|
Match
|
Document |
Document Title |
|
|
7618961 |
Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the...
|
|
|
7615569 |
Inhibitors of ion channels
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly,...
|
|
|
7612052 |
Combinations comprising epothilones and pharmaceutical uses thereof
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I
wherein A represents O...
|
|
|
7605269 |
Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
|
|
|
7605172 |
Thiazolo-naphthyl acids
The present invention relates to thiazolo-naphthyl acids of the formula
and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
|
|
|
7605156 |
Methods for the use of inhibitors of cytosolic phospholipase A2
This invention provides methods for the use of substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms thereof. The invention provides methods for the...
|
|
|
7598280 |
Heterocyclic compounds, compositions comprising them and methods of their use
Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed....
|
|
|
7598245 |
Aminotriazole compounds useful as inhibitors of protein kinases
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the...
|
|
|
7595334 |
Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors
The present invention concerns the compounds having the formula
N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
|
|
|
7595318 |
Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the...
|
|
|
7592361 |
Indole acetic acid derivatives and their use as pharmaceutical agents
This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and...
|
|
|
7592337 |
Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
|
|
|
7585880 |
Phenylpropanoic acid derivatives
The present invention provides a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, a drug for the prophylaxis or treatment of diabetes...
|
|
|
7582664 |
Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein R 1 , R 2 , R 2′ , R 3 , R 4 and R 5 are as defined herein. The invention also relates to the use of said compound in therapeutics.
|
|
|
7579477 |
Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof
Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of...
|
|
|
7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
|
|
|
7572790 |
Biphenyl carboxylic amide p38 kinase inhibitors
Compound of formula (I):
or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
|
|
|
7569688 |
Propane-1, 3-dione derivative
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
|
|
|
7563901 |
Intermediates of 2-substituted carbapenem derivatives and process for production thereof
The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having...
|
|
|
7563813 |
Iminothiazolidinone derivatives as SFRP-1 antagonists
Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided:
which are inhibitors of secreted frizzled related protein-1. The compounds, and compositions containing the...
|
|
|
7560568 |
Thiazole compounds
The present invention provides compounds of formula (I):
wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their...
|
|
|
7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
|
|
|
7560475 |
Phenylacetic acid derivative, process for producing the same, and use
The present invention relates to the compound represented by formula (I)
(wherein R 1 and R 2 is hydrogen atom, C1-8 alkyl etc.; R 3 is C1-8 alkyl which may be substituted with 1 to 3...
|
|
|
7557095 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are...
|
|
|
7553859 |
Macrocycles for the treatment of cancer
The present invention relates to new Macro-cycles of Formula (I), and their use for the treatment of cancer.
|
|
|
7550491 |
Ionic liquids having [N(CF3)2]− anions
The present invention relates to salts comprising bis(trifluoromethyl)imide anions and saturated, partially or fully unsaturated, heterocyclic cations, to a process for the preparation thereof, and...
|
|
|
7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
|
|
|
7547701 |
Haloalkyl containing compounds as cysteine protease inhibitors
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these...
|
|
|
7541354 |
Bicyclo-pyrazoles
Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
|
|
|
7538128 |
Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula:
wherein X, Y, a, R 1 , and R 2 are as defined herein.
|
|
|
7531563 |
Thiazoline acid derivatives
The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are...
|
|
|
7531562 |
Compositions and methods for protecting cells during cancer chemotherapy and radiotherapy
Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course...
|
|
|
7531531 |
Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles
Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
|
|
|
7528160 |
Fused heterocyclic derivatives as PPAR modulators
The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are...
|
|
|
7524957 |
Compounds effecting glucokinase
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
|
|
|
7524876 |
Luciferin derivatives
A compound represented by the following general formula (I) or a salt thereof:
[wherein R 1 and R 2 represent hydrogen atom, a C 1-6 alkyl group, or a group represented by the following...
|
|
|
7524870 |
Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
The present invention relates to compounds of formula (I)
wherein Ar, Ar 2 , R 2 , R 3 , R 4 , m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts...
|
|
|
7521563 |
Hydroxamic acid derivative and medicine containing the same as active ingredient
A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which...
|
|
|
7521461 |
Benzoic acid derivatives as modulators of PPAR alpha and gamma
A compound of formula (I) wherein R 1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group...
|
|
|
7517535 |
Non-systemic control of parasites
Use of agonists and antagonists of the nicotinergic acetylcholine receptors of insects for the non-systemic control of parasitic insects, such as fleas, lice and flies, on humans and on animals.
|
|
|
7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
|
|
|
7504513 |
Thiazolyl-benzimidazoles
The invention is directed to compounds of formula (1)
and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
|
|
|
7504431 |
Sulfonyl amide inhibitors of calcium channel function
Compounds of formula I
its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in...
|
|
|
7504423 |
α-amino acid derivatives and use thereof as medicines
Compounds represented by the α-amino acid derivative or a pharmaceutically acceptable salt thereof of the present invention have a therapeutic effect due to a DPP-IV inhibitory action and useful...
|
|
|
7504420 |
Compounds which inhibit beta-secretase activity and methods of use
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
|
|
|
7504402 |
Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
|
|
|
7476742 |
Indane acetic acid derivatives and their use as pharmaceutical agents
This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases and to...
|
|
|
7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
|
|
|
7462635 |
Thiazole and oxazole VDAC regulator
The present invention provides a VDAC regulator comprising a compound represented by the formula (I):
wherein R 1 is a halogen atom, an optionally substituted heterocyclic group, an optionally...
|
|
|
7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
|