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7166625 Method for treating fibrotic diseases and other indications  
Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a...
7166616 Substituted alkanoic acids  
The invention is directed to physiologically active compounds of general formula (I): wherein: represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl...
7166626 Therapeutic treatment for sexual dysfunction  
A method for improving sexual function is described. A mammal suffering from sexual dysfunction or otherwise in need of enhanced sexual function is administered a compound selected from those that...
7144883 Bicyclic sulfonamide compounds  
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
7144893 4-aryl quinols and analogs thereof as therapeutic agents  
The present invention pertains to compounds of the formula (1) which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or...
7138425 Phthalimide carboxylic acid derivatives  
The present invention relates to phthalimide carboxylic acid derivatives of formula (I), methods for their preparation, pharmaceutical compositions containing them and their use in medicine,...
7129257 Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma  
Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
7119075 Use of herbal agents for potentiation of bioefficacy of anti infectives  
The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of...
7119105 Methods for treating neurodegenerative disorders using aspartyl protease inhibitors  
The present invention relates to () non-peptide aspartyl protease inhibitors; (ii) methods for modulating the processing of an amyloid precursor protein (APP); (iii) methods for modulating the...
7115632 Sulfonyl aryl or heteroaryl hydroxamic acid compounds  
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
7115641 Antimicrobial oxazolidine/iodopropynyl-butyl carbamate composition containing less than 0.1wt% free formaldehyde  
This invention relates to a broad spectrum antimicrobial composition, effective against gram negative and gram positive bacteria and fungi, which comprises a synergistic composition comprising...
7105535 Oxazolyl-pyrazole derivatives as kinase inhibitors  
Compounds which are oxazolyl-pyrazole derivatives, as defined in the specification, and pharmaceutically acceptable salts thereof; are useful in the treatment of diseases caused by and/or...
7101875 Methods for treating arthritic disorders  
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms...
7087626 Pyrrole derivatives as pharmaceutical agents  
Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the...
7071221 Heterocyclic oxime compounds  
Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description,A represents an alkylene chain as defined in the...
7060257 Cosmetic or dermatological light-protective formulation comprising a water-soluble UV filter substance and a benzoxazole derivative  
The invention is a light-protective cosmetic or dermatological preparation comprising (a) at least one water-soluble UV-filter substance and (b) at least one benzoxazole derivative. The invention...
7045518 Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors  
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention...
7045539 Therapeutic benzoxazole compounds  
Compounds of the formula (I) for use as an estrogen receptor-β-selective ligand are described wherein: X is O or S; and R1, R3 R6 are as described in the specification. The use of these compounds...
7022720 Synthetic diazonamides as novel anti-mitotic agents  
The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The...
7019020 2-benzoxazolyl benzene derivatives and their use as UV screening agents  
Novel benzoxazolyl benzene derivatives of formula (I): wherein R1 is hydrogen, C1-20-alkyl or C2-20-alkenyl; R2 and R3 are independently a group —C(R4,R5)C(R6)═C(R7,R8) (a) or a group...
7012087 p53 inhibitors and therapeutic use of the same  
The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
7005440 Therapeutic uses of tri-aryl acid derivatives  
The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists...
6995154 Heterocyclic topoisomerase poisons  
The invention provides compounds of formula I: wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical...
6960607 Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents  
This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt...
6951873 Methods for treating age-related behavioral disorders in companion animals  
Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically...
6933309 Halogenobenzyl aminopropionic acid derivatives  
A halogenobenzylaminopropionic acid derivative represented by the following formula (1): or a pharmaceutically acceptable salt of the derivative, and a drug containing the same as an active...
6919366 Benzimidazole derivatives as modulators of IgE  
This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases...
6919362 Heterocyclic derivatives, preparation method and pharmaceutical compositions containing same  
Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH2 or R1 and R2 represent a hydrogen atom, or a group as defined in the description,A represents an alkylene chain as...
6911445 Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans  
Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
6867226 Serotonin 5-HT3 receptor partial activator  
This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not...
6867236 Method of preventing of delaying the onset and progression of Alzheimer's disease and related disorders  
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of...
6858633 Substituted 2-arylbenzazole compounds and their use as antitumour agents  
Substituted 2-phenylbenzazole compounds of formula (I) wherein X represents S or O and Q represents a direct bond, —CH2— or —CH═Ch—, exhibt selective antiproliferactive activity in respect of...
6858607 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof  
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein...
6849620 N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease  
The invention provides compounds of Formula I: wherein Azabicyclo is W0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or compositions, may be in pure...
6833375 N-&lsqb 4-(heteroarylmethyl)phenyl&rsqb -heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
6825185 Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use  
The invention describes novel substituted aryl compounds that are cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective...
6815448 Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta&lsqb a&rsqb naphthalene as 5-HT1A antagonists  
Compounds of the formula are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia. The compounds...
6800637 Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines  
Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
6800648 Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta&lsqb a&rsqb naphthalen-2-one  
Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
6797708 Inhibitors of cytosolic phospholipase A2  
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
6797721 Phorboxazole derivatives for treating cancer  
Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.
6794402 Bicyclic cyclohexylamines and their use as NMDA receptor antagonists  
Described are bicycle-substituted cyclohexylamines of Formula I and their pharmaceutically acceptable salts thereof: The compounds are antagonists of NMDA receptor channel complexes useful for...
6787561 Benzimidazole compounds  
A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of an orally available medicament for preventive and/or...
6787556 Benzoic acid derivatives for the treatment of diabetes mellitus  
The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR)...
6784199 Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals  
The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug...
6777433 Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates  
The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods...
6777410 Isoindole derivatives  
This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3...
6764996 9a-azalides with antibacterial activity  
Compounds of formula (I) formula (II) formula (III) andformula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds,...
6762199 Indane derivatives  
The invention is directed to physiologically active compounds of general formula (I): wherein:R1 represents aryl, heteroaryl or a group R3—L2—Ar1—L3—;R2 represents hydrogen or lower alkyl;R3...
6743817 Substituted fused pyrroleimines and pyrazoleimines  
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists,...