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6534531 |
Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy
The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount...
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6521653 |
Microbicidal benzotriazoles
Novel benzotriazoles of the formula in which R, X 1 , X 2 , X 3 , X 4 and Y have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for the...
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6521633 |
Treating NIDDM with RXR agonists
This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPARγ agonist such as a...
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6518268 |
Telomerase inhibitors and methods of their use
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The...
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6515003 |
Heterocyclic derivatives for the treatment of diabetes and other diseases
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes,...
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6515004 |
N-&lsqb 5-&lsqb &lsqb &lsqb 5-alkyl-2-oxazolyl&rsqb methyl&rsqb thio&rsqb -2-thiazolyl&rsqb -carboxamide inhibitors of cyclin dependent kinases
The present invention describes compounds of formula I: and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and...
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6514955 |
Multi-faceted method to repress reproduction of latent viruses in humans and animals
Disclosed are methods for repressing reproduction of latent viruses, such as HIV, in animals by the generally concurrent administration of (1) antioxidants including a glutathione agent; and (2) an...
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6515006 |
Ophthalmic formulation which modulates dilation
An ophthalmic formulation is disclosed which reduces dilation in dim light and reduces redness.
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6506751 |
Thiazolidinone compounds useful as chemokine inhibitors
Disclosed are compounds of the Formula I wherein: Z is C or nothing, provided that when Z is nothing, R 3 and R 4 are nothing; A is S, S═O or O═S═O; R 1 and R 2 are independently...
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6506755 |
Thiazolidinecarboxyl acids
5-Arylidene-4-oxo-2-thioxo-3-thiazolidinecarboxylic acids of formula I in which the symbols R 1 , R 2 , A, A 1 and A 2 have the significance given in the description as medicaments for the...
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6500817 |
Thiazolyl urea derivatives and their utilization as antiviral agents
The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.
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6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6498174 |
Substituted oxazoles and thiazoles derivatives as hPPAR&ggr and hPPARα activators
The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual...
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6472406 |
Sulfonamidomethyl phosphonate inhibitors of beta-lactamase
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
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6468963 |
Methods and formulations for reducing toxicity associated with diabetes treatments
Formulations and methods for reducing the unwanted toxicity and complications associated with treatments for diabetes mellitus. The formulations include co-formulations of an anti-diabetic agent...
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6465497 |
Arylthiazolidinedione derivatives
Substituted 5-aryl-2,4-thiazolidinediones and oxazolidinediones are potent agonists of PPAR, and are therefore useful in the treatment, control or prevention of diabetes, hyperglycemia,...
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6458782 |
Remedies for diabetes
Medicaments comprising a compound represented by the following formulas: wherein, R 1 represents hydrogen atom or a C 1-6 alkyl group; R 2 and R 3 represent hydrogen atom or a C 1-6 alkyl...
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6448286 |
Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors
The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
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6441011 |
Combined preparation consisting of 2-methylthiazolidine-2,4-dicarboxylic acid and paracetamol
This invention relates to a pharmaceutical containing a combination of 2-methyl-thiazolidine-2,4-dicarboxylic acid and paracetamol, and to the use of a combination of...
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6441005 |
Oxazolidinone compounds and compositions, and methods of using the same
Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising...
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6432993 |
Substituted fused heterocyclic compound
Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: wherein R 1 is a group of the formula (II) or (III): R 4 is a substituted phenyl or...
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6432996 |
Pharmaceutical composition
To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of...
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6429219 |
Treatment of chronic hypertension and related conditions with thiol complexes
This invention relates to the synthesis of certain complexes of cysteine, N-acetylcysteine, N-(2-mercaptopropionyl)glycine, and L-2-oxothiazolidine-4-carboxylate and to the nutritional use of these...
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6426357 |
Antagonists of follicle stimulating hormone activity
The present invention provides a compound of the formula: and methods for using the same, wherein R 1 , R 2 , R 3 , R 4 and X are those defined herein.
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6413999 |
Treatment for acute physical insult to the central nervous system
A method of promoting functional recovery and reducing oxidative stress and inflammation following an acute physical insult to the central nervous system, comprising administering to a mammalian...
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6413997 |
3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds
3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds,...
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6403656 |
Use of ppar-&ggr activators in dermatology
The invention concerns the use of at least one activator of receptors of the PPAR-γ type for preparing a pharmaceutical composition for treating skin disorders related to an anomaly of the...
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6403625 |
Fluorescent labeling reagents
Compounds represented by the following formula (I),: wherein R represents a lower alkyl group which may be substituted; n represents an integer of from 1 to 10; and X represents an anion...
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6403612 |
Thrombin receptor antagonists
A thrombin receptor antagonist having the formula or a pharmaceutically acceptable salt thereof, useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method...
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6399639 |
Apoptosis inhibitor
An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a...
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6399640 |
Arylthiazolidinedione and aryloxazolidinedione derivatives
Substituted 5-aryl-2,4-thiazolidinediones or 5-aryl-2,4-oxazolidinediones that also carry a second substituent in the 5-position of the heterocyclic ring are potent agonists of PPAR, and are...
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6391901 |
Thrombin inhibitors
This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical...
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6384078 |
Method of treating elevated cholesterol levels by enhancing the effectiveness of the human immune system
There is disclosed a method of treating elevated blood levels of cholesterol in a person in need of such treatment, which comprises enhancing the effectiveness of the person's immune system by the...
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6380255 |
Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
The present invention is directed to a method for treating dermal atrophy of the skin. The method of the invention includes applying a composition to the skin of a mammal suffering from dermal...
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6380229 |
2-(N-cyanoimino)thiazolidin-4-one derivatives
This invention provides novel 2-(N-cyanoimino)thiazolidin-4-one derivatives represented by formula I or a pharmaceutically acceptable salt or solvate thereof: wherein ring A represents a benzene...
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6376502 |
Osteoporosis compounds
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6372742 |
Substituted indole compounds and methods of their use
5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated...
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6365607 |
Anticachectic composition
A medicinal composition for the prophylaxis and treatment of cachexia which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a...
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6358983 |
Heterocyclically substituted α-hydroxycarboxylic acid derivatives, method for producing the same and their use as endothelin receptor antagonists
The present invention relates to carboxylic acid derivatives of the formula I the substituents having the meanings explained in the description, preparation and use as endothelin receptor...
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6358942 |
Phenyloxazolidinones having a c-c bond 4-8 membered heterocyclic rings
A compound of Formula (I): or pharmaceutical acceptable salts thereof wherein X is NR 1 ; R 1 is H, C 1-6 alkyl optionally substituted with one or more OH, CN, or halo, or R 1 is —(CH 2 ) h...
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6353006 |
Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones,...
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6353011 |
1,2-dithiolane derivatives
This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of cardiovascular diseases, certain endocrine diseases,...
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6353009 |
Method for the treatment and prevention of hyperuricemia
Insulin sensitivity enhancers, such as troglitazone, have the ability to treat and/or prevent hyperuricemia and may thus be used for the therapy or prophylaxis of such diseases as gout, urinary...
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6329403 |
Pharmaceutical composition for the treatment of diabetes
A pharmaceutical composition which comprises an insulin sensitizer in combination with an anorectic, which is useful as an agent for preventing or treating diabetes.
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6313164 |
Dithiolin derivatives, their preparation and their therapeutic effect
Compounds of the formula (I): ##STR1## wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R 1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an...
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6303661 |
Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals
Novel therapeutic regimens are provided which comprise the administration of therapeutically effective amounts of an inhibitor to dipeptidyl peptidase (DP-IV) or enzymes of similar activity whereby...
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6294559 |
Antiproliferative agents associated with peroxisome proliferator activated receptors gamma1 and gamma2
This invention is directed to compounds and ligands that bind to peroxisome proliferator activated receptors (PPAR) γ1 and γ2 and which function as antiproliferative, antiviral and antitumour...
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6291495 |
Method and composition for the treatment of diabetes
This invention is directed to a novel method and composition for the treatment of diabetes mellitus (Type I, Impaired Glucose Tolerance ["IGT"] and Type II). More specifically, this invention...
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6288071 |
1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
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6288096 |
Thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives
Novel thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives, process for their manufacture, pharmaceutical preparations containing them and the use of the compounds in conditions...
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