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7709513 Benzooxazol-2-one derivatives as lipase and phospholipase inhibitors  
The invention relates to benzooxazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as...
7666864 Bicyclic nitroimidazole-substituted phenyl oxazolidinones  
The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl...
7659296 Vitamin D receptor modulators  
The present invention relates to novel, non-secosteroidal, phenyl-benzoxazole compounds of Formula (I) wherein the variables R, R′, RP, RP3, LP1, LP2, ZP, RB, RB′, LXB and ZXB are as hereinafter...
7652125 Resin composition, polyimide resin composition, polybenzoxazole resin composition, varnish, resin film and semiconductor device using the same  
A resin composition having high heat resistance and low dielectric constant after heat treatment, a varnish thereof and a semiconductor device using the same are provided by a resin composition...
7625929 Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics  
The invention relates to the compounds of general formula (I) where R1 represents H, a (C1-C4)alkyl, —CO(C1-C4)alkyl, (C1-C4)alkylphenyl or —CO-phenyl group, said phenyl being optionally...
7625923 Bicyclic modulators of androgen receptor function  
The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen...
7622490 Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors  
The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H,...
7605156 Methods for the use of inhibitors of cytosolic phospholipase A2  
This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use...
7598282 Neuroprotective agents  
Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3, 4-c]oxazol-7a-yl)methanol (TH-237A) and...
7592361 Indole acetic acid derivatives and their use as pharmaceutical agents  
This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and...
7538129 Diazonamide A analog  
A specific diazonamide A analog and its salts and conjugates are effective in treating proliferative diseases.
7534804 Benzoxazole inhibitors of 15-lipoxygenase  
The present application provides benzoxazole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
7531564 Substituted benzoxazoles as estrogenic agents  
This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically...
7528133 Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation  
The present invention provides methods of preventing or reducing oxytocin-mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods...
7524516 Corrosion inhibiting mildew remover kit  
The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The...
7517895 Synthetic diazonamides  
The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The...
7504440 Poly(meth)acrylate compositions containing amide acetals  
The present invention relates to novel poly(meth)acrylate compositions formed by polymerization of (meth)acrylate amide acetals.
7494670 Composition and process for removing and preventing mildew and fungal growth  
This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal...
7491733 Bicyclic guanidine derivatives and therapeutic uses thereof  
The invention relates to compounds of general formula (I), in which A, X, Y and R1 are defined in Claim 1. These compounds may be used in the treatment of pathologies associated with insulin...
7482344 Tricyclic steroid hormone nuclear receptor modulators  
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in...
7456204 Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes  
The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
7452912 Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
RE40558 Therapeutic uses of di-aryl acid derivatives  
The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their...
7419974 Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same  
The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an...
7378433 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
7365087 Oxazole derivatives of tetracyclines  
This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
RE40245 Gyrase inhibitors and uses thereof  
The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity....
7354946 Biarylurea derivatives  
The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group;...
7354949 Therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia  
The present invention provides a therapeutic agent for bladder irritative symptoms associated with benign prostatic hyperplasia comprising, as an active ingredient, a tricyclic compound...
7348322 Glucocorticoid receptor modulators as antiinflammatory agents  
The present invention relates to compounds of formula I: wherein A, X, R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to methods of...
7345068 Aromatic amino acid derivatives and medicinal compositions  
1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group,R2 is a halogen atom or an...
7335674 Benzothiazole-4,7-diones and benzoxazole-4,7-diones with substituents in position 5 or 6 and method for production thereof  
A targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted.
7335653 Bis-aryl sulfonamides  
Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for...
7332516 Geminally di-substituted NSAID derivatives as Aβ42 lowering agents  
The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative...
7323494 Compounds and methods  
Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as...
7307076 Beta agonists for the treatment of respiratory diseases  
The present invention relates to compounds of general formula 1 wherein the groups n, A, B, R1, R2 and R3 may have the meanings given in the claims and in the specification, processes for...
7307094 Benzoxazole carboxamides for treating CINV and IBS-D  
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to...
7294643 UK-1 analogues: methods of preparation and use  
The present invention includes a number of structural analogues of UK-1. A comparision of the anticancer activity of the UK-1 analogues with their ability to inhibit the growth of...
7294650 Benzothiophen and thiochrone containing phenethanolamine derivatives for the treatment of respiratory disorders  
Compounds of formula (I): and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective...
7291633 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands  
Compounds of the formula I in which R1, R2, R3 and R4 are as defined in claim 1, are ligands of the nicotinic acetylcholine receptor and/or serotonergic ligands and are suitable for the...
7282514 Reactive probes for two-photon fluorescent imaging and sensing  
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
7268135 Biaryl sulfonamides and methods for using same  
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
7262212 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles  
The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R1 represents a hydrogen atom or C1-C6 alkyl group, n...
7253154 Substituted thiazolopyrimidines as xanthine oxidase inhibitors  
The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a...
RE39743 2-halogenated derivatives of 5-0 desosaminyl-erythronolide a, their preparation process and their antibiotic use  
Novel compounds of the formula wherein the substituents are defined as in the application having antibiotic properties.
7232815 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof  
The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation...
7230020 11β-hydroxysteroid dehydrogenase inhibitors  
A compound having Formula I R1—Z—R2Formula I wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L— wherein...
7230021 Potent, simplified derivatives of pateamine A  
The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim...
7214695 Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding  
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin...
7202251 Bicyclic anilide spirohydantoin CGRP receptor antagonists  
The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved,...