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8633182 Indanyloxyphenylcyclopropanecarboxylic acids  
The present invention relates to compounds of general formula I, wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular...
8623897 Methods and compositions for treatment of diabetes and dyslipidemia  
The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.
8604070 Use of inhibitors of the renin-angiotensin system  
It has been found that inhibitors of the rennin-angiotensin system are useful for the treatment or prevention of conditions associated with hypoxia or impaired metabolic function or efficiency. In...
8592412 Plant disease control agent  
The present invention provides a plant disease control agent containing at least one of tetrazoyloxime derivatives and salts thereof, and at least one selected from the group consisting of...
8592461 Plant disease control agent  
The present invention provides a plant disease control agent containing at least one of tetrazoyloxime dirivatives and salts thereof, and at least one selected from the group consisting of...
8575205 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases  
Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with...
8569381 Combination therapy for the management of hypertension  
The present invention includes a combination comprising: a) mecamylamine; and b) an ACE inhibitor, an AT2 receptor inhibitor, a renin inhibitor, or a combination thereof.
8568747 Enalapril compositions  
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain...
8569334 P2X7R antagonists and their use  
The present application is directed to novel P2X7R antagonists that are indol-3-carboxamide or azaindole-3-carboxamide compounds, pharmaceutical compositions comprising the same and their use for...
8563586 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation  
The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for...
8557850 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Plant disease control agent
 
The present invention provides a plant disease control agent containing at least one of tetrazoyloxime dirivatives and salts thereof, and at least one selected from the group consisting of...
8546432 Tetrazolones as inhibitors of fatty acid synthase  
Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are...
8546374 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and...
8546389 Viral polymerase inhibitors  
The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof, processes for their preparation and...
8536211 Process for the preparation of 5-substituted 1-alkyltetrazoles  
The present invention relates to a process for the preparation of 5-substituted 1-alkyltetrazoles.
8530506 Process for production of biphenyl derivative  
The invention provides a production method of a biaryltetrazole derivative useful as an intermediate for an angiotensin II receptor antagonist. The method comprises reacting an aryltetrazole...
8501811 TASPASE1 inhibitors and their uses  
Provided herein are small molecule inhibitors of Taspase1 and methods of using the small molecule inhibitors of Taspase1 to treat neoplasm in subjects in need thereof.
8475839 Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same  
Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.
8470812 Substituted benzo-pyrimido-tetrazolo-diazepine compounds  
The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical...
8466145 Dipeptidyl peptidase IV inhibitors  
Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts,...
8455526 Therapeutic use of imidazole-5-carboxylic acid derivatives  
The invention discloses the use of 2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl)1,1′-biphenyl-methy l]-imidazole-5-carboxylic acid, 1-[(isopropoxycarbonyl)oxy] methyl ester and the pharmaceutically...
8445527 Organic compounds and their uses  
The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or...
8440008 Preparation of a lead-free primary explosive  
Described are compounds and materials that may be used as a lead-free primary explosive, such as copper(I) nitrotetrazolate. Copper(I) nitrotetrazolate may he prepared by a process comprising the...
8435563 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same
 
Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.
8431606 Medicament for treating schizophrenia comprising cilostazol  
The invention relates to a medicament for preventing and/or treating schizophrenia which comprises as an active ingredient cilostazol or a pharmaceutically acceptable salt thereof.
8410141 Insecticidal arylpyrrolines  
The invention relates to novel arylpyrroline compounds of formula (I) which have excellent insecticidal activity and which can thus be used as an insecticide.
8410106 Hydrazine-substituted anthranilic acid derivatives  
The present invention constitutes new hydrazine-substituted anthranilic acid derivatives of the general formula (I), in which R1, R2, R3, R4, R5, R6, Qx, A, Qy and n have the definitions indicated...
8410154 Tetrazole compounds for reducing uric acid  
Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I. The uric acid-lowering effects of the compounds of this invention are...
8410097 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect...
8404730 3-substituted propanamine compounds  
Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed....
8404744 Methods of treatment and pharmaceutical composition  
The invention relates a pharmaceutical composition comprising a combination of (i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof and (ii) a NEP inhibitor or a...
8404727 Pharmaceutical composition that includes a dipeptidyl peptidase-IV inhibitor  
The present patent application relates to a pharmaceutical composition for oral administration that includes a certain pyrrolidine derivative as DPP-IV inhibitor, and a pharmaceutically acceptable...
8394846 Dual-acting antihypertensive agents  
The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I...
8394844 EP4 agonist  
Provided is a compound represented by the formula (1): wherein R1 and R2 are each independently a hydrogen atom or a straight chain alkyl group having a carbon number of 1-3, R3 is a hydrogen...
8394845 Method of using combination preparation comprising angiotensin-II-receptor blocker and HMG-CoA reductase inhibitor  
Disclosed herein is a combination therapy and a combination preparation of an angiotensin-II-receptor blocker and an HMG-CoA reductase inhibitor characterized in that the angiotensin-II-receptor...
8394799 Compounds that inhibit HIF-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component  
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer...
8389500 Fused heterocyclic compounds as ion channel modulators  
The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In...
8383660 Dibenzyl amine compounds and derivatives  
Dibenzyl amine compounds and derivatives of Formula I, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high...
8383654 Heterocyclic antagonists of prostaglandin D2 receptors  
Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described....
8377978 Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors  
The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also...
8367711 Angiotensin II receptor antagonists  
A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) —C(R1R2) (C(R3R4))0-1Y1R5, and 3) —C(R1R2)—O—Y1R5; R1, R2, R3 and R4 are...
8367709 Dipeptide analogs as coagulation factor inhibitors  
Disclosed are novel dipeptide analogs compounds of Formula (I), (II) or (III): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a solvate, or a prodrug thereof, which are...
8367710 Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof  
The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions...
8361959 Spiro-imidazolone derivatives as glucagon receptor antagonists  
The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to...
8362054 Therapeutic substituted lactams  
Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.
8362017 C-kit modulators and methods of use  
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death,...
8357705 Substituted cyclohexyldiamines  
The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these...
8344002 Compound having β-secretase inhibitory activity  
A novel compound represented by the formula (1) below which has β-secretase inhibitory activity, its pharmaceutically acceptable salt or a prodrug thereof. wherein Ar is a substituted or...
8338440 Inhibitors of IAP  
Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
8338418 Dual-acting antihypertensive agents  
In one aspect, the invention relates to compounds having the formula: wherein: Ar, r, Z, X, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...