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5223517 |
Heterocyclically substituted cycloalkano[b]-indolesulphonamides
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
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5217982 |
Compounds having antihypertensive properties
This invention relates to compounds which are derivatives of cyclopentane which are useful as antihypertensive agents, to pharmaceutical compositions including such compounds, and to their use in...
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5214062 |
Method and composition for treating immune disorders, inflammation and chronic infections
The present invention provides a method of treating a viral infection or immune disorder as well as a composition for same. The method of treatment comprises administering to a patient having a...
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5208250 |
Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents
The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having...
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5208249 |
Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate
A method for stimulating the intracellular synthesis of glutathione comprising the step of administering to a mammal a therapeutically effective amount of an ester of...
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5204374 |
Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by heterocycles
New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R 1 , R 2 , R 3 and R 4 are identical or different and represent...
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5202342 |
N-alkyl thiazolidine derivatives
This invention relates to the compounds of the formula [I] and salts thereof, which are useful for treatment of liver disorders, ##STR1## wherein X is oxygen or sulfur; R 1 is lower alkyl which...
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5202341 |
Hydroxystyrene compounds having tyrosine kinase inhibiting activity
A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R 1 and R 2 : phenyl group, benzyl group or phenethyl group, or R 1 : R 5 O- (R 5 : H, a C 1 to C 5 alkyl...
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5198454 |
Use of OB-104 to treat ocular inflammation
A novel compound for the treatment and prevention of ocular inflammation is disclosed. The compound, OB-104, is effective at both the early and late phases of inflammation.
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5198445 |
Composition and use of substituted 3-thio-2-propynenitriles as industrial antimicrobials
Substituted 3-thio-2-propynenitriles are prepared which correspond to the formula: R--S--C.tbd.C--C.tbd.N wherein R is an alkyl, cyclic alkyl, aryl, or heterocyclo group. These compounds have...
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5192781 |
Thiazole derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
The present invention relates to the derivatives of formula (I): ##STR1## and their addition salts, and to their use in therapeutics, especially for the treatment of cardiovascular diseases and in...
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5185354 |
Pyrazolecarboxamide, insecticidal and miticidal composition, and fungicidal composition for use in agriculture and horticulture
A pyrazolecarboxamide derivative represented by the following formula (I): ##STR1## wherein R 1 represents a C 1 .about.C 3 alkyl group, R 2 represents a C 1 .about.C 3 alkyl group, R 3 ...
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5177091 |
Use of carbazones as novel active ingredients in medicaments
Compounds of formula I ##STR1## wherein X and Y are each independently of the other thio or sulfynyl, R 1 is lower alk-2-en-1-yl, lower alk-3-en-2-yl, lower alk-2--yn-1-yl, or lower alkyl that is...
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5177095 |
Triazole angiotensin II antagonists incorporating a substituted benzyl element
Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
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5175179 |
Method for treating hypertension
A method of using certain thiazolidine-2,4-diones in the treatment of hypertension.
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5169859 |
Thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same
The present invention relates to novel compounds of the general formula (I) ##STR1## wherein R means hydrogen or C 1 -4 alkyl group; and Y stands for cyano, trifluoromethyl, aryloxy or aryl(C 1...
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5166167 |
α-Methylene-4-(phenoxymethyl)-5-thiazolacetate
A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenoxy, phenyl, --CF 3 and alkyl,...
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5164381 |
Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same
1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and...
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5153211 |
Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
Disclosed are substituted or unsubstituted planar tricyclic fluorene or nuclear analogs thereof, spiro-coupled to a five-membered ring containing a secondary amide, and the pharmaceutically...
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5153210 |
Compounds
A compound of the general formula (I): ##STR1## or a pharmaceutically acceptable ester thereof; or a pharmaceutically acceptable salt thereof, wherein, R o represents a substituted or...
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5145855 |
6- and 7-deoxyforskolin and derivatives thereof
Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are...
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5143927 |
3-(thiazolidone, oxazolidinone, imidazolidinone)-indoles as antiinflammatory agents
The present invention is for selected novel compounds which are 3-[thiazolidinone, oxazolidinone, imidazolidinone]-indoles as well as pharmaceutical compositions and methods of use thereof. These...
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5143930 |
Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
Compounds of formula (I): ##STR1## in which: A is a group of formula (II) or (III): ##STR2## W is methylene, carbonyl or >CN--OV, where V is hydrogen, sulfo, acyl or alkyl; U is methylene, or...
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5143929 |
2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents
The present invention is for selected novel compounds which are 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates, as well as pharmaceutical compositions and...
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5132317 |
Compounds
A compound of formula (I): ##STR1## or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein: A 1 represents...
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5130379 |
Hypoglycemic thiazolidinedione derivatives
Hypoglycemic thiazolidine-2,4-dione derivatives ##STR1## wherein the dotted line represents a bond or no bond; V is --CHCH--, --NCH--, --CHN-- or S; W is CH 2 , CHOH, CO, CNOR or...
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5128350 |
Pyrazolyl acrylic acid derivatives and agricultural/horticultural fungicides containing said derivatives
A pyrazolyl acrylic acid derivative of formula (I): ##STR1## wherein R 1 and R 2 are independently hydrogen or C 1 -C 5 alkyl; W is C 1 -C 4 alkylene optionally substituted by C 1 -C 4 ...
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5126349 |
Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial
Substituted 3-thio-2-propynenitriles are prepared which correspond to the formula: R--S--C.tbd.C--C.tbd.N wherein R is an alkyl, cyclic alkyl, aryl, or heterocyclo group. These compounds have...
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5124342 |
4-hydroxythiazoles as 5-lipoxygenase inhibitors
A composition for the inhibition of lipoxygenase enzymes comprising a pharmaceutically acceptable carrier and a compound of the formula: ##STR1## wherein R 1 and R 2 are independently selected...
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5120755 |
Fungicidal substituted acrylic acid esters
Fungicidal substituted acrylic acid esters of the formula ##STR1## in which R 1 and R 2 independently of one another each stand for hydrogen, alkyl, alkenyl or for in each case optionally...
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5116855 |
Rhodanine derivatives and pharmaceutical compositions
Disclosed is a rhodanine derivative of formula (I). A rhodanine derivative of formula (I) ##STR1## wherein R 1 is hdyrogen, C 1 -C 8 alkyl, carboxyl(C 1 -C 4 )alkyl or (C 1 -C 4...
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5104888 |
Thiazolidine derivatives, their preparation and use
Compounds of formula (I): ##STR1## (in which R 1 -R 7 are hydrogen or various organic groups, n is 1-10, Ar is an aromatic group, U is CH 2 or a carbon atom doubly bonded to either one of its...
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5095027 |
Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid
The present invention provides a method for treating and/or reducing ischemic reperfusion injury. To this end, in embodiment, a method for treating and/or reducing reperfusion injury is provided...
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5089513 |
5-lipoxygenase inhibitory thiazoles
The invention concerns a thiazole of the formula I, ##STR1## wherein Ar 1 is optionally substituted aryl of up to 10 carbon atoms; A is a direct link to X, or is (1-6C)alkylene,...
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5089514 |
3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl, or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.
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5081142 |
Derivatives of 1-hydroxy-1,2,4-triazole and fungicides and growth regulators containing them
Compounds of the formula I ##STR1## where Ar is unsubstituted or substituted phenyl, pyridyl, thienyl or napthyl, R 1 is hydrogen or CN, R 2 is unsubstituted or substituted aryl, hetaryl,...
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5075326 |
Pesticidal 4-halogeno-5-nitrothiazoles
Fungicidal 4-halogeno-5-nitrothiazoles of the formula ##STR1## in which Hal represents halogen, A represents O, S, SO, SO 2 or N--R 1 , wherein R and R 1 each independently is hydrogen or...
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5071871 |
Pharmaceutically useful benzo(β)pyranes and pyranopyridines
New benz[b]pyranes and pyranopyridines of formula I, ##STR1## wherein the significances of substituents V, T, W, R 3 to R 5 , R 9 , R 10 , m, X, Y and Z are given in claim 1 and their N-oxides and...
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5061720 |
Substituted-4-thiazolidinone derivatives
Disclosed are novel substituted 4-thiazolidinone derivatives having cyclooxygenase and 5-lipoxygenase inhibiting properties and which are topical antiinflammatory agents for inflammed conditions of...
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5055477 |
Pyrazolyl acrylic acid derivatives, useful as systemic fungicides for plant and material protection
A pyrazolyl acrylic acid derivative having plant fungicidal activity of formula (I): ##STR1## wherein: R 1 and R 2 are independently hydrogen or C 1 -C 5 alkyl; A is a group of the formula:...
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5053430 |
Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new 2,7-diamino-1,2,3,4-tetrahydronaphthalenes and processes for their preparation
Novel compounds having the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
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5037842 |
Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
A series of 5-(4-[2-substituted benzoxazolylmethoxy]benzyl)oxa- and thiazolidine-2,4-diones as antidiabetic and cholesterol lowering agents.
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5034405 |
Admixtures of 2-bromo-2-bromomethyl-glutaronitrile, 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one
The instant invention is directed to synergistic antimicrobial admixtures comprising 2-bromo-2-bromomethylglutaronitrile, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one...
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5032590 |
Substituted hydroxylamines
Substituted hydroxylamines of the formula ##STR1## in which R 1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia...
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5032588 |
Thiazole lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
Compounds of the formulae: ##STR1## and pharmaceutically acceptable salts, esters and prodrugs thereof, wherein M and R 1 are independently selected from among optionally substituted alkyl,...
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5032591 |
Pharmaceutical preparations
A pharmaceutical product comprising a potassium channel activator antihypertensive agent and a β-blocker antihypertensive agent as a combined preparation for simultaneous, separate or sequential...
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5017591 |
Thiazolyl methyl)-2-2'-Bi-1H-imidazoles and use as hypertensive agents
This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated,...
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4990524 |
2-thiazolones in a method of treating a gastric ulcer
The present invention relates to a method of treating a gastric ulcer by administering a 2-thia-zolone of the formula (I), ##STR1## wherein X stands for --CN, --CONH 2 , --CO 2 H or --CO 2 R...
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4988719 |
3,7-disubstituted benzothiazolones and fungicidal use thereof
Fungicidally active 3,7-disubstituted benzothiazolones of the formula ##STR1## in which n stands for the numbers 0, 1, 2 or 3, R 1 stands for hydrogen or optionally substituted alkyl, R 2 ...
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4988718 |
Pesticidal substituted 4-heterocyclyloximino-pyrazolin-5-ones, compositions and use
Fungicidal substituted 4-heterocyclyloximinopyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another in each case represent hydrogen, alkyl, alkenyl, alkinyl,...
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