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5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5480902 Thienylpyrrole fungicidal agents  
There are provided fungicidal thienyl- and furylpyrrole compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from...
5475014 Oxazolidone derivative  
An oxazolidone derivative represented by formula (I) which has a monoamine oxidase inhibition effect: ##STR1## {wherein A and B each represents a nitrogen atom, a sulfur atom or an oxygen atom,...
5472961 Acetamides  
Novel acetamides of the formula I ##STR1## in which Q, R, X and Y have the meanings defined herein, have analgesic and neuroprotective properties and bind with high affinity to kappa receptors.
5462964 Dipeptide boronic acid inhibitors of trypsin-like enzymes  
The present invention relates to the discovery of new C-terminal boronic acid dipeptide inhibitors of trypsin-like enzymes such as thrombin and pharmaceutical compositions thereof.
5462953 Benzoxazolyl derivatives useful as 5-lipoxygenase inhibitors  
The invention concerns a bicyclic heterocyclic derivative of the formula I ##STR1## wherein Q is an optionally substituted 9-membered bicyclic heterocyclic moiety containing 1 or 2 N's and...
5451596 Cycloalkyl amine bis-aryl squalene synthase inhibitors  
This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or...
5451594 Heterocyclic compounds  
The invention provides compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their...
5436267 N-phenylcarbamate compound, process for preparing the sasme and biocidal composition for control of harmful organisms  
A novel N-phenylcarbamate compound or its salt where possible, which is useful as the active ingredient of a biocidal composition for control of harmful organisms, is represented by the following...
5428048 Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents  
This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and...
5395846 Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors  
This invention relates to a class of novel amino bi- and tri-carbocyclic alkane compounds having bis-aryl substitution which exhibit squalene synthase inhibition properties. The bi- and...
5391565 Oxazolidine dione derivatives  
Compounds of the formula: ##STR1## or tautomeric forms and a pharmaceutically acceptable salt, and pharmaceutically acceptable solvates thereof, wherein: A1 is a substituted or unsubstituted...
5378715 Sulfonamide endothelin antagonists  
Compounds of the formula ##STR1## inhibit endothelin, wherein: one of X and Y is N and the other is O; R is naphthyl or naphthyl substituted with R1, R2 and R3 ; R1, R2 and R3 are each...
5364875 Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis  
Disclosed are imidazoles linked to bicyclic heterocyclic groups, as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), processes for their preparation, pharmaceutical compositions, and...
5350760 Aza-5,5-fused hetrocyclic acids as leukotriene antagonists  
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
5350751 Substituted imidazoles, pharmaceutical compositions containing these, and the use thereof as antagonists of angiotensin II receptors for the treatment of high blood pressure  
The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR2, R1 and R2 are as defined in the description, L is an alkylene radical,...
5330981 Arylalkyl esters of 4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid having therapeutical activity  
This application describes 3-arylalkyl esters of 4,5-dihydro-9,10-dioxo-2-anthracenecarboxylic acid and a process for making them. Also described is a method of using the compounds in the...
5326775 Benzoxazolinonyl alkylamides  
Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
5308850 (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5302589 Heterocyclic inhibitors of 5-α-testosterone reductase  
The present invention relates to certain substituted 17 β-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I): ##STR1## wherein R1 and R2 are i) independently hydrogen or lower alkyl and...
5288761 Open chain enediyne dihydroperoxides having DNA cleaving properties  
Open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.
5288732 2-cyano-2-alkoximino-acetamides  
Novel fungicides of the formula ##STR1## in which R1 represents optionally substituted hydroxyalkyl, optionally substituted hydroxyalkoxyalkyl, optionally substituted heteroarylalkyl or optionally...
5286741 N-oxy- and thioalkylcarbonyloxyalkylpyrrole insecticidal, acaricidal and molluscicidal agents  
There are provided N-oxy- and thioalkylcarbonyloxyalkylpyrrole compounds of formula I and their use for the control of insects, acarina and mollusks. Further provided are compositions and methods...
5273988 2-(3,4,4,-trifluorobutenylmercapto) alkoxy or nitro benzoxazoyl compounds  
Compounds of formula (I): ##STR1## wherein R1, R2 and R3 are independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, halogen, haloalkyl, alkoxy, alkenoxy, alkoxyalkyl,...
5268381 Aminoalkyl-benzothiazolinone and -benzoxazolinone compounds having a high 5-HT1A affinity  
Compounds of general formula (I): ##STR1## wherein R1, R2, R3, n, X and A are defined in the description. Medicinal products containing the same are useful as antidepressives or anxiolytics due to...
5266320 Aminovinyl-substituted heterocyclic compounds as stabilizers for organic materials  
The use of an aminovinyl-substituted heterocyclic compound of the general formula I ##STR1## in which R1 denotes hydrogen, C1 -C4 -alkyl, C1 -C4 -alkoxy, or halogen, and, if more than one radical...
5256661 Substituted 2-aminotetralins and pharmaceutical use  
Certain novel compounds having the structural formula ##STR1## where R2, R3 and R4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of...
5246927 Benzazole derivatives, processes for their preparation containing such compounds and the use thereof  
The invention relates to new benzazole derivatives of the formula I ##STR1## wherein X is oxygen or sulphur, R1 is lower alkyl, lower alkenyl or cycloalkyl, R2 and R3 independently of one another...
5240919 Benzthiazolinonyl-substituted alkylamides  
Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
5238690 Isolate of trichoderma fungicidal compositions containing said isolate and use against B. cinerea and S. sclerotiorum  
The present invention relates to a novel biologically pure culture of Triderma Harzianum, I-952, to biological control compositions containing same and to methods of protecting plants from the...
5238724 Arthropodicidal use of 6-methoxy-2-benzoxazolinone combined with insecticides and/or biocontrol agents  
Control of arthropods, particularly the larvae of Diabrotica spp., by application of 6-methoxy-2-benzoxazolinone (6-MBOA) alone or in combination with an insecticide or biocontrol agent; and...
5232945 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives  
A method of using certain 3-aryl-2-hydroxypropionic acid derivatives and analogs in the treatment of hypertension.
5223523 Fungicidal oxazolidinones  
Compounds for an methods of controlling plant diseases using thiooxazolidinones, oxazolidindiones and agriculturally suitable compositions containing them are disclosed.
5223517 Heterocyclically substituted cycloalkano[b]-indolesulphonamides  
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
5206255 Heterocyclic compound  
A novel heterocyclic compound represented by the following formula (I): ##STR1## wherein X represents an oxygen atom or sulfur atom; R1 represents a hydrogen atom or halogen atom; R2 represents a...
5202340 Amino acid derivatives  
The compounds of the formula: ##STR1## (wherein R1 is hydrogen or alkyl; R2 is carbocyclic or heterocyclic ring, unsubstituted or substituted by R3 s; R3 is halogen, trihalomethyl, hydroxy, alkyl,...
5200394 Derivatives of type A and B synergimycins  
The invention synergimicin derivatives having the general formula: Z--X--R, in which Z is a type A or type B synergimycin radical linked by its reactive carbonyl position, through a branch X,...
5196454 Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines  
The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical...
5192753 Anti-rheumatoid arthritic drugs in the treatment of dementia  
This invention pertains to the novel use of anti-rheumatoid arthritic drugs in the treatment of dementia. A method of treating dementia in human beings which comprises administering to the human...
5189050 Fermentation analogs of Virginiamycin M1 to treat panic and anxiety disorder  
Pharmaceutical compositions containing Virginiamycin M1 having the Formula: ##STR1## and Virginiamycin M1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment...
5188830 Methods for thrombolytic therapy  
Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either...
5179093 Quinoline-diones  
Compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein, R is H, halogen, (C1 -C6) alkyl, N(C1 -C6 alkyl/aryl)2, OH, O--(C1 -C6) alkyl/aryl, CH2 OH, COOH,...
5158964 Benzoxazole sulfonamide anti-arrhythmic agents  
A series of novel N-alkyl N-(alkanesulphonamidoheterocyclicmethyl)-4-alkanesulphonamid ophenethylamin es have been prepared, including their pharmaceutically acceptable salts and various key novel...
5151436 Derivatives of thioformamide  
Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl,...
5147883 Acylbenzoxazolinones compounds  
Compounds of general formula (I): ##STR1## in which: R1 represents a hydrogen atom or a lower alkyl group,A represents a hydrogen atom, and in this case B represents a group CO-G, G being: either...
5137900 Therapeutic virginiamycin M1 analogs  
Virginiamycin M1 having the Formula: ##STR1## and virginiamycin M1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and...
5132305 Benzoxazolinone compounds, compositions and use  
Compounds of general formula (I): ##STR1## in which: R1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group, R2 and R3 : a--identical or different, denote a...
5112843 Arthropodicidal use of 6-methoxy-2-benzoxazolinone to attract and control corn rootworm (Diabrotica)  
Control of arthropods, particularly the larvae of Diabrotica spp., by application of 6-methoxy-2-benzoxazolinone (6-MBOA) alone or in combination with an insecticide or biocontrol agent; and...
5112841 Imidazole derivatives and antiepileptics comprising said imidazole derivatives as effective ingredients  
Described herein are imidazole derivatives having a specific structure and satisfactory as antiepileptics from the standpoint of the strength of action, prolonged action and side effects as well...
5110821 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents  
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; R' is lower-alkyl or hydroxy-lower-alkyl or 1-5 carbon atoms; R1 and R2 are hydrogen, halogen, lower-alkyl,...