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7943118 |
Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of...
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7825095 |
Methods and unit dose formulations for the inhalation administration of aminoglycoside antibiotics
A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from...
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7749971 |
Aminoglycoside treatment for lysosomal storage diseases
The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of...
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7745235 |
Method for manufacturing semiconductor sensor
A semiconductor sensor is disclosed that includes a substrate including at least a semiconductor layer. The substrate includes a weight arranging part in the vicinity of the center of the...
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7691641 |
Polysaccharide-peptide conjugates for use as thrombin substrates
The present invention relates to macromolecular polysaccharide-peptide conjugates which contain a peptide portion which C-terminally contains the amino acid sequence Ala-Gly-Arg, which is cleaved...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7371733 |
Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are...
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7345024 |
Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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6890907 |
Methods and unit dose formulations for the inhalation administration of tobramycin
A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from...
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6858589 |
Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria
The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and...
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6818625 |
Method for increasing survival rate of cells in animal cell culture under hypoxia condition
The present invention relates to a method for increasing survival rate of cells in animal cell culture under hypoxia condition by adding antibiotics to the culture media. The method of present...
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6716822 |
Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition
The present invention relates to a therapeutic agent for ischemia which inhibits apoptosis under ischemic condition. The therapeutic agent of the present invention comprises antibacterial agents of...
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6620782 |
Substituted 2-aminobenzamide caspase inhibitors and the use thereof
The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R1-R3, X, and A—D are defined herein. The present invention also relates to the d...
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6541507 |
Indolecarboxylic compounds for inducing/stimulating hair growth and/or retarding hair loss
Indolecarboxylic acid compounds and derivatives thereof, notably 4,6-dimethoxyindole-2-carboxylic acid and derivatives thereof, are especially useful for inducing/stimulating mammalian hair growth...
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6528490 |
Oenothein medicaments
The invention provides medicaments comprising an oenothein, including topical formulations for use as free radical scavengers, or to treat irritation, or to treat inflammation. The oenothein for...
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6475993 |
Treatment of hereditary diseases with gentamicin
This invention relates to a method of treating an inherited disease due to a point mutation producing a stop codon by administering an effective dose of an aminoglycoside antibiotic or a derivative...
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6379882 |
Method for selecting compounds for treating ischemia-related cellular damage
A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke...
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6284739 |
Antileishmanial composition for topical application
The instant invention provides compositions containing as active agents paromomycin in combination with gentamicin. When given in combination, the compositions appear much more effective than when...
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6083922 |
Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
A method for treatment, prevention and containment of acute and chronic tuberculosis using a preservative-free concentrated tobramycin aerosol formulation delivering tobramycin to the lung...
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6037140 |
Selective media for the culture and isolation of gram bacteria, antibiotic composition
This invention relates to a selective medium for the culture and isolation of Gram- bacteria comprising at least one antibiotic specifically active against Gram+ bacteria and at least one bacteriocin.
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5900406 |
Use of antibiotics of the type 2-deoxystreptamine substituted with aminosugars to inhibit growth of microorganisms containing group I introns
The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The...
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5843911 |
Hyaluronidase inhibitor containing god-type ellagitannin as active ingredient
Hyaluronidase inhibitor containing GOD-type ellagitannin as an active ingredient, as well as pharmaceuticals and cosmetics containing the inhibitor. The activity of hyaluronidase which hydrolyses...
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5677288 |
Use of aminoglycosides to protect against excitotoxic neuron damage
A method is disclosed for reducing excitotoxic damage to neurons, which can occur as a result of stroke, cardiac arrest, or other events or conditions. This method involves administering an...
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5663152 |
Potentiators for aminoglycosides
The present invention provides antimicrobial compositions, especially compositions comprising an antimicrobial (microbiocidal or microbiostatic) compound and a potentiator of antimicrobial...
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5662929 |
Therapeutic liposomal formulation
The invention relates to a liposomal formulation containing a therapeutic agent. The formulation of the invention when administered to animals, allows a substantial increase in antibacterial...
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5595977 |
Salts of amino glycosides
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid8- ]-[R-(NH3+)x ]y -Mzn+) (I) (xy)+(zn)=8 xy...
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5571821 |
Sulfonamides and derivatives thereof that modulate the activity of endothelin
Sulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods...
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5508269 |
Aminoglycoside formulation for aerosolization
An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100% of susceptible...
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5470836 |
Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases
A compound of formula (I): ##STR1## wherein: R1 is a hydroxy group or an amino group optionally substituted with a C1 -C4 alkyl or phenyl-(C1 -C4) alkyl group,R2 is hydrogen or a hydroxy group,R3...
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4877775 |
Polymeric aminosaccharides as antihypercholesterolemic agents
Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful...
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4749694 |
Novel lysine esters used as absorption
Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as...
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4650790 |
Drug combinations having synergistic effect
The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. The composition...
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4612337 |
Method for preparing infection-resistant materials
An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved...
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4505901 |
Compositions and methods for topical treatment of cutaneous leishmaniasis with paromomycin
The compositions contain a mixture of paromomycin or a non-toxic acid addition salt thereof and dimethylsulfoxide or a quaternary ammonium salt having topical anti-infective activity, together with...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474753 |
Topical drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a...
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4407792 |
Sustained release ophthalmic drug dosage
The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of...
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4351830 |
Polymeric compound, MF-300, with protective activity against bacterial infections and its preparation
A new polymeric compound, MF-300, is provided, which possesses a specific protective activity against bacterial infections caused particularly by Pseudomonas aeruginosa. The compound is derived...
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4170643 |
Aminoglycoside-aminocyclitol derivatives and method of use
Novel aminoglycoside-aminocyclitol derivatives corresponding to the general formula: ##STR1## wherein R1 and R2, which are different, represent hydrogen or CH2 NH2 and R is selected from the group...
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4170641 |
1-N-(ω-aminoalkanesulfonyl) derivative of aminoglycosidic antibiotic and process for preparation thereof
A new 1-N-(ω-aminoalkanesulfonyl) derivative of an aminoglycosidic antibiotic such as ribostamycin, 3'-deoxy- or 3',4'-dideoxy-ribostamycin, kanamycin A or B, and 3'-deoxy- or ...
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4169890 |
Pharmaceutical composition containing 5"-amino-3',5"-dideoxy-ribostamycin and intermediate compounds
A process for preparing a novel antibiotic, 5"-amino-3',5"-dideoxy-ribostamycin, which comprises subjecting a ribostamycin derivative represented by the formula: ##STR1## to selective sulfonylation...
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4122171 |
Agent for protecting against renal failure
D-glucaro-1,5-lactam and its pharmaceutically acceptable salts are useful as an agent of protecting against renal failure or damage induced by administration of aminoglycosidic antibiotics.
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4066753 |
Neomycin and paromomycin derivatives
The invention relates to novel neomycin and paromomycin derivatives having antibiotic activity. The derivatives have the formula: ##STR1## wherein R' is --NH2 or --OH, either R2 or R3 is --CH2 NH2...
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3962429 |
Method for reducing side effects of aminoglycoside antibiotics and composition therefor
Side effects of an aminoglycoside antibiotic, renal toxicity and 8th nerve toxicity, are reduced by administering a glucosaccharic acid as well as the aminoglycoside antibiotic. An improved method...
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3282783 |
Method for causing hypocholesterolemic activity in animals with poly-n-lower alkyl derivatives of polyamino antibiotics
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3052605 |
Fungicidal compound and process of making same
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2895876 |
Catenulin and its production
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