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7618650 |
Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
The invention concerns the combination of a short-acting hypnotic agent and a compound of formula (I):
Wherein X, Y, Z, A, B, D, Ar, R 1 and R 2 are as defined herein. The combination of this...
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7615570 |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
Compounds having formula (I)
or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R 1 , R 2 and R 3 are as defined herein. These compounds are...
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7595403 |
Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment,...
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7524842 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions...
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7504424 |
Compounds for the treatment of inflammatory disorders
This invention relates to compounds of the Formula (I):
or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or...
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7495020 |
2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders
A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin...
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7479536 |
Chiral, charged peptide nucleic acid oligomers from cyclic monomers
A novel class of peptide nucleic acid compounds, which are positively charged, chiral analogs based on cyclic monomeric units, bind to complementary ssDNA, dsDNA and RNA strands with more affinity...
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7468439 |
Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function
Disclosed are sultam compounds of Formula (I)
or a pharmaceutically-acceptable salt thereof. Also disclosed are methods of using such compounds in the treatment of at least one nuclear hormone...
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7468384 |
Microbicidal composition
A microbicidal composition of 1,2-benzisothiazolin-3-one; and at least one of benzalkonium chloride, benzethonium chloride, benzyl alcohol, caprylyl glycol, chlorphenesin, diazolidinyl urea,...
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7453000 |
Substituted oxazolobenzoisothiazole dioxide derivatives method for production and use thereof
The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7402597 |
Activator of peroxisome proliferator-activated receptor δ
A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient:
(wherein A represents O or S; B 1 ...
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7388024 |
Indeno[2,1A]indenes and isoindolo[2,1-A]indoles
The present invention provides indeno[2,1a]indene and isoindolo[2,1-a]indole derivatives of the Formula I, its salts and its stereoisomers, wherein X, R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , R 8 , R 9...
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7377968 |
Blends of encapsulated biocides
The present invention relates to blends of encapsulated biocides with free biocides. In particular, the present invention relates to blends of encapsulated...
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7351732 |
Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications
New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT 1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for...
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7291637 |
Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions...
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7232839 |
Benzoisothiazolone compositions
A composition, suitable for topical application to the skin, containing at least one benzoisothiazolone of formula (I):
Novel benzoisothiazolones of formula (I) and a method of caring for dry...
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7220766 |
3-phenylpropionic acid derivatives
The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or —COO—C 1 –C 4 -alkyl group; Y represents NH,...
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7211592 |
Substituted an unsubstituted benzooxathiazoles and compounds derived therefrom
The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to...
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7175831 |
Light sensitive compounds for instant determination of organ function
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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7144883 |
Bicyclic sulfonamide compounds
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
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7125893 |
6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I
in which R 1a , R 1b , R 2a , R 3a , R 3b , R 4 , R 5 , R 6 , R 7 , A, Y, D, E, G, Y and Z...
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7125887 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula (I), (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7119104 |
Activator of peroxisome proliferator-activated receptor delta
A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient:
(wherein A represents O or S; B 1...
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7105555 |
Stable, neutral pH VOC-free biocidal compositions of 1,2-benzisothiazolin-3-one
What is described herein is a neutral pH, VOC-free biocidal composition of 1,2-benzisothiazolin-3-one which is stable at low temperatures for an extended period of time. The compositions are...
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RE39265 |
Heteroarylpiperidines, and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7091229 |
Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors
A compound of formula (I)
wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase...
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7081464 |
Topical compositions of cyclic amides as immunotherapeutic agents
Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory...
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7078403 |
Antiviral agents
Disclosed herein are compounds of formula II:
wherein Alk, Z, X 1 , X 2 , R 1 , —R 10 and R 11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as...
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RE39198 |
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7064140 |
Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine
The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated...
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7041691 |
Compounds for the modulation of PPARγ activity
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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6951873 |
Methods for treating age-related behavioral disorders in companion animals
Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically...
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6936606 |
Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 and X are defined herein. The...
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6864271 |
Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine...
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6858623 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Het and X are defined herein. The...
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6849620 |
N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
W 0 is a bicyclic moiety and is
These compounds may be in the form of pharmaceutical salts or...
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6753016 |
Preservation of wood products
A method for the protection of wood and other wood materials without affecting dimensional stability or surface integrity of the treated material is described. The method involves treating wood...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6726937 |
Antifungal composition
The present invention provides use of a composition containing 2-n-octyl-4-isothiazolin-3-one and N-n-butyl-1,2-benzisothiazolin-3-one for providing antifungal efficacy to a wood preservative...
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6723343 |
Pharmaceutical tramadol salts
Disclosed are a compound of tramadol and a sugar substitute, pharmaceutical compositions and sustained-release formulations comprising the compound, and methods of treatment using the compound. The...
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6716841 |
Nitrogen containing heterobicycles as factor Xa inhibitors
This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical...
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6689770 |
Aryl sulfonyls as factor Xa inhibitors
The present application describes aryl sulfonyls of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein D, E, and M are defined below, are effective factor Xa...
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6676954 |
Controlled release compositions
Solid compositions containing low water solubility 3-isothiazolone compounds and carbon-based adsorbents that do not rapidly release the 3-isothiazolone when added to a locus to be protected are...
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6670385 |
α-phenyl-βketosulfone
The present invention relates to novel aryl-substituted S(O) m cycles of the formula (I) in which F 1 , F 2 , G, V, W, X, Y, Z and m are each as defined in the description, to processes for...
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6610282 |
Polymeric controlled release compositions
Disclosed are compositions containing biologically active compounds that slowly release the biologically active compound. These compositions may be directly incorporated into the locus to be...
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6605255 |
Repinotan kit
The invention relates to a kit comprising a pharmaceutical composition containing repinotan or a physiologically acceptable salt of repinotan, and a means for the determination of the concentration...
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6596754 |
Preventives/remedies for multiple organ failure
The present invention relates to a preventive and/or therapeutic drug for hypercytokinemia, liver diseases, and syndromes caused by the aggravation of sepsis, containing an anti-thrombin agent...
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6593349 |
Bisarylamines as potassium channel openers
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More...
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