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5874455 Method for treatment of cataract with radical scavenger  
The invention provides a method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract...
5872117 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same  
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
5866601 Carbocyclic compounds  
Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane...
RE36068 Methods for treatment of sundamaged human skin with retinoids  
Various effects of photoaging or sundamage of skin including impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and...
5863946 Iminoxyderivatives of fenamates as inhibitors of prostaglandin biosynthesis  
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is...
5854268 Azetidine, pyrrolidine and piperidine derivatives  
A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1Dα receptor subtype whilst...
5846986 Therapeutic phenoxyalkylazoles and phenoxyalkylazines  
Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl or is chosen from the group consisting of oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl,...
5846991 Pyrazole derivatives  
Pyrazole compounds of formula 1! and their tautomers and salts: ##STR1## (wherein R1 is an alkyl group, etc.; R2 is a carboxyl group, etc.; R3 is a halogen atom, an alkyl group, a phenyl group,...
5843997 Excitatory amino acid receptor antagonists  
The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods...
5840758 Oxime derivatives of fenamates as inhibitors of prostaglandin biosynthesis  
Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; A is selected from (a) optionally...
5840741 Arteriosclerosis depressant  
9-methyl-3-(1H-tetrazol-5-yl)-4H-pyrido 1, 2-a!pyrimidin-4-one represented by the following formula; ##STR1## and the physiologically-acceptable salts thereof showed to have excellent inhibitory...
5834521 Substituted dibenz (A F)azulenes and methods of preparation  
Tetracyclic compounds having the following structure are described: ##STR1## wherein R1 -R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues...
5830909 Angiotensin (AII) antagonists as inhibitors of the growth of adipose tissue  
The invention is a method of using Angiotensin (AII) Antagonists as inhibitors of the growth of adipose tissue, reducing adipocyte growth and body weight gain.
5824691 Guanidine derivatives as inhibitors of Na+ /H+ exchange in cells  
Guanidine derivatives of the formula: ##STR1## wherein Y is C--R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) R2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., R3 is...
5824696 Medicaments  
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of chronic inflammatory disease states.
5817684 Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke  
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
5807883 2-oxoindoline derivative  
Disclosed is a 2-oxoindoline derivative represented by the formula (I): ##STR1## wherein Ring A represents a benzene ring which is substituted in the 5-position or 6-position by a lower alkyl...
5795904 Enhanced functional recovery of the heart by losartan treatment after an ischemic attach  
Losartan, its active metabolite, EXP3174, or the pharmaceutically acceptable salts of these compounds for use in enhancing the functional recovery of the heart after an ischemic attack.
5792783 3-heteroaryl-2-indolinone compounds for the treatment of disease  
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
5783600 Carboxyalkylethers, formulations, and treatment of vascular diseases  
Dialkyl ethers lower Lp(a) and triglycerides, and elevate HDL-cholesterol, and are thereby useful for treating vascular diseases and noninsulin-dependent diabetes mellitus.
5783593 Inhibitors of squalene synthetase and protein farnesyltransferase  
The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia,...
5780498 Endothelin receptor antagonists  
The present invention provides novel compounds represented by the general formula I: ##STR1## wherein R1 is a straight or branched lower alkyl, a cycloalkyl-lower alkyl, an aryl-lower alkyl, a...
5776927 Methionine sulfone and S-substituted cysteine sulfone derivatives as enzyme inhibitors  
This invention relates to compounds which inhibit thrombin or factor Xa. The compounds contain an aldehyde functionality and a methionine sulfone or S-substituted cysteine sulfone residue. The...
5770624 Certain alpha-substituted arylsulfonamido acetohydroxamic acids  
Particularly the invention relates to the compounds of formula I ##STR1## wherein Ar represents carbocyclic aryl, heterocyclic aryl or biaryl; R1 represents lower alkyl, cycloalkyl, aryl-lower...
5770598 Heterocyclic compounds  
The present invention relates to heterocyclic compounds which have been found to have anti-tumour activity. More specifically, the invention concerns Pyrrolo 3,2-b! carbazoles, 1H-Benzofuro 3,2-ƒ!...
5767139 Indoles which have steroid 5-α reductase inhibitory activity  
The present invention provides compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, together with pharmaceutically compositions containing, uses of, processes for...
5766578 Axillary malodor neutralization  
A method of neutralizing axillary malodor by contacting the malodor with a sulfhydryl reactant.
5767151 3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds  
The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these...
5760037 Derivatives of N'N'-di(aralkyl)-N,N'-di(2-azaaralkyl)alkylene diamine and the use thereof in pharmaceutical and cosmetic compostions  
These compounds correspond to the following general formula: ##STR1## where: n is 0, 1, or 2, m is are 1, 2, or 3, R, R1, R2, and R3, whether identical or different, represent an atom of hydrogen...
5753651 Method of modifying angiotensin receptor activity for mediation of pain  
The present invention relates to a method of modifying Angiotensin II subtype 1 (AT1) receptor activity for the treatment of premenstrual syndrome (PMS) and the symptoms associated therewith, and...
5750551 Treatment for viral diseases  
An angiotensin II antagonist compound is administered to mammals with viral disease. This administration ameliorates virus-associated cell injuries, producing therapeutic effects in viral...
5750549 Cycloalkyl tachykinin receptor antagonists  
The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, A,...
5739164 Pharmaceutical compounds for the treatment of CNS diseases  
Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X...
5736561 Vascular hypertrophy suppressor  
This invention relates to a method for the prophylaxis or treatment of vascular hypertropy in a mammal by administering a pharmaceutically effective amount of a compound represented by the formula...
5731335 (1-Heteroazolyl-1-heterocycane derivatives and their use as neuroprotective agents  
This invention provides heterocyclic compounds of formula (I) that are potentially useful in the treatment of neuropsychiatric disorders associated with progressive processes leading to neuronal...
5719173 Method for the treatment of sclerosis of the glomeruli  
This invention relates to prophylactic or therapeutic drug for diabetic nephropathy or glomerulonephritis, comprising, as an active ingredient, a compound or salt thereof represented by general...
5719182 Endothelin receptor anatagonists  
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
5712287 Method of treating urinary bladder dysfunctions  
The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.
5710153 Tetrazole compound  
A tetrazole derivatives of formula (I) ##STR1## a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof which has an inhibitory effect on interleukin-1β converting enzyme (ICE).
5708016 Pseudopeptides derived from neurokinins  
A compound of formula (I): ##STR1## in which: R1 represents an indolyl, naphthyl, tetrahydronaphthyl, thienyl, phenyl, optionally substituted, or (C3 -C7)cycloalkyl group, n represents an integer...
5703107 3-aminoindolyl derivatives  
The present invention is directed to a new class of 3-amido and 3-sulfamido-indolyl NMDA antagonists and their use in the treatment of a number of disease states.
5703108 Bone deposition by certain prostaglandin agonists  
Methods for the treatment of bone disorders utilizing certain prostaglandin agonists/antagonists.
5693657 Heterocyclic-substituted alkyl amide acat inhibitors  
Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R2 R3 H; R1 is phenyl, substituted...
5693633 Angiotensin II antagonists  
This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.
5693619 Method of using renin inhibiting N-(2-amino-2-oxoethyl) butanediamide derivatives  
Disclosed herein is a method of using compounds of the formula: A-N(R1)C(O)CH2 CHR2 C(O)-Bwherein A is R3 R4 NC(O)CH2 when, for example, R3 is hydrogen or alkyl and R4 is hydrogen, alkyl or a...
5688809 5-heteroarylindole derivatives  
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical...
5684028 Sulphorous derivatives of imidazole, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions  
Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of...
5684046 Hydrogenated naphthalenes and related LTB4 antagonists  
Described herein are Benzopyran and other benzo-fused leukotriene B4 antagonists have the formula ##STR1## wherein R1 is a phenyl or substituted phenyl group, and A, n, R2 and R3 are as defined...
5684029 Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them  
The invention relates to benzimidazoles of general formula ##STR1## wherein R1 to R4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are...
5684024 Pyrazole dimers compositions and methods for treating influenza  
Substituted pyrazole dimers are useful in prophylaxis and treatment of influenza virus infections.