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5679670 Sulfonamides useful as carbonic anhydrase inhibitors  
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration...
5674905 Bicyclooctane and bicycloheptane derivatives  
Compounds of formula (I), wherein A is selected from (a), (b), (c), (d), (e), (f) and B is selected from (g), (h), and (i), wherein W is a carbonyl, sulphonyl or sulphinyl group, and X is a...
5674879 Compositions including and methods of using conformationally restricted angiotensin II antagonist  
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders.
5668136 Trisubstituted benzene derivatives, composition and methods of treatment  
A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R1 stands for a lower alkyl group, an amino...
5663053 Inhibition of inflammatory lipid mediators  
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme...
5663187 Treatment of atherosclerosis with angiotensin II receptor blocking imidazoles  
A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II antagonist. This method of treatment can be used in conjunction with the treatment of hypertension....
5663188 Synergistic therapeutic compositions of angiotensin I converting enzyme inhibitors and angiotensin II antagonists and methods  
This invention relates to compositions and methods for achieving a therapeutic effect such as lowering blood pressure and treating congestive heart failure in a mammal. More specifically, this...
5661158 Use of angiotensin II antagonists for the treatment of hyperlipidemia  
A lipids-lowering agent which comprises an angiotensin II antagonist as an active ingredient.
5658936 Enhancement of erectile function with renin-angiotensin system inhibitors  
A method for treating patients having erectile dysfunction is described. The method involves treating patients with a renin-angiotensin system inhibitor. A method for treating a subject to improve...
5648372 Antifungal agents, and compositions  
A compound represented by the general formula: ##STR1## wherein R1 and R2 denote a halogen atom or hydrogen atom; R3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N...
5648355 Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin  
A method for treating endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a...
5646170 Tetrazole alkyl amide acat inhibitors  
Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R2 R3 H; R1 is phenyl, substituted...
5646171 Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use  
An angiotensin II antagonist of the formula: ##STR1## in which: Rp1 represents hydrogen, C1 -C6 alkyl, C3 -C6 cycloalkyl or C1 -C6 alkanoyl; Rp2 represents a single bond, C1 -C4 alkylene or C1 -C4...
5641798 Bicyclic compounds and their use as excitatory amino acid receptor antagonists  
This invention provides novel bicyclic compounds which are useful as excitatory amino acid receptor antagonists and in the treatment of neurological disorders. This invention also provides...
5631281 N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives  
Novel unnatural dipeptoids of α-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, colorectal...
5629331 Process for the preparation of a tetrazole derivative in two crystalline forms and novel the crystalline forms thereof  
The present invention relates to a process for the preparation of the 2-n.butyl-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-di azaspiro [4.4]-non-1-en-4-one by reaction of the corresponding...
5616599 Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use  
Compounds of the following formula (I) or the formula (I)p : ##STR1## wherein R1 is alkyl or alkenyl; R2 and R3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to...
5607956 1-heteroazolyl-1-heterocyclyl alkane derivatives and their use and their use as neuroprotective agents  
The present invention relates to novel heterocyclic compounds having the general formula (1) ##STR1## geometric and optical isomers and racemates thereof where such isomers exist, as well as...
5607957 Imidazole, triazole and tetrazole derivatives  
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular...
5605917 Method of treating dysmenorrhea employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog  
A method is provided for treating dysmenorrhea (menstrual cramps) employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog thromboxane A2 receptor...
5604251 Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors  
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their useCompounds of the formula (I) ##STR1## in which R1 is, for...
5602161 Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component  
The tetrazolylphenyl pivalate of the the following general formula or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 and R2 each represents a hydrogen atom, a lower alkyl group or...
5602127 (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists  
Angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted...
5599830 Sulphorous derivatives of imidazole and their use as medicaments  
The invention relates to the products: ##STR1## in which: R1 =alkyl, alkenyl, alkynyl, alkylthio, R2B, R3B representing: hydrogen, mercapto, formyl, acyl, carboxy nitro, cyano, --PO3 (R)2, R...
5594016 Naphthalene derivatives  
Naphthalene derivatives represented by the formula (I): ##STR1## wherein the symbol ##STR2## --X-- represents --O-- or --S--, Y-- represents N-- or CR5 --, R1, C2, R3, R4 and R5 represent...
5591762 Benzimidazoles useful as angiotensin-11 antagonists  
Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally...
5587390 Imidazole derivatives having a II antagonist activity  
Imidazole derivatives having A II antagonist activity, of Formula I, the processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof as therapeutic...
5585394 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives  
The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: ##STR1## to their preparation and to the pharmaceutical compositions in which they...
5583128 Contraception in female primates without affecting the menstrual cycle  
The invention relates to the use of aromatase inhibitors for contraception in female primates and to a method for contraception in female primates using such substances and to the use of those...
5583152 Method for treating vasospastic cardiovascular diseases heterocyclic amide derivatives  
The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts...
5580896 Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives  
This invention relates to the treatment of pain and inhibiting the growth of colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives.
5580542 Method of testing for nephritis  
Disclosed is an acetyltransferase activity measuring agent which contains an arylamine derivative. As the arylamine derivative, sodium p-aminohippurate can be used preferably. Use of the...
5578634 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors  
A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for...
5565480 Substituted histidines  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5565485 Biphenyl compounds useful or endothelin antagonists  
Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as...
5563164 Phospholipase A2 inhibitors  
This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of...
5556788 Fructosmaine reagent and calibrator system  
A system for determining the concentration of fructosamine in sera which consists of a first reagent in which a tetrazolium salt which reduces all reactive substances in sera including...
5554633 Substituted amines as tachykinin receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H...
5552422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents  
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a...
RE35321 Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity  
A tetrazoleacetic acid derivative represented by the following general formula (I): ##STR1## [in Formula (I), wherein R1 represents a hydrogen atom or an alkyl group; R2 represents a hydrogen...
5545651 Imidazole 5-position substituted angiotensin II antagonists  
Novel substituted imidazoles of Formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5543433 Azine-substituted phenylacetic acid derivatives and fungicides containing these  
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH3, CHOCH3 or...
5543428 Method for treating resistant tumors  
This invention provides a method of reversing multidrug resistance in a multidrug resistance tumor comprising administering a multidrug resistance reversing amount of any of a series of phenoxy...
5541163 Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives  
Disclosed herein are compounds of the formula: A--N(R1)C(O)CH2 CHR2 C(O)--Bwherein A is R3 R4 NC(O)CH2 wherein, for example, R3 is hydrogen or alkyl and R4 is hydrogen, alkyl or a substituted...
5541209 Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative  
The invention relates to the use of an N-substituted heterocyclic derivative and its pharmaceutically acceptable salts for the treatment or prevention of cardiac arrhythmia. These derivatives have...
5541229 Benzimidazoles and medicaments containing these compounds  
The invention relates to benzimidazoles of the formula ##STR1## in which R1 to R2 are as defined in claim 1,1 and 3 isomer mixtures thereof and addition salts thereof which have valuable...
5538987 Imidazole ethers having a II antagonist activity  
Compounds of general formula (I) ##STR1## wherein E is O or S; R is C1 -C5 straight, branched or cyclic alkyl or C2 -C5 alkenyl; X can be H, F, Cl, Br, I, CF3 ; n is an integer 1 to 4; m is an...
5534534 Pharmaceutical compositions for oral use and method of preparing them  
A pharmaceutical composition for oral use comprising an effective amount of a compound of the formula (I) having antagonistic action to angiotensin II ##STR1## (wherein the ring W is an optionally...
5530016 Substituted 2,4-imidazolidinediones  
Novel substituted 2,4-imidazolidinediones are prepared either by reaction of α-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization...
5527815 Carboxymethylidenecycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds  
New therapeutic agent of carboxymethylidenecycloheptimidazole derivatives and method for the manufacture thereof are disclosed, which are represented by the following formula or its alkali...