|
Match
|
Document |
Document Title |
|
|
7612069 |
Acyl guanidines as beta-secretase inhibitors
There is provided a series of substituted acyl guanidines of Formula (I)
or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 as defined...
|
|
|
7605164 |
Compositions and methods for treating heart failure
Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including...
|
|
|
7598280 |
Heterocyclic compounds, compositions comprising them and methods of their use
Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed....
|
|
|
7598245 |
Aminotriazole compounds useful as inhibitors of protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the...
|
|
|
7585859 |
PDE4B inhibitors and uses therefor
Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
|
|
|
7557133 |
Caspase inhibitors containing isoxazoline ring
The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and...
|
|
|
7544704 |
Aryl-4-ethynyl-isoxazole derivatives
The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula I
wherein R 1 to R 5 are as described in the specification and pharmaceutically acceptable salt...
|
|
|
7541372 |
Aryl-isoxazolo-4-yl-oxadiazole derivatives
The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula
wherein
R 1 , R 2 , and R 3 , are as defined in the specification and pharmaceutically acceptable acid...
|
|
|
7538132 |
Isoxazolo derivatives
The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula
wherein
R 1 , R 2 , R 3 , R 4 , and R 5 , and m are as defined herein...
|
|
|
7538127 |
Medicinal compounds
A compound of formula (I) or a salt, solvate, or physiologically functional derivative thereof, wherein: m is an integer of from 2 to 8; n is an integer of from 2 to 5; with the proviso that m+n is...
|
|
|
7521469 |
Phosphinic amino acid compounds
Compounds of formula (I):
wherein:
R 1 represents hydrogen, alkylcarbonyloxyalkyl or alkylcarbonylthioalkyl, R 2 represents hydrogen, alkylcarbonyloxyalkyl, arylcarbonylthioalkyl or...
|
|
|
7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
|
|
|
7495107 |
Method for manufacturing isoxazole derivative or dihydroisoxazole derivative
There is provided with a method for manufacturing an isoxazole derivative at a high yield and without discharging waste products, and a novel isoxazole derivative. An isoxazole derivative expressed...
|
|
|
7491740 |
Isoxazoline compounds having MIF antagonist activity
Methods of use and pharmaceutical compositions for a genus of low molecular weight compounds comprising optionally substituted isoxazoline ring systems that act as inhibitors of MIF (macrophage...
|
|
|
7488725 |
Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula:
wherein R 1 , R 2 , R 2′ , R 3 , R 3′ , R 4 , R 4′ , R 5 , X, Y and Z are as defined herein.
|
|
|
7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
|
|
|
7473705 |
Hexafluoroisopropanol substituted ether derivatives
The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I):
wherein R 1 to R 3 are as defined in the description and in the claims, as well as...
|
|
|
7470715 |
Estrogen modulators
The present application is directed to a new class of isoxazoles and their use as estrogen modulators.
|
|
|
7465805 |
Isoxazoline derivatives and their use as herbicides
Compounds of formula: (I) wherein the substituents are as defined in claim 1 , are suitable for use as herbicides. Also claimed are processes for the preparation of the claimed compounds, a...
|
|
|
7465718 |
Ansamycins having improved pharmacological and biological properties
Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and...
|
|
|
7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
|
|
|
7452878 |
Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
|
|
|
7446118 |
3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof
The present invention provides compounds of the formula:
or pharmaceutically acceptable salts, solvates or prodrugs thereof,
wherein p, Ar, R 1 , R 2 , R 3 , R a , R b , R c , R d and R e ...
|
|
|
7442839 |
Phenethanolamine derivative for the treatment of respiratory diseases
The present invention relates to novel compounds of formula (I),
to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular...
|
|
|
RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
|
|
|
7435750 |
Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I:
wherein Ar 1 , Ar 3 , A, B and D are defined herein. The...
|
|
|
7432285 |
Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase...
|
|
|
7425553 |
Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases
The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder...
|
|
|
7414061 |
Aryl-isoxazol-4-yl-imidazole derivatives
The present invention is concerned with aryl-isoxazol-4-yl-imidazole derivatives of formula I:
wherein
R 1 to R 6 are as defined in the specification and pharmaceutically acceptable acid...
|
|
|
7414048 |
4,5-dihydro-isoxazole derivatives and their pharmaceutical use
The present invention is concerned with the compounds of formula
wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; -A 1 =A 2 -A 3 =A 4 - is a pyridinylidene,...
|
|
|
7405226 |
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions...
|
|
|
7402606 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
|
|
|
7402601 |
Pharmaceuticals for the treatment of rejection reactions in organ transplantations
The use of compound 1 and/or 2 of the formulae
and of physiologically tolerable salts of compound 2 for the treatment of rejection reactions of the organ recipient to the transplanted organ is...
|
|
|
7399765 |
Substituted diazabicycloalkane derivatives
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
|
|
|
7396847 |
Oxazolidinone and/or isoxazoline as antibacterial agents
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
and compounds as shown in (I) wherein C is for example
wherein A and B are...
|
|
|
7396843 |
5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors
Compounds of formula (I):
or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
|
|
|
7393870 |
3-(heteroarylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
|
|
|
7388025 |
3-aryl-isoxazole-4-carbonyl-benzofuran derivatives
The present invention is concerned with 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives of formula I
wherein
R 1 , R 2 , and R 3 are as defined in the specification and claims and...
|
|
|
7388017 |
Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
The present invention relates to compounds, methods and pharmaceutical compositions for inhibiting proteases, particularly serine proteases, and more particularly HCV NS3 proteases. The compounds,...
|
|
|
7384929 |
N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds,...
|
|
|
7378448 |
Diphenylether amide derivatives as opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
|
|
|
7378435 |
Aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives
The present invention is concerned with aryl-isoxazole-4-carbonyl-indole-carboxylic acid amide derivatives of formula I
wherein
R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the...
|
|
|
7365088 |
Indazole-derivatives as factor Xa inhibitors
The present invention relates to a compound of the formula I
wherein J 1 , J 2 , R 0 , R 1 , R 2 , Q, V, G and M are as defined herein. The compounds of the formula I are valuable...
|
|
|
7358268 |
Imidazole derivatives as factor Xa inhibitors
This invention is directed to the compound of formula (I) which is useful for inhibiting the activity of Factor Xa. The present invention is also directed to compositions containing said compounds,...
|
|
|
7354919 |
Isoxazole compositions useful as inhibitors of ERK
Described herein are compounds that are useful as protein kinase inhibitors, especially inhibitors of ERK, having the formula:
where A, B, R 1 , R 2 , T and Ht are described in the...
|
|
|
7348322 |
Glucocorticoid receptor modulators as antiinflammatory agents
The present invention relates to compounds of formula I:
wherein A, X, R 1 , R 2 and R 3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to...
|
|
|
7319109 |
Farnesoid X receptor agonists
The invention relates to a compound of formula (I):
wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.
|
|
|
7304062 |
Peroxisome proliferator activated receptor alpha agonists
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or...
|
|
|
7294650 |
Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders
Compounds of formula (I):
and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β 2...
|
|
|
7291647 |
Guanylhydrazone compounds, compositions, methods of making and using
The present invention relates to compounds having the formula:
salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of...
|