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8071628 Indazole derivatives  
The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically...
8063082 Certain chemical entities, compositions, and methods  
Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin...
8058301 Salt hydrates  
The invention relates to new forms of salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical...
8053455 Angiotensin II receptor antagonists  
A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of and...
8053453 Pyrazolone compounds and thrombopoietin receptor activator  
A preventive, therapeutic or improving agent for diseases against which activation of the thrombopoietin receptor is effective or a platelet increasing agent, which contains a thrombopoietin...
8053454 Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3  
Compounds of formula (I), useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4 are as defined above. Pharmaceutical...
8053431 Pharmaceutical use of substituted amides  
The use of substituted amides for modulating the activity of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a...
8048903 5-iodotetrazoles  
The compounds of the formula (I) in which R1 represents hydrogen or in each case optionally substituted alkyl, alkenyl, alkynyl or phenyl are highly suitable as microbicides for protecting plants...
8039019 Pharmaceutical formulation containing a biguanide and an angiotensin antagonist  
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a angiotensin antagonist is herein...
8039495 Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
8034810 Arylsulfonamido-substituted hydroxamic acid derivatives  
α-Amino hydroxamic acid derivative of the formula I, in which R is C2-C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3-C5-cycloalkyl or...
8030307 Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease  
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of...
8022086 Therapeutic agent for glomerular disease  
The present invention relates to a preventive and/or therapeutic agent for a glomerular disease containing, as active ingredients, pitavastatin or a salt thereof and candesartan cilexetil or a...
8017607 N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions  
There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, and R5 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof which are...
RE42700 Induction of apoptosis in cancer cells  
The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
8008290 Compounds  
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein:R3 is selected from cyclopentyl and...
8003680 Therapeutic compounds  
Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
8003679 Use of inhibitors of the renin-angiotensin system  
Inhibitors of the rennin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia, such as stroke.
7981914 Tetrazole-substituted aryl amide derivatives and uses thereof  
Compounds of the formula: wherein R1, R2, Ar1, Ar2, and n are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
7964625 Antibiotics comprising bis(1-aryl-5-tetrazoly1)methane derivatives  
The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds, the bis(1-aryl-5-tetrazolyl)methanes,...
7960422 Pharmaceutically active compounds containing tetrazolyl and triazolyl rings  
Compounds of formula (I) wherein R1 is as well as pharmaceutically acceptable salts, hydrates and/or enantiomers thereof are useful as compounds that exhibit activity at metabotropic glutamate...
7960417 Benzazole potentiators of metabotropic glutamate receptors  
The present invention is directed to benzazole compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or...
7956054 Dual-acting pyrazole antihypertensive agents  
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
7943644 Stabilization of iodine-containing biocides by means of special azole compounds  
Specific azole compounds are outstandingly suitable for stabilizing iodine-containing biocides in industrial materials, more particularly in paints based on alkyd resin.
7943648 Salts of imidazole-5-carboxylic acid derivatives, a method for preparing same and pharmaceutical compositions comprising same  
The present invention provides pharmaceutically acceptable salts of imidazole-5-carboxylic acid derivatives, methods for preparing same and pharmaceutical compositions comprising same. The salts...
7943647 Process for the preparation of tetrazole derivatives from organo aluminium azides  
The present invention relates to a method for preparing substituted tetrazoles of the formula or a tautomer or salt thereof, wherein R represents an organic residue. Also provided are compounds...
7943650 Methods of treating cancer with imidazolyl compounds  
Disclosed in certain embodiments is a method of treating and/or mitigating prostate cancer, ovarian cancer, melanoma, colorectal cancer, breast cancer or lung cancer, comprising administering to...
7932279 Substituted tetrazole compounds and uses thereof  
The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole...
7919506 Dibenzyl amine compounds and derivatives  
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density...
7906513 Hydrazide-containing hepatitis C serine protease inhibitors  
The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine...
7906501 Pyrrole derivatives with angiotensin II antagonist activity  
Compounds which may be represented by the general formula (I) shown below and in which: R1 is a group independently selected from among: CHO, —COOH, —CH2OH R2 is hydrogen or a linear or branched...
7906546 Tetrahydrocarbazoles and derivatives  
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts...
7906539 Imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions  
The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the mixtures...
7893097 Methods and compositions for increasing solubility of azole drug compounds that are poorly soluble in water  
The combination of any two of a polyol, a polyol ether, and a low carbon organic alcohol provides a synergistic effect on the solubility of azole compounds, such as metronidazole, in aqueous fluid.
7888380 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives  
1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of...
7884118 1-cycloalkyl-5-iodotetrazoles  
The compounds of the formula (I) in which R1 represents cycloalkyl, and its stereoisomers and any mixtures thereof are highly suitable as microbicides for protecting plants and materials.
7879893 Ligands for the HisB10 Zn2 + sites of the R-state insulin hexamer  
The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to...
7875641 Sesquihydrate hydrochloride salt of irbesartan  
The present invention relates to sesquihydrate hydrochloride salt of irbesartan and pharmaceutical compositions comprising the same.
7872035 Angiotensin II antagonists  
The present invention relates to the use of an angiotensin II type 1 receptor antagonist of the general formula (I) in the manufacture of a medicament for the prophylactic and/or therapeutic...
7867991 Compositions comprising novel PPAR ligands and anti-hyperlipemic agents  
Methods are provided for treating or preventing conditions comprising hypertension and dyslipidemia using antihyperlipemic agents and compounds that antagonize the angiotensin II type 1 (AT1)...
7858651 Imidazole-5-carboxylic acid derivatives, the preparation method therefor and the uses thereof  
The invention discloses imidazole-5-carboxylic acid derivatives, and their preparation methods. The derivatives of the invention are Angiotensin II receptor antagonists with angiotensin II...
7858645 Indazole derivatives  
The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically...
7858646 Potentiators of glutamate receptors  
The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
7851492 ERG channel openers for the treatment of cardiac arrhythmias  
This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention...
7851494 Method for the treatment of metabolic disorders  
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
7842708 Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors  
The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as...
7842711 Indazolecarboxamide derivatives for the treatment and prevention of malaria  
The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of...
7834041 Dual-acting antihypertensive agents  
The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have...
7834042 Angiotensin II receptor antagonists  
A compound having the structure (Formula I), wherein Y is —Y1—Y2—Y3—Y4—Y5—; Y1 is C(O) or C(R1R2); Y2 is O, C(O), P(O)(OH) or CH2, provided that when Y1 is C(O), Y2 is not C(O); R1 is selected...
7825152 Organic compounds and their uses  
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.