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5364876 Omega-[2-(alkyl)phenyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors  
The present invention pertains to antagonists of excitatory amino acid receptors, their method of preparation as well as compositions pertaining to them, which have the general formula: ##STR1##...
5362744 Tetrazole-substituted urea acat inhibitors  
Novel ACAT inhibitors useful in the treatment of atherosclerosis which are tetrazole-substituted ureas,
5356919 Leukotriene B4 synthesis inhibitors  
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CHCH--, or --CHN--; wherein R1 is --CO2 R2 or...
5352690 1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists  
This invention provides 1,2,4-trioxygenated benzene derivatives which are leukotriene B4 antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment...
5350751 Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure  
The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR2, R1 and R2 are as defined in the description, L is an alkylene radical,...
5340826 Pharmaceutical agents for treatment of urinary incontinence  
The present invention relates to a method of treating or preventing urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane...
5338740 Angiotensin II receptor antagonists  
The present invention relates to novel heterocyclic derivatives of the formula Ar--W--Hetwherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising...
5338756 Benzimidazole compounds  
Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5328919 Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof  
Pivaloyloxymethyl2-ethoxy-1-[['-(1H-tetrazol-5-yl)biphenyl-4 -yl]methyl]benz imidazole-7-carboxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR1 R2 --CO--Y--NR3 --CHR4 --CR5 --CH2 --(CR6 R7)r --Z--Het Iin which R1 to R7, W, X, Y, Z, r and Het have the meanings defined herein, and the...
5318981 Cholecystokinin antagonists useful in the treatment of panic attacks  
Unnatural dipeptoids of α-substituted Try-Phe derivatives are useful as agents in the treatment of panic disorders. These dipeptoids are Cholecystokinin-B Receptor (CCKB) antagonists having...
5318980 Sulphonylbenzyl-substituted imidazoles  
Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary...
5314880 Benzimidazole derivatives  
Compounds of general formula I: ##STR1## wherein: each of R1 -R8, k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their...
5312828 Substituted imidazoles having angiotensin II receptor blocking activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5312760 Fructosamine reagent and calibrator system  
A system for determining the concentration of fructosamine in sera which consists of a first reagent in which a tetrazolium salt which reduces all reactive substances in sera including...
5312820 Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines  
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT1 and AT2 activity useful in the treatment of hypertension and related...
5312818 Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromboxane A2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation  
A method is provided for protecting against and/or treating ulcerative gastrointestinal conditions, including anti-inflammatory drug-induced gastrointestinal ulcers, using a thromboxane A2...
5308853 Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties  
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and method of using them. Intermediates...
5302610 Renal-selective biphenylmethyl imidazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These...
5298519 Acylals of imidazole-5-carboxylic acid derivatives, and their use as angiotensin (II) inhibitors  
Novel imidazole-5-carboxylic acid acylals of the general formula ##STR1## in which R1 denotes an optionally unsaturated, straight-chain alkyl group having 1-6 carbon atoms, R2 denotes hydrogen,...
5298520 Triazole containing indole derivatives  
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular...
5296499 Indole derivatives, their production and use  
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl...
5294631 Substituted benzimidazoles useful as angiotension II receptor antagonists  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5294613 Method of treating endotoxic shock in mammals  
This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.
5294633 Imidazolyl-propenoic acid derivatives  
Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in...
5294632 Phosphono/biaryl substituted dipetide derivatives  
The invention relates to the N-phosphonomethyl-biaryl substituted dipeptide derivatives of formula I ##STR1## and tetrazole derivatives of the formula Ia ##STR2## wherein A represents a direct...
5281615 Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension  
A class of cycloheptimidazolone compounds is described as angiotensin II antagonists for use in control of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein...
5276048 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity  
Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates...
5273990 Phosphono substituted tetrazole derivatives  
The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula I ##STR1## and tautomers thereof wherein R1 is aryl or biaryl; n is zero, 1 or 2...
5270317 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present  
The invention relates to N-substituted heterocyclic derivatives and its salts.These derivatives have the formula ##STR1## in which the substituents are as defined in the specification....
5266583 Angitotensin II antagonist  
A human urinary metabolite of Losartan has been isolated and identified as structure I. ##STR1## This compound is an active angiotensin II receptor antagonist useful in the treatment of...
5264447 Angiotensin II antagonist  
A human urinary metabolite of Losartan has been isolated and identified as Structure I: ##STR1## This compound is an active angiotensin II receptor antagonist useful in the treatment of...
5262433 Tetrazoleacetic acid derivatives and method of aldose reductase inhibition therewith  
A tetrazoleacetic acid derivative represented by the following general formula I: ##STR1## wherein in the formula I, R represents a hydrogen atom or a lower alkyl group; A is an alkylene group...
5260325 Angiotensin II receptor blocking tertiary amides  
Novel substituted tertiary amides of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5260322 Angiotension II antagonists in the treatment of hyperuricemia  
A pharmaceutical composition comprising a non-peptide type angiotension II receptor antagonist is useful for the treatment of hyperuricemia.
5254595 Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them  
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
5254546 Fused aryl substituted imidazole angiotensin II receptor inhibitors  
Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
5250529 Method alleviating migraine headache with mast cell degranulation blocking agents  
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the...
5250554 Benzimidazole derivatives useful as angiotensin II inhibitors  
Novel imidazole derivatives of the formula (I): ##STR1## wherein R1 is an optionally substituted alkyl group, R2 and R3 are independently a group capable of forming an anion or a group which can...
5246940 Substituted N-biphenylyl lactams  
This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof.The...
5242939 Anilide derivatives with angiotensin II antagonist properties  
This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension,...
5240946 ((2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino)alkyl)-acid derivatives  
A compound of the formula: ##STR1## in which R1 is hydrogen, alkyl or phenylalkyl; R2 is hydrogen, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together are --CH2 CH2 --, --CH2 C(R6)(R7)CH2...
5238952 N-substituted imidazol-2-one compounds for treatment of circulatory disorders  
A class of N-substituted imidazol-2-one compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula...
5236928 Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists  
There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists. ##STR1##
5236943 Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia  
The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole,...
5234942 Heterocyclic amides and leucotriene antagonistic use thereof  
The invention provides a series of novel heterocyclic amides of the formula I in which the group A; CRa can be --CRbCRa--, --CHRb--CHRa-- or --NCRa--, the amidic group Re.L can be Rd.X.CO.NH,...
5234917 Substituted 5-(alkyl)carboxamide imidazoles  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
5232948 Substituted monocyclic aryl compounds exhibiting selective leukotriene B4 antagonist activity  
Monocyclic aryl compounds having selective LTB4 antagonists properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a...
5232937 Derivatives of N-phenylbenzamide with anti-ulcer and anti-allergy  
Derivatives of N-phenylbenzamide with general formula (1) in which R1 is a cyano, nitro, halogen, hydrozy, C1 -C4 alkyl methyl, methoxy or tetrazol-5-yl group, R2 is hydrogen, hydroxy, or methoxy,...
5229406 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders  
A class of 1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula...