Patents in Class 514/367

Matches 1 - 50 out of 614

Match	Document	Document Title
1	7625923	Bicyclic modulators of androgen receptor function The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen...
2	7622467	Aryl aniline derivatives as β₂adrenergic receptor agonists The invention provides novel β 2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat...
3	7601745	Heterocyclic NF-kB inhibitors The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a...
4	7601360	Excitatory amino acid inhibitors for treating sensitive skins Sensitive human skin/scalp/mucous membrane conditions, for example skin irritation and/or dry patches and/or erythemas and/or dysaesthesic sensations and/or sensations of heating and/or pruritus,...
5	7595343	Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
6	7592361	Indole acetic acid derivatives and their use as pharmaceutical agents This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and...
7	7576110	Benzothiazole cyclobutyl amine derivatives Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
8	7569688	Propane-1, 3-dione derivative Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
9	7563901	Intermediates of 2-substituted carbapenem derivatives and process for production thereof The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having...
10	7560483	Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
11	7557138	5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects,...
12	7553859	Macrocycles for the treatment of cancer The present invention relates to new Macro-cycles of Formula (I), and their use for the treatment of cancer.
13	7553848	Vanilloid receptor ligands and their use in treatments bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
14	7531564	Substituted benzoxazoles as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R 1 , R 2 , R 2a , R 3 , R 3a , and R 4 , and X as defined in the specification, or a...
15	7524876	Luciferin derivatives A compound represented by the following general formula (I) or a salt thereof: [wherein R 1 and R 2 represent hydrogen atom, a C 1-6 alkyl group, or a group represented by the following...
16	7514460	Benzazole analogues and uses thereof The present invention relates to N 2 -heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer.
17	7514457	Substituted aryloxymethyl bicyclicmethyl acetamide compounds Compounds of the general formula (I): pharmaceutical compositions comprising a compound of general formula (I); and methods of treating disease conditions caused by overactivation of the VR1...
18	7495021	Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In...
19	7495020	2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin...
20	7491733	Bicyclic guanidine derivatives and therapeutic uses thereof The invention relates to compounds of general formula (I), in which A, X, Y and R1 are defined in Claim 1 . These compounds may be used in the treatment of pathologies associated with insulin...
21	7482344	Tricyclic steroid hormone nuclear receptor modulators The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in...
22	7476763	Oxo-substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
23	7473784	Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors A compound of Formula (I) an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is as described herein. Also disclosed is a compound of Formula (II) an...
24	7473783	Bicyclic pyrazolo protein kinase modulators The present invention provides novel bicyclic pyrazolo kinase modulators and methods of using the novel bicyclic pyrazolo kinase modulators to treat diseases mediated by kinase activity.
25	7456204	Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or...
26	7456183	Guanidino compounds Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH 2 , N, NR 9 , C═O, C═S, S═O, SO 2 , S, O, (CR 6 R 7 ) n ,...
27	7452912	Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
28	7446118	3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R 1 , R 2 , R 3 , R a , R b , R c , R d and R e ...
29	RE40558	Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
30	7419993	Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
31	7419967	Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
32	7410987	Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative A method of treating pain or pruritis comprising administering to a patient in need thereof a pharmaceutically effective amount of a κ opioid receptor agonist of the formula wherein R is an...
33	7407950	N-(heteroaryl)-1H-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Z 1 , Z 2 , Z 3 , Z 4 , Z 5 and W are as defined herein. Said compounds are ligands of the TRPV 1 ...
34	7402606	Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
35	7402598	Arylethanolamine β₂-adrenoreceptor agonist compounds The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them...
36	7393867	Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous...
37	7388029	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
38	7384966	2-arylbenzothiazole derivatives A compound of general structure I, wherein the compound is optionally in the form of an N-oxide or S-oxide or prodrug form and/or pharmaceutically acceptable salt thereof wherein: each of R 1 ...
39	7384964	Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions...
40	7384625	Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount...
41	7365086	Pramipexole acid addition salts The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.
42	7361681	Method of treating amytrophic lateral sclerosis using melatonin The present invention relates to the treatment of amyotrophic lateral sclerosis (ALS) and/or the improvement of motor function in individuals in need of such improvement using a melatonin compound...
43	7358263	Fused bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
44	7351733	Tetrahydrocarbazole derivatives and their pharmaceutical use The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
45	7348347	Substituted 4,5,6,7-tetrahydrobenzthiazol-2-ylamine compounds Substituted 4,5,6,7-tetrahydrobenzothiazol-2-ylamine compounds, a method for their production; pharmaceutical compositions comprising them, and methods of use for modulating biological functions...
46	7345068	Aromatic amino acid derivatives and medicinal compositions 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R 1 is a hydrogen atom or an amino-protecting group, R 2 is a...
47	7342033	Use of riluzole for the treatment of multiple sclerosis Methods and compositions for the treatment of multiple sclerosis comprising riluzole (6-(trifluoromethoxy)-benzothiazolamine) are disclosed herein.
48	7338956	Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals The present invention relates to acylamino-substituted heteroaromatic compounds of formula I, wherein R 1 , R 2 , R 3 , R 4 and R 5 and X are as defined herein, to pharmaceutical compositions...
49	7335674	Benzothiazole-4,7-diones and benzoxazole-4,7-diones with substituents in position 5 or 6 and method for production thereof A targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted.
50	7323494	Compounds and methods Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables...

Matches 1 - 50 out of 614

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