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4987146 |
N-hetaryl imidazole derivatives
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
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4973599 |
Phenylthioheterocyclic derivatives
Compounds of the formula ##STR1## wherein n is a integer of 0 to 2; R 1 ' and R 2 ' are, independently, hydrogen, halogen, trifluoromethyl, lower alkoxy or lower alkyl; and X is pyrimidinyl,...
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4970222 |
Nitrogen-containing heterocyclic compounds, and their production and use
A nitrogen-containing heterocyclic compound of the formula: ##STR1## wherein R 1 is either one of the following groups: ##STR2## (in which R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15...
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4968707 |
Oxazolidin-2-one derivatives as hypoglycemic agents
Certain 4-[2-(5-(optionally-substituted-aryl- and heteroaryl)oxazolidin-2-on-3-yl)alkyl]benzoic acids and ester, glycinamide, oxazole and thiazolidinedione derivatives thereof are useful as...
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4968709 |
Fungicidal 2-thiazolyloxy-thio- or amino-3-substituted acrylic acid esters
Fungicidal substituted acrylic acid esters of the formula ##STR1## in which R 1 and R 2 independently of one another each stand for hydrogen, alkyl, alkenyl or for in each case optionally...
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4963577 |
Use of the thiazole derivative tiprotimod for the preparation of an agent for the therapy of virus infections
The use of the thiazole derivative tiprotimod for the preparation of a pharmaceutical for the therapy of virus infections is described.
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4962117 |
Heterazole dialkanoic acids
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and...
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4956375 |
N-indanyl carboxamide derivative and agricultural/horticultural fungicide containing the derivative as active ingredient
Disclosed herein is an N-indanyl carboxamide derivative as a novel compound, represented by the following general formula (I): ##STR1## wherein A represents a group of the formula, ##STR2##...
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4952580 |
Pesticidal polyhaloalkene derivatives
Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y 1 and Y 2 are fluorine, Z is hydrogen or the same as Y 1 and Y 2 , and n is 1-4; provided that: ...
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4952599 |
Phenylthioureas, phenylisothioureas, phenylcarbodiimides, pesticidal compositions containing them and their use in pest control
Novel substituted phenylthioureas, phenylisothioureas and phenylcarbodiimides of formula I ##STR1## wherein R 1 is C 1 -C 10 alkyl, unsubstituted or substituted by one or more halogen atoms...
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4943584 |
(p-Phenoxyphenoxy)-methyl-five-membered hetaryls
Novel (p-phenoxyphenoxy)-methyl-five-membered heeroaromatic radicals of the formula ##STR1## where the substituents have the following meanings: R 1 , R 2 , R 3 hydrogen, halogen, C 1 -C 8 ...
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4937255 |
Disubstituted pyrroles
For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R 1 is aryl or heteroaryl, R 2 is...
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4937252 |
2-thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same
The present invention relates to novel 2-thiazolidinone derivatives of the general formula (I), ##STR1## wherein A stands for hydrogen, halogen or a C 1 -4 alkyl, C 1 -4 alkoxy or nitro group; and ...
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4933355 |
Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
Compounds of formula (I): ##STR1## in which: R 1 and R 2 are independently hydrogen, alkyl, aliphatic hydrocarbon groups having one or two carbon-carbon double or treble bonds, cycloalkyl, aryl,...
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4929618 |
Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar 1 , Ar 2 , n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical...
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4918091 |
Novel thiazolidinediones
A compound of formula (I): ##STR1## or a tautomeric form thereof, or a pharmaceutically acceptable salt thereof, wherein: R represents hydrogen or alkyl; R 1 represents an alkyl group or a...
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4914113 |
Insecticidal imidazolines
The present invention relates to novel imidazolines of the formula (I) ##STR1## to processes for their production and to their use as very potent insecticides. In formula (I) above R represents...
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4914116 |
Nitrogen-containing heterocyclic compounds, and their use as insecticides
A nitrogen-containing heterocyclic compounds are representable by the formula: ##STR1## wherein R 1 is either one of the following groups: ##STR2## (in which R 4 is a hydrogen atom, a halogen...
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4902710 |
Serotonin and norepinephrine uptake inhibitors
The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake...
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4900736 |
Salts of alkyl-2-benzimidazole-carbamate and fungicidal compositions thereof suitable for paints and plaster
A water insoluble compound of formula I ##STR1## wherein R 1 is an alkyl group having 1 to 4 carbon atoms and R 2 is a straight-chain or branched-chain alkyl group having from 10 to 16 carbon...
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4900741 |
Combined cimetidine-pirensepine formulation for treating peptic ulcers and erosions
An orally administered pharmaceutical composition for treating peptic ulcers and other gastrointestinal conditions associated with hyperacidity, which includes both the H 2 -receptor antagonist...
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4897397 |
Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents
Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
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4889863 |
New thiazole compounds having fungicidal activity
The invention relates to new thiazole compounds of the general formula ##STR1## wherein R is an C 1 -C 12 alkyl group or a phenyl group, which groups are unsubstituted or substituted with...
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4886817 |
Imidazolidinones as brain activators
This invention relates to imidazolidinone compounds of the formula ##STR1## wherein Q is methylene group or a single bond: R is a heterocyclic group selected from the group consisting of...
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RE33125 |
3- and 5-[3-(1-arylureido)]-1,2,4-triazoles
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4877785 |
Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
Non-peptidyl compounds characterized generally as β-succinamidoacyl aminodios are useful as renin inhibitors for the treatment of hypertension.
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4873255 |
Thiazolidinone derivatives, their preparation and their use
Thiazolidinone derivatives of formula (I): ##STR1## in which R 1 , R 2 , R 3 , R 4 and R 5 are various atoms or organic groups, Ar is an aromatic group and n is an integer have valuable...
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4863947 |
N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production
This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests...
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4857538 |
New compounds for the study and treatment of microfilament organization in cells
A compound, and composition including same, for effecting irreversible change in cell morphology having the following structures: ##STR1## wherein R is --(CH 2 ) n ZH in which n=1, 2, 3 and 4 and...
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4851406 |
Heterocyclic-substituted indoles and pharmaceutical compositions containing them
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
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4847259 |
Nitrogen-containing heterocyclic compounds, and use as insecticide
Nitrogen-containing heterocyclic compounds are represented by the formula: ##STR1## wherein R 1 is either one of the following groups: ##STR2## in which R 4 is a hydrogen atom, a halogen atom or...
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4831032 |
Cardiotonic benzimidazoles
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
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4831045 |
Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient
The rhodanine derivatives of the general formula: ##STR1## [wherein (I) R 1 and R 2 are taken together to represent a tetramethylene or pentamethylene group; (II) R 1 represents a hydrogen atom,...
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4808588 |
Heterocyclic ureas and carbonates useful as pharmaceuticals
Compounds of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein: Het is monocyclic heteroaryl having two adjacent carbon atoms, a and b, depicted in formula (I); p1 R 1 ...
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4798835 |
dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)m ethyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent
This invention relates of the use of a certain thiazolidine-2,4-dione, namely, dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazo
lidine-2,4-dio ne, or a pharmaceutically acceptable...
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4795755 |
Heterocyclic derivatives
This invention relates to heterocyclic derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative...
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4791125 |
Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
The present invention relates to certain compounds of the formula ##STR1## wherein the broken line is a bond or no bond, and the pharmaceutically acceptable cationic salts thereof having utility as...
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4786639 |
Method for the treatment of reversible airways obstruction and asthma
A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective...
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4782083 |
3,4-dihydro-2H-1-benzopyrans useful as anti-hypertensive agents
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: one of R 1 and R 2 is hydrogen or C 1 -4 alkyl and the other is C 1 -4 alkyl or R 1 and R 2 together...
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4775677 |
[3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene]acetic acids having activity as leukotriene antagonists
The present invention provides novel [3-substituted-2-(substituted imino)-4-oxo-5-thiazolidinylidene]acetic acids, and novel pharmaceutical compositions and methods of use thereof. The novel acids...
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4775675 |
Thiazolidinecarboxylic acid derivatives and treatment of liver diseases therewith
The invention relates to novel thiazolidine-4(S)-carboxylic acid derivatives of the general formula (I) ##STR1## wherein R 1 stands for an optionally substituted furyl, pyrrolyl, thienyl,...
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4775687 |
Thiazolidine derivatives, their production and use
A thiazolidinedione derivative of the general formula: ##STR1## wherein X is an oxygen or sulfur atom, R 1 and R 2 each independently is hydrogen or a hydrocarbon residue which may optionally be...
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4774240 |
N-indolylethyl-sulphonic acid amides and their use
The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined in the specification and X is carboxyl, alkoxycarbonyl,...
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4772603 |
Method for treating congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals
A method for the treatment and/or prophylaxis of congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals, such as humans, which method...
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4767775 |
Substituted pyrazolin-5-ones, composition containing them, and method of combating fungi or bacteria
Microbicidal substituted pyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another each represent hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl,...
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4764514 |
Oxothiazolidine compound and composition containing same
This invention provides a oxothiazolidine compound of the formula: ##STR1## wherein R 1 is acyl; di(lower)alkylamino(lower)alkylcarbamoyl(lower)alkyl; arylcarbamoyl(lower)alkyl; ...
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4764527 |
Hydroxypyrazole derivatives, composition containing them and their use against microorganisms
1-Hydroxypyrazoles of the formula ##STR1## where R 1 , R 2 and R 3 independently of one another are each hydrogen or halogen, and microbicides containing these compounds.
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4762849 |
Cardiotonic alkanoylthiazolones
Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
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4762848 |
1,3-thiazoles and their use as immunomodulators
Heterocyclic sulfides of the general formula heterocycle-S-R, a process for their preparation and, in particular, their use for immunostimulation, immunorestoration and cytostatic treatment, and...
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4760067 |
Allylsulfoxide enzyme inhibitors
Organic sulfoxides having a latent allyl group bound to the sulfur are enzyme inhibitors of the suicide or K cat type.
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