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5110823 Pyrrolidine derivatives as nootropic agents  
Pyrrolidine derivatives of formula (I) are disclosed. ##STR1## wherein the ring A represents the following heterocyclic ring ##STR2## The compounds of formula (I) are useful as nootropic agents.
5108747 Stable oxpenem-3-carboxylic acids as beta-lactamase inhibitors  
A pharmaceutical preparation comprising an antibiotic, a pharmaceutical excipient therefor, and in addition an oxapenem-3-carboxylic acid of the formula ##STR1## or a pharmaceutically acceptable...
5102898 Benzoxazolone compounds and the use thereof as microbicides  
Novel compounds of the formula ##STR1## wherein X is I or Br; and Y is independently selected from the group consisting of H, halogen, NO2, (C1 -C4) alkyl, (C1 -C4) alkoxy, CN, OCO (C1 -C4) alkyl,...
5086062 Antiallergy and antiinflammatory benzoxazolinones  
This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase enzymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in...
5084468 DC-88A derivatives  
A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.
5071863 4,5,6,7-trisubstituted benzoxazolones  
Certain 6-aryl- or 6-heteroaryl- alkylaminobenzoxazolones, and their pharmaceutically-acceptable salts, are dual inhibitors of lipoxygenase and cyclooxygenase enzymes, and so are useful as...
5064846 Heterocyclic insecticides  
Insecticides of the general formula ##STR1## wherein R1 is an optionally substituted 5- to 10-member heterocyclic moiety; R2 is an optionally substituted alkyl, cycloalkyl or alkenyl moiety; X is...
5057526 Pharmaceutically active pyridinyl substituted 5,7-dihydropyrrolo-[3,2-f]benzoxazole-6-ones  
Compounds of the formula I ##STR1## wherein R is a hydrogen atom or an alkyl radical, R1 is a hydrogen atom or an alkyl, alkenyl or a cycloalkyl radical, R2 is a hydrogen atom or an alkyl,...
5037842 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents  
A series of 5-(4-[2-substituted benzoxazolylmethoxy]benzyl)oxa- and thiazolidine-2,4-diones as antidiabetic and cholesterol lowering agents.
5036088 Antiallergy and antiinflammatory agents, compositions and use  
Compounds of the formula ##STR1## where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or...
5032590 Substituted hydroxylamines  
Substituted hydroxylamines of the formula ##STR1## in which R1 stands for an aromatic or heterocyclic radical,are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and...
4999042 Phenyl oximino-acetate fungicides  
Compounds of the fomrula (I): ##STR1## and sterioisomers thereof, wherein X is halogen, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl,...
RE33533 Polycyclic heterocyclic compounds, a process for their preparation and their use in human and veterinary medicine  
A polycyclic heterocyclic compound has the formula ##STR1## wherein n is 1 or 2, R1 represents (i) lower alkyl, (ii)--CH2 OH or (iii) ##STR2## R2 represents (a) hydrogen, (b) ##STR3## or (c)--OR3,...
4988718 Pesticidal substituted 4-heterocyclyloximino-pyrazolin-5-ones, compositions and use  
Fungicidal substituted 4-heterocyclyloximinopyrazolin-5-ones of the formula ##STR1## in which R1 and R2 independently of one another in each case represent hydrogen, alkyl, alkenyl, alkinyl,...
4981864 Method for inhibition of erythrocyte aggregation using anellated tricyclic compounds  
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein R1 is a phenyl radical of the general formula: ##STR2## or R1 is a 5 or 6 membered heterocycle...
4963576 Dithioacetal compounds, processes for preparation thereof and pharmaceutical composition comprising the same  
The invention relates to dithioacetal compounds having 5-lipoxygenase-inhibiting activity, of the formula: ##STR1## wherein R1 is lower alkyl, di-(lower)alkylamino, aryl, or heterocyclic group...
4957932 Benzoheterazoles  
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and...
4954518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient  
This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising...
4952599 Phenylthioureas, phenylisothioureas, phenylcarbodiimides, pesticidal compositions containing them and their use in pest control  
Novel substituted phenylthioureas, phenylisothioureas and phenylcarbodiimides of formula I ##STR1## wherein R1 is C1 -C10 alkyl, unsubstituted or substituted by one or more halogen atoms and/or C1...
4937255 Disubstituted pyrroles  
For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R1 is aryl or heteroaryl, R2 is cycloalkyl or...
4897408 Water-soluble lysine salts of (T)2-(4-Fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process  
Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid with DL-lysine, D-lysine or L-lysine, suitable for the preparation of medicinal specialities such as syrups,...
4889864 Carbamoylimidazole derivatives and their use as fungicides  
Compounds of the formula (I) ##STR1## in which n denotes a number from 2 to 6, m denotes 1 or 2, R denotes ##STR2## R1 denotes (substituted) alkyl, (substituted) alkenyl, C3 -alkynyl, cycloalkyl,...
4885292 N-heterocyclic alcohol renin inhibitors  
Compounds of the formula ##STR1## are disclosed wherein R1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are...
4861785 Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents  
Benzoxazol-and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia.
4835167 Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides new tricyclic benzotriazoles of the general formula: ##STR1## wherein Z is a hydrogen atom or an acyl radical, Y is an oxygen or sulphur atom or two hydrogen atoms...
4831032 Cardiotonic benzimidazoles  
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R1, X, A, and R2 are as defined in the specification. The present invention also provides processes for the...
4822809 Benzazole lipoxygenase inhibiting compounds  
Compounds of the formula: ##STR1## wherein R1 is (1) hydrogen, (2) C1 to C4 alkyl, (3) C2 to C4 alkenyl, or (4) NR2 R3, wherein R2 and R3 are independently selected from (1) hydrogen, (2) C1 to C4...
4818758 2-azolylmethyl-2-phenyl-4-[benzazol-2-yloxy-or-thio-methyl]-1,3 dioxolanes and salts thereof, pharmaceutical compositions containing them and their use  
Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1;...
4784682 6-chlorobenzazolyloxyacetamides  
Herbicidally and fungicidally active novel 6-chlorobenzazolyloxyacetanilides of the formula ##STR1## in which R1 is alkyl with 1 to 6 carbon atoms, and R2 is phenyl which is optionally mono-, di-...
4771061 Substituted piperazine-1,4-naphthalenediones useful for treating asthma, allergic diseases and/or inflammation  
This disclosure describes certain substituted piperazine-1,4-naphthalenediones useful as anti-asthmatic agents.
4753956 Hypoglycemic 5-substituted oxazolidine-2,4-diones  
Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the...
4748160 Angiotensin converting enzyme inhibitors and their formulation and use as pharmaceuticals  
There are described compounds of formula I, ZCHRCON(--NCR4 R5)CHR6 (CH2)n COY Iwhere the substituents are defined in the disclosure.There are also described methods for making the compounds,...
4730003 Tricyclic compounds for treating heart and circulatory diseases  
The present invention provides compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow. The compounds are used for the treatment and/or prophylaxis of...
4725611 Synergistic microbiocidal compositions containing a mixture of a bicyclicpolyoxymethyleneoxazolidine and a 4-isothiazolin-3-one  
A synergistic microbiocidal composition comprising as Component (1) a 4-isothiazolin-3-one and as Component (2) a bicyclic polyoxymethyleneoxazolidine of the formula: ##STR1## in which each R...
4725613 Synergistic microbiocidal composition containing a mixture of a N-alkyldimethylbenzyl ammonium halide and a bicyclicpolyoxymethylene oxazolidine  
A synergistic microbiocide comprising a member selected from the group consisting of (1) an N-alkyl (C8 -C30) dimethylbenzylammonium halide and (2) a polycondensation product of...
4725612 Synergistic microbiocidal compositions containing a mixture of a bicyclic polyoxymethylene oxazolidine and a 1,2-benzisothiazolin-3-one  
A synergistic microbiocidal composition for inhibiting bacterial growth comprising Component (1) having the formula: ##STR1## in which R represents hydrogen or a halogen atom, and alkali ammonium...
4724143 Synergistic microbiocidal composition containing a mixture of a bicyclic polyoxymethyleneoxazolidine and an acroloin/formaldehyde polycondensation product  
A synergistic microbiocide comprising a member selected from the group consisting of (1) an N-alkyl (C8 -C30) dimethylbenzylammonium halide and (2) a polycondensation product of...
4695571 Tricyclic oxindole antiinflammatory agents  
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents...
4694015 Pharmaceutical or veterinary compositions containing thiosulfonate derivatives  
The invention relates to pharmaceutical or veterinary compositions for initing the malformation or destruction of red blood corpuscules due to a genetic modification of haemoglobin or to...
4684658 Anti-thrombotic ortho-condensed pyrrole derivatives, compositions, and method of use therefor  
The invention provides novel pyrrole derivatives of formula: ##STR1## in which R'=H, alkyl or phenyl optionally substituted by halogen, alkyl, alkyloxy or alkylthio, Z=0 or S, p=0 or 1, and either...
4681883 Histamine H2 -antagonist oxazole and thiazole derivatives and compositions therefor  
This invention relates to aminoalkylphenoxyalkyl substituted heterocycles. These compounds antagonize the action of histamine on histamine H2 -receptors in the brain. A compound of the invention...
4680301 6-isothiocyanato-2,5-substituted benzothiazoles or benzoxazoles useful as anthelmintic effective agents  
The invention relates to novel benzazole derivatives of the formula I ##STR1## wherein X is oxygen or sulphur, R1 is lower alkyl, lower alkenyl or cycloalkyl, optionally substituted R2 is...
4675331 Arthropodicidal benzothiazolyl and benzoxazolyl benzamides  
Novel arthropodicidally active benzamides of the formula ##STR1## in which X is a halogen atom, a lower alkyl group, a lower alkoxy group or a halogen-substituted lower alkyl group, Y is a halogen...
4670451 Benzoxazolone-2 compounds and fungicidal use thereof  
3,4-Disubstituted benzoxa(thia)zole-2-one derivatives of the formula; ##STR1## wherein R1 is a halogen atom or methyl group, R2 is a methyl or ethyl group and X and Y are individually an oxygen or...
4659736 Benzoyl urea compounds as agents for repelling snails and slugs  
A method of combating slugs and snails comprising applying to a plant or to an area from which it is desired to exclude such slugs and snails a repellent amount of at least one benzoyl urea of the...
4657920 (1,2,4-triazol-1-yl)-2-thiazol-2-yl ethanol as fungicides  
1,2,4-Triazol-1-yl-methyl-carbinols of the formula ##STR1## in which Ar is optionally substituted aryl, and Het is optionally substituted heteroaryl with at least 2 different hetero-atoms,or...
4649149 Process for the manufacture of novel benzazole derivatives, pharmaceutical preparations containing these derivatives, and their use  
The invention relates to a process for the manufacture of novel benzazole derivatives of the formula I ##STR1## in which R1 represents an optionally 4-substituted piperazino group or a group of...
4647563 Heterocyclic compounds  
Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R1 is H or acyl, R2 is H, R1 O, --NHSO2 R7, --NHCOR8, --NHCONHR8, --NH--CH2...
4647562 Anti-spasmodic agents having three branch chains  
A new class of anti-spasmodic compounds having three branch chains is provided. These compounds have the general formula: ##STR1## where R1, R2 and R3 are saturated straight chain or branched...
4634701 Furan derivatives having anti-ulcer activity  
Compounds of formula (I): ##STR1## wherein: A represents a CH-NO2 group or a N-CN group; B represents CH2, O, S or a direct bond; R represents a bicyclic or polycyclic residue, variously...