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5227393 α-fluoro-α-tetrazolyl-phenylmethyl derivatives useful as aromatase inhibitors  
Compounds of formula I ##STR1## wherein Z, R, R1, R2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are...
5225428 Cyclic-substituted imidazolyl-propenoic acid derivatives  
Cyclic-substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes and subsequent elimination of water. The cyclic-substituted imidazolylpropenoic acid derivates are...
5225429 Fluorinated arachidonic acid derivatives  
Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example,...
5223517 Heterocyclically substituted cycloalkano[b]-indolesulphonamides  
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
5223516 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same  
Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
5216004 Method for preventing malaria  
A method is provided for preventing malaria by administering to a subject an effective amount of activin, inhibin, an inhibin chain, a butyrate analog, or mixtures thereof, to inhibit the...
5215994 Angiotenin II antagonizing heterocyclic derivatives  
The invention relates to compounds of the formula ##STR1## wherein ##STR2## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification....
5216003 Diacid-containing benzimidazole compounds for treatment of neurotoxic injury  
A class of diacid-containing benzimidazole compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or...
5212195 Substituted indole antagonists derivatives which are angiotensin II  
Compound of the Formula (I), (II), or (III): ##STR1## wherein: R1 is lower alkyl or 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl; R2 is lower alkyl when R1 is...
5210079 Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists  
Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)meth yl]-5-(hydroxy methyl)imidazole and...
5210092 Angiotensin II antagonizing heterocyclic derivatives  
The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin...
5206253 Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds  
The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if...
5196444 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-c arboxylate and compositions and methods of pharmaceutical use thereof  
1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzi midazole-7-car boxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II...
5192800 Glutaramide diuretic agents  
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent...
5192788 Porphyrin antiviral compositions  
Compositions for the treatment or prevention of AIDS or other diseases resulting from infection with the Human Immunodeficiency Virus containing one or more porphyrins.Porphyrins are tetrapyrrole...
5189051 Treatment of glaucoma and ocular hypertension with pyrrole angiotensin-II receptor antagonists  
Substituted pyrrole, angiotensin-II receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating glaucoma and ocular hypertension.
5189048 Substituted 1,2,3 triazole angiotensin II antagonists  
This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and...
5183810 Imidazole angiotensin II antagonists incorporating a substituted benzyl element  
Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
5179112 Heterocyclic amide derivatives and pharmaceutical use  
The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts...
5179113 Treatment of central nervous disorders with imidazole compounds  
Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamid omethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically...
5177092 Medicinal use of certain tetrazolium salts  
Azole compounds including azoles and azolium salts, and their use as transglutaminase inhibitors are disclosed.
5177096 Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5175180 N-substituted N-(alpha-triazolyl-toluyl)pyrrole compounds and use for treatment of circulatory disorders  
A class of N-substituted N-(α-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
5173500 Pharmaceutical compositions and methods of sulphonamides containing a tetrazolyl radical  
The present invention provides sulphonamides of the general formula: ##STR1## wherein R is a hydrogen or halogen atom, a cyano group or a C1 -C6 -alkyl or trifluoromethyl radical, n is 1, 2 or 3,...
5171748 Benz[4,5]imidazole-containing angiotensin antagonists  
The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The...
5166212 Certain n-substituted butyramide derivatives  
Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and...
5164381 Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same  
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
5155126 Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists  
Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as...
5155118 Method and composition for preventing NSAID-induced renal failure  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5153214 Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity  
The present invention is concerned with compounds of formula I ##STR1## wherein A, B, M, R, Ar and Het are as defined in the specification, pharmaceutically acceptable ester and amide derivatives...
5153197 Treatment of hypertension with angiotensin II blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5147885 N-amino bicyclic compounds  
N-amino hexahydrocyclopenta imidazole-2(1H)-one derivatives useful for treating or preventing thrombo-embolic disorders and ocular diseases characterized by increased ocular pressure.
5143931 Leukotriene antagonists containing tetrazolyl groups  
This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such...
5137902 4-Alkylimidazole derivatives and anti-hypertensive use thereof  
Angiotensin II antagonist antihypertensive compounds such as ##STR1## where R2 is --CHO or --COOH and R1 is ethyl have outstanding orally potency.
5135941 LTB4 synthesis inhibitors  
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CHCH-- or --CHN--; wherein R1 is alkyl, alkenyl or...
5135940 Leukotriene antagonists  
Compounds of the Formulae: ##STR1## are antagonists of leukotrienes of C4, D4 and E4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic,...
5134142 Pyrazole derivatives, and pharmaceutical composition comprising the same  
The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.
5128356 Benzimidazole derivatives and their use  
Novel imidazole derivatives of the formula (I): ##STR1## wherein R1 is an optionally substituted alkyl group, R2 and R3 are independently a group capable of forming an anion or a group which can...
5128355 Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles  
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
5128346 Derivatives of D-glutamic acid and D-aspartic acid  
A compound of the formula: ##STR1## wherein R1 and R2 are substituents; R6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a...
5118700 Indole derivatives and compositions for their use in medicaments  
Indole derivative for leukotriene antagonists of the formula ##STR1## wherein groups A, B, D, E, F & G are as described in the specification.
5110825 Benzofuran derivative  
The compounds of the present invention inhibit HMG-CoA reductase, subsequently suppress the synthesis of cholesterol; and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia,...
5100910 Aryl substituted tetrazole derivatives, and application thereof in therapeutics  
Compounds for therapeutic use of formula: ##STR1## where the chain--W--V--N--represents--NN--N--, --N--NN--, --O--CO--N--, --O--CS--N--, --S--CO--N-- or --S--CS--N--; Ar is an aryl group; and A...
5098920 1H-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders  
A class of 1H-substituted-1,2,4-triazole compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of the formula...
5093346 Substituted 1,2,4-triazole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5093339 Pyrano[f]quinoline derivatives and pharmaceutical compositions containing the same  
Pyrano[f]quinoline derivatives of the formula (I): ##STR1## wherein R1 and R2 represent hydrogen, hydroxyl group or a group of the formula: ##STR2## wherein n represents an integer from 1 to 4, R3...
5091397 1-aza-bicyclico(2.2.1)heptanes  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents --CH2 --Z where Z is a group ##STR2## in...
5081138 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith  
Compounds having the formula: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5081127 Substituted 1,2,3-triazole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5073574 Tetrazolyl substituted benzonitriles and anti-tumor use thereof  
Compounds of formula I, ##STR1## wherein Tetr, R, R0, R1 and R2 are as defined in the description, have valuable pharmaceutical properties and are especially effective against tumors. They are...