Matches 501 - 550 out of 621 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >
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4740517 Antidiabetic spiro-3-heteroazolidines  
A spiro-3-heteroazolidine compound and agents comprising that compound which have special utility as an antidiabetic composition and as a substance to inhibit aldose reductase enzyme activity.
4738963 Method for the treatment of incontinence in mammals  
A method for the treatment and/or prophylaxis of incontinence in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula...
4738972 Hypoglycemic thiazolidinediones  
Hypoglycemic 5-[1-(5,6,7,8-tetrahydro-2-napthyl-; 1,2,3,4-tetrahydro-6-quinolyl-; 2-indanyl-; and 2-indolyl)alkyl]thiazolidine-2,4-dione derivatives, pharmaceutically acceptable salts thereof, and...
4735957 Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same  
New thiazole derivatives of the formula: ##STR1## wherein R 1 is lower alkyl, carboxy, a drivative of carboxy, hydroxymethyl, halomethyl, lower alkylthiomethyl, hydroxyiminomethyl or alkenyl which...
4734422 Cardiotonic aroylthiazolones and the use thereof  
Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
4725610 Thiazolidinedione derivatives, their production and use  
Thiazolidinedione derivatives of the general formula: ##STR1## [wherein R 1 is hydrogen or a hydrocarbon residue or heterocyclic residue which may each be substituted; R 2 is hydrogen or lower...
4722932 2-substituted-4-thiazolidones  
Disclosed herein novel compounds, 2-substituted-4-thiazolidones having anti-peptic ulcer activity, and methods for producing the same.
4703044 Imidazoquinolines containing other heterocyclic groups, useful as anti-ulcer or anti-secretory agents  
The invention provides novel imidazoquinolines, processes for their preparation and pharmaceutical compositions containing them. The compounds have Formula I ##STR1## wherein A is a C 1 -C 4 ...
4696937 Thiosulfonate derivatives for inhibiting malformation or destruction of red blood corpuscules  
The invention relates to novel thiosulfonate derivatives of general formu a: R--S--SO 2 --R 1 in which R represents a 1H-imidazol-2-yl, quinolin-2-yl, 5-amino-1,3,4-thiadizol-2-yl or...
4695567 Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases  
The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 3 -C 7 cycloalkyl; ...
4683228 Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion  
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
4678789 Triazole antifungal agents  
Compounds of the general formula: ##STR1## wherein Ar is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and Het is a heterocyclic group which may optionally be substituted or...
4670450 Cardiotonic thiazolones  
Thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
4665082 Cysteine delivery system  
L-2-oxothiazolidine-4-carboxylate, a sulfur analog of 5-oxoproline, is cleaved by the enzyme 5-oxo-L-prolinase to form cysteine, thus providing the basis for a cysteine delivery system by the...
4663341 Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides  
This invention relates to N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and...
4649138 Pharmaceutical compositions  
S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
4647571 Cysteine delivery composition  
L-2-oxothiazolidine-4-carboxylate, a sulfur analog of 5-oxoproline, is cleaved by the enzyme 5-oxo-L-prolinase to form cysteine, thus providing the basis for a cysteine delivery system by the...
4639460 Fungicidal substituted N-(1-iodopropargyl)thiazolidinones  
Compounds of the formula: ##STR1## wherein R is hydrogen, lower alkyl; or aryl or aralkyl having from 6 to 12 carbon atoms, optionally substituted with one to three substituents, each independently...
4636516 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds  
Novel 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds shown by the formula ##STR1## wherein .circle.Het -- represents a specific heterocyclic group and the salts thereof. The...
4636505 Amide derivatives  
Acylanilides of the formula ##STR1## wherein R 1 and R 2 , the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R 3 is hydrogen or...
4623651 Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones  
Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
4617312 Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones  
A series of 5-(2-alkoxyphenyl)thiazolidinediones and pharmaceutically acceptable salts thereof useful as hypoglycemic agents, aldose reductase inhibitors and as therapeutic agents for the treatment...
4602026 Ophthalmic topical agent for remedy of diseases of iris and ciliary body  
An ophthalmic topical agent for remedy of diseases of iris and ciliary body containing 5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione or its physiologically acceptable salt as an active...
4587256 Novel thiazolidine derivatives  
The invention relates to with novel thiazolidine derivatives of the formula ##STR1## wherein X is methylene, oxygen or sulfur; R 1 is halogen; R 2 is hydrogen, nitro, cyano, OR 3 or NHR 3 ; or...
4584306 Nematicidal 2-(substituted thio)-4,5-dihydrothiazoles  
Compounds of the formula ##STR1## their preparation, and use for the control of nematodes are disclosed and exemplified.
4582841 Substituted thiazolidinyl esters of mineral acids  
Compounds of the formula ##STR1## in which one of the symbols R 1 and R 2 represents an alkyl radical that has 3 or 4 carbon atoms and is unsaturated in the 2,3-position, and the other represents...
4581453 Guanidinothiazole derivatives containing alkylene bridges, and their use for influencing lipid metabolism  
The invention relates to guanidinothiazol derivatives of Formula (I) as defined herein, said compounds being useful for influencing lipid metabolism, as antithombotic agents and as antimycotic...
4578388 Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted...
4572912 Thiazolidine derivatives, their preparation and compositions containing them  
The compounds of formula (I): ##STR1## [in which: R 1 and R 2 are the same or different and each represents hydrogen or C 1 -C 5 alkyl; R 3 represents hydrogen, an acyl group, a (C 1 -C 6 ...
4571406 Anti-hypertensive chromans and chromenes  
Compounds of formula (I): ##STR1## wherein: either one of R 1 and R 2 is hydrogen and the other is selected from the class of C 1 -6 alkylcarbonyl, C 1 -6 alkoxycarbonyl, C 1 -6 alkylcarbonyloxy,...
4567192 Acylaminophenol derivatives  
Compounds of formula I ##STR1## wherein n=1 to 5 possessing analgesic activity with reduced hepatoxicity as compared with paracetamol.
4563471 4-Oxothiazolidin-2-ylidene-acetamide derivatives as CNS agents  
4-Oxothiazolidin-2-ylidene-acetamide derivatives, processes for their preparation, pharmaceutical compositions and a method for treating diseases of the central nervous system such as epilepsy are...
4563476 Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents  
Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted...
4556670 Spiro-3-hetero-azolones for treatment of diabetic complications  
Spiro-oxazolidones, -thiazolidones and -imidazolidones are disclosed which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from...
4551472 Unsymmetrical bis-carbamate compounds  
Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.
4532138 Thiazolidin-2-one analogs  
Compounds of the formula: ##STR1## and the pharmaceutically acceptable, non-toxic salts and esters (alkyl, 1-6C) thereof, wherein: X is O or S; R 1 is selected from the group consisting of: ...
4525477 2-Thiazolyl, isothiazolyl, oxazolyl and isoxazolyl alkylamino-3-nitro-heterocyclic compounds  
2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur...
4501750 Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds  
The present invention provides new thiazole compounds possessing immuno-modulating activity, i.e. thiazole compounds of the general formula (1): ##STR1## wherein R 1 stands for a hydrogen or...
4496565 Chromans and chromenes, compositions and hypertensive method  
Compounds of formula (I): ##STR1## a pharmaceutically acceptable salt or solvate thereof having anti-hypertensive activity, a process for their preparation and their use as pharmaceuticals.
4490393 Thiazolylurea derivatives, a process for preparing same and a pharmaceutical composition containing same  
The present invention provides thiazolyl derivatives as new chemical substance represented by the general formula: ##STR1## wherein R 1 stands for a lower alkyl group or a substituted or...
4477460 Topical treatment of ocular hypertension  
This invention concerns the novel use of certain known thiazoles, particularly acylaminothiazoles and thiazolecarboxamides, as intraocular pressure lowering agents. When administered topically to...
4457930 Todopropargylsulphamides, microbicidal compositions and use  
3-Iodopropargyl-sulphamides of the formula ##STR1## in which R represents hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted phenylalkyl, optionally substituted...
4454339 9-Fluoroprostaglandin derivatives, and use as medicinal agents  
9-Fluoroprostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is the residue ##STR3##...
4451475 Cyclic sulphenamide compounds, their production and their medicinal use  
The invention relates to cyclic sulphenamides of Formula I and methods for their manufacture. Also included in the invention are compositions containing said cyclic sulphenamides and methods for...
4450169 Insecticidal esters  
Novel esters of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## W is selected from the group consisting of hydrogen and --CN, Z is selected from the group...
4450159 Carbamic acid derivatives as selective immunosuppresive agents  
Novel cyclized ω-carboxyethyl mono or dithiocarbanilic acids are disclosed as immunoregulatory agents, useful in the treatment of organ transplant reject phenomenon and autoimmune diseases...
4446150 Naphthalenylthiazole derivatives  
Disclosed herein are new aldose reductase inhibitors of the formula ##STR1## wherein R is ##STR2## wherein R 1 is lower alkyl; R 2 is halo and R 3 is hydrogen, or R 2 and R 3 each is a...
4446143 Rhodanine derivatives  
The rhodanine derivatives of the general formula: ##STR1## possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as...
4434174 Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines  
3-Phenoxy-2-hydroxypropylamines having an N-benzimidazolyalkyl substituent and similar compounds are described herein. They are obtained by the reaction of the appropriate imidazole-1-alkanamine...
4434172 2-Substituted-phenyl-5-alkylthiazolidine-4-one  
Compounds of 2-substituted-phenyl-5-alkylthiazolidine-4-one having the formula (I) ##STR1## wherein R 1 and R 2 represent respectively a lower alkyl group of 1 to 3 carbon atoms and n denotes an...
Matches 501 - 550 out of 621 < 1 2 3 4 5 6 7 8 9 10 11 12 13 >