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9034319 Methods of treating cancer of the central nervous system  
A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an...
9029357 Benzazole derivatives as histamine H4 receptor ligands  
The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
9018206 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
9012481 Benzoarylureido compounds, and composition for prevention or treatment of neurodegenerative brain disease containing the same  
Novel benzoarylureido compounds and a use thereof for prevention and/or treatment of the neurodegenerative brain disease are provided. The neurodegenerative brain diseases may include Alzheimer's...
9012445 Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors  
In one aspect, the invention relates to substituted 4-(1H-pyrazol-4-yl)benzyl analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of...
9006275 Compounds as cannabinoid receptor ligands and uses thereof  
The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined...
9006139 Active compound combinations  
The present invention relates to compositions, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a further fungicidally active...
9006229 Benzothiazole compounds and their pharmaceutical use  
The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for...
8993604 Treatment and prevention of dengue virus infections  
Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective...
8993561 Nitrobenzothiazole derivatives, preparation thereof and therapeutic applications thereof  
The invention relates to the nitrobenzothiazole derivatives of general formula (I): and to the use thereof for treating tuberculosis.
8987314 Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase  
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors...
8987250 Therapeutic compounds  
Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds...
8980929 Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes  
The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which...
8980892 Insecticidal compounds  
A compound of formula (I): wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5a, R5b and R6 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to...
8962664 Selective glycosidase inhibitors and uses thereof  
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the...
8951999 Compounds  
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as...
8952058 Heterocyclic compounds and methods of use thereof  
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and...
8946232 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8940764 Compositions and methods of treating retinal disease  
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for...
8940776 2-acylaminopropoanol-type glucosylceramide synthase inhibitors  
A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a...
8933107 Pesticide thiazolyloxy substituted phenylamidine derivatives  
The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as...
8933108 Benzothiazolone compound  
The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic...
8933109 Furo[3, 2-B] pyrrol-3-ones as cathespin S inhibitors  
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein: one of R3 and R4 is H, and the other is...
8933040 Selective glycosidase inhibitors and uses thereof  
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The...
8927507 Selective glycosidase inhibitors and uses thereof  
The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The...
8927584 Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof  
The present invention provides a photodynamic therapy to a patient having at least one tumor comprising the steps of: administering a compound of formula 6 (wherein R1 and R2 are defined as the...
8927551 Isoxazolines as inhibitors of fatty acid amide hydrolase  
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The...
8916595 Plant disease controlling composition and method for controlling plant disease  
The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more...
8912186 Allosteric protein kinase modulators  
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein...
8906962 Compositions and methods for treating hair loss using non-naturally occurring prostaglandins  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
8906919 Treatment of non-neuronal and non-myocardial cell, tissue and organ damage and associated pain with persistent sodium current blockers  
The present invention relates to a method for slowing the development of mammalian organ, tissue and cellular damage and death by using a persistent sodium current blocker (or a pharmaceutically...
8901087 Selective glycosidase inhibitors and uses thereof  
The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and...
8895563 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8889703 Inhibitors of beta-secretase  
The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
8889710 Parasiticidal dihydroisoxazole compounds  
Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by...
8883834 Methods and compositions for locally increasing body fat  
Provided are methods for increasing fat locally in a body of a subject in need thereof comprising percutaneously administering to the subcutaneous fat of the subject a thiazolidinedione or an...
8883833 Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders  
The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for...
8883831 Compositions and methods for minimizing or reversing agonist-induced desensitization  
Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated administration of the drug to a patient....
8877751 Benzothiazolone derivatives  
Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be...
8865752 Cytochrome P450 inhibitors and uses thereof  
The present invention provides compounds having the general structural formula (I) and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein,...
8865736 Antibacterial agents  
Compounds of formula (I) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is ═C(R1)—; R1 is hydrogen and R2 is hydrogen, methyl, or fluorine; or R1...
8859599 Androgen receptor modulating compounds, preparation and uses thereof  
The present invention concerns compounds of general formula (I): Method of preparation and uses thereof.
8846685 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8835428 Diacylglycerol acyltransferase inhibitors  
The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in...
8835473 Methods and compositions for treating cancer  
The present invention provides methods of treating cancer using 2-amino-6-trifluoromethoxybenzothiazole (riluzole). In one aspect, the present invention provides methods of reducing cancer cell...
8829034 Compounds which modulate the CB2 receptor  
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
8829035 Agent for treatment or prevention of diseases associated with activity of neurotrophic factors  
A compound depicted by the formula below, or a pharmaceutically acceptable salt or solvate thereof. wherein, R1 represents (1) a C3-6 alkyl group, (2) a C1-6 alkyl group substituted with one or...
8815864 Indanyloxydihydrobenzofuranylacetic acids  
The present invention relates to compounds of general formula I, wherein the group (Het)Ar is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40...
8809381 Highly selective sigma receptor ligands  
A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which R1 can be a...
8802664 Benzazole derivatives as histamine H4 receptor ligands  
The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.