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9012445 Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors  
In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of...
8940779 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8940778 Indazole, benzisoxazole, and benzisothiazole kinase inhibitors  
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and...
8921427 Antiseptic alginate preparation  
An antiseptic preparation is provided for the production of wound dressings or bandages. The preparation includes at least one alginate and at least one antiseptically active substance selected...
8921404 Azole derivatives in the form of lipase and phospholipase inhibitors  
The invention relates to azole derivatives of the general formula I as defined in the present application as well as to their uses in treatment of conditions that would benefit from their...
8912186 Allosteric protein kinase modulators  
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein...
8901170 Malononitrile compounds  
Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures...
8901158 Treatment of bipolar disorder  
The invention relates to sulphur- and/or selenium-containing compounds that can inhibit the enzyme inositol mono-phosphatase (IMPase), and which can be used in treating conditions that are...
8895594 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8895593 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8895595 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8877755 Dopamine-agonist combination therapy for improving sleep quality  
The present invention generally relates to pharmaceutical compositions comprising a dopamine agonist and sedative agent. In a preferred embodiment, the dopamine agonist is optically pure...
8846732 Inhibition of biogenic sulfide production via biocide and metabolic inhibitor combination  
Biogenic sulfide production is synergistically inhibited by treating sulfate-reducing bacteria (SRB) with a biocide and a metabolic inhibitor. The biocide directly kills a first portion of the...
8835475 Compounds as cannabinoid receptor ligands  
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds,...
8785490 Compounds for treating disease, for administering, and for pharmaceutical compositions  
Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by...
8772322 Synergistic preservative compositions  
A preservative composition comprising: (a) 1,2-Benzisothiazolin-3-one (BIT); (b) 3-Iodo-2-propynyl carbamate (IPBC); and (c) a mixture of 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and...
8765657 Antimicrobially effective use solutions comprising combinations of isothiazolones and amines  
The invention relates to a microbicidal use solution which comprises a) one or more isothiazolin-3-ones and b) one or two organic amines selected from N-dodecylpropane-1,3-diamine and...
8765806 Biocidal composition of 2,6-dimethyl-M-dioxane-4-OL acetate and methods of use  
Provided is a biocidal composition comprising 2,6-dimethyl-m-dioxane-4-ol acetate and an isothiazolinone biocidal compound. The composition is useful for controlling microorganisms in aqueous or...
8741940 Microbicidal composition  
Synergistic microbicidal compositions containing N-(n-butyl)-1,2-benzisothiazolin-3-one or N-methyl-1,2-benzisothiazolin-3-one.
8722713 Synergistic antimicrobial composition of 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane  
A synergistic antimicrobial composition containing 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane.
8697754 Aminoalcohol and biocide compositions for aqueous based systems  
Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula...
8680128 Synergistic antimicrobial composition of 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane  
A synergistic antimicrobial composition containing 1,2-benzisothiazolin-3-one and tris(hydroxymethyl)nitromethane.
8658679 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8614229 Substituted indole derivatives and methods of use thereof  
The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for...
8604068 Insecticidal compositions of 2-cyanobenzene sulfonamide compounds and isomeric forms thereof having improved effect  
The present invention comprises 2-cyanobenzenesulfonic acid amides of the formula (I) and isomeric forms thereof (I-A) and (I-B) wherein R1, R2, R3, R4, R5 and A have the aforesaid meaning for the...
8592468 Bacterial thioredoxin reductase inhibitors and methods for use thereof  
The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed...
8569346 Thiazoline ring compounds as botulinum antagonists  
Compositions and methods for inhibiting BoNT protease activity are presented. In most preferred aspects, inhibitors comprise a thiol reactive group, a zinc binding group, a redox active group, an...
8524745 Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators  
The present invention relates to novel benzisothiazol-3(1H)-one-5-sulfonyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals...
8501794 Compounds as cannabinoid receptor ligands  
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds,...
8466184 Biocide  
Aqueous solutions of the tetramethylammonium salt of 1,2-benzothiazolone stable below 0° C.
8466171 Fused heterocyclic compounds useful as modulators of nuclear hormone receptor function  
Disclosed are fused heterocyclic compounds of Formula (I): or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at...
8398759 Environmental friendly anti-microbial adhesion agents for anti-fouling paints and anti-fouling paints containing them  
An ecologically compatible anti-microbial-adhesion agent is described, which is particularly suitable for use in anti-fouling paints, preferably for boats, characterized in that it comprises a...
8318785 Pharmaceutical compounds  
Compounds of formula (I) exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.
8309588 Synergistic microbicidal compositions  
This invention relates to synergistic combinations of selected microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater...
8309582 Small molecule Bcl-Xl/Bcl-2 binding inhibitors  
Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of...
8273740 2-sulfanyl-benzoimidazol-1-yi-acetic acid derivatives as CRTH2 antagonists  
The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent “chemoattractant receptor-homologous molecule expressed on Th2 cells” antagonists in the...
8252819 Low-melting biocidal formulation  
A low-melting biocidal composition comprising 4,5-dichloro-2-octyl-3(2H)-isothiazolone, 3-iodopropargyl-N-butyl carbamate and at least one C1-C4 alkyl 4-hydroxybenzoate. The composition is stable...
8188127 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8173679 Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents  
The present invention relates to compounds of formula (I): in which R1, R2, R3, X, Y and A are as defined in the specification. The compounds are modulators of the estrogen receptors.
8163784 Biocidal compositions  
The present invention relates to biocidal compositions comprising at least one biocidal active substance and at least one solvent from the group of polyglycol monobutyl ethers, and to their use as...
8138212 Synergistic microbicidal compositions  
This invention relates to synergistic combinations of selected isothiazolin-3-one microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations...
8129419 Microbicidal composition  
Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one.
8093278 Substituted indoles  
The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders.
8003675 3,4-dihalogenoisothiazole derivative, and agricultural or horticultural plant disease-controlling agent  
A 3,4-dihalogenoisothiazole derivative represented by the general formula [I] (wherein R1 is a halogen atom; A is an oxygen atom or a sulfur atom; and R is a C1-C6 alkyl group, a C2-C5 alkenyl...
7968578 Indole amide derivatives as EP4 receptor antagonists  
The invention is directed to indole amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis,...
7964600 Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof  
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with...
7951830 Compounds effecting glucokinase  
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a...
7939554 Protein phosphatase inhibitors  
A method of inhibiting protein tyrosine phosphatase in a subject includes administering to the subject a therapeutically effective amount of at least one benzo-1,4-quinone, phenyl isothiazolone,...
7879890 Compounds for the treatment of inflammatory disorders  
This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions...
7872033 Compounds as cannabinoid receptor ligands  
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds,...

Matches 1 - 50 out of 345 1 2 3 4 5 6 7 >