Matches 451 - 500 out of 725 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
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5314880 Benzimidazole derivatives  
Compounds of general formula I: ##STR1## wherein: each of R 1 -R 8 , k, and V represent disclosed functional groups that have been chosen such that all disclosed variations of compound I and their...
5312818 Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromboxane A.sub.2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation  
A method is provided for protecting against and/or treating ulcerative gastrointestinal conditions, including anti-inflammatory drug-induced gastrointestinal ulcers, using a thromboxane A 2 ...
5312760 Fructosamine reagent and calibrator system  
A system for determining the concentration of fructosamine in sera which consists of a first reagent in which a tetrazolium salt which reduces all reactive substances in sera including fructosamine...
5312828 Substituted imidazoles having angiotensin II receptor blocking activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5312820 Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines  
Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT 1 and AT 2 activity useful in the treatment of hypertension and...
5308853 Substituted-5-methylidene hydantoins with AT.sub.1 receptor antagonist properties  
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and method of using them. Intermediates...
5302610 Renal-selective biphenylmethyl imidazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs...
5298519 Acylals of imidazole-5-carboxylic acid derivatives, and their use as angiotensin (II) inhibitors  
Novel imidazole-5-carboxylic acid acylals of the general formula ##STR1## in which R 1 denotes an optionally unsaturated, straight-chain alkyl group having 1-6 carbon atoms, R 2 denotes hydrogen,...
5298520 Triazole containing indole derivatives  
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in...
5296499 Indole derivatives, their production and use  
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl...
5294613 Method of treating endotoxic shock in mammals  
This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.
5294633 Imidazolyl-propenoic acid derivatives  
Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in...
5294631 Substituted benzimidazoles useful as angiotension II receptor antagonists  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5294632 Phosphono/biaryl substituted dipetide derivatives  
The invention relates to the N-phosphonomethyl-biaryl substituted dipeptide derivatives of formula I ##STR1## and tetrazole derivatives of the formula Ia ##STR2## wherein A represents a direct...
5281615 Cycloheptimidazolone compounds as angiotensin II antagonists for control of hypertension  
A class of cycloheptimidazolone compounds is described as angiotensin II antagonists for use in control of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein...
5276048 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity  
Novel substituted 4-(1-H-pyrrol-1-yl)imidazoles are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and methods of using them. Novel intermediates...
5273990 Phosphono substituted tetrazole derivatives  
The present invention relates to the N-phosphonomethyl substituted tetrazole derivatives of formula I ##STR1## and tautomers thereof wherein R 1 is aryl or biaryl; n is zero, 1 or 2...
5270317 N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present  
The invention relates to N-substituted heterocyclic derivatives and its salts. These derivatives have the formula ##STR1## in which the substituents are as defined in the specification. ...
5266583 Angitotensin II antagonist  
A human urinary metabolite of Losartan has been isolated and identified as structure I. ##STR1## This compound is an active angiotensin II receptor antagonist useful in the treatment of...
5264447 Angiotensin II antagonist  
A human urinary metabolite of Losartan has been isolated and identified as Structure I: ##STR1## This compound is an active angiotensin II receptor antagonist useful in the treatment of...
5262433 Tetrazoleacetic acid derivatives and method of aldose reductase inhibition therewith  
A tetrazoleacetic acid derivative represented by the following general formula I: ##STR1## wherein in the formula I, R represents a hydrogen atom or a lower alkyl group; A is an alkylene group...
5260325 Angiotensin II receptor blocking tertiary amides  
Novel substituted tertiary amides of formula (I), which are useful as angiotensin II antagonists, are disclosed: ##STR1##
5260322 Angiotension II antagonists in the treatment of hyperuricemia  
A pharmaceutical composition comprising a non-peptide type angiotension II receptor antagonist is useful for the treatment of hyperuricemia.
5254546 Fused aryl substituted imidazole angiotensin II receptor inhibitors  
Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
5254595 Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them  
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
5250554 Benzimidazole derivatives useful as angiotensin II inhibitors  
Novel imidazole derivatives of the formula (I): ##STR1## wherein R 1 is an optionally substituted alkyl group, R 2 and R 3 are independently a group capable of forming an anion or a group which...
5250529 Method alleviating migraine headache with mast cell degranulation blocking agents  
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the...
5246940 Substituted N-biphenylyl lactams  
This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof. The...
5242939 Anilide derivatives with angiotensin II antagonist properties  
This invention relates to anilide derivatives of Formula I ##STR1## which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart...
5240946 ((2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino)alkyl)-acid derivatives  
A compound of the formula: ##STR1## in which R 1 is hydrogen, alkyl or phenylalkyl; R 2 is hydrogen, alkyl, alkenyl or phenylalkyl; or R 1 and R 2 taken together are --CH 2 CH 2 --, --CH 2 ...
5238952 N-substituted imidazol-2-one compounds for treatment of circulatory disorders  
A class of N-substituted imidazol-2-one compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1##...
5236928 Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists  
There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists. ##STR1##
5236943 Method for the treatment of cardiac and of vascular hypertrophy and hyperplasia  
The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole,...
5234942 Heterocyclic amides and leucotriene antagonistic use thereof  
The invention provides a series of novel heterocyclic amides of the formula I in which the group A; CRa can be --CRbCRa--, --CHRb--CHRa-- or --NCRa--, the amidic group Re.L can be Rd.X.CO.NH,...
5234917 Substituted 5-(alkyl)carboxamide imidazoles  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
5232937 Derivatives of N-phenylbenzamide with anti-ulcer and anti-allergy  
Derivatives of N-phenylbenzamide with general formula (1) in which R 1 is a cyano, nitro, halogen, hydrozy, C 1 -C 4 alkyl methyl, methoxy or tetrazol-5-yl group, R 2 is hydrogen, hydroxy, or...
5232948 Substituted monocyclic aryl compounds exhibiting selective leukotriene B.sub.4 antagonist activity  
Monocyclic aryl compounds having selective LTB 4 antagonists properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a...
5229406 1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders  
A class of 1,3,5-trisubstituted-1,2,4-triazole compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula...
5227393 α-fluoro-α-tetrazolyl-phenylmethyl derivatives useful as aromatase inhibitors  
Compounds of formula I ##STR1## wherein Z, R, R 1 , R 2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are...
5225428 Cyclic-substituted imidazolyl-propenoic acid derivatives  
Cyclic-substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes and subsequent elimination of water. The cyclic-substituted imidazolylpropenoic acid derivates are...
5225429 Fluorinated arachidonic acid derivatives  
Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example,...
5223517 Heterocyclically substituted cycloalkano[b]-indolesulphonamides  
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
5223516 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same  
Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
5217985 Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension  
Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs...
5216004 Method for preventing malaria  
A method is provided for preventing malaria by administering to a subject an effective amount of activin, inhibin, an inhibin chain, a butyrate analog, or mixtures thereof, to inhibit the...
5215994 Angiotenin II antagonizing heterocyclic derivatives  
The invention relates to compounds of the formula ##STR1## wherein ##STR2## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification....
5216003 Diacid-containing benzimidazole compounds for treatment of neurotoxic injury  
A class of diacid-containing benzimidazole compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or...
5212195 Substituted indole antagonists derivatives which are angiotensin II  
Compound of the Formula (I), (II), or (III): ##STR1## wherein: R 1 is lower alkyl or 2"-(1H-tetrazol-5-yl)biphenyl-4'-ylmethyl; R 2 is lower alkyl when R 1 is...
5210079 Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists  
Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)meth yl]-5-(hydroxy methyl)imidazole and...
5210092 Angiotensin II antagonizing heterocyclic derivatives  
The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin...
Matches 451 - 500 out of 725 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >