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5523312 Antipicornaviral agents  
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
5521177 Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them  
The invention relates to benzimidazoles of general formula ##STR1## Exemplary compounds are: (a) 4'-[[2-Ethyl-4-methyl-6-[(2-dimethylamino-3,4-dioxo-1-cyclob uten-1-yl)amin...
5519043 Fluorenyl derivatives  
The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one...
5510362 Imidazole, triazole and tetrazole derivatives  
A class of substituted imidazole, triazole and tetrazole derivatives of formula (I), wherein the broken circle represents two non-adjacent double bonds in any position in the five-membered ring;...
5508297 Vascular hypertrophy suppression treatment  
This invention relates to a method for the prophylaxis or treatment of vascular hypertropy in a mammal by administering a pharmaceutically effective amount of a compound represented by the formula...
5506243 Sulfonamide derivatives  
Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as...
5504099 Injection solutions of azosemide which are ready for injection  
Aqueous injection solution that is ready-for-injection of a water-soluble, physiologically well-tolerated azosemide salt of an organic amide, which contains an organic solvent and if desired, a...
5494926 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR8 (R8 is H or C1-6...
5492904 Composition of angiotensin-II receptor antagonists and calcium channel blockers  
Novel pharmaceutical compositions containing a combination of an angiotensin-II antagonist and a calcium channel blocker such as 2-butyl-4...
5482957 Azole derivatives, process for their preparation and their use  
Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R1, X, Y, Z and q have the meanings given, process for their...
5478857 Use of PLA2 inhibitors as treatment for alzheimer's disease  
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of...
5472973 Fluorenyl derivatives as anti-inflammatory agents  
The compound having the formula: ##STR1## and a method of treating an inflammatory condition comprising administering to an animal in need of such treatment an effective amount of at least one...
5466704 N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists  
Compounds are disclosed having the formula ##STR1## These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
5464854 Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.  
The method of treatment moderating, blocking and/or eliminating premenstrual syndrome embodies the intermittent administering of an AT1 antagonist to a female having menstrual cycles characterized...
5462963 Chelator compositions comprising α-diamine compounds  
The present invention involves photoprotective compositions which are useful for topical application to prevent damage to skin caused by acute or chronic exposure to ultraviolet light comprising...
5462954 Substituted phenyl phenol leukotriene antagonists  
Antagonists having a substituted phenyl phenol or a substituted phenolic biphenyl structure, and various derivatives thereof, are specific leukotriene antagonists. Their structures, use and...
5461049 Amide tetrazole ACAT inhibitors  
Amide tetrazoles of the formula ##STR1## wherein aryl includes phenyl and naphthyl, unsubstituted or substituted, X is O, N--R5, or --NR3 R4, where R2, R4, and R5 include alkyl and alkoxy and R3...
5459134 (Fused) benz (thio) amides  
A novel (fused) benz(thio)amide of the general formula: ##STR1## or a non-toxic salt thereof, wherein R4 represents:(i) when B represents a closed ring, a group of the general formula: ##STR2##...
5459148 Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease  
Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R1 is alkyl, alkenyl, cycloalkyl or a group of formula R4 --Y--R5 --, where: R4 is hydrogen,...
5457114 Amidinophenylalanine derivatives, a process for the preparation thereof, use thereof and agents containing these as anticoagulants  
Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.
5455222 1-substituted-5-thiomethylthiocyanato-1H-tetrazoles, compositions containing them and their use as antimicrobial and marine antifouling agents  
Disclosed are substituted-5-thiomethylthiocyanato-1H-tetrazole compounds corresponding to the formula ##STR1## wherein R represents a C1 -C6 straight or branched chain alkyl radical, a C3 -C6...
5451597 Treatment of circulatory disorders using n-substituted (α-imidazolyl-toluyl) pyrrole angiotensin II antagonists  
A class of N-substituted (α-imidazolyltoluyl)pyrrole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
5449682 Angiotensin II antagonists incorporating a substituted benzyl element  
Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents...
5444081 Substituted histidines having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5444080 Substituted [1H-imidazol-5-ylialkanoic acids having angiotension II receptor antagonist activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5436260 Angiotensin II receptor antagonists  
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Intermediates...
5434167 Imidazolines N-substituted by a biphenylmethyl group, their medical use and the pharmaceutical compositions therefor  
The invention relates to compounds of the formula ##STR1## in which X and R1 -R5 are defined in the specification and their salts where appropriate, all of which are useful as angiotensin II...
5430047 Neurotensin antagonists  
Neurotensin antagonists are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful...
5426113 Method of preventing ulcer formation caused by nonsteroidal antiinflammatory drugs employing tetrazol-benzothiophene carboxamide compounds  
Tetrazol-benzothiophenes carboxamides or a pharmaceutically acceptable salt thereof are useful in preventing ulcer formation caused by nonsteroidal antiinflammatory drugs in mammals.
5426114 ω-[2-(tetrazolylalkyl)cyclohexyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors  
The present invention pertains to antagonists of excitatory amino acid receptors, their method or preparation as well as compositions pertaining to them, which have the general formula: ##STR1##...
5426105 Conformationally restricted angiotensin II antagonists  
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest...
5414008 Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives  
Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The...
RE34918 Azaazulene compounds which are useful as antiallergic and antiinflammatory agents  
An azaazulene derivative having the general formula (I): ##STR1## wherein R1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond or...
5409947 Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds  
New therapeutic agents of cycloheptimidazole derivatives are disclosed, which are represented by the following formula or its alkali-addition salts. ##STR1## (wherein R1 represents H or isopropyl...
5407951 Sulphonamidocycloalkane compounds, pharmaceutical compositions containing them, and methods of use thereof  
The present invention provides sulphonamides of the general formula: ##STR1## wherein R1 and R2, which can be the same or different, are hydrogen or halogen atoms or C1 -C6 -alkyl,...
5401764 Benzimidazole derivative compositions and medical use thereof  
1-Acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzi midazole-7-car boxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II antagonistic activity...
5395840 Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives  
Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides.The compounds can be employed...
5393762 Pharmaceutical agents for treatment of emesis  
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives...
5393767 Insect control with substituted triazole and tetrazole compounds  
Insects, especially sucking insects, such as brown planthoppers, and phytophageous mites, such as two-spotted spider mites, are controlled by applying an triazole or tetrazole compound substituted...
5393768 Leukotriene antagonists  
This invention provides novel benzene derivatives which are leukotriene antagonists, formulations of those derivatives, intermediates for preparing the derivatives, and a method of using those...
5389641 Fused heterocyclic compounds, having angiotensin II antagonistic activity  
Fused heterocyclic compounds of the formula (I): ##STR1## wherein R1 is an optionally substituted hydrocarbon residue which may be attached through a hetero atom; R2 is a group capable of forming...
5389663 1-(1h-1,2,4-triazole-yl)-2-propanol compounds  
An azole compound represented by the formula (I): ##STR1## wherein X is a nitrogen atom; Ar is a phenyl group substituted by halogen or a halogenated C1-4 alkyl group; R1 and R2 independently are...
5389659 C-linked pyrazole derivatives  
The invention provides compounds of the general formula (I): ##STR1## or a physiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof.The compounds may be used...
5389661 Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties  
This invention relates to novel substituted imidazole and triazole derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of...
5389634 Imidazole derivatives having angiotensin II receptor antagonistic activity  
Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
5380739 Substituted indole derivatives  
Compounds of the Formula (I), (II), or (III): ##STR1## wherein the variables are as defined in the specification and the pharmaceutically acceptable salts thereof, exhibit useful pharmacological...
5376666 Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl  
Novel heterocycle substituted azocycloalkane benzylimidazoles of Formula (I), which are useful as angiotensin-II antagonists, are disclosed: ##STR1##
5374615 Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives  
Novel compounds are disclosed having the formula ##STR1## wherein X, R1, R2, R3, R4, and R5 are substituents. These compounds inhibit the action of angiotensin II and are useful, therefore, for...
5374638 Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma  
Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as...
5371100 Optically active tetrazole compounds, and fungicidal compositions thereof  
An optically active azole compound of the formula (I): ##STR1## wherein R1 and R2 are independently a hydrogen atom, a halogen atom, a haloalkyl group, a haloalkoxy group or an optionally...