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6294580 Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to PPAR-gamma  
A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C1-6 alkyl, C1-3 alkoxy,...
6294564 Benzimidazoles and benzoxazoles  
The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.
6274600 Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors  
Compounds ##STR1##are useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof and methods for their use for treatment of...
6271248 Substituted biphenysulfonamide endothelin antagonists  
Compounds of the formula ##STR1##wherein X, Y, R1, R2, R3, R4 and R5 are as described herein, inhibit the activity of endothelin.
6262095 Use of tricyclic derivatives of 1,4-dihydro-1,4-dioxo-1H-naphthalene, novel compounds obtained and their application in theraphy  
The invention concerns the therapeutic use of tricyclic salts and their pharmaceutically acceptable salts having the general formula: ##STR1##in which: A is either a sulfur atom, an oxygen atom,...
6242471 Condensed 4,5,6,7-tetrahydrobenzo[C]thiophenes as enhancer for cell differentiation induction factor action  
A compound represented by the formula: ##STR1##wherein X represents a sulfur atom or an oxygen atom; Y represents an optionally oxidized sulfur atom or an oxygen atom; Z represents a bond or a...
6211220 Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives  
A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to amino or pyridylamino cyclobutane derivatives.
6211227 Tricyclic compounds  
The present invention provides tricyclic compounds which are useful for the treatment of pollakiuria and urinary incontinence and which are represented by general formula (I): ##STR1##(wherein R1...
6207690 Troglitazone compounds for treating climacteric and cancer  
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
6204278 Anilide compounds, including use thereof in ACAT inhibitition  
The invention provides novel anilide compounds and pharmaceutical compositions comprising them.The invention relates to compounds of a formula: ##STR1##where Ar is an optionally-substituted aryl...
6197804 4,5-azolo-oxindoles  
Disclosed are novel 4,5-azolo-oxindoles having the formula ##STR1##These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. Thus, these compounds and their pharmaceutically...
6180655 Sulfonyl benzazolones  
Sulphonylbenzazolones of the formula ##STR1##in which R1, R2, R3, R4, R5 and Q are each as defined in the description. a process for preparing these compounds and their use as microbicides in crop...
6174907 Benzimidazole compounds containing 1,2,4-triazole ring, and compositions and methods of use containing the same  
Benzimidazole compounds represented by the formula set out below and analogs thereof, wherein Y represents a single bond or sulfur atom; Z represents oxygen atom, sulfur atom, or N--R4 ; R1 and R2...
6169105 Potentiation of drug response  
The power of citalopram, fluvoxamine and paroxetine to increase the availability of sarotonin, norepinephrine and dopamine, particularly serotonin, is augmented by administration in combination...
6166049 Use of an antagonist of PPARα and PPARγ for the treatment of syndrome X  
A method for the treatment or prophylaxis of Syndrome X in a human or non-human mammal is disclosed. The method comprises the administration of an effective, non-toxic and pharmaceutically...
6160018 Prophylactic composition and method for alzheimer's Disease  
A method of preventing or delaying the onset of symptoms of Alzheimer's Disease includes the step of administering to a patient in need of such treatment a composition having an effective...
6150416 Nanomolar, non-peptide inhibitors of cathepsin D  
The present invention provides non-peptide cathepsin D binding compounds and methods for using such compounds in the detection, labelling and inhibition of cathepsin D.
6136831 Pyrazole derivatives and COX inhibitors containing them  
The purpose is to provide anti-inflammatory agents which have potent pharmacological actions and exert a selective inhibitory activity on COX-2, thereby being expected to reduce adverse effects...
6127395 Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands  
Disclosed are compounds of the formula: ##STR1## wherein: T is NH, O, or S; X is hydrogen, hydroxyl, lower alkyl, or an optionally substituted amide; the W ring is an optionally substituted aryl...
6124277 Antithrombotic agents  
This invention relates to peptide derivatives, pharmaceutical formulations containing those compound and methods of their use as thrombin inhibitors.
6114329 5-HT4 receptor antagonists useful in the treatment of gastroinstestinal, cardiovascular and CNS disorders  
Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--CH2 --Z (I)wherein X is a...
6110952 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists  
This invention relateds to compounds of formula I, (2-imidazolinylamino)benzoxazoles. The compounds have been found to be alpha-2 adrenocepto agonists and are useful for treatment of disorders...
6107293 Tachykinin antagonists  
Compounds of formula (I) wherein X is --CH2 --, --CO-- or direct linkage, Y is --O--, --S-- or --NH--, R1 is phenyl, R2 H or phenyl and R3 is H or --CH3 -- and their pharmaceutically acceptable...
6069160 Heteroatom-containing benzocyclopentane-oxazolidinones  
The invention relates to heteroatom-containing benzocyclopentaneoxazolidinones, to processes for their preparation and their use as medicaments, especially as antibacterial medicaments.
6048883 Heterocyclic compounds as pharmaceutical  
This invention provides compounds of formula (I): A1 --X--(CH2)n --O--A2 --A3 --Y.R2(I)or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable...
6046212 Chalcone derivatives and drugs containing the same  
This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the...
6046190 Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors  
The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as...
6043269 cis-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes  
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
6020339 Aryl furan derivatives as PDE IV inhibitors  
The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the...
6011033 Phenylene derivatives  
This invention relates to a phenylene derivative represented by the following formula (1) or a salt thereof and also to a medicine containing it as an effective ingredient. ##STR1## wherein R1...
5994379 Bisaryl COX-2 inhibiting compounds, compositions and methods of use  
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include...
5994390 Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes  
The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel...
5985891 Prevention of adverse behavior, diarrhea, skin disorders and infections of the hind gut associated with acidic conditions in humans and animals by the application of antibiotics  
A method of treating adverse behavior in animals, manifested in secondary effects such as, in horses, excitability, difficult handling, coprophagy, wood chewing and grasping, or wind sucking, by...
5981592 Method and composition for treating cystic fibrosis  
A composition for use in preventing colorectal cancer and other neoplastic diseases, such as breast cancer, includes an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt...
5981559 Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A2 antagonizing activity  
An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and...
5955504 Colorectal chemoprotective composition and method of preventing colorectal cancer  
A composition for use in preventing colorectal cancer and other neoplastic diseases includes an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof in an amount effective...
5952354 Tris carbamic acid esters: inhibitors of cholesterol absorption  
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
5942535 a!-Annelated pyrrole derivatives and pharmaceutical use thereof  
The present invention relates to heterocyclic compounds of the formula ##STR1## in which R1 -R7, B, a and X have the meanings recited in the specification. These compounds are usable in the...
5939415 A!-annellated pyrrole derivatives and their use in pharmacology  
The present invention relates to heterocyclic compounds with the formula ##STR1## in which R1 to R7, B, a, and X have the meanings indicated in the specification. These compounds can be used for...
5900427 N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis  
This invention relates to the use of heteroarenesulfonyl groups as protecting groups for amino groups, particularly the amino groups of amino acids, and specifically to nitrogen-protected...
5889022 Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity  
Novel indole, indoline and quinoline derivatives of formula (I) processes for their preparation, pharmaceutical compositions containing them, and their use in medicine is disclosed. A structurally...
5886046 Dicarbonyl-containing compounds  
This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other...
5863915 Substituted 4-arylbutyric acid derivatives as matrix metalloprotease  
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention...
5861424 Composition and method for treating cancer  
A pharmaceutical composition for treatment of cancer in a mammal comprising: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds...
5843972 Heterocyclic β-adrenergic agonists  
The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs...
5843968 Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis  
Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted...
5840721 Imidazole derivatives as MDR modulators  
The present invention relates to polysubsituted imidazole having formula 1 ##STR1## These compounds are useful for restoring the sensitivity of multidrug resistant cells to cancer chemotherapeutic...
5837702 4-arylamino-benzopyran and related compounds  
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH2 --, --C(O)--, --O--, --S-- or --N(R8)-- where R8 is hydrogen,...
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5814647 Use of troglitazone and related compounds for the treatment of the climacteric symptoms  
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...