Matches 201 - 250 out of 459 < 1 2 3 4 5 6 7 8 9 10 >
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5843975 Oxazolidinone derivatives, their preparation and therapeutical use  
The present invention relates to isoindole derivatives, and more particularly to 5-(hydroxymethyl)oxazolidine-2-one derivatives which are substituted at the 3 position by an indazole, benzisoxazole...
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5814647 Use of troglitazone and related compounds for the treatment of the climacteric symptoms  
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
5789404 3-substituted 1-arylindole compounds  
3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or...
5783591 Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation  
Pharmaceutical preparations for the local treatment of inflammations are claimed herein, characterized in that they contain as the active ingredient one or two compounds of general Formula I...
5756532 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives  
The compounds of formula I: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R 1 and R 2 , taken together, are benzylidene optionally substituted with R 3 ...
5723479 Benzofuran compounds and their use  
Benzofuran compound represented by the formula: ##STR1## wherein ##STR2## represents a group capable of releasing a cation in which ....... represents a single or double bond: R 1 represents an...
5719170 Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations  
Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in...
5719163 Substituted oxazolyl compounds for the treatment of inflammation  
A class of substituted oxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1##...
5705516 Oxazoles and their agricultural compositions  
A compound having the formula R--S(O) n CH 2 CH 2 CHCF 2 , wherein R is a phenyl group or a heterocyclic group selected from furyl, thienyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl,...
5703065 Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds  
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R 3 , Q and R 1 are as defined herein. The compounds of formula I, and...
5698574 5-membered heteroaryl-oxazolidinones  
The present invention relates to 5-membered heteroaryl-oxazolidinones, to processes for their preparation and to their use as medicaments, in particular as antibacterial medicaments.
5688823 Thiazolidine and oxazolidine derivatives their preparation and their medical use  
Compounds of formula (I): ##STR1## Z is a group of formula (iii), (iv),: ##STR2## and salts, esters and solvates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a...
5684023 Benzofuranyl -and benzothienyloxazolidinones  
The present invention relates to benzofuranyl- and benzothienyloxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
5672564 Aqueous, multiphase, stable finished formulation for crop protection active compounds and its preparation  
An aqueous, multiphase, stable finished formulation for crop protection active compounds is described, containing in addition to water a) 10 to 700 g/l of one or more crop protection active...
5670530 Anti-cancer composition comprising rhodacyanine compound and cyclodextrin  
An anti-cancer composition comprising a rhodacyanine compound and cyclodextrin or derivative thereof, wherein said rhodacyanine compound is selected from the group consisting of compounds...
5668163 Fungicidal compositions  
A novel fungicidal composition comprising a fungicidally effective amount of a combination consisting of the known 2-cyanobenzimidazole of the formula ##STR1## in which A has the meanings given in...
5668164 Process for synthesis of chiral cis-and trans-3-amino-4 substituted pyrrolidine compounds  
Process for preparation of chiral cis-3,4-substituted pyrrolidine compounds having the formulas: ##STR1## and chiral 3,4-trans-substituted pyrrolidine compounds having the formulas: ##STR2## with...
5658935 Heterocycles, their preparation and their use  
The invention concerns heterocyclic compounds of the general formula (I) in which A, B, R, R 2 , R 3 , W, Y, Z 1 , Z 2 and r are as defined in the description, methods of preparing them and their...
5643926 Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof  
Novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin (CCK) receptors and gastrin receptors in the brain and/or peripheral sites such as the pancreas,...
5629330 Fungicidal composition for seed dressing  
The present invention relates to a fungicidal composition intended for the protection of the multiplication products of cultivated plants, containing: (a)...
5624937 Chemical compounds as inhibitors of amyloid beta protein production  
A compound of the formula I in which ##STR1## Z is O or S; R 11 is a halogen atom; R 12 is a halogen atom or a trifluoromethyl group; and X is S, SO, SO 2 , O or NH; R 4 is naphthyl,...
5616596 Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis  
The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More...
5614541 Pharmacologically active catechol derivatives  
New catechol derivatives and pharmaceutically acceptable salts and esters thereof useful as pharmaceutical antioxidants are disclosed. Cellular damage by oxygen derived radicals is a significant...
5610171 Inhibition of metastasis in patients having cancer with pyridyloxazole-2-ones  
This invention is directed to pyridinyloxazole-2-ones which are useful in inhibiting metastasis in patients having cancer. The pyridinyloxazole-2-ones act to inhibit protein kinase C and thereby...
5604182 Milbemycin ether derivatives, their preparation and their therapeutic and agrochemical uses  
Compounds of formula (I): ##STR1## and salts and esters thereof have valuable anthelmintic, acaricidal and insecticidal activities. Methods of preparing the compounds are also provided.
5597840 Microemulsion formulation for injection into trees  
An agrochemical microemulsion composition for injection into trees, and the use of said composition for preventing and treating damage to trees from disease and pests or regulating tree growth. The...
5597843 Use of a substituted 1,3-benzodioxole to reduce a wasting condition  
The present invention provides a method of reducing a wasting condition, which can occur due to a pathology or to a particular physiologic or metabolic state in a subject, by administering to the...
5578638 Treatment of glaucoma and ocular hypertension with β.sub.3 -adrenergic agonists  
This invention relates to a method of treating glaucoma or reducing intraocular pressure in a patient in need of such treatment which is based on the topical administration to the eye of a mammal...
5574055 Oxazolidinone derivatives  
The present invention relates to compounds of the formula: ##STR1## wherein R is H or alkyl; Y 1 is --CH or --N; and Y 2 --CH, --C(OH), --C(NO 2 ), --C(NH 2 ),...
5567735 Therapeutic amides  
Amides having formula I: ##STR1## wherein E, X, R 2 and R 3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo...
5563166 Thienyl- and furylpyrrole fungicidal agents  
There are provided fungicidal thienyl- and furylpyrrole compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from...
5563158 Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists  
This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using...
5536749 Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents  
Disclosed is a method for attenuating sympathetic nervous system hyperactivity or onset of migraine in a patient in need of such treatment, by the sublingual, buccal or intranasal administration to...
5532255 Adhesion receptor antagonists  
Compounds of the formula ##STR1## in which R 1 , X and Y have the meanings defined herein, and their salts, inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for treating...
5523312 Antipicornaviral agents  
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
5510379 Sulfonate ACAT inhibitors  
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
5508296 Bisheterocyclic derivative or salt thereof  
5506243 Sulfonamide derivatives  
Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as...
5500425 Chroman derivatives and a method of treating 5-HT mediated disorders  
Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.
5500420 Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia  
Administration of metabotropic glutamate receptor agonists protect neuronal cells from death from cerebral ischemia. Examples of agents are L(+)-2-amino-4-phosphonobutyric acid, trans-amino...
5498621 Oxazolidinedione hypoglycemic agents  
Compounds of the formulae ##STR1## where R is cycloalkyl or aryl; R 1 is alkyl, X is O or CO; A is O or S; and B is N or CH are useful as hypoglycemic agents.
5494926 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR 8 (R 8 is H or C...
5492925 Thienyl-and furylpyrrole insecticidal and acaricidal agents  
There are provided thienyl- and furylpyrrole compounds of formula I ##STR1## and their use for the control of insects and acarina. Further provided are compositions and methods comprising those...
5482966 Oxime derivatives  
The invention concerns oxime derivatives of the formula I ##STR1## wherein R 4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and...
5480899 Oxazolidine derivatives and pharmaceutically acceptable salts thereof  
An oxazolidine derivative represented by the formula (I) ##STR1## wherein R 1 , R 2 and R 3 are H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO 2 , amino optionally...
5480902 Thienylpyrrole fungicidal agents  
There are provided fungicidal thienyl- and furylpyrrole compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from...
5475014 Oxazolidone derivative  
An oxazolidone derivative represented by formula (I) which has a monoamine oxidase inhibition effect: ##STR1## {wherein A and B each represents a nitrogen atom, a sulfur atom or an oxygen atom,...
5472965 Imidazole derivatives having anti-HIV activity  
A novel imidazole derivatives of formula I: ##STR1## wherein R 1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R 2 is alkyl, optionally substituted aryl optionally substituted...
5470866 Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol  
The natural product cephalomannine can be converted to the important anticancer natural product taxol by a simple process involving the steps of dihydroxylation to give cephalomannine-diols, diol...
Matches 201 - 250 out of 459 < 1 2 3 4 5 6 7 8 9 10 >