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7122566 |
Metaxalone products, method of manufacture, and method of use
Disclosed herein is a method of using metaxalone. In one embodiment, the method comprises obtaining metaxalone from a container providing information that metaxalone affects the activity of a...
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7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
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7109223 |
Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which...
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7105552 |
Heterocyclic analogs of diphenylethylene compounds
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7087629 |
Heterocyclylaminomethyloxazolidinones as antibacterials
Compounds of formula (I)
or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an optionally substituted C-linked 5-membered...
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7074785 |
Δ1-pyrrolines used as pesticides
Novel Δ 1 -pyrrolines of the formula (I)
in which
R 1 , R 2 , R 3 , A, R 4 and m have the meanings given in the description,
a number of processes for preparing these substances, and their...
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7053122 |
Therapeutic use of aryl amino acid derivatives
The compounds of formula (I)
are useful in the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain,...
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7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7012088 |
Indolone oxazolidinones and derivatives thereof
The present invention provides antibacterial agents of formula I described herein and intermediates for their preparation.
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6992103 |
Benzamide derivatives, processes for their preparation, and their pharmaceutical use
The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them...
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6969726 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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6964976 |
Amino alcohol derivatives
Compounds of formula (I) which exhibit excellent immune suppression activity, pharmacologically acceptable salts thereof, esters thereof or other derivatives:
wherein R 1 and R 2 are a...
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6951873 |
Methods for treating age-related behavioral disorders in companion animals
Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically...
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6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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6939867 |
β3 agonists and uses thereof
Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity,...
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6927229 |
Difluorothioacetamides of oxazolidinones as antibacterial agents
The present invention describes difluororthioacetamide oxazolidinones of formula I:
R is —CH 2 — or —CH 2 CH 2 —; R 2 and R 3 are independently —H or —F; X is —CH—; Y is...
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6924301 |
Composition for treating or preventing arrhythmia
A composition for treating or preventing arrhythmia containing as an active ingredient a cPLA 2 inhibitor, for example a compound represented by formula (I):
wherein R 1 is optionally...
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6897230 |
Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof
Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci,...
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6890928 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
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6884813 |
Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
The present invention provides a compound of formula I
or a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or iv
X is CR 7 ; Y is —S(═O) n —,...
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6875784 |
Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are...
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6869965 |
Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
Substituted quinolone derivatives in which an oxazolidinone, isoxazolinone, or isoxazoline is covalently bonded to a quinolone, methods of using the quinolone derivatives, and pharmaceutical...
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6869968 |
2-(3H)-oxazolone derivatives and their use as COX-2 inhibitors
The invention relates to 2-(3H)-oxazolone derivatives. They may be used as COX-2 inhibitors. The compounds may be used in the treatment of colorectal cancer.
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6867226 |
Serotonin 5-HT3 receptor partial activator
This invention provides a serotonin 5-HT 3 receptor partial activator which has a serotonin 5-HT 3 receptor activating action, in addition to its serotonin 5-HT 3 receptor antagonism, and does...
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6852716 |
Substituted-aryl compounds for treatment of disease
The invention provides compounds of Formula I:
These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of...
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6846492 |
Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
The use of compounds of formula (1) is described, in which compounds R 1 , R 2 and R 3 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 2 -C 20 alkenyl; C 4...
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6828341 |
Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
Described are cyclohexylamine derivatives of Formula I and pharmaceutically acceptable salts thereof, wherein R 1 , g, *, R, V, B, E, Y, G, H, X 1 , and d are as defined in the description. The...
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6821991 |
2-substituted thiazolidinones as β-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined hereinbefore or a pharmaceutically acceptable salt...
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6794401 |
Amino acid phenoxy ethers
Novel amino acid phenyl ethers are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases and diabetes.
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6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
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6784199 |
Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals
The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug...
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6770664 |
Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of Formulae II or III: in which the substituents have the meaning indicated in the...
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6759402 |
Cyclic felbamate derived compounds
The present invention relates to novel felbamate derivatives and their use to treat neurological diseases such as epilepsy and to treat tissue damage resulting form ischemic events. The felbamate...
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6756360 |
Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
Pharmaceutical compositions containing an FBPase inhibitor and an insulin sensitizer are provided as well as methods for treating diabetes and diseases responding to increased glycemic control, an...
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6743814 |
Nematicidal trifluorobutenes
The present invention relates to novel trifluorobutenes of the formula (I) wherein R 1 represents hydrogen; halogen; alkyl that is unsubstituted or substituted with halogen, hydroxy, alkoxy,...
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6743811 |
Oxazalidinone compounds and methods of preparation and use thereof
Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising...
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6696456 |
Beta disubstituted metalloprotease inhibitors
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have...
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6689794 |
Aromatic sulfone hydroxamates and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
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6686363 |
Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and...
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6683102 |
Methods of using metaxalone in the treatment of musculoskeletal conditions
A method of increasing the bioavailability of metaxalone by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of...
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6617337 |
Use of nitroxides for the treatment of essential hypertension
The present invention encompasses methods of treating patients for essential hypertension. The invention also includes related pharmaceutical compositions of nitroxides. Specific drugs, such as...
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6617339 |
Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and...
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6605631 |
Ortho-substituted 2-methoxyiminophenyl-N-methylacetamides
Compounds of the general formula I where the index and the substituents have the following meanings: n is 0 or 1 to 4; X is O or S; Y is a five-membered heteroaromatic ring; R 1 is nitro;...
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6602876 |
Adhesion receptor antagonists
Compounds of the formula I wherein R 1 , R 2 and R 3 have the meanings defined herein, and also their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding...
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6586452 |
C1 to C4 side chain modified nodulisporic acid analogs
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
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6579893 |
Use of troglitazone and related compounds for the treatment of cancer
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
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6576632 |
Biaryl compounds useful as anticancer agents
The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 10 , R 11 , b, m, n, p...
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