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5206253 |
Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds
The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if...
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5196444 |
1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-c arboxylate and compositions and methods of pharmaceutical use thereof
1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzi
midazole-7-car boxylate or a pharmaceutically acceptable salt thereof has potent angiotensin II...
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5192788 |
Porphyrin antiviral compositions
Compositions for the treatment or prevention of AIDS or other diseases resulting from infection with the Human Immunodeficiency Virus containing one or more porphyrins. Porphyrins are tetrapyrrole...
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5192800 |
Glutaramide diuretic agents
A series of novel spiro-substituted glutaramide derivatives have been prepared, including the pharmaceutically acceptable salts thereof and bioprecursors therefor, wherein the spiro-substituent...
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5189048 |
Substituted 1,2,3 triazole angiotensin II antagonists
This invention includes substituted pyrroles, pyrazoles and triazoles, processes for their preparation, pharmaceutical compositions containing them, and their use as antihypertensive agents, and as...
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5189051 |
Treatment of glaucoma and ocular hypertension with pyrrole angiotensin-II receptor antagonists
Substituted pyrrole, angiotensin-II receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating glaucoma and ocular hypertension.
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5183810 |
Imidazole angiotensin II antagonists incorporating a substituted benzyl element
Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
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5179113 |
Treatment of central nervous disorders with imidazole compounds
Imidazole compounds such as 5-[4-(3-(N-isopropylamino)hydroxypropoxy)indole-2-carboxamid
omethyl]-2-n-b utyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloroimidazole and their pharmaceutically...
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5179112 |
Heterocyclic amide derivatives and pharmaceutical use
The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts...
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5177096 |
Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
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5177092 |
Medicinal use of certain tetrazolium salts
Azole compounds including azoles and azolium salts, and their use as transglutaminase inhibitors are disclosed.
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5175180 |
N-substituted N-(alpha-triazolyl-toluyl)pyrrole compounds and use for treatment of circulatory disorders
A class of N-substituted N-(α-triazolyltoluyl)pyrrole compounds described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the...
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5173500 |
Pharmaceutical compositions and methods of sulphonamides containing a tetrazolyl radical
The present invention provides sulphonamides of the general formula: ##STR1## wherein R is a hydrogen or halogen atom, a cyano group or a C 1 -C 6 -alkyl or trifluoromethyl radical, n is 1, 2 or...
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5171748 |
Benz[4,5]imidazole-containing angiotensin antagonists
The invention concerns novel heterocyclic compounds of the formula I as defined herein and their physiologically acceptable salts, together with pharmaceutical compositions containing them. The...
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5166212 |
Certain n-substituted butyramide derivatives
Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and...
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5164381 |
Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
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5155126 |
Treatment of central nervous system disorders with pyrazole, pyrrole and triazole angiotensin-II receptor antagonists
Substituted pyrazole, pyrrole and triazole angiotensin-II-1 receptor antagonists and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as...
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5155118 |
Method and composition for preventing NSAID-induced renal failure
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
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5153214 |
Certain (arylsulfonamido- and imidazolyl-)-substituted carboxylic acids and derivatives thereof and use for suppressing thromboxane activity
The present invention is concerned with compounds of formula I ##STR1## wherein A, B, M, R, Ar and Het are as defined in the specification, pharmaceutically acceptable ester and amide derivatives...
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5153197 |
Treatment of hypertension with angiotensin II blocking imidazoles
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
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5147885 |
N-amino bicyclic compounds
N-amino hexahydrocyclopenta imidazole-2(1H)-one derivatives useful for treating or preventing thrombo-embolic disorders and ocular diseases characterized by increased ocular pressure.
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5143931 |
Leukotriene antagonists containing tetrazolyl groups
This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such...
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5137902 |
4-Alkylimidazole derivatives and anti-hypertensive use thereof
Angiotensin II antagonist antihypertensive compounds such as ##STR1## where R 2 is --CHO or --COOH and R 1 is ethyl have outstanding orally potency.
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5135941 |
LTB.sub.4 synthesis inhibitors
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CHCH-- or --CHN--; wherein R 1 is alkyl, alkenyl or...
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5135940 |
Leukotriene antagonists
Compounds of the Formulae: ##STR1## are antagonists of leukotrienes of C 4 , D 4 and E 4 , the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic,...
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5134142 |
Pyrazole derivatives, and pharmaceutical composition comprising the same
The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.
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5128346 |
Derivatives of D-glutamic acid and D-aspartic acid
A compound of the formula: ##STR1## wherein R 1 and R 2 are substituents; R 6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is...
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5128356 |
Benzimidazole derivatives and their use
Novel imidazole derivatives of the formula (I): ##STR1## wherein R 1 is an optionally substituted alkyl group, R 2 and R 3 are independently a group capable of forming an anion or a group which...
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5128355 |
Treatment of congestive heart failure with angiotensin 11 receptor blocking imidazoles
Substituted imidazoles such as ##STR1## are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive heart failure.
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5118700 |
Indole derivatives and compositions for their use in medicaments
Indole derivative for leukotriene antagonists of the formula ##STR1## wherein groups A, B, D, E, F & G are as described in the specification.
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5110825 |
Benzofuran derivative
The compounds of the present invention inhibit HMG-CoA reductase, subsequently suppress the synthesis of cholesterol; and are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia,...
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5100910 |
Aryl substituted tetrazole derivatives, and application thereof in therapeutics
Compounds for therapeutic use of formula: ##STR1## where the chain--W--V--N--represents--NN--N--, --N--NN--, --O--CO--N--, --O--CS--N--, --S--CO--N-- or --S--CS--N--; Ar is an aryl group; and...
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5098920 |
1H-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders
A class of 1H-substituted-1,2,4-triazole compounds is described for use in treatment of cardiovascular disorders. Compounds of particular interest are angiotensin II antagonists of the formula...
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5093346 |
Substituted 1,2,4-triazole angiotensin II antagonists
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
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5093339 |
Pyrano[f]quinoline derivatives and pharmaceutical compositions containing the same
Pyrano[f]quinoline derivatives of the formula (I): ##STR1## wherein R 1 and R 2 represent hydrogen, hydroxyl group or a group of the formula: ##STR2## wherein n represents an integer from 1 to 4,...
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5091397 |
1-aza-bicyclico(2.2.1)heptanes
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents --CH 2 --Z where Z is a group ##STR2## in...
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5081138 |
3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith
Compounds having the formula: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5081127 |
Substituted 1,2,3-triazole angiotensin II antagonists
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
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5073566 |
Angiotensin II antagonist 1,3-imidazoles and use thereas
This invention provides novel phenyl and heterocyclic derivatives, their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals.
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5073565 |
Tetrazole ureas and thioureas and their use as ACAT inhibitors
Novel ACAT inhibitors useful in the treatment of atherosclerosis which are N-aryl-N'-tetrazole ureas and thioureas.
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5073574 |
Tetrazolyl substituted benzonitriles and anti-tumor use thereof
Compounds of formula I, ##STR1## wherein Tetr, R, R 0 , R 1 and R 2 are as defined in the description, have valuable pharmaceutical properties and are especially effective against tumors. They...
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5071866 |
Arylpyrazole derivatives as anti-platelet agents
Compounds of the formula ##STR1## wherein R 1 and R 2 each are independently hydrogen or phenyl, provided that R 1 and R 2 may not both be hydrogen; m is an integer from 3 to 9; n is an...
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5070098 |
Substituted pyrazoline derivatives, pesticidal compositions and use
This invention relates to novel substituted pyrazoline derivatives of the general formula ##STR1## processes for their preparation and their use as pesticides.
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5070099 |
Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more...
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5066667 |
Thioxotetrazolines and insecticidal use thereof
Novel 1-phenyl-5-thioxo-2-tetrazolines of formula I ##STR1## in which R 1 is C 1 -C 8 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 6 cycloalkyl, C 5 -C 6 -cycloalkenyl, C 1 -C 4 ...
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5064848 |
Benzophenone oxime ether compounds, pharmaceutical compositions and treatment methods
A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative....
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5051449 |
Treatment of cellulite with retinoids
A method for retarding and reversing cellulite comprises topically applying to human skin a retinoid in an amount and for a period of time effective to retard or reverse cellulite where said amount...
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5049572 |
Substituted di-t-butylphenols and anti-allergic use thereof
Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic...
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5043349 |
Substituted pyrrole angiotensin II antagonists
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
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5039684 |
Tetrazole amide derivatives of heterocyclic alkenyl acid and their use as antiallergic substances
Tetrazole amide derivatives of heterocyclic alkenyl acids, of general formula ##STR1## in which Y=NH, O or S when m=1; Y=N when m=2; m=1 or 2; l=0 or 4; R=H, C 1 -4 alkyl, Cl, Br, CF 3...
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