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7407978 Heterocyclic analogs of diphenylethylene compounds  
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
7402600 Nitroderivatives of cardiovascular agents  
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the...
7390824 Method for treating diabetes employing an aP2 inhibitor and combination  
A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as...
7375124 Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity  
The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the...
7351732 Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications  
New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT 1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for...
7348348 Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers  
Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl...
7348342 Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine  
We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment...
7339065 Design and synthesis of optimized ligands for PPAR  
This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors...
7338667 Pharmaceutical formulation  
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
7332481 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
7323481 Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth  
Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour...
7300927 Method for treating or preventing Alzheimer's disease  
Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an...
7294641 Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses  
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
7265139 RXR activating molecules  
The invention relates to molecules having Formula (100): wherein ————— represents a bond present or absent; Ar is a substituted or unsubstituted benzene or pyridine ring; V is a C or...
7259176 Process for the preparation of the insulin sensitizer  
A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I...
7256211 8-azaprostaglandin derivatives and medical use thereof  
The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of...
7253196 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1  
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to...
7250430 Thiophene-and thiazolesulfonamides as antineoplastic agents  
The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
7241783 Thrombopoietin mimetics  
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an...
7241756 Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus  
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
7235573 Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors  
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for treating...
7232838 2-amino-4,5-trisubstituted thiazolyl derivatives  
This invention concerns the use of a compound of formula (I′), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z...
7226940 Substituted heterocycles for the treatment of diabetes and other diseases  
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
7220764 Sphingosine kinase inhibitors  
The invention relates to compositions and methods for inhibiting sphingosine kinase and for treating hyperproliferative disease.
7189722 Aryl spirohydantoin CGRP receptor antagonists  
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
RE39502 Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids  
Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The...
7183321 Antidiabetic formulation and method  
An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in...
7183302 Iminothiazolidinones as inhibitors of HCV replication  
Compounds having the structure of formula I are described wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
7169782 Aryl substituted thiazolidinones and the use thereof  
This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The...
7166620 Thiazole derivatives with fungicidal activity  
Compounds having general formula (I) are described, together with their use for the control of phytopathogenic fungi
7166607 Substituted indoles  
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
7157490 Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes  
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
7148219 Biaryl heterocyclic compounds and methods of making and using the same  
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
7144905 Small molecules used to increase cell death  
The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that...
7144900 Pharmaceutical composition  
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent...
7141533 Hetaryl-substituted heterocycles  
The present invention relates to novel compounds of the formula (I) in which A, B, W, G and Het are each as defined in the description, to a plurality of processes for their preparation...
7129267 Methods for SHP1 mediated neuroprotection  
The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the...
7129243 Peptide compounds  
The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto...
7125865 Therapeutic compounds for treating dyslipidemic conditions  
The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic...
7125863 Inhibitors of dipeptidyl peptidase IV  
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
7115658 Inhibitors of hepatitis C virus RNA-dependent RNA polymerase  
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
7115640 Heterocyclic modulators of nuclear receptors  
Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X...
7115605 Peptide deformylase inhibitors  
PDF inhibitors and novel methods for their use are provided.
7109223 Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma  
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which...
7105564 Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton  
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
7105556 Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method  
Compounds are provided which have the structure wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
7105554 Benzylidene thiazolidinediones and their use as antimycotic agents  
A compound of formula I or a salt thereof wherein, A is O or S, X and Y independently represent O, CH 2 and may be the same or different, Q is (CH 2 ) m —CH(R1)-(CH 2 ) n , R is OR6, NHR8, R1 is...
7105553 Thiazolyl amide derivatives  
The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
7105552 Heterocyclic analogs of diphenylethylene compounds  
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
7084170 Thiophene-amd thiazolesulfonamides as antineoplastic agents  
The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.