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4619926 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acid salts and the production thereof  
The invention relates to pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, in particular compounds of the formula ##STR1## wherein R1 is a group of...
4591596 Treating pain, inflammation and/or platelet aggregation  
This invention relates to chemical products of general formula ##STR1## wherein R is an amino group, mono or bi-hydroxyalkyl substituted, or a thio group, mono hydroxyalkyl substituted, in which...
4581367 1-phenyl-2-(heterocyclyl-alkyl-amino)-ethanols  
Compounds of the formula wherein Het is a heterocycle; n is an integer from 1 to 4, inclusive, preferably 2 or 3; R1 is H or acyl; R2 is H, R1 O, --NHSO2 R7, --NHCOR8, --NHCONHR8, --NH--CH2 --C6...
4579865 Benzofuranyl carbamates  
Compounds of the structure; ##STR1## and pharmaceutically acceptable salts thereof, wherein: R1 is H, alkyl, alkoxy, carboxyl, alkylcarboxy, trifluoromethyl, halogen, nitro or hydroxy; X is O, N,...
4558060 Benzoxazolinones  
The invention relates to compounds of the formula: ##STR1## in which R represents hydrogen or a lower alkyl radical and R1 and R2 separately represent hydrogen, a lower alkyl, cycloalkyl or benzyl...
4554284 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones  
Certain aminoethyl substituted 1,3-benzthiazol- and 1,3-benzoxazol-2(3H)-ones are D2 -dopamine agonists. These compounds are prepared by reacting an appropriate o-aminophenol or thiophenol with...
4552876 Bisbenzoxazines and pharmaceutical use  
Compounds of the formula: ##STR1## wherein, R is H, alkyl, cycloalkyl, aryl, or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl, heteroaryl, substituted heteroaryl, aralkyl, substituted aryl, halo,...
4547523 Polyether antibiotic from streptomyces  
A new polyether antibiotic has been isolated from fermentations of a new microorganism of the genus Streptomyces. This new microorganism is designated as N478-13 and it has ben named Streptomyces...
4529597 Substituted 1-azabicyclo(3.2.0)hept-6-en-2-one-7-carboxylic acids  
Disclosed are substituted 1-azabicyclo [3.2.0]-hept-6-en-2-one-7-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics. ##STR1## wherein R is...
4529734 2-formyloxymethyl-clavam  
2-Formyloxymethyl-clavam is described and its use as an antifungal compound against a range of fungi for both medical and horticultural and agricultural use is disclosed. Processes for isolating...
4511567 6-[(4-Substituted piperazin-l-yl)thiocarbonylamino]benzazoles and their use  
The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R1 represents an optionally 4-substituted piperazino group or a group of...
4490373 Method of treating asthma  
A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.
4485104 1,2,4-Triazole-3-amines and their pharmaceutical use  
Compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H2...
4476137 [1-(2-Benzoxazolyl)hydrazino]alkyl nitrile derivatives  
Described are compounds of the formula ##STR1## wherein R is hydrogen or loweralkyl, X, Y and W independently of one another denote hydrogen, halogen, loweralkyl, nitro, amino, amido, loweralkoxy,...
4460581 (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones  
Compounds of the formula ##STR1## wherein A is a single bond, ##STR2## R1 is --OH, --0--acyl, chlorine or hydrogen; R2 is hydrogen, methyl or ethyl; R3 is ##STR3## m is 2, 3 or 4; n is 1, 2 or 3;...
4456466 Herbicidally active benzoxazolyl acetophenone oxime derivatives  
Disclosed are certain herbicidally active benzoxazolyl acetophenone oxime derivatives, herbicidal compositions containing these compounds and the use of such compounds to control the growth of...
4444770 New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use  
The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and...
4438126 Lower alkanoic acid derivatives of 2-oxo-benzoxazolines and aldose reductase inhibiting compositions thereof  
The invention is directed to compounds of the formula ##STR1## wherein Ra1 is phenyl, R2 is halogen, R3 is carboxy or lower alkoxycarbonyl, Ya is oxygen, A is C1 -C6 alkylene,pharmaceutically...
4438128 Cardioactive aryloxypropanolamines  
The present invention provides aryloxypropanolamines of the general formula: ##STR1## wherein R1, R2, R3 and R4, which may be the same or different, are hydrogen or halogen atoms or lower alkyl,...
4426380 Benzofuran-2-ones and pharmaceutical compositions  
The invention relates to novel furans, especially benzofuranones of the general formula ##STR1## in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group...
4420486 Benzoxazolone derivatives, processes for preparation thereof and compositions containing them  
Certain new 5,6,7-trichlorobenzoxazolone derivatives are highly active against a wide range of plant fungal and bacterial diseases and have a reduced phytotoxicity. These derivatives are also...
4416892 Method of treating hypersensitivity disease with benzoxazole derivatives  
The invention relates to a method for the prophylactic or therapeutic treatment of an immediate hypersensitivity disease, which comprises administering to a mammal, including a human, a compound...
4405633 Method of treatment of asthma  
Provided is a method of treating asthma. The method is the administering to a patient requiring treatment of an effective dose of a benzoxazole-2-carboxylic acid or an ester or...
4388319 N-Heterocyclic alkyl-N'-thiadiazolyl, thiazolyl and isothiazolyl alkylthioureas, ureas and guanidines  
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is...
4372962 Clavulanic acid derivatives their preparation and use  
The compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof wherein X is a sulphur atom or SO or SO2 group and R is a hydrogen atom or...
4369186 4,5-Dichloroimidazole-2-carboxylic acid derivatives  
4,5-Dichloroimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which the group ##STR2## represents a carbon atom which has three bonds to hetero-atoms, and their salts with bases,...
4363814 Aminoalkyl-substituted heterocycles  
Racemic or optically active compounds of the formula Q--Cn H2n --NH--Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4359473 α-Amino deoxy clavulanic acid antibacterial agents  
The compounds of the formula (XVII) ##STR1## and their esters wherein R2 is a hydrogen, fluorine, chlorine or bromine atom or an alkyl group of 1-3 carbon atoms, an alkoxyl group of 1-3 carbon...
4328219 2-Substituted benzazole pesticide synergists  
2-Substituted benzazoles of the formula ##STR1## in which R represents optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl,...
4324793 4-Nitro-2-trichloromethylphenyl disulfides  
4-Nitro-2-trichloromethylphenyl disulfides, their manufacture, agents containing these compounds as active ingredients for use on microorganisms, and the use of these compounds for protecting...
4303665 Methylaminodeoxy-clavulanic acid derivatives, their production and use  
Compounds of the formula (II): ##STR1## wherein X is sulphur or oxygen and R is hydrogen or alkyl of 1 to 3 carbon atoms, are useful for their antibacterial, β-lactamase inhibitory activity and...
4302450 Polyether ionophores as antiobesity and hypotriglyceridemic agents  
A method is disclosed for the use of polyether ionophores as antiobesity and hypotriglyceridemic agents in warm blooded animals by the administration to an animal in need of such treatment of a...
4271158 Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones  
Racemic and optically active compounds of the formula Q--Cn H2n --NH--Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4269846 Heterocyclic compounds useful as anti-allergy agents  
New benzoheterocyclic oxadiazolones and triazolones are described. These compounds are useful as anti-allergic reagents.
4258047 Pyrazole derivatives, pharmaceutical formulations thereof  
Pyrazole derivatives of the formula ##STR1## wherein R1 is H or Cl; R2 is 1-methyl-4-piperidyloxy-carbonyl, 2-(4-phenylpiperazino)-ethoxycarbonyl, benzoxazol-2-yl, benzthiazol-2-yl, tetrazol-5-yl...
4258050 Antibacterial agents  
Compounds of the formula (II): ##STR1## wherein A is a group such that CO2 A is carboxylic acid, a non-toxic salt thereof or non-toxic ester thereof; R1 is COR4 or OR5 wherein R4 is lower alkyl,...
4226868 Processes for inhibiting the growth of sea urchin eggs  
The growth of sea urchin eggs is inhibited with a composition comprising a methine dye having a reduction potential equal to or more negative than -1.0 volt which is capable of being absorbed by...
4215119 Aminoalkyl-substituted benzimidazolidin-2-ones  
Racemic and optically active compounds of the formula Q-Cn H2n -NH-Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4172895 6-(1'-Hydroxyethyl)-2-aminoethylthio-oxapen-2-em-3-carboxylic acid  
Disclosed is 6-(1'-Hydroxyethyl)-2-aminoethylthiooxapen-2-em-3-carboxylic acid: ##STR1## Such compound and its pharmaceutically acceptable salt and ester derivatives are useful as antibiotics....
4172896 Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same  
Methane-sulfonamide derivatives of the formula: ##STR1## wherein R1 is hydrogen or a halogen atom, R2 and R3 are the same or different and are each hydrogen or a straight or branched alkyl having...
4154829 Aminoalkyl-substituted benzoxazine derivatives  
Racemic and optically active compounds of the formula Q--Cn H2n --NH--Rwherein Q is ##STR1## where R1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms,...
4147693 βLactam antibiotics and process for their use  
6-[α-(Imidazolidin-2-on-1-ylcarbonylamino)-substutited acetamido]penicillanic acids, and the correspondingly 7-substituted ceph-3-em-4-carboxylic acids, characterized by the presence of a...
4132799 N-(Benzoxazolinyl-2-one)-tricyclic dicarboximides  
Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted...
4113871 Hypoglycemically and hypolipidemically active derivatives of phenyl-alkane-carboxylic acids  
Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy,...
4088770 Substituted 2-anilinobenzoxazoles used as immunosuppressive agents  
Compositions comprising certain 2-(substituted anilino)benzoxazoles, such as 2-[4-bromo-3-(trifluoromethyl)anilino]benzoxazole, and methods for using same as immunosuppressive agents,...
4078068 3-(β-Aminoethylidene)-6-(α-hyd roxyethyl)-7-oxo-4-oxaazabicyclo[3.]heptane-2-carboxylic acid and derivatives thereof  
3-(β-aminoethylidene)-6-(α-hydroxyethyl)-7-oxo-4-oxaazabicyc lo[3 .2.0]heptane-2-carboxylic acid having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and amide...
4078067 3-(.beta .-Aminoethylidene)-7-oxo-4-oxaazabicyclo[3.2.0]heptane-2-carboxylic acid and derivatives thereof  
3-(β-aminoethylidene)-7-oxo-4-oxaazabicyclo [3.2.0]heptane-2-carboxylic acid and derivatives thereof having the structural formula: ##STR1## and the pharmaceutically acceptable salt, ester and...
4065572 Amino acids and esters thereof useful as antihypertensive agents  
A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their...
4065557 Amino sugars and their use in improving the meat:fat ratio in animals  
Glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2- en-1-ylamino)- α-D-glucopyranose, which are inhibitors of glycoside hydrolases of the...
4064261 Agent for the control of plant-pathogenic organisms  
Methods employing and compositions comprising, for the control of plant-pathogenic organisms, specified triazolobenzoxazole and triazolobenzothiazole compounds; and novel methods for the...