|
Match
|
Document |
Document Title |
|
|
7407978 |
Heterocyclic analogs of diphenylethylene compounds
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
|
|
|
7402600 |
Nitroderivatives of cardiovascular agents
Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the...
|
|
|
7390824 |
Method for treating diabetes employing an aP2 inhibitor and combination
A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as...
|
|
|
7375124 |
Use of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
The use is described of derivatives of α-phenylthiocarboxylic and α-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the...
|
|
|
7351732 |
Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications
New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT 1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for...
|
|
|
7348348 |
Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers
Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl...
|
|
|
7348342 |
Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine
We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment...
|
|
|
7339065 |
Design and synthesis of optimized ligands for PPAR
This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors...
|
|
|
7338667 |
Pharmaceutical formulation
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
|
|
|
7332481 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
|
|
|
7323481 |
Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
Use of thiazolidinedione derivatives for the preparation of medicaments for inhibiting or reducing tumour growth or metastases, alone or in combination with an RXR agonist or well-known antitumour...
|
|
|
7300927 |
Method for treating or preventing Alzheimer's disease
Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an...
|
|
|
7294641 |
Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses
Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or...
|
|
|
7265139 |
RXR activating molecules
The invention relates to molecules having Formula (100):
wherein ————— represents a bond present or absent; Ar is a substituted or unsubstituted benzene or pyridine ring; V is a C or...
|
|
|
7259176 |
Process for the preparation of the insulin sensitizer
A novel process for the preparation of compounds of formula I
and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I...
|
|
|
7256211 |
8-azaprostaglandin derivatives and medical use thereof
The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I)
(wherein, all the symbols have the same meanings as that of...
|
|
|
7253196 |
Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (I), (II), (III) or (IV):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to...
|
|
|
7250430 |
Thiophene-and thiazolesulfonamides as antineoplastic agents
The present invention provides antineoplastic compounds of the formula:
and antineoplastic methods.
|
|
|
7241783 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an...
|
|
|
7241756 |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
|
|
|
7235573 |
Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for treating...
|
|
|
7232838 |
2-amino-4,5-trisubstituted thiazolyl derivatives
This invention concerns the use of a compound of formula (I′), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z...
|
|
|
7226940 |
Substituted heterocycles for the treatment of diabetes and other diseases
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
|
|
|
7220764 |
Sphingosine kinase inhibitors
The invention relates to compositions and methods for inhibiting sphingosine kinase and for treating hyperproliferative disease.
|
|
|
7189722 |
Aryl spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
|
|
|
RE39502 |
Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids
Pharmaceutical compositions that have excellent storage stability even though they include a active component that is susceptible to degradation in an acidic environment are disclosed. The...
|
|
|
7183321 |
Antidiabetic formulation and method
An antidiabetic pharmaceutical formulation is provided, especially adapted for treating Type II diabetes, which includes a combination of metformin and glipizide in a manner to control moisture in...
|
|
|
7183302 |
Iminothiazolidinones as inhibitors of HCV replication
Compounds having the structure of formula I are described
wherein R, R′, R 1 , R 2 , and R 3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV)...
|
|
|
7169782 |
Aryl substituted thiazolidinones and the use thereof
This invention relates aryl substituted thiazolidinones of Formula I:
or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The...
|
|
|
7166620 |
Thiazole derivatives with fungicidal activity
Compounds having general formula (I) are described, together with their use for the control of phytopathogenic fungi
|
|
|
7166607 |
Substituted indoles
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
|
|
|
7157490 |
Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
|
|
|
7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
|
|
|
7144905 |
Small molecules used to increase cell death
The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that...
|
|
|
7144900 |
Pharmaceutical composition
Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent...
|
|
|
7141533 |
Hetaryl-substituted heterocycles
The present invention relates to novel compounds of the formula (I)
in which A, B, W, G and Het are each as defined in the description, to a plurality of processes for their preparation...
|
|
|
7129267 |
Methods for SHP1 mediated neuroprotection
The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the...
|
|
|
7129243 |
Peptide compounds
The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto...
|
|
|
7125865 |
Therapeutic compounds for treating dyslipidemic conditions
The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic...
|
|
|
7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
|
|
|
7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
|
|
|
7115640 |
Heterocyclic modulators of nuclear receptors
Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of farnesoid X...
|
|
|
7115605 |
Peptide deformylase inhibitors
PDF inhibitors and novel methods for their use are provided.
|
|
|
7109223 |
Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which...
|
|
|
7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
|
|
|
7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
|
|
|
7105554 |
Benzylidene thiazolidinediones and their use as antimycotic agents
A compound of formula I or a salt thereof wherein, A is O or S, X and Y independently represent O, CH 2 and may be the same or different, Q is (CH 2 ) m —CH(R1)-(CH 2 ) n , R is OR6, NHR8, R1 is...
|
|
|
7105553 |
Thiazolyl amide derivatives
The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
|
|
|
7105552 |
Heterocyclic analogs of diphenylethylene compounds
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin,...
|
|
|
7084170 |
Thiophene-amd thiazolesulfonamides as antineoplastic agents
The present invention provides antineoplastic compounds of the formula:
and antineoplastic methods.
|