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9012481 Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same  
Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's...
8993607 Therapeutic compounds  
The invention provides compounds of formula I, II, and III as defined herein, as well as salts thereof. The compounds may have activity as anti-proliferative agents.
8957097 Hemi-phorboxazole A derivatives and methods of their use  
The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl...
8952058 Heterocyclic compounds and methods of use thereof  
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and...
8940764 Compositions and methods of treating retinal disease  
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for...
8912186 Allosteric protein kinase modulators  
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein...
8895591 Tricyclic compound and pharmaceutical use thereof  
The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof...
8883833 Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders  
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for...
8877773 Methods for treating chronic obstructive pulmonary disease  
Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are disclosed.
8871738 Fused bicyclic oxazolidinone CETP inhibitor  
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol,...
8859592 Insecticidal compounds  
A compound of formula (I): wherein A1, A2, A3, A4, A5, G1, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and...
8853212 Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes  
The present invention is directed to novel substituted aminotetrahydrothiopyrans and derivatives thereof of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and...
8846734 Diazonamide analogs  
Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
8829035 Agent for treatment or prevention of diseases associated with activity of neurotrophic factors  
A compound depicted by the formula below, or a pharmaceutically acceptable salt or solvate thereof. wherein, R1 represents (1) a C3-6 alkyl group, (2) a C1-6 alkyl group substituted with one or...
8796300 Therapeutic compounds  
The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as...
8791114 Dihydropyrazoles  
Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the...
8778921 Ansamycin hydroquinone compositions  
Aspects of the present invention provide compositions comprising a sulfur containing compound and a compound of the formula (I); and also provide methods of their preparation and use.
8772323 Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists  
The present invention relates to pyridazinone derivatives of general formula I, wherein the groups A, G and R1 are as defined in the application, the tautomers thereof, stereoisomers thereof, the...
8765731 Benzimidazole analogues for the treatment or prevention of flavivirus infections  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are...
8754083 Compositions of dibromomalonamide and their use as biocides  
A biocidal composition comprising 2,2-dibromomalonamide and an aldehyde-based biocidal compound, and its use for the control of microorganisms in aqueous and water-containing systems.
8754113 Oxadiazole derivative having endothelial lipase inhibitory activity  
A compound represented by the formula: or its pharmaceutically acceptable salt. Ring A is aromatic carbocycle or aromatic heterocycle, Z is —O— or —S—, R1 is hydrogen, halogen, hydroxy, cyano,...
8747873 Compositions of dibromomalonamide and their use as biocides  
A biocidal composition comprising 2,2-dibromomalonamide and an aldehyde-based biocidal compound, and its use for the control of microorganisms in aqueous and water-containing systems.
8748465 Phenylamino-benzoxazole substituted carboxylic acids, method for their production and use thereof as medicaments  
This invention relates to a compound of formula I, wherein R1, R2, R6, R7, R8, R9, R10, m and X are as defined herein, or a physiologically tolerated salt thereof, its pharmaceutical composition...
8748427 Compositions of dibromomalonamide and their use as biocides  
A biocidal composition comprising 2,2-dibromomalonamide and an aldehyde-based biocidal compound, and its use for the control of microorganisms in aqueous and water-containing systems.
8729060 Macrocyclic polyoxazole compounds and use thereof  
The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n′ and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as...
8722715 Antimicrobial oxazolidinone, hydantoin and imidazolidinone compositions  
The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula I or pharmaceutically acceptable salts thereof, and associated compositions and...
8710052 Compounds and compositions for treating chemical warfare agent-induced injuries  
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
8703804 Ryanodine receptor inhibitors and methods relating thereto  
The present invention provides novel ryanodine receptor type 2 (RyR2) inhibitors and methods of their use in the treatment of cardiac conditions. In general, the RyR2 inhibitors of the present...
8703758 Bicyclic compound  
The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia,...
8691859 Broad spectrum antibacterial compounds  
Disclosed herein are methods of inhibiting, reducing or preventing growth of or destroying bacteria of at least one bacterial strain which comprises contacting the bacteria with the compounds...
8653070 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8653119 Methods for treating transthyretin amyloid diseases  
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin...
8629168 Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors  
The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo[5,4-c]pyridine compounds of the formula I given below, as well as salts thereof, processes for the preparation...
8618110 Compositions and methods for apoptosis modulators  
The present invention includes and relates generally to compounds of structural Formula (I), or a salt, solvate, or prodrug thereof, which modulate apoptosis in cells. The present invention also...
8614240 Benzoxazole derivatives having inhibitory activity against interleukin-6, preparation method thereof, and pharmaceutical composition containing the same  
The present invention relates to benzoxazole derivatives represented by the Formula 1, which has an inhibitory activity against interleukin-6 (IL-6), a method for preparation thereof, and a...
8614239 Heterocyclic sulfonamide derivatives  
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in...
8614238 Cyclopentanecarboxamide derivatives, medicaments containing such compounds and their use  
The invention relates to cyclopentanecarboxamide derivatives of formula 1, to their use as Fatty Acid Synthase inhibitors, to methods for their therapeutic use and to pharmaceutical compositions...
8609705 Fused heterocyclic compounds, and compositions thereof, for use in arthropod pest control  
Disclosed is a harmful arthropod control composition comprising, as an active ingredient, a fused heterocyclic compound represented by formula (1) [wherein A1 and A2 independently represent a...
8598168 Inhibitors of histone deacetylase  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
8592469 Diazonamide analogs  
Diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders, and related pharmaceutical compositions are provided.
8586609 Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament  
The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof;...
8569282 Carboxamide compounds and their use  
Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or...
8552037 Tricyclic compound and pharmaceutical use thereof  
The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof...
8546376 Pharmaceutical compounds  
The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as...
8518980 Treatment of Duchenne muscular dystrophy  
There are disclosed compound of Formula (1): A1, A2, A3 and A4 which may be the same or different, represent N or CR1, X is a divalent group selected from O, S(O)n, C═W, NR4, NC(═O)R5 and CR6R7, W...
8519010 Antimicrobial compositions  
What is described herein are antimicrobial compositions which are defined blends of a 1,2-diol and phenoxyethanol which show broad activity against bacteria, fungi and mold spores. This activity...
8513290 Method for preparing largazole analogs and uses thereof  
Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally...
8507539 Potassium channel blockers and uses thereof  
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also...
8497283 Autotaxin inhibitors  
The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or...
8481532 PDE-10 inhibitors  
Vicinal substituted cyclopropyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical...