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RE37355 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds as pharmaceutical active ingredients  
6-dimethylaminomethyl-1-phenyl-cyclohexane compounds, methods of preparing them and the use of these compounds in drugs are described.
6281234 (2-Acylaminothiazole-4-yl)acetic acid derivative  
This invention provides compounds of Formula I having the structure ##STR1## wherein R 1 , R 2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of...
6258832 Method for producing thiazolidinediones, and new thiazolidinediones  
Improved process of compound of formula III ##STR1## in which A denotes CHCH or S W denotes O X denotes S, O or NR 2 in which the residue R 2 is hydrogen or C 1 -C 6 alkyl, Y...
6255330 Heterocyclically substituted phenylglycinolamides  
The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted...
6251928 Treatment of alzheimer's disease employing inhibitors of cathepsin D  
This invention provides novel benzylidene rhodanines which are useful as agents in treating or preventing conditions associated with β-amyloid peptide. This invention further provides methods of...
6242470 Adamantane derivatives  
The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use...
6239157 Inhibition of osteoclastogenesis  
A method for inhibiting the differentiation of CD34+ cells into osteoclasts by treating the cells with a peroxisome proliferator-activated receptor-γ agonist.
6214852 N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases  
The present invention describes compounds of formula I ##STR1## and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors...
6214842 Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia  
This invention provides compounds of Formula I having the structure ##STR1## wherein: R is hydrogen or alkyl of 1-6 carbon atoms; A is ##STR2## R 1 , R 2 , R 3 are each, independently,...
6207690 Troglitazone compounds for treating climacteric and cancer  
The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel...
6200998 Arylthiazolidinedione derivitives  
Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including...
6197749 Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes  
A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of...
6191154 Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases  
The present invention relates to methods and compositions for treating Alzheimer's disease and other diseases and conditions with an inflammatory component (e.g., central nervous system injury). In...
6174908 Potassium channel inhibitors  
Certain thiazolidinone and metathiazanone compounds, as described, are useful as potassium channel inhibitors and are especially useful for the treatment of cardiac arrhythmias and other diseases,...
6162823 LTA.sub.4 hydrolase inhibitors  
The present invention provides compounds having the of the formula I: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory...
6159997 Treatment of arteriosclerosis and xanthoma  
A combination of one or more HMG-CoA reductase inhibitors (for example pravastatin, lovastatin, simvastatin, fluvastatin, rivastatin or atorvastatin) with one or more insulin sensitizers (for...
6150387 Heterocyclic carboxamide compounds effective in the treatment of drug abuse  
This invention relates to the use of heterocyclic carboxamide compounds for preventing or reducing self-administration, by a human or animal patient, of a drug or a substance capable of giving rise...
6150371 Method for preventing and for treating autoimmune disease  
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
6147101 N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same  
The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for...
6147100 Pyrrolidine derivatives having phospholipase A.sub.2 inhibitory activity  
A compound represented by the formula (I): ##STR1## wherein, for example, R 1 is optionally substituted aralkyl, Z is nitrogen atom which optionally substituted with alkyl, X 1 is --CH 2 NHCO--,...
6143765 Pharmaceutical compositions and methods for modulating signal transduction  
The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate...
6127422 Anti-viral method  
A method of inhibiting an envelope virus selected from the group consisting of influenza bovine diarrheal, hepatitis C and tick borne encephalitis virus that udergoes hemagglutinin-mediated fusion...
6124333 Metalloproteinase inhibitors  
Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are...
6121288 Visceral fat lowering agent  
Methods for decreasing visceral fat, inhibiting accumulation of visceral fat and improving the distribution of visceral fat all include the administration of a thiazolidine derivative represented...
6110951 Thiazolidine derivatives for the treatment of hypertension  
This invention relates to a second medical use of thiazolidine compounds having anti-diabetic properties. These compounds are also of use for the control of essential hypertension.
6100252 Heterocyclic compounds and their use as angiotensin antagonists  
6090801 Pharmaceutical compositions containing ceftriaxone and penems  
6080771 DC107 derivatives  
DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R 1 represents...
6075023 Method for combatting fish mycoses and one-celled ectoparasites  
6063799 Alternate crystal form of Tazofelone  
The instant invention provides novel crystalline Form II of (±)-5-{[3,5-bis(1,1dimethylethyl)-4-hydroxyphenyl]methyl}-4 -thiazolidin one having an x-ray powder diffraction patter with specific d...
6057349 2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use  
The present invention concerns novel compounds represented by the Formula: ##STR1## wherein: A is R 1 q (R 3 R 60 N) m (Z)(NR 2 ) n ; m and q are each 0 or 1, with the proviso that when q is...
6046222 Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus  
Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin-dependent diabetes mellitus (NIDDM) and complications...
6040328 Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use  
The objects of the present invention are: novel organoselenium compounds: aromatic diselenides and selenosulphides; the use of said novel compounds as antioxidant agents; pharmaceutical...
6040322 Medicaments for ameliorating endothelial cell activation  
The use of compound of formula (I) in which: R 1 and R 2 are the same or different and each represents a hydrogen atom or a C 1 -C 5 alkyl group; R 3 represents a hydrogen atom, a C 1 -C 6 ...
6013663 Dithiolan derivatives, their preparation and their therapeutic effect  
A compound of formula (I): ##STR1## wherein one of m and n represents 0, and the other represents 0, 1 or 2; k represents 0 or 1 to 12; R 1 is hydrogen, an aryl, a heterocyclic, an alkyl, a...
6013649 Thiol sulfone metalloprotease inhibitors  
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors,...
6011049 Combinations for diabetes  
Combinations of a glitazone antidiabetic agent and a biguanide antidiabetic agent, and optionally a sulfonylurea antidiabetic agent, are useful for treating diabetes mellitus and improving glycemic...
6008237 Arylthiazolidinedione derivatives  
Substituted 5-aryl-2,4-thiazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia, hyperlipidemia (including...
6004543 L-2-oxothiazolidine-4-carboxylic acid derivatives and use thereof for skincare  
The invention relates to novel compounds of formula (I): ##STR1## where R1 is chosen from hydrogen, saturated or unsaturated linear or branched C1 to C8 alkyl groups which are optionally...
6001862 N-benzyldioxothiazolidylbenzamide derivatives and processes for preparing the same  
The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for...
5998452 Benzene derivatives, compositions and methods for treating ischemic diseases  
The present invention is directed to a compound represented by formula (I): wherein, for example, R 1 , R 2 , R 3 , and R 4 each represents a hydrogen atom; R 6 and R 7 each represent a...
5990135 Retroviral protease inhibiting compounds  
A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.
5990139 Thiazolidinedione derivatives or salts thereof and pharmaceutical compositions containing the same  
This invention relates to a thiazolidinedione derivative represented by the following formula (1): ##STR1## wherein R 1 and R 2 individually represent H, a halogen atom, or a halogen-substituted...
5981559 Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A.sub.2 antagonizing activity  
An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and...
5972944 Use of thiazolidinedione derivatives in the treatment of anovulation, hyperandrogenism and hirsutism  
The present invention provides methods of using thiazolidinone derivatives to treat anovulation, hyperandrogenism and hirsutism.
5968958 5-Methanesulfonamido-3H-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2  
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a...
5968918 Method for the prevention of coronary artery spasm  
The present invention relates to the prevention of coronary artery spasm in mammals by the administration of an effective amount of an antiestrogen compound to block estrogen receptors for the...
5968960 Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism  
The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and...
5965589 Thiazolidinedione derivatives, their production and use  
A 2,4-thiazolidinedione derivative of the formula (I): ##STR1## wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n...
5952359 Thiazoles and their agricultural compositions  
A compound of formula (I), R--S(O) n CH 2 CH 2 CHCF 2 or a salt thereof, wherein n is 0, 1 or 2; and R is a group of formula (V) or (VII) ##STR1## wherein: at least one of R 2 , R 3 , R 4 ...
Matches 201 - 250 out of 622 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >