Matches 251 - 300 out of 443 < 1 2 3 4 5 6 7 8 9 >
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5252595 Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines  
A pharmaceutical composition, preferably ophthalmic solution or ophthalmic suspension, useful for treating animals of the mammalian species, including humans, to reduce or maintain intraocular...
5240918 2-(substituted imino)-thiazolidines and process for the preparation thereof  
The invention relates to new 2-(substituted imino)-thiazolidines, a process for the preparation thereof, pharmaceutical compositions comprising the same, the use of the said 2-(substituted...
5240950 Carbazate derivatives, their production and use  
There are provided carbazate derivatives of the formula: R 1 --NCH--NHNH--R 2 wherein R 1 is a heterocyclic group; and R 2 is an esterified carboxyl group, and their salts, which are useful...
5234917 Substituted 5-(alkyl)carboxamide imidazoles  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
5232921 Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions  
The invention relates to thiazole derivatives corresponding to the general formula: ##STR1## in which: R 1 and R 2 each independently represent hydrogen; a C 1 -C 4 alkyl group; a phenyl group...
5229137 Methods and pharmaceutical compositions for treating episodic heartburn  
Pharmaceutical medications and methods are disclosed for providing instant and sustained relief from pain or symptoms associated with episodic heartburn in humans. The medications consist...
5223517 Heterocyclically substituted cycloalkano[b]-indolesulphonamides  
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
5206253 Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds  
The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if...
5192781 Thiazole derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present  
The present invention relates to the derivatives of formula (I): ##STR1## and their addition salts, and to their use in therapeutics, especially for the treatment of cardiovascular diseases and in...
5164381 Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same  
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
5162360 2-heteroatom containing urea and thiourea ACAT inhibitors  
The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R 1 , R 2 and R 3 are hydrogen, fluorine, chlorine, bromine,...
5158950 1,3-dithiol-2-ylidene derivatives and process for the preparation thereof  
2-(1,3-Dithiol-2-ylidene)-2-[N-(substituted) carbamoly] acetate esters and salts thereof, having potent therapeutic or prophylactic effect for hepatic disorder, are provided. Processes for their...
5130126 Polymer-drug conjugate and a method of producing it  
The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group...
5120755 Fungicidal substituted acrylic acid esters  
Fungicidal substituted acrylic acid esters of the formula ##STR1## in which R 1 and R 2 independently of one another each stand for hydrogen, alkyl, alkenyl or for in each case optionally...
5118681 S-beta-dicarbonyl substituted beta-thioacrylamide biocides and fungicides  
S-beta-dicarbonyl substituted beta-thioacrylamide compounds have been discovered to be useful as biocides and fungicides. Compositions comprising the compound and isothiazolin-3-ones and/or...
5116856 Aminoethylthiazole and aminoethyloxazole derivatives  
The invention relates to aminoethylthiazole and aminoethyloxazole derivatives with the general formula I ##STR1## wherein X is O or S; ALK is a hydrocarbyl (C 2 -C 6 ) group; R 1 is a...
5116857 Method of increasing gastrointestinal motility with substituted benzamides  
The present invention relates to the use of substituted benzamides of formula (1): ##STR1## in which: A is linear or branched C 1 -C 3 alkyl; allyl or diethylaminoethyl; R 1 is hydrogen or...
5114965 Flubenzimine containing agents for combating pests  
The foregoing invention relates to new soil pest combating agents which contain at least one conventional active agent, especially a carbamate, P-esters (phosphoric and phosphonic acid esters,...
5112841 Imidazole derivatives and antiepileptics comprising said imidazole derivatives as effective ingredients  
Described herein are imidazole derivatives having a specific structure and satisfactory as antiepileptics from the standpoint of the strength of action, prolonged action and side effects as well as...
5104889 Thiazole derivatives  
This invention provides thiazole derivative of the general formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 and A are as defined above, and salts thereof. These compounds have particularly...
5104890 Benzopyran derivatives and processes for preparation thereof  
Benzopyrene derivatives effective for the treatment of hypertension have been prepared.
5096914 Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds  
Benzopyran derivatives of the general formula I ##STR1## wherein the substituents are as defined herein are provided. The compounds show vasodilating and vascular spasmolytic activity and are...
5089513 5-lipoxygenase inhibitory thiazoles  
The invention concerns a thiazole of the formula I, ##STR1## wherein Ar 1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene,...
5081142 Derivatives of 1-hydroxy-1,2,4-triazole and fungicides and growth regulators containing them  
Compounds of the formula I ##STR1## where Ar is unsubstituted or substituted phenyl, pyridyl, thienyl or napthyl, R 1 is hydrogen or CN, R 2 is unsubstituted or substituted aryl, hetaryl,...
5071865 Pesticidal 2-acylamino-4-halogeno-5-nitrothiazoles  
Pesticidal 2-acylamino-4-halogeno-5-nitrothiazoles of the formula ##STR1## in which Hal represents halogen, x represents an integer 0 or 1, A represents O, S or N--R 2 , where R 2 ...
5071864 Aminoalkyl-substituted 2-aminothiazoles and therapeutic agents containing them  
Aminoalkyl-substituted 2-aminothiazole derivatives of the general formula I ##STR1## where R 1 and R 2 , which may be identical or different, are each hydrogen, C 1 -C 5 -alkyl, phenyl or C 1 ...
5071841 Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production  
The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon...
5066664 2-(hydroxy-2-alkylphenylamino)-oxazolines and thiazolines as anti-glaucoma and vasoconstrictive agents  
Compounds of the formula ##STR1## where X is O or S; R 1 is lower alkyl having 1 to 6 carbons; R 2 is H, lower alkyl having 1 to 6 carbons; or OR 2 * where R 2 * is lower alkyl having 1 to 6...
5053430 Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new 2,7-diamino-1,2,3,4-tetrahydronaphthalenes and processes for their preparation  
Novel compounds having the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
5051421 Benzo-[b]thiophene derivatives  
Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered...
5032591 Pharmaceutical preparations  
A pharmaceutical product comprising a potassium channel activator antihypertensive agent and a β-blocker antihypertensive agent as a combined preparation for simultaneous, separate or sequential...
5026715 2-guanidino-4-arylthiazoles for treatment of peptic ulcers  
2-Guanidino-4-arylthiazole compounds of the formula ##STR1## a pharmaceutically acceptable cationic or acid addition salt thereof wherein R 1 is hydrogen, (C 1 -C 10 )alkyl, optionally...
4988723 Benzopyran derivatives and their use as anti-hypertensives  
Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension....
4987146 N-hetaryl imidazole derivatives  
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
4980356 2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharamaceutical compositions containing them and their treatment of medical conditions associated with the effects of glutamate  
Compounds of formula: ##STR1## and their salts, in which R 1 represents polyfluoroalkoxy, and R 2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl,...
4968709 Fungicidal 2-thiazolyloxy-thio- or amino-3-substituted acrylic acid esters  
Fungicidal substituted acrylic acid esters of the formula ##STR1## in which R 1 and R 2 independently of one another each stand for hydrogen, alkyl, alkenyl or for in each case optionally...
4966896 Derivative of N-methylcarbamate and insecticide containing the same  
An insecticide having high insecticidal activities against various harmful insects, which is low in toxicity to warm-blooded animals and fishes to be used safely. The insecticide comprises a...
4962117 Heterazole dialkanoic acids  
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and...
4956375 N-indanyl carboxamide derivative and agricultural/horticultural fungicide containing the derivative as active ingredient  
Disclosed herein is an N-indanyl carboxamide derivative as a novel compound, represented by the following general formula (I): ##STR1## wherein A represents a group of the formula, ##STR2##...
4940718 7-substituted bicyclic pyrazolidinones, pharmaceutical compositions and use  
7-Substituted bicyclic pyrazolidinone compounds as antimicrobials and the corresponding intermediates, are discussed or provided. The use of the antimicrobial compounds in pharmaceutical...
4929618 Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same  
Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar 1 , Ar 2 , n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical...
4918090 Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents  
A series of substituted 2-aminobenzothiazoles and derivatives useful for treating cerebrovascular disorders are disclosed. Also disclosed is a new method for treating such disorders.
4914117 Novel benzamides, intermediates and process for the preparation and therapeutic use thereof  
New substituted benzamides have the general formula: ##STR1## their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.
4904660 Histidine derivatives as superior renin inhibitors  
Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful...
4897397 Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents  
Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
4892871 Azido-substituted octopamine agonists and the use thereof to control invertebrate pests  
The invention is directed to azido-substituted octopamine agonists and the radiolabeled derivatives thereof. The invention also relates to past controlling compositions comprising the...
RE33125 3- and 5-[3-(1-arylureido)]-1,2,4-triazoles  
4880627 Skin therapeutic mixture containing eupatorium extract and formulations  
According to the present invention, a skin therapeutic mixture is useful for the alleviation of certain skin disorders such as acne, psoriasis, burns, pimples, blackheads, and open sores, and such...
4879293 Pyrrols [3,4-8]pyrazine derivatives, their production and use as anti-anxiety agents  
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is...
4877441 Fungicidal substituted carboxylic acid derivatives  
A substituted carboxylic acid derivative which is fungicidally active is provided. The compound has the formula: ##STR1## wherein R 1 stands for a methyl or ethyl group, A stands for ##STR2## R 2 ...
Matches 251 - 300 out of 443 < 1 2 3 4 5 6 7 8 9 >