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5792786 Non-steroidal anti-inflammatory fatty acid conjugates and their therapeutic use thereof  
The present invention provides therapeutic conjugates which comprise a therapeutic compound bound to one to three acyl groups derived from fatty acids. The therapeutic compounds are preferably...
5789428 Amino-acid amide derivatives, processes for preparing the same, agricultural or horticultural fungicides, and method for killing fungi  
The present invention provides an amino-acid amide derivative represented by the formula: ##STR1## (wherein R1 represents a C1.about.C6 alkyl group, a C3.about.C8 cycloalkyl group, or a phenyl...
5783586 Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis  
Compounds having the formula: ##STR1## wherein W1 and W2 are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted...
5760065 Anti-HIV agent  
The present invention relates to an anti-HIV agent which comprises, as an active ingredient, Mycalolide B represented by formula (Ia): ##STR1## or the like.
5756532 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives  
The compounds of formula I: ##STR1## wherein R1 and R2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R1 and R2, taken together, are benzylidene optionally substituted with R3 as...
5721259 Method of using 2-formylpyridine thiosemicarbazone compounds  
A method of treatment of tumors is provided based upon a compound of the formula ##STR1## wherein one of R1 is NHR4 or NR4 R5 or R3 is NHR4, NR4 R5 or OH, and the other is hydrogen; R2 is hydrogen...
5705509 Tricyclic heterocyclic compounds as 5-HT4 receptor antagonists  
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 --(CH2)x --X2 and the aromatic carbon atoms to which they are attached form 5-7 membered ring wherein X1 is O or...
5705498 Piperidine derivatives as 5-HT4 receptor antagonists  
Compounds of formula (I): ##STR1## wherein Xg is O, S, SO, SO2, CH2, CH, N or NR wherein R is hydrogen or C1-6 alkyl; A is a saturated or unsaturated polymethylene chain of 2-4 carbon atoms; R1g...
5696137 Azaheterocyclymethyl-chromans  
Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R6 represents hydrogen, hydroxyl,...
5696136 Method of treating psychosis using azaheterocyclylmethyl  
A method of treating psychosis by administering to a patient an azaheterocyclylmethyl-chroman of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group...
5693653 Method of treating depression using azaheterocyclylmethyl-chromans  
Azaheterocyclylmethyl-chromans are prepared by reaction of corresponding methylchromans with corresponding azaheterocyclic compounds, optionally with subsequent variation of the substituents. The...
5688809 5-heteroarylindole derivatives  
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical...
5688822 Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as inhibitors of 5-lipoxygenase  
Compounds of the formula: ##STR1## Formula I and the pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising a therapeutically-effective amount of the compounds or salts...
5688820 Aminoalkyl benzoxazolinones and benzothiazolinones  
The invention relates to a compound selected from those of formula (I): ##STR1## in which R1, R2, R3, X and n are as defined in the description, the optical isomers thereof, and the addition salts...
5672583 Carboxy-peptidyl derivatives as antidegenerative active agents  
Novel Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis,...
5670530 Anti-cancer composition comprising rhodacyanine compound and cyclodextrin  
An anti-cancer composition comprising a rhodacyanine compound and cyclodextrin or derivative thereof, wherein said rhodacyanine compound is selected from the group consisting of compounds...
5668148 Alpha1a adrenergic receptor antagonists  
Compounds that specifically bind to the human alpha1a adrenergic receptor, including compounds effective to reduce symptoms of benign prostatic hypertrophy include compounds of formula: ##STR1##...
5665737 Substituted benzoxazoles  
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard...
5643960 Method of delaying onset of alzheimer's disease symptoms  
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The method involves the administration to...
5639446 Derivatives of benzoxazole useful as UV stabilizers  
Compounds of formula (I) ##STR1## wherein the groups are as defined in the description, are useful as sunscreens in cosmetics and in the stabilization of synthetic polymers.
5635522 Immunosuppressive agents  
A suppression of the human immune system is accomplished by administering to the person an effective amount of a non-toxic thioheterocycle compound having the formula ##STR1## wherein R1 is a...
5631253 Fungicidal propenoic acid derivatives  
Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4...
5627200 β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia  
This invention relates to methods for treating intestinal motility disorders, intestinal ulcerations, including inflammatory bowel disease, ulcerative colitis, Crohn's disease and proctitis, and...
5604224 Substituted heterocyclylisoquinolinium salts and compositions and methods of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5594008 Pyrrolidine derivatives inhibitors of leukotriene biosynthesis  
2-(1-pyrrolidino)-benzoxazoles of general formula ##STR1## are disclosed which are inhibitors of leukotriene biosynthesis.
5591762 Benzimidazoles useful as angiotensin-11 antagonists  
Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally...
5589492 Heterocyclic compounds and their use in the treatment of Type-II diabetes  
A compound of the formula A1 --X--(CH2)n --O--A2 --A3 --CO.R2 (I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate...
5585091 Use of benzazoles UV absorbers, new benzazoles and a process for their preparation  
Compounds which, per molecule, contain at least 2 benzazolyl groups are outstandingly suitable as UV absorbers for sunscreen compositions.
5569666 Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical conpositions and methods of treatment  
A method for treating a human or non-human animal afflicted with malignant cells sensitive to parabactin or vibriobactin or a pharmaceutically acceptable salt or complex thereof comprising...
5569655 Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof  
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
5567735 Therapeutic amides  
Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable...
5563166 Thienyl- and furylpyrrole fungicidal agents  
There are provided fungicidal thienyl- and furylpyrrole compounds of formula I ##STR1## Further provided are compositions and methods comprising those compounds for the protection of plants from...
5556855 N-heterocyclic substituted salicylic acids  
A compound of the formula Het--NR--SO2 --Ph2 --A--Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene...
5554633 Substituted amines as tachykinin receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H...
5552422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents  
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a...
5541205 Aryl-n-hydroxyureas as inhbitors of 5-lipoxygenase and anti-arteriosclerotic agents  
This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and...
5541199 Chroman-2-ylmethylamino derivatives  
Compounds of the formula: ##STR1## in which n is one of the integers 1, 2, 3,or 4; m is one of the integers 0 or 1; R is ##STR2## or a pharmaceutically acceptable salt thereof, are inhibitors of...
5529998 Benzoxazolyl- and benzothiazolyloxazolidinones  
The invention relates to benzoxazolyl- and benzothiazolyloxazolidinones, processes for their preparation and their use as medicaments, in particular as antibacterial medicaments.
5523312 Antipicornaviral agents  
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
5519033 Azabicyclo derivatives for treatment of urinary incontinence  
The present invention relates to a method of treating urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives...
5518713 Benzoxazole derivatives, the use thereof as sunscreens and cosmetic compositions containing them  
Benzoxazole derivatives having the following formula (I): ##STR1## wherein the groups are hereinafter defined are disclosed together with the use thereof as sunscreen agents and cosmetic...
5516789 Lipoxygenase and cyclooxygenase inhibiting compounds  
Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B4,...
5498610 Neuroprotective indolone and related derivatives  
The present invention is directed to a method of blocking N-methyl-D-aspartic (NMDA) acid receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and...
5498621 Oxazolidinedione hypoglycemic agents  
Compounds of the formulae ##STR1## where R is cycloalkyl or aryl; R1 is alkyl, X is O or CO; A is O or S; and B is N or CH are useful as hypoglycemic agents.
5496853 Benzoxa condensed ring compounds, process for producing the same and pharmaceutical composition comprising the same  
Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In...
5496826 Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides  
New central nervous system agents conform to formula I: ##STR1## wherein R=H or C1-4 alkoxy; X=CH or N; Y=NH, O or S; Z=C1-4 alkyl, C3-6 cycloalkyl, C2-3 alkenyl, NH2, C1-4 alkylamino, or C1-4...
5494926 2/3-(heterocyclic alkyl amino)-1-(subst.-phenyl-methoxy)-ethanes/propanes as tachykinin-receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents phenyl or benzhydryl; X and Y each represent H or X and Y together form a group =0; Z is O, S or NR8 (R8 is H or C1-6...
5492925 Thienyl-and furylpyrrole insecticidal and acaricidal agents  
There are provided thienyl- and furylpyrrole compounds of formula I ##STR1## and their use for the control of insects and acarina. Further provided are compositions and methods comprising those...
5491156 Benzoxazole, benzothiazole and benzimidazole derivatives as fungicides  
PCT No. PCT/GB92/01860 Sec. 371 Date Feb. 16, 1994 Sec. 102(e) Date Feb. 16, 1994 PCT Filed Oct. 12, 1992 PCT Pub. No. WO93/08180 PCT Pub. Date Apr. 29, 1993. (I) Fungicidal compounds having...
5482962 Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines  
This invention relates to N,N'-disubstituted-N,N'-diacylhydrazines which are useful as insecticides, compositions containing those compounds and methods of their use. This invention also relates...