Matches 151 - 200 out of 443 < 1 2 3 4 5 6 7 8 9 >
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6080772 Thiazole compounds and methods of modulating signal transduction  
The present invention relates to thiazole containing compounds capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such compounds to modulate or...
6075023 Method for combatting fish mycoses and one-celled ectoparasites  
6057349 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use  
The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R 1 q (R 3 R 60 N) m (Z)(NR 2 ) n ; m and q are each 0 or 1, with the proviso that when q is...
6048883 Heterocyclic compounds as pharmaceutical  
This invention provides compounds of formula (I): A 1 --X--(CH 2 ) n --O--A 2 --A 3 --Y.R 2 (I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a...
6040322 Medicaments for ameliorating endothelial cell activation  
The use of compound of formula (I) in which: R 1 and R 2 are the same or different and each represents a hydrogen atom or a C 1 -C 5 alkyl group; R 3 represents a hydrogen atom, a C 1 -C 6 ...
6022875 Use of substituted 2,4-imidazolidinedione compounds as analgesics  
Disclosed in this invention is a method of analgesic treatment comprising administering an effective analgesic amount of a substituted 2,4-imidazolidinedione compound.
6020353 2-(hydroxy)-N-(5-nitro-2-thiazolyl) benzamide  
The present invention relates to a pharmaceutical composition containing a compound of formula I ##STR1## with one of the symbols R 1 , R 2 , R 3 , R 4 and R 5 representing OH, whereas the...
5990135 Retroviral protease inhibiting compounds  
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5981547 Homochroman derivatives and related compounds useful as anti-inflammatory agents  
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or straight,...
5972957 Dihydrobenzopyran compounds and related compounds useful as anti-inflammatory agents  
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO 2 ; (c) Y is independently hydrogen or...
5968960 Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism  
The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and...
5965491 Pesticidal 1-aryl-3-iminopyrazoles  
1-Aryl-3-iminopyrazoles of the formula: ##STR1## wherein R 31 , R 32 , R 33 , R 4 , R 5 , R 12 , R 13 , R 14 , R 15 and Z are as defined in the specification, are useful as pesticides or as...
5958910 Use of N-(4-aryl-thiazol-2-yl)-sulfonamides  
The invention is concerned with the use of sulfonamide derivatives of the general formula ##STR1## wherein R Signifies lower-alkyl, phenyl, benzyl, naphthyl, pyridyl or thienyl, optionally...
5935973 Heterocyclcarboxamide derivatives and their use as therapeutic agents  
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R 1 is an optional substituent; U is an alkylene...
5932606 Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors  
A compound which inhibits human thrombin and where has the structure and pharmaceutically acceptable salts thereof, wherein such as ##STR1## which are useful for inhibiting formation of blood...
5925657 Use of PPARĪ³ agonists for inhibition of inflammatory cytokine production  
Disclosed herein are methods for reducing or preventing cytokine production associated with an inflammatory response, involving administering to a mammal a therapeutically-effective amount of a...
5922744 Ethane-1-2-diamine derivatives and tachykinin antagonists  
The present invention provides a compound of formula: ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a and R 6b are defined herein or a pharmaceutically acceptable salt thereof, a process...
5891874 Anti-viral compound  
A series of benzimidazole compounds having the following general structure are provided which inhibit the growth of picornaviruses (e.g., rhinoviruses, enteroviruses, polioviruses, coxsackieviruses...
5889033 Method and composition for the treatment of apathy-amotivation syndrome  
In accordance with the present invention, neuropsychiatric symptoms of apathy-amotivation syndrome and particularly those symptoms in: Alzheimer's disease, multiple sclerosis, Huntington's chorea,...
5885990 Substituted amidinonaphthyl ester derivative  
Substituted amidinonaphthyl ester compounds effective for treatment of thrombosis are represented by the following formula (I) and pharmaceutically acceptable acid addition salts thereof: ##STR1##...
5886013 Antiviral composition  
The present invention relates to a pharmaceutical composition containing a compound of formula I ##STR1## with one of the symbols R 1 , R 2 , R 3 , R 4 and R 5 representing OH, whereas the...
5880135 Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them  
A compound, as well as its stereoisomers and addition salts, possssing antagonist activity with respect to corticotropin releasing hormone (CRF) has the formula: ##STR1## in which R 1 , and R 21 ...
5874472 Aminoacid derivatives as no synthase inhibitors  
Compounds of formula (I) and salts, esters and amides thereof, wherein R 1 is a C 1 -6 straight or branched chain alkyl group, a C 3 -6 cycloalkyl group, a thiol group optionally substituted by a...
5866595 Calcium antagonists for treatment of vascular restenosis  
According to the present invention, compounds selected from the thiozole class of organic molecules are employed as antagonists for receptor-operated ion channels (ROICs) useful in the treatment of...
5856347 Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof  
An antibacterial agent or bactericide, comprising a 2-aminothiazole derivative represented by the following formula (I) and a salt thereof: ##STR1## wherein R 1 and R 2 each represent a hydrogen...
5854234 Amidino dervatives useful as nitric oxide synthase inhibitors  
The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
5854267 Method for preventing heartburn  
A method for preventing heartburn episodes in a patient susceptible to suffering heartburn episodes following ingestion of heartburn-inducing food or beverage, comprising administering to the...
5843974 Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se  
A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are independently hydrogen,...
5824694 Thiazolidine derivatives for the treatment of psoriasis  
A new medical use for certain thiazolidine derivatives is disclosed. Specifically, treatment of hyperproliferative epithelial cell conditions, such as psoriasis, by administration of...
5821255 Branched-amino-substituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them  
The invention concerns compounds of the formula I: ##STR1## in which R 1 to R 5 are as defined in claim 1. These compounds find their application in the treatment of pathologies involving CRF.
5817340 Pharmaceutical compositions containing famotidine and aluminum hydroxide or magnesium hydroxide  
A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a therapeutically effective amount of guanidinothiazole compound; and a...
5804590 Treatment and prophylaxis of osteoporosis  
Compounds of formula (I): ##STR1## where R 1 , R 2 , R 4 and R 5 are hydrogen or alkyl and R 3 is hydrogen, alkyl or various organic groups are effective against osteoporosis at doses at which...
5756532 Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives  
The compounds of formula I: ##STR1## wherein R 1 and R 2 are, independently, hydrogen, alkyl, phenyl or benzyl; or R 1 and R 2 , taken together, are benzylidene optionally substituted with R 3 ...
5753681 Treatment and prophylaxis of pancreatitis  
Insulin sensitizers, especially thiazolidinedione compounds, such as troglitazone, are useful for the treatment and prevention of pancreatitis.
5747515 Heterocyclic compounds and compositions having nevropharmacological potential  
Novel heterocyclic compounds having a structure according to general formula (1), pharmaceutically acceptable acid addition salts and solvates thereof are described as having a pharmacological...
5747518 Substituted thiophene derivative and agricultural and horticultural fungicide containing the same as active ingredient  
The substituted thiophene derivative of the invention which is represented by the general formula (1) has a broad disease spectrum for a pathogenic fungus of various crops, exhibits an excellent...
5739142 4-aminobenzoylguanidine derivatives  
4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R 1 , R 2 and R 3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties...
5733882 Retroviral protease inhibitors  
The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating...
5728696 Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides  
Acaricidal, insecticidal and nematicidal substituted (hetero)arylalkyl ketone oxime O-ethers, processes for their preparation, agents containing them, and their use as pesticides. The invention...
5726197 Isoindolinyl derivatives  
Compounds of the Formula: ##STR1## wherein: R 1 and R 2 are independently hydrogen or lower alkyl; R 3 is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, optionally substituted phenyl,...
5710159 Integrin receptor antagonists  
This invention relates to novel heterocycle compounds including but not limited to 3- 3- 3-(imidazolin-2-yl amino)propyloxy!isoxazol-5-ylcarbonylamino!-2-(benzyloxycarb onylamino)-pro pionic acid,...
5708015 Method for using pharmaceutical compositions containing 2-(2-alkyphenyl-amino)-thiazolines as adrenergic agents  
A pharmaceutical composition, useful for treating animals of the mammalian species, including humans, to treat diseases and conditions which normally respond to treatment with alpha 2 adrenergic...
5708012 Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus  
Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations exhibiting insulin resistent non-impaired glucose tolerance (IRNIGT) in order to prevent...
5703065 Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds  
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R 3 , Q and R 1 are as defined herein. The compounds of formula I, and...
5700820 Polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation  
Novel polymorphic forms of Troglitazone and methods for preparing the polymorphic forms of Troglitazone. The polymorphic forms of Troglitazone can be used to treat diabetic ailments.
5668161 Substituted thiazoles for the treatment of inflammation  
A class of substituted thiazolyl compounds is described for use in treating inflammation disorders. Compounds are defined by Formula II ##STR1## wherein R 1 is selected from hydrido, alkyl,...
5656652 Compositions containing histamine-H.sub.2 -receptor antagonists at low dosage  
Compositions for oral administration for the treatment of gastric disorders comprising histamine H 2 -receptor antagonist, and antacid, optimally buffered to promote local absorption of the H 2 ...
5650421 Premixed famotidine formulation  
A pharmaceutical composition comprising a solution having an effective amount of famotidine, the solution having a pH in the range of about 4.5 to about 8.0, and a shelf life greater than 30 days.
5650405 Treatment for toxoplasmosis with a composition comprising a sulfonamide and a spiropiperidyl derivative of rifamycin S.  
A method of reducing the severity of toxoplasmosis resulting from infection of a patient with Toxoplasma gondii by administering to a patient in need of such treatment, either after infection or...
5643960 Method of delaying onset of alzheimer's disease symptoms  
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The method involves the administration to...
Matches 151 - 200 out of 443 < 1 2 3 4 5 6 7 8 9 >