Match Document Document Title
8063067 Hexenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof  
Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
8034833 Phosphorus binder for treatment of renal disease  
The present invention relates to oral compositions which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of subjects. A method...
8030337 Tricyclic compound and pharmaceutical use thereof  
The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof...
8026260 Histone deacetylase inhibitors with aryl-pyrazolyl-motifs  
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this...
8022075 Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition  
To provide a diagnostic drug which binds specifically to an amyloid aggregate and/or an amyloid deposit, to thereby realize imaging and quantification of a disease caused by amyloid aggregation...
8017637 Inhibitors of cdc phosphatases  
A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C...
7998991 Neurotherapeutic treatment for sexual dysfunction  
A method for improving sexual function is described. A mammal suffering from sexual dysfunction or otherwise in need of enhanced sexual function is administered a compound selected from those that...
7994203 Organic compounds  
There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
7989482 Indoline anti-cancer agents  
Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.
7985749 Compounds and compositions as cathepsin S inhibitors  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
7968576 Preparation and use of aryl alkyl acid derivatives for the treatment of obesity  
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
7968572 Nitrogen-containing heterocyclic compound and pharmaceutical application thereof  
It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description;which has a p38 MAP kinase inhibitory activity, a salt thereof, an...
7964598 ApoE4 domain interaction inhibitors and methods of use thereof  
The present invention provides compounds that inhibit apoE4 domain interaction; and compositions, including pharmaceutical compositions, comprising the compounds. The present invention provides...
7964622 Indole acetic acid derivatives and their use as pharmaceutical agents  
This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and...
7960420 Diazonamide analogs with improved solubility  
Diazonamide A analogs, and the salts, esters and conjugates thereof, having improved aqueous solubility are provided. Also provided are pharmaceutical compositions, and methods for preparing and...
7947719 Biologically active compounds obtainable from Sorangium cellulosum  
The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus Sorangium,...
7943623 Pharmaceutical composition comprising 2,3-dihydro-6-nitroimidazo [2,1-B] oxazole derivatives  
A pharmaceutical composition according to the present invention comprises: (I) at least one member selected from the group consisting of oxazole compounds, optically active isomers thereof, and...
7939528 Heterocycle compounds  
The present invention relates to novel compounds which are antagonist or inverse agonists at an opioid receptor. Such compounds are useful in the treatment of obesity and related diseases and/or...
7935701 Microbicidal composition based on formaldehyde donor compounds and antioxidants  
Microbicidal composition for product preservation, including a microbicidal composition which comprises a) at least one formaldehyde donor compound and b) at least one antioxidant chosen from...
7928123 Compounds which modulate the CB2 receptor  
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
7923446 Biaryl sulfonamides and methods for using same  
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
7919515 3-phenylpropionic acid derivatives  
The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH,...
7910579 Benzoxazole derivatives  
It is intended to provide a benzoxazole derivative or a pharmaceutically acceptable salt or solvate thereof which is useful in the early diagnosis of a conformation disease; a composition or a kit...
7902196 Synthesis of avrainvillamide, strephacidin B, and analogues thereof  
The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is...
7897627 Heteroaryl derivatives as orexin receptor antagonists  
The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or...
7893096 Use of small molecule compounds for immunopotentiation  
The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of...
7888332 Hydrazide-containing CFTR inhibitor compounds and uses thereof  
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and...
7879850 Organic compounds  
The present invention provides compounds of the following structure; A-Q-B—C-D that are useful for treating conditions or disorders associated with DGAT1 activity in animals, particularly humans.
7879891 Caspase inhibitor prodrugs  
This invention relates to prodrugs of caspase inhibitors comprising of a furo[3,2-d]oxazolin-5-one moiety which, under specific conditions, can convert into biologically active compounds,...
7868004 Menthane carboxamide derivatives having cooling properties  
A compound of the formula I in which X and Y are selected as follows: (i) X is H and Y is selected from the group consisting of (ii) X and Y together form a bivalent radical selected from the...
7868033 Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding  
Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one...
7863305 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors  
Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical...
7863306 Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors  
The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H,...
7825145 Antimicrobial and radioprotective compounds  
The present invention relates to a method of treatment and/or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which...
7825155 Oxindole derivative as feeding control agent  
Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent...
7816376 Cyclic amides  
The invention relates to compounds of the formula (I) and pharmaceutically usable derivatives, salts, solvates and stereoisomers and mixtures thereof, in which X, Y, Z, R1, R3, R4, R8, p, k, E, G,...
7812040 Histamine-3 receptor antagonists  
This invention is directed to a compound of the formula Ia or Ib, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I,...
7794761 Methods for inducing anti-anxiety and calming effects in animals and humans  
Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, or their precursor...
7790717 Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators  
Compounds in accord with Formula I: wherein R1, L, A, B, D, E, m, n, x and y are as defined in the description, processes for the preparation of such compounds and to new intermediates employed in...
7790741 Imidazothiazoles and imidazoxazoles  
The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be...
7781430 Benzoxazole carboxamides for treating CINV and IBS-D  
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds that exhibit central activity are useful in treating CINV; those that inhibit peripheral receptors are useful to...
7750034 Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes  
The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment...
7749994 Pentacyclic kinase inhibitors  
The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z,...
7750021 Immunosuppressant compounds and compositions  
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
7741327 Pyrrolidinone glucokinase activators  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
7737166 Antifungal bicyclic hetero ring compounds  
A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and...
7732435 Chromone derivatives useful as antagonists of VR1 receptors  
The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their...
7728010 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase  
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either...
7718646 Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same  
The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an...
7713964 Methods for treating asthmatic conditions  
This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms...