators as antiinflammatory agents  
The present invention relates to compounds of formula I: wherein A, X, R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to methods of...
7348333 Cycloalkyl derivatives as inhibitors of bone resorption and vitronectin receptor antagonists  
There are described cycloalkyl derivatives of the formula (I) R1—Y-A-B-D-E-F-G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as...
7345071 Process for the synthesis of Losartan potassium  
Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of...
7345095 Sulfonamide compounds for the treatment of neurodegenerative disorders  
The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The invention...
7345072 Phenyltetrazole compounds  
Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
7342039 Substituted indole oximes  
The present invention relates to substituted indole oximes and methods of using them.
7332514 Dibenzylamine compound and medicinal use thereof  
A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 alkyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom,...
7332516 Geminally di-substituted NSAID derivatives as Aβ42 lowering agents  
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative...
7323480 Substituted triazoles as modulators of PPAR and methods of their preparation  
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present...
7323483 Processes and compounds for the preparation of substituted naphthylindole derivatives  
The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain...
RE40000 Method of treatment for decreasing mortality resulting from congestive heart failure  
A method of treatment using a compound of Formula I: wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;R2 is hydrogen, lower alkyl of up...
7307078 Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof  
Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and...
7291623 Compounds that interact with kinases  
A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose...
7285565 Benzamides and related inhibitors of factor Xa  
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
7271187 Compositions and methods for promoting tissue regeneration  
The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl...
7250433 Tetrazole and oxadiazolone substituted β-amino acid derivatives  
This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical...
7230022 Substituted fused bicyclic amines as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (Ia) and (Ib): or pharmaceutically acceptable salt forms thereof, wherein Z, R1, R2, R3, R4, R5, R5′, R6, a, b, c, d, and u are as...
7223780 Triazole-derivatives as blood clotting enzyme factor Xa inhibitors  
The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to...
7223746 Omega cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists  
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
7220771 Methods of using indazole derivatives as JNK inhibitors  
Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined...
7220734 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists  
The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as defined in...
7211594 Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith  
This invention is generally directed to Indazole Derivatives having the following structure: or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds...
7208505 β3 adrenergic agonists  
The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and,...
7205323 Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation  
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein.
7199144 Process for the preparation of valsartan and intermediates thereof  
Provided are process for the preparation of valsartan and the precursors thereof.
7186749 Pyrrolo-naphthyl acids and methods for using them  
The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
7169797 Protein-tyrosine phosphatase inhibitors and uses thereof  
The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine...
7157078 Devices and methods for eliminating termite colonies  
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such...
7138415 Indolamid derivatives which possess glycogenphosphorylase inhibitory activity  
Heterocyclic amides of formula (1) wherein: is a single or double bond;A is phenylene or heteroarylene;m is 0, 1 or 2;n is 0, 1 or 2;R1 is selected from for example halo, nitro, cyano, hydroxy,...
7138414 Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals  
The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives. Compounds are described of the...
7135490 Method for the treatment of glomerulonephritis  
A treatment for glomerulonephritis is disclosed comprising administering (±)-1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1 -[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazo le-7-carboxylate.
7135491 5-Aryltetrazole compounds and uses thereof  
The present invention relates to 5-Aryltetrazole Compounds, compositions comprising an effective amount of a a 5-Aryltetrazole Compound, and methods for treating an inflammation disease, a...
7132437 Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These...
7132409 Adenosine derivatives and use thereof  
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects...
7115624 Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48  
The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ,...
7112600 Fused-ring compounds and use thereof as drugs  
The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
7109203 Sulfonamide derivatives  
Sulfonamide derivitives of the formula I wherein R1-R6 are as defined in the description, processes for their production, their use as pharmaceuticals, particularly for use in the treatment or...
7105557 Polymorphs of valsartan  
Provided are crystalline and amorphous form of valsartan, and processes for their preparation.
7105172 Treatment of rosacea  
Disclosed herein are methods for the treatment or prevention of rosacea in a patient, including administering a compound that inhibits one or more components of the bradykinin activation pathway...
7101875 Methods for treating arthritic disorders  
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms...