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9023876 Compounds and methods for regulating integrins  
The application describes small molecules capable of modulating activity of beta2 family of integrins, such as integrin CD11b/CD18 (also known as Mac-1, CR3 and αMβ2). Such compounds may be used...
9018136 Pesticidal compositions and processes related thereto  
This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
9000018 Thiazolidin-4-one-derivatives  
The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the...
8987306 Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold  
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use....
8987256 Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof  
The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment...
8933075 Compounds useful as antiviral agents, compositions, and methods of use  
Novel 3-N-cycloalkyl-5-substituted-2-thioxothiazolidin-4-one derivatives that are effective for use in treating viral infections are described. Also described are pharmaceutical compositions...
8912224 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals  
The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors...
8906948 Choline cocrystal of epalrestat  
The invention relates to a novel choline cocrystal of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3- thiazolidineacetic acid. The preparation and characterization of the novel...
8901167 Product and process for inhibition of biofilm development  
Disclosed are compositions and methods for the inhibition of biofilm formation or reduction of existing or developing biofilms in a patient. These methods also inhibit the aggregation of bacteria...
8883834 Methods and compositions for locally increasing body fat  
Provided are methods for increasing fat locally in a body of a subject in need thereof comprising percutaneously administering to the subcutaneous fat of the subject a thiazolidinedione or an...
8871792 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula X: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The...
8846667 Compounds for modulating integrin CD11b/CD18  
The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds...
8835448 Methods and formulations for modulating lyn kinase activity and treating related disorders  
The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in...
8815922 Pesticidal compositions and processes related thereto  
This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
8815921 Active substance combination based on trifluorobutinyl compounds and exhibiting nematicidal and insecticidal properties  
The invention relates to novel active substance combinations consisting of heterocyclic trifluorobutenylen of formula (I), wherein X is halogen and N is 0, 1 or 2, and of known insecticide...
8808742 Compositions and methods for preparing and using same  
This invention relates to compositions, methods for preparing the compositions and methods for treating or preventing diseases, comprising administering the compositions.
8796256 Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-α modulators  
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not...
8795984 Production of glycoproteins with reduced O-glycosylation  
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an...
8790925 Methods of generating hyper iNOS expressing cells and uses thereof  
A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to...
8785484 Dosing regimen for a selective S1P1 receptor agonist  
The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the...
8778981 Methods and compositions for locally increasing body fat  
Provided are methods for increasing fat locally in a body of a subject in need thereof comprising percutaneously administering to the subcutaneous fat of the subject a thiazolidinedione or an...
8765752 3-hydroxyisothiazole 1-oxide derivatives  
[Object] To provide a GPR40 activating agent containing, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the compound or the salt, or...
8729060 Macrocyclic polyoxazole compounds and use thereof  
The invention provides compounds of formula (I) wherein A, B, R1, F, G, n, n′ and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as...
8697735 Solid forms of epalrestat  
The invention relates to novel crystalline salts of 5-[(1Z,2E)-2-methyl-3-phenylpropenylidene]-4-oxo-2-thioxo-3- thiazolidineacetic acid and a novel betaine cocrystal of...
8691820 CDK inhibitors  
The present invention relates to CDK inhibitors and their use in the treatment of cell proliferative diseases such as cancer.
8686009 Prodrugs of NH-acidic compounds  
The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a...
8686010 Aryl- or heteroaryl-sulfonyl compounds as acid secretion inhibitors  
The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the...
8686011 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1  
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions...
8686160 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Compound having detrusor muscle-contracting activity and urethral sphincter muscle-relaxing activity
 
Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a...
8669246 Substituted amide compound  
A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid...
8668931 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative  
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is...
8658635 Benzpyrazol derivatives as inhibitors of PI3 kinases  
The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
8653115 Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents  
The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical...
8637558 Thiazolidinedione derivative and use thereof  
The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel...
8637556 Linked Myc-max small molecule inhibitors  
Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of...
8632808 Taste-masking solid preparation of pioglitazone  
A solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof; a solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof and...
8614229 Substituted indole derivatives and methods of use thereof  
The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for...
8586607 Compounds for the treatment of metabolic diseases  
There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in...
8580832 Substituted phenoxy aminothiazolones as estrogen related receptor-α modulators  
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not...
RE44578 Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids  
Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The...
8569302 Inhibitors of flaviviridae viruses  
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus...
8552038 Crystalline forms of thiazolidinedione compound and its manufacturing method  
A crystalline form of a hydrate of a dihydrochloride 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimid azol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione represented by the following...
8546382 Methods for enhancing hematopoietic progenitor cell engraftment  
Described herein are methods for improving engraftment of hematopoietic cells in an individual following hematopoietic progenitor cell transplantation (e.g., via bone marrow or cord blood...
8524752 Thiazolidin-4-one derivatives  
The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the...
8513252 Pyrazole derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors  
The present invention relates to novel compounds of Formula (I), wherein M, P, X1, X2, (A)m and (B)n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate...
8501438 Production of glycoproteins with reduced O-glycosylation  
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an...
8501793 Blood flow promoters for cauda equina tissues  
It is intended to provide highly safe and efficacious blood flow promoters for cauda equina tissues. Among prostaglandin-like compounds having a weak hypotensive effect, compounds having an effect...
8492417 Topical use of thiazolidine derivatives against consequences of oxidative stress of skin  
The invention concerns a cosmetic care method for opposing destructive effects of oxidative stress and its toxic by-products, comprising administering topically to a patient in need thereof, a...
8470368 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative  
A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is...
8466177 Treating and preventing viral infections  
Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using...