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7824710 Crystalline and stable form of andolast  
Described is a new crystalline Form A of Andolast disodium salt, triclinic, displaying a thermal event at 98-112° C. and melting with decomposition at about 400° C. (DSC). Andolast disodium Form A...
7820663 Substituted enaminones, their derivatives and uses thereof  
The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of...
7816387 β secretase inhibitor  
The present invention relates to a compound of the formula (1): wherein R1 is group of the formula (2): (wherein X is nitrogen atom or C(R5), Y is nitrogen atom or C(R6), R5 and R6 are each...
7812044 Anticancer agents  
Remedies/preventives for hormone-independent cancer, hormone-independent cancer cell proliferation inhibitors, apoptosis inducers for cancer cells, etc. each containing a compound having an...
7807701 Dibenzylamine compounds and pharmaceutical use thereof  
A dibenzylamine compound represented by the formula (1) wherein R1 and R2 are each a C1-6 allyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom,...
7807702 Substituted thiophene carboxylic amide glucagon receptor antagonists, preparation and therapeutic uses  
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as...
7790770 Heterocyclic CETP inhibitors  
Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
7781470 Aminodicarboxylic acid derivatives having pharmaceutical properties  
The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these...
7745440 Pyrazole analogs acting on cannabinoid receptors  
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or...
7741353 Lead-free primary explosives  
Lead-free primary explosives of the formula (cat)Y[MII(T)X(H2O)6-X]Z, where T is 5-nitrotetrazolate, and syntheses thereof are described. Substantially stoichiometric equivalents of the reactants...
7741354 Inhibitors of glutaminyl cyclase  
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, wherein: R1 represents heteroaryl, -carbocyclyl-heteroaryl, -alkenylheteroaryl or...
7741352 KCNQ channel modulating compounds and their pharmaceutical use  
This invention relates to novel compounds useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
7728024 Metal salts of 2′-(1H-Tetrazol-5yl)-1.1′-biphenyl-4-carboxaldehyde  
The invention relates to a method or process for the manufacture of blood pressure lowering agents, such as valsartan, novel intermediates as well as process steps in said synthesis. The method or...
7728023 Indole compound and use thereof  
The present invention relates to a compound represented by the formula (I), wherein all symbols are as defined in the description, a salt thereof, a solvate thereof, or a prodrug thereof, which...
7728021 Process for the preparation of Valsartan and precursors thereof  
This invention relates to a process for preparing intermediates useful in preparing Valsartan and to a process for preparing the latter, together with synthesis intermediates of formula (IV), (V)...
7728022 (4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease  
Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of Aβ in the brain.
7723362 Pesticidal heterocyclic dihaloallyl compounds  
The invention relates to compounds of formula whereinHet, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z isomers,...
7723367 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and...
7713964 Methods for treating asthmatic conditions  
This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms...
7705016 Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus  
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in...
RE41226 Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase  
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine...
7691891 Diphenylurea derivatives and their use as chloride channel blockers  
The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy,...
7687528 Pharmaceutical compositions of an AT1-receptor antagonist and an insulin secretion enhancer  
The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients (i) an AT1-receptor antagonist or a pharmaceutically acceptable salt...
7687481 Cannabinoid receptor antagonists/inverse agonists useful for treating obesity  
The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity,...
7678794 Potentiators of glutamate receptors  
The present invention provides a compound of formula (I): pharmaceutical compositions thereof, and methods of using the same, processes for preparing the same, and intermediates thereof.
7666857 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3′-(1h-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline  
An improved thrombopoietin mimetic, the choline salt of 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3′-(1H-tetrazol-5-yl)bi phenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one.
7666866 Antithrombotic diamides  
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of...
7666865 Calcium channel blockers  
Compounds of the formula wherein m is 0, 1 or 2;wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C;Y is H, OH, NH2, or an organic moiety of 1-20C, optionally additionally...
7662804 Thrombopoietin activity modulating compounds and methods  
Disclosed herein are novel diazenyl pyrazole compounds and related compounds. Also disclosed herein are methods of using these compounds for the treatment of diseases and conditions associated...
7659294 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists  
The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive,...
7642277 Non-nucleoside reverse transcriptase inhibitors  
Disclosed herein are compounds of formula Ar1—X—W—Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles...
7638514 Pesticidally active phenol derivatives  
There are described compounds of formula (I) wherein X1 and X2 are each independently of the other fluorine, chlorine or bromine; A1 and A2 are, for example, a bond or a C1-C6alkylene bridge; A3...
7629369 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation  
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl,...
7625933 Indoles having anti-diabetic activity  
Indoles of Formula I having —X-aryl-(CH2)x-oxazolidinedione and —X-heteroaryl-(CH2)x-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and —X— is a bond or —CH2—,...
7625932 Pyrrole and pyrazole derivatives as potentiators of glutamate receptors  
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive...
7625926 P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same  
The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a...
7605156 Methods for the use of inhibitors of cytosolic phospholipase A2  
This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use...
7601747 One-pot process for making di-functional di-tetrazole diols to produce tetrazole based polymers  
A one-pot process for making energetic cast cured binders making di-tetrazoles to produce di-functional di-tetrazole diols for making tetrazole base polymers. Embodiments of the present invention...
7592337 Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5  
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
7576112 Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives  
A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
7576098 Heterocyclic compounds as inhibitors of factor VIIa  
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
7563804 FMF treatment  
The method of improving FMF control, in humans, which includes administering, on an average daily basis, between 5 and 15 milligrams of LTRA to a patient suffering from FMF.
7553861 Dipeptidyl peptidase-IV inhibitors  
The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods...
7538128 Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them  
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein.
7538133 Benzimidazole derivatives, their production and use  
Benzimidazole derivatives of the formula (I): wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R′ group; R1 is hydrogen or an optionally...
7528156 Compounds  
The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation,...
7517896 Aminodicarboxylic acid derivatives having pharmaceutical properties  
The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these...
7491741 Diaminopropionic acid derivatives  
A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
7482371 N-phenylbenzamide derivatives as drugs for the treatment of COPD  
The invention relates to the use of a pharmaceutically active derivative of N-phenylbenzamide of Formula (I) or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the...
7468390 Methods of treatment and pharmaceutical composition  
The invention relates a pharmaceutical composition comprising a combination of: (i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof; and(ii) a NEP inhibitor or a...