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5583152 |
Method for treating vasospastic cardiovascular diseases heterocyclic amide derivatives
The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts...
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5580891 |
N-[heteroaryl-1-pyrrolidinyl)alkyl]-2-benoxazolinones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5580875 |
1-[(2-pyrimidinyloxy)alkyl]-3-(heteroaryl)pyrrolidines and related compounds and therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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5580886 |
Cis-2-[(4-heteroaryl-1 -piperidinyl)alkyl]hexahydro-1H-isoindole-1,3(2H)-diones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5580879 |
N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]-1H-benz[DE]isoquinoline-1;3(2H)-di ones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5578605 |
N-[(4-heteroaryl)-1-piperidinyl)alkyl]-1,2,3,4-tetrahydroquinolines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5578624 |
Heteroarylpyrrolidines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5574032 |
N-[(4-(he teroaryl)-1-piperazinyl)alkyl]-10,11-dihydro-5H-dibenz[BFS]azepines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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5571828 |
N-[(3-heteroaryl-1-pyrrolidinyl)alkyl]-2,3-napthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5571814 |
N-[(4-heteroaryl-1-pyrrolidinyl)alkyl]phthalimides and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5569655 |
Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof
Substitutued heterocyclylisoquinolinium salts, pharmaceutical compositions containing them and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries...
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5561128 |
N-[(4-(hete roaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5559126 |
1-[(1,4-benodioxanyl)alkyl]-4-(heteroaryl)piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5558816 |
Stable liquid compositions and their use
Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by...
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5559117 |
N-[(4-heteroaryl-1-piperazinyl) alkyl]-2-Benoxazolinines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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5556855 |
N-heterocyclic substituted salicylic acids
A compound of the formula Het--NR--SO 2 --Ph 2 --A--Ph 1 (COOH)(OH) and tautomic form, salts, solvates, C 1 -6 alkyl esters and pharmaceutical compositions of the compound. Ph 1 and Ph 2 are...
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5556858 |
Cis-2-[(4-heteroaryl-1-piperazinyl)alkyl] hexahydro-1H-isoindole-1,3 (2H)-diones and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents the compounds are especially useful for treating psychoses by administering to a mammal a...
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5554636 |
N-acylated 4-hydroxphenylamine derivatives with analgesic properties and pharmaceutical compositions containing them
The present invention relates to a series of new N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group,...
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5550130 |
1-[(1,4-benzodioxanyl)alkyl]-4-(heteroaryl)piperidines and related compounds and their therapeutic utility
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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RE35279 |
Hydantoin derivatives
The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives...
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5521204 |
Benzimidazole anthelmintic agents
This invention is directed to certain 2-(alkoxycarbonylamino)- and 2-(alkoxycarbonylimino)benzlmidazole derivatives which are useful in the topical, oral or parenteral treatment of animals...
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5519033 |
Azabicyclo derivatives for treatment of urinary incontinence
The present invention relates to a method of treating urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives of...
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5506246 |
Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues
A method of treating depression or stroke in a patient suffering therefrom by administering a substituted aminomethylchroman of the formula ##STR1## in which Z--denotes a group of the formula...
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5498619 |
Aminoketone derivative and use thereof
Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing...
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5498610 |
Neuroprotective indolone and related derivatives
The present invention is directed to a method of blocking N-methyl-D-aspartic (NMDA) acid receptor sites in a mammal in need thereof with an effective NMDA blocking (neuroprotective and...
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5489604 |
2-saccharinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
4-R 4 -R 5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R 4 -R 5 -2-halomethylsaccharin with an aryl or...
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5482962 |
Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
This invention relates to N,N'-disubstituted-N,N'-diacylhydrazines which are useful as insecticides, compositions containing those compounds and methods of their use. This invention also relates to...
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5472972 |
Agrochemical compositions and methods employing hymexazol and 1,2-benzisothiazolin-3-one
A combination of 3-hydroxy-5-methylisoxazole with an antimicrobial agent has good agricultural fungicidal activity which lasts longer than 3-hydroxy-5-methylisoxazole alone. The dihydrate of the...
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5466701 |
Saccharin derivative proteolytic enzyme inhibitors
Compounds having the structural formula ##STR1## which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of...
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5464851 |
Biocide composition and use
A composition which contains a 2-halo-2-halomethyl glutaronitrile and a 4,5-polymethylene-4-isothiazolin-3-one. The compositions exhibit anti-microbial activity and certain combinations of...
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5451595 |
Nematicidal compositions
Benzisothiazoles of the general formula I ##STR1## in which the group RO-- is in one of the positions of the benzene ring and R is a pure or halogenated hydrocarbon radical which is aliphatic or...
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5430046 |
Solid 3-isothiazolone biocidal concentrates
Composition as a highly useful concentrated biocide, said composition being solid at 20° C., easily meltable and solidifyable, capable of undergoing remelt and resolidification without loss of...
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5424324 |
Use of carbonyl stabilizers for 3-isothiazolones
Disclosed herein are compositions comprising a) at least one 3-isothiazolone of the formula (I) ##STR1## wherein Y is an unsubstituted or substituted (C 1 -C 18 ) alkyl, an unsubstituted or...
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5411978 |
Benzisothiazolinone-1-dioxide derivatives as elastase inhibitors
A composition is reported that includes an elastase inhibitor in a pharmaceutically or cosmetically acceptable carrier, the inhibitor being at least one benzisothiazolinone-1-dioxide derivative...
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5384326 |
Girondalones
Girondalones of the formula I useful as microbicides ##STR1## wherein A is a residue of a dialdehyde; R 1 is independently selected from the group consisting of R 2 and (C 1 -C 18 )alkyl and;...
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5373016 |
Protection of isothiazolinone biocides from free radicals
Biocidal isothiazolinone or isothiazolothione compounds are stabilized with an effective amount of a free-radical scavenger compound. Exemplary of the biocidal isothiazolones are...
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5364857 |
Combination having a neuroprotective effect
The effect of neuroprotective 5-HT 2 -receptorantagonistic 4-fluoro-phenyl compounds is intensified synergistically by 5-HT 1A -receptoragonistic aminomethyl-chromans. The combination of 5-HT 1A ...
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5364866 |
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5350761 |
Indolyl substituted hydroxylamine derivatives
Disclosed are the compound of the formula ##STR1## wherein R represents hydrogen, lower alkyl, aryl, biaryl, C 3 -C 7 -cycloalkyl, aryl-lower alkyl, aryl-lower alkenyl, aryl-lower alkynyl,...
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5342836 |
Nitrogen-based stabilizers for 3-isothiazolones
A method of protecting 3-isothiazolones of the formula: ##STR1## wherein Y is (C 1 -C 18 )alkyl or (C 3 -C 12 )cycloalkyl each optionally substituted with one or more of hydroxy, halo, cyano,...
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5338747 |
Benzoisothiazolinone-1-dioxide derivatives as elastase inhibitors
The invention relates to pharmaceutical and cosmetic compositions comprising at least one benzisothiazolinone-1-dioxide derivative with the formula: ##STR1## where R 1 can be hydrogen, and R 2 ...
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5330997 |
1H-indazole-3-acetic acids as aldose reductase inhibitors
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic...
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5328915 |
Arthropodicidal amidrazone ureas
Arthropodicidal compounds, compositions and arthropodicidal use of compounds having the formula ##STR1## wherein A, X, R 1 , R 2 , R 3 , R 4 , R 5 , m and n are as defined in the text.
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5296496 |
2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
4-R 1 -R 2 -R 3 -2-Saccharinylmethyl and 4,7-C-4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates of formulas I and IIA respectively herein, useful in the treatment...
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5288693 |
2-(3-oxoalk(en)yl)-3-isothiazolones and derivatives as antimicrobial agents
Antimicrobial compounds of the formula ##STR1## wherein R is hydrogen, halogen or (C 1 -C 4 )alkyl group; R 1 is hydrogen or halogen; alternatively, R and R1 may be taken together with the...
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5287967 |
Bag containing three component biocidal composition
A particulate composition comprising an isothiazolinone or isothiazolothione or a salt or complex thereof and a water soluble metal salt. The salt is typically a metal salt, for example the sodium...
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5276047 |
Liquid 1,2-benzoisothiazoline-3-one preparation
The invention relates to a liquid preparation containing 1,2-benzoisothiazoline-3-one (BIT) and amines and optionally containing additional solvents and common additives, and containing as amine...
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5268381 |
Aminoalkyl-benzothiazolinone and -benzoxazolinone compounds having a high 5-HT1A affinity
Compounds of general formula (I): ##STR1## wherein R 1 , R 2 , R 3 , n, X and A are defined in the description. Medicinal products containing the same are useful as antidepressives or anxiolytics...
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5256681 |
[5(6)-(benzisoxa-,benzisothia-or indazol-3-yl)-1H-benzimidazol-2-yl]carbamates
[5(6)-(benzisoxa-, benzisothia- or indazol-3-yl)-1H-benzimidazol-2-yl]carbamates of formula (I) wherein R 1 is hydrogen, C 1 -4 alkyl, halo, hydroxy or C 1 -4 alkyloxy; R 2 is C 1 -4 alkyl; and X...
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