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7615569 |
Inhibitors of ion channels
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly,...
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7608625 |
Method for treating bruxism and bruxism-related diseases
The present invention provides a preventive or therapeutic agent for bruxism or bruxism-related diseases that contains as an active ingredient at least one selected from the group consisting of...
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7605174 |
Indane derivatives as modulators of ion channels
The present invention relates to indane derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the...
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7601746 |
Compounds exhibiting thrombopoietin receptor agonism
A compound represented by the general formula (I):
wherein R 1 is a hydrogen atom, a halogen atom, or the like; R 2 , R 3 , and R 4 are each independently a hydrogen atom, a halogen atom,...
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7598392 |
2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof
The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below:
in which R 1 , R 2 , R 3 , Y, m, n, and p are as defined in the disclosure; as well as to their...
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7582664 |
Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein R 1 , R 2 , R 2′ , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the use of said compound in therapeutics.
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7576079 |
Viral polymerase inhibitors
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein:
A is O, S, NR 1 , or CR 1 , wherein R 1 is defined herein; represents either a single...
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7572817 |
2,5-disubstituted 3-mercaptopentanoic acid
The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus...
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7563813 |
Iminothiazolidinone derivatives as SFRP-1 antagonists
Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided:
which are inhibitors of secreted frizzled related protein-1. The compounds, and compositions containing the...
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7560568 |
Thiazole compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7541373 |
Aryl carbonyl derivatives as therapeutic agents
This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where...
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7538123 |
Indole derivative having piperidine ring
The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical:
wherein R 1 and R 2 are...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
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7514566 |
Thiazole compounds and methods of use
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the...
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7476742 |
Indane acetic acid derivatives and their use as pharmaceutical agents
This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to...
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RE40525 |
Hepatitis C inhibitor tri-peptides
A racemate diastereoisomer and optical isomer of a compound of formula (I):
wherein B is H, a C 6 or C 10 aryl, C 7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally...
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7423055 |
2-(3-Aminoaryl)amino-4-aryl-thiazoles for the treatment of diseases
The present invention relates to novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain...
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7417150 |
Azoles having an insecticidal action
The present application relates to novel heterocyclic compounds, to processes for their preparation, and to their use as crop protection agents, particularly for controlling animal pests.
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7414067 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in...
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7384968 |
Thiazole-amine compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula I
wherein R 1 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined. Compounds of the Formula I have activity inhibiting production of...
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7381736 |
Thiazole and thiadiazole inhibitors of tyrosine phosphatases
Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit...
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7371770 |
Acylaminothiazole derivatives and use thereof as β-amyloid inhibitors
Compounds of formula (I) as defined herein:
inhibit the formation of the β-amyloid peptide (β-A4) and are, therefore, useful in the treatment of pathologies in which a β-amyloid peptide...
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7371751 |
Thiazole derivatives
The present invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 and R 4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use...
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7358267 |
Bis-aryl thiazole derivatives
Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the...
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7358266 |
Cyclopropyl and cyclobutyl epothilone analogs
The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV
wherein Ar is a radical represented by the following structure:
and the other...
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7329680 |
Heterocycle substituted carboxylic acids
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I):
which are useful in the treatment of metabolic disorders related to insulin resistance, leptin...
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7323482 |
Thiazolyl-based compounds useful as kinase inhibitors
The present invention provides thiazolyl-based compounds of formula (I),
useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R 2 , R 3 , Z 1 ...
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7317024 |
Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...
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7304081 |
Amido compounds and their use as pharmaceuticals
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The...
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7294642 |
1,3-Diamino-2-hydroxypropane pro-drug derivatives
The present invention relates to compounds of formula (AA) (I) and (X):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the...
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7285567 |
Halogenated benzamide derivatives
A halogenated benzamide derivative characterized by greater specificity for viral pathogens and less disruptive to beneficial gut microflora, according to formula (III):
in which R 1 is a...
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7273880 |
Selective NPY (Y5) antagonists
This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a...
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7271186 |
Nanomolar β-lactamase inhibitors
New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C β-lactamase AmpC. The new compounds improve inhibition by...
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7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7265134 |
Tyrosine kinase inhibitors
The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to...
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7262204 |
Modulation of CCR4 function
Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity.
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7262200 |
Indazolinone compositions useful as kinase inhibitors
The present invention provides compounds of formula I:
These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as...
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7256205 |
Nitrosated and nitrosylated H2 receptor antagonist compounds, compositions and methods of use
The invention describes novel nitrosated and/or nitrosylated H 2 receptor antagonist compounds, and novel compositions comprising at least one H 2 receptor antagonist compound that is optionally...
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7253197 |
Aminothiazole derivatives
Compounds of formula I
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 4 have the significance given in the specification, and the compounds, salts and...
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7250431 |
Thiazole derivatives
Thiazole derivatives of formula I are provided
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 , a and b have the significance given in the specification....
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7241780 |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein,...
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7232838 |
2-amino-4,5-trisubstituted thiazolyl derivatives
This invention concerns the use of a compound of formula (I′), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z...
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7220765 |
Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use
The present invention is drawn to compounds of the formula
in racemic and enantiomeric form or all combinations of these forms wherein the various substituents are as defined in the application...
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7211576 |
Diaminothiazoles
Novel diaminothiazoles of formula (I):
are discussed. These compounds selectively inhibit the activity of Cdk4 and are thus useful in the treatment or control of cancer, in particular, the...
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7202251 |
Bicyclic anilide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds of the formula:
that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is...
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7196104 |
Thiazolyl urea compounds and methods of uses
Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs,...
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7189750 |
Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of...
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7186743 |
Substituted pyrazolyl compounds for the treatment of inflammation
The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating...
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7183302 |
Iminothiazolidinones as inhibitors of HCV replication
Compounds having the structure of formula I are described
wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
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7179827 |
Thiazoles and methods of their use
This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical...
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