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7582666 |
Substituted 2-oxo-3-phenyl-5-carbonylaminomethyl-1,3-oxazolines and their use as anticoagulant and antithrombotics
The invention relates to the field of blood coagulation, more particularly, to novel compounds of general formula (I),
to a method for producing the compounds and to their use as active...
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7582659 |
Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and...
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7576111 |
Substituted oxazolidinones and their use in the field of blood coagulation
The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I)
processes for their preparation and their use as medicinally active compounds...
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7563774 |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7544667 |
Hypocholesterolemic compounds
The present invention relates to novel hypocholesterolemic compounds of formula (I) useful in the treatment and prevention of atherosclerosis and for the reduction of cholesterol levels as well as...
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7521465 |
Diphenyl ether derivatives
Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation,...
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7514567 |
Oxazolidinone nicotinic acetylcholine receptor agonists
Compounds of formula I:
and pharmaceutically-acceptable salts thereof, wherein Q, Ar 1 , A and Ar 2 are as defined in the specification, pharmaceutical compositions and formulations containing...
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7514462 |
ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
The invention relates to the use of derivatives of E-type prostaglandins as EP 2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
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7482467 |
N-thiolated 2-oxazolidinone-derived antibiotics
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by...
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7473699 |
3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein —N-HET is, for example, (Ic) or (If)
wherein R1 is (1-4C)alkyl;
Q...
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7462633 |
Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and ...
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7456206 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7435751 |
7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
The present invention provides a compound of formula I
or a pharmaceutically acceptable salt thereof wherein R 1 is C 1-4 alkyl, optionally substituted with a fluoro atom, or R 1 is a...
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7429583 |
Betamimetics for the treatment of respiratory complaints
The present invention relates to compounds of formula 1
wherein the groups n, m, B, X and R 1 may have the meanings given in the claims and specification, processes for preparing them and...
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7423036 |
Long-acting betamimetics for the treatment of respiratory complaints
The present invention relates to compounds of formula 1,
wherein n, A, R 1 , R 2 and R 3 may have the meanings specified in the description and claims, processes for preparing them and their...
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7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily...
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7396847 |
Oxazolidinone and/or isoxazoline as antibacterial agents
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
and compounds as shown in (I) wherein C is for example
wherein A and B are...
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7390826 |
Inhibitors of animal cell motility and growth
Cell motility and growth inhibitors, including compounds of the general structural formula
and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts,...
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7390825 |
Process for the preparation of oxazolidinones and method of use thereof
Substituted oxazolidinone of the formula:
wherein R 2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
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7390824 |
Method for treating diabetes employing an aP2 inhibitor and combination
A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as...
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7378434 |
Metaxalone products, method of manufacture, and method of use
Disclosed herein is a method of using metaxalone. In one embodiment, the method comprises obtaining metaxalone from a container providing information that metaxalone affects the activity of a...
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7375124 |
Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the...
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7342035 |
Process for preparing zolmitriptan compounds
In particular, zolmitriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and...
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7321063 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7294641 |
Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
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7282515 |
Derivatives of azaspiro compounds for the treatment of pain
This invention relates to azaspiro compounds and their use as medications especially for the treatment of chronic, chronic-phlogistic and/or neuropathic pain. Compounds that lend themselves...
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7282503 |
Fungicidal mixtures based on imidazole derivatives
Disclosed are fungicidal mixtures containing a synergistically effective amount of A) a triazolopyrimidine of formula I, and B) imidazole derivatives of formula II, wherein X 1 and X 2 represent...
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7279494 |
Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I
or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents,...
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7265140 |
Acyloxymethylcarbamate prodrugs of oxazolidinones
The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and...
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7220767 |
Pharmaceutical formulations containing zolmitriptan
A pharmaceutical formulation of the 5HT1-agonist, zolmitriptan, for use in intranasal administration. The formulation is useful in treating migraine and related disorders.
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7217726 |
Antibacterial agents
The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their...
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7199143 |
Chemical compounds
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein —N-HET is, for example, (Ic) or (If)
wherein R1 is, for example,...
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7199125 |
Spiro-cyclic compounds useful as anti-inflammatory agents
The present invention is directed to compounds having the formula (I):
useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or...
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7192954 |
Monocyclic anilide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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7186738 |
Antibacterial oxalidinones
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl,...
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7179794 |
Multivalent macrolide antibiotics
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial...
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7166607 |
Substituted indoles
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
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7160912 |
Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them.
The present invention also...
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7157482 |
Antibacterial 1,3-oxazolidin-2-one derivatives
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R 1 ; R 1 is for example...
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7153866 |
Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia
The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at...
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7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7144911 |
Anti-inflammatory medicaments
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein...
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7144900 |
Pharmaceutical composition
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent...
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7129259 |
Halogenated biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7125893 |
6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I
in which R 1a , R 1b , R 2a , R 3a , R 3b , R 4 , R 5 , R 6 , R 7 , A, Y, D, E, G, Y and Z...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7122566 |
Metaxalone products, method of manufacture, and method of use
Disclosed herein is a method of using metaxalone. In one embodiment, the method comprises obtaining metaxalone from a container providing information that metaxalone affects the activity of a...
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