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7595333 |
Agent for improving acidosis
An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7566732 |
Rhodanine compositions for use as antiviral agents
This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the...
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7563813 |
Iminothiazolidinone derivatives as SFRP-1 antagonists
Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided:
which are inhibitors of secreted frizzled related protein-1. The compounds, and compositions containing the...
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7563774 |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
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7560568 |
Thiazole compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
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7557095 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are...
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7528133 |
Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation
The present invention provides methods of preventing or reducing oxytocin-mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods...
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7521466 |
Dipeptide phenyl ethers
Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or...
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7521465 |
Diphenyl ether derivatives
Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation,...
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7514462 |
ω-Cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists
The invention relates to the use of derivatives of E-type prostaglandins as EP 2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the...
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7514461 |
Chroman derivatives
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I
wherein the substituents are as defined in the specification. They are...
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7511059 |
Thiazolidinones, their production and use as pharmaceutical agents
The invention relates to thiazolidinones of general formula (I)
their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases.
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7482371 |
N-phenylbenzamide derivatives as drugs for the treatment of COPD
The invention relates to the use of a pharmaceutically active derivative of N-phenylbenzamide of Formula (I) or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7452874 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
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7439260 |
7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors
The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory,...
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7439248 |
Pharmaceutical composition and the process for its preparation
The present invention provides a new stable pharmaceutical composition containing 5-[[4-[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]phe
nyl-methyl]thiadiazolidine-2,4-dione as active...
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7439242 |
PPARγ modulators
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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7435828 |
Thiazolidin-4-one derivatives
The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the...
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7407978 |
Heterocyclic analogs of diphenylethylene compounds
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
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7402600 |
Nitroderivatives of cardiovascular agents
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the...
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7390824 |
Method for treating diabetes employing an aP2 inhibitor and combination
A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as...
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7375124 |
Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the...
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7351732 |
Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications
New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT 1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for...
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7348348 |
Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers
Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl...
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7338667 |
Pharmaceutical formulation
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
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7323481 |
Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour...
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7300927 |
Method for treating or preventing Alzheimer's disease
Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an...
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7294641 |
Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
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7265139 |
RXR activating molecules
The invention relates to molecules having Formula (100):
wherein ————— represents a bond present or absent; Ar is a substituted or unsubstituted benzene or pyridine ring; V is a C or...
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7259176 |
Process for the preparation of the insulin sensitizer
A novel process for the preparation of compounds of formula I
and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I...
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7256211 |
8-azaprostaglandin derivatives and medical use thereof
The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I)
(wherein, all the symbols have the same meanings as that of...
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7253196 |
Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (I), (II), (III) or (IV):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to...
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7250430 |
Thiophene-and thiazolesulfonamides as antineoplastic agents
The present invention provides antineoplastic compounds of the formula:
and antineoplastic methods.
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7241756 |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
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7235573 |
Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for treating...
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7232838 |
2-amino-4,5-trisubstituted thiazolyl derivatives
This invention concerns the use of a compound of formula (I′), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z...
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7226940 |
Substituted heterocycles for the treatment of diabetes and other diseases
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
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7189722 |
Aryl spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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RE39502 |
Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids
Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The...
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7183321 |
Antidiabetic formulation and method
An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in...
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7183302 |
Iminothiazolidinones as inhibitors of HCV replication
Compounds having the structure of formula I are described
wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
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7169782 |
Aryl substituted thiazolidinones and the use thereof
This invention relates aryl substituted thiazolidinones of Formula I:
or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The...
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7166620 |
Thiazole derivatives with fungicidal activity
Compounds having general formula (I) are described, together with their use for the control of phytopathogenic fungi
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7166607 |
Substituted indoles
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
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7157490 |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
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7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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