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6143776 Tosylproline analogs as thymidylate synthase inhibitors  
Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful...
6143790 L-N6 -(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors  
There is disclosed a novel amino glycol derivatives of L-N6 -(1-iminoethyl)lysine, pharmaceutical compositions containing these novel compounds, and to their use in therapy, in particular their...
6140352 Carbazolyl-substituted ethanolamines as selective β-3 agonists  
Disclosed herein are selective beta 3 adrenergic agonists represented by the following structural formula: ##STR1## The variables in the structural formula shown above are defined in the...
6133302 5-(3-Phenyl-3-oxo-propyl)-1H-tetrazole derivatives  
5-(3-phenyl-3-oxo-propyl)-1H-tetrazole derivatives of formula (I) wherein each of R and R1, being the same or different, is hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl,...
6110963 Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia  
This invention provides compounds of Formula I having the structure ##STR1## wherein A is C or N; B is O, S, N, or CHCH; E is ##STR2## or --X--D; D is ##STR3## or alkyl of 1-12 carbon atoms; X is...
6096772 Use of Angiotensin II type 1 receptor antagonists in the treatment of dyspeptic symptoms  
A method for the prophylaxis and treatment of dyspeptic symptoms comprising administering angiotensin II type 1 receptor antagonists in pharmaceutical preparations is disclosed.
6096766 3-benzylaminopiperidines as tachykinin receptor antagonists  
PCT No. PCT/GB96/02998 Sec. 371 Date Jun. 9, 1998 Sec. 102(e) Date Jun. 9, 1998 PCT Filed Dec. 6, 1996 PCT Pub. No. WO97/21702 PCT Pub. Date Jun. 19, 1997The present invention relates to certain...
6087386 Composition of enalapril and losartan  
The present invention discloses a pharmaceutical composition of enalapril and losartan and a pharmaceutically acceptable carrier.
6071931 AT1 -receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys  
The compound (S)-N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2'(1H-tet razol-5-yl)bip henyl-4-yl-methyl]amine (valsartan) of formula ##STR1## or a salt thereof, in particular a pharmaceutically...
6057319 3,4-Diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors  
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for...
6054448 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives  
Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR'...
6051572 Azetidine, pyrrolidine and piperidine derivatives  
A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT1 -like...
6048895 Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists  
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R1, R2, R3, R4, X, and Z...
6046224 12 (S)--hete receptor blockers  
The 12-lipoxygenase product, 12(S)-HETE, mediates hyperproliferative and hyperplastic responses seen in atherosclerosis, diabetes, Parkinson's disease, Alzheimer's, stroke-induced nerve damage and...
6046205 Indole and indazole compounds  
Compound of formula (I): ##STR1## wherein: n is 0 or 1, A represents a σ bond or alkylene or alkenylene, X represents nitrogen or C--R2, R1 represents hydrogen or alkyl, G1 represents any one of...
6040317 Sulfonamide fibrinogen receptor antagonists  
A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases...
6034114 Medicament  
The present invention relates to the use of an angiotensin II receptor antagonist in the manufacture of a medicament for the treatment of left ventricular hypertrophy regression.
6020355 Pesticidal tetrazole derivatives  
Tetrazole derivatives of the formula wherein R is a substituted or unsubstituted phenyl group, heterocyclic group, or benzo-fused heterocyclic group,which exhibit activity as insecticides and...
6013644 Spiro-substituted azacycles as modulators of chemokine receptor activity  
The present invention is directed spiro-substituted azacycles of formula I: (wherein R1, R2, R3, R4, R5, k, l and m are defined herein) which are useful as modulators of chemokine receptor...
6013673 Naphthyloxy acetic acid derivatives  
A naphthyloxyacetic acid derivative of the formula (I) ##STR1## wherein R1 is H, alkyl, alkylene-(--COOR10, --OH, --CONR4 R5, --CONR6 -alkylene-OH, --NR4 R5, -cyano or -tetrazolyl); A is single...
6004988 Carboxylic acid derivatives, their preparation and their use  
Carboxylic acid derivatives of the formula I ##STR1## here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
5998454 Leukotriene antagonists useful for treating iritis  
This invention provides methods for the treatment or inhibiting of iritis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
5981438 1-phenyl-5-anilinotetrazoles  
The present invention relates to novel 1-Phenyl-5-anilinotetrazoles of the formula (I): ##STR1## wherein, R1, R2, R3, R4, m and n have the meaning provided in the specification, precesses for...
5981545 N-linked azabicyclic heterocycles useful for treating dementia  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents Z, where Z is a group ##STR2## in which Q...
RE36375 Treatment of Alzheimer's disease using azacyclic compounds  
The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and...
5976576 Pharmaceutical composition for inhalation containing CR 2039 (Andolast)  
A pharmaceutical composition comprising, as active ingredient, N-4-(1H-tetrazol-5-yl)phenyl-4-(1H-tetrazol-5-yl)benzamide disodium salt (CR 2039, Andolast) or another pharmaceutically-acceptable...
5977160 Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims  
The invention involves a method for treating a human survivor of a heart attack and provides further improvement in survival following the heart attack by the early initiation and long-term...
5972930 Pyridinylamino tricyclic compounds as substance P antagonists  
This invention provides a compound of the formula: ##STR1## and its pharmaceutically acceptable salts, wherein Ar1 is selected from groups of the following formulae: ##STR2## wherein, R1 and R2...
5968963 PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption  
Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease...
5965565 Piperidines promote release of growth hormone  
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R1, R1a, R2a,...
5965592 Acyl compounds  
Compounds of the formula ##STR1## and their salts, in which R1, is a C1 -C7 aliphatic hydrocarbon radical; X1 is --CO; X2 is a divalent aliphatic hydrocarbon radical which comprises an ethyl group...
5965619 Method for treating patients having precancerous lesions with substituted indene derivatives  
Substituted indene derivatives are useful for treating patients having precancerous lesions and for inhibiting the growth of neoplastic cells.
5962491 Benzimidazole derivatives and use thereof  
Benzimidazole derivatives of the formula (I): ##STR1## wherein the ring A is a benzene ring which may optionally contain substitution in addition to the R' group; R1 is hydrogen or an optionally...
5958884 Compositions and methods for treating erectile dysfunction  
Methods and compositions for treating patients having erectile dysfunction are described. The method involves the step of treating a patient with a combination of an AT1 specific Angiotensin II...
5955491 Method for treating osteoporosis  
The present invention provides a cathepsin L inhibitor containing a compound of the formula: ##STR1## wherein R1 is a hydrogen atom or an arylalkyl, heterocyclic-alkyl or lower alkyl group which...
5955487 N-acyl-N-heterocyclylalkyamino acids compositions and method of use  
The invention relates to N-acyl-N-heterocyclylalkylamino acids of the formula ##STR1## R1 is C1 -C7 alkyl that is unsubstituted or substituted by halogen or by hydroxy, or is C2 -C7 -alkenyl, C3...
5948779 Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes  
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell...
5945450 Naphthalene derivative  
Naphthalene derivatives represented by formula I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C7 -C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1 -C12...
5935973 Heterocyclcarboxamide derivatives and their use as therapeutic agents  
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene...
5932575 Cardiac diseases improving agents  
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly,...
5922763 Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them  
The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof,...
5922744 Ethane-1-2-diamine derivatives and tachykinin antagonists  
The present invention provides a compound of formula: ##STR1## wherein R, R1, R2, R3, R4, R5, R6a and R6b are defined herein or a pharmaceutically acceptable salt thereof, a process for its...
5919810 1H-indole-3-glyoxylamide sPLA2 inhibitors  
A class of novel 1H-indole-3-glyoxylamides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as...
5914340 Leukotriene antagonists useful for treating dermatoses  
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
5912260 Gastrin and CCK antagonists  
Described herein are compounds of formula (I) or a pharmaceutically acceptable salt thereof, ##STR1## wherein L is N or C, one of X and Y is --NH--CH2 --R2 and the other is the substituent of...
5910505 Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma  
This invention provides methods for the treatment or inhibitor of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having...
5908852 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation  
A class of 1,3,5-substituted pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula...
5906985 Pharmaceutical compounds  
Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R1 is hydrogen, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, phenyl, naphthyl, C1-10 alkyl-phenyl, C2-10...
5900428 Pharmacological use of AII-receptor antagonists  
A method for the prophylaxis and treatment of MOF using certain angiotensin II type 1 receptor antagonists and a pharmaceutical preparation comprising these compounds.
5877191 Phenyl spiroethercycloalkyl tachykinin receptor antagonists  
The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, m,...