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9034871 Compounds for Alzheimer's disease  
The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH,...
9023874 Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests  
The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or...
9018206 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
9012360 Synergistic combinations of active ingredients  
The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R1 and A have the meanings given in the description...
9012362 Active compound combinations  
The present invention relates to compositions, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I) and a further fungicidally active...
9006266 Heteroarylpiperidine and -piperazine derivatives as fungicides  
Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes...
9006276 Substituted oxindole derivatives, medicaments containing said derivatives and use thereof  
The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments...
9006274 Thiazole derivatives for treating dyskinesias caused by a chemical treatment  
The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical...
9000017 Combinations of imazalil and silver compounds  
The present invention relates to combinations of imazalil, or a salt thereof, and silver compounds which provide an improved biocidal effect. More particularly, the present invention relates to...
9000010 Alkyl-heterocycle carbamate derivatives, their preparation and their therapeutic application  
The invention relates to compounds corresponding to the general formula (I): in which R2 represents a hydrogen, fluorine, hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or —NR8R9; n and...
8993578 Methods for treating HCV  
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks....
8993606 Oral formulations for treating metal overload  
The present invention provides, among other things, effective oral formulations based on desazadesferrithiocin polyether (DADFT-PE) analogs, salts and polymorphs thereof, as well as their...
8993604 Treatment and prevention of dengue virus infections  
Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective...
8987258 Chromenone analogs as sirtuin modulators  
The present invention relates to novel chromenone analog sirtuin modulator compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and...
8987313 Inhibitors of cytochrome P450  
The present application provides for a compound of formula I, or a salt thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and...
8987308 Compounds for the treatment of Clostridium difficile-associated disease  
Disclosed are compounds of formula (I): or a pharmaceutically acceptable N-oxide, salt, hydrate, solvate, complex, bioisostere, metabolite or prodrug thereof, which are of use in the treatment of...
8987312 Alpha-keto heterocycles as FAAH inhibitors  
The invention provides a series of -αketoheterocyclic compounds, for example, compounds of formula (I). The compounds can inhibit fatty acid amide hydrolase and can be useful for treatment of...
8980920 Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C  
The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for...
8975254 Androgen receptor modulating compounds  
The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising...
8969392 Pesticide composition comprising propamocarb-fosetylate and an insecticidally active substance  
The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of...
8969357 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8962580 Chemical modifications of monomers and oligonucleotides with cycloaddition  
The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to...
8957094 Therapeutic agent or prophylactic agent for fibromyalgia  
A therapeutic agent or prophylactic agent has an analgesic effect on both nociceptive pain and neuropathic pain and is effective in treatment of fibromyalgia. The agent includes as an effective...
8957086 Compounds and methods of treating brain disorders  
Nitrated and non-nitrated compounds capable of protecting brain tissue from injury and useful as therapeutic agents to treat neurodegenerative diseases and conditions are disclosed. Methods of...
8957070 Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity  
The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug...
8951999 Compounds  
This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as...
8946232 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8946233 Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents  
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8946231 P2X3, receptor antagonists for treatment of pain  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
8946267 Therapeutic agent or prophylactic agent for neuropathic pain  
A therapeutic agent or a prophylactic agent for neuropathic pain provides a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side...
8940795 Plant disease controlling composition and method for controlling plant disease  
The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more...
8940735 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8940777 Pest controlling composition and method of controlling pest  
A pest controlling composition comprising tolclofos-methyl and a neonicotinoid compound represented by the formula (1) as active ingredients.
8940776 2-acylaminopropoanol-type glucosylceramide synthase inhibitors  
A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a...
8937065 Compositions and methods for modulating a kinase  
The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
8933107 Pesticide thiazolyloxy substituted phenylamidine derivatives  
The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as...
8927578 Compositions and methods for the treatment of metabolic disorders  
The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for...
8927551 Isoxazolines as inhibitors of fatty acid amide hydrolase  
The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The...
8921370 Bicyclo[3.2.1]octyl amide derivatives and uses of same  
The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical...
8920846 Microcapsule and production method thereof  
A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I), wherein R represents a...
8916592 Malononitrile compounds  
Compounds of formula I wherein X is O or S(═O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl,...
8906894 Methods for preventing and treating thrombotic disorders  
Compositions and methods for anti-thrombotic and antiplatelet therapy in a subject are provided. Administration of an MAO-B inhibitor results in reduced platelet aggregation or reversion of...
8906947 Method for the separation and purification of epothilones  
The invention discloses a method for the separation and purification of epothilones, especially discloses a method for the separation and purification of epothilones B and A using normal phase...
8901152 Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme  
The present invention relates to compounds of formula (I): wherein Q, G1, G2, and G3, are defined herein. Pharmaceutical compositions and methods for treating DGAT-1 related diseases or conditions...
8901119 Peptide deformylase inhibitors  
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods...
8901157 Compositions and methods of use of ritonavir for treating HCV  
The present invention discloses compositions and a method of improving the pharmacokinetics of pharmaceutical agents (or pharmaceutically acceptable salts, esters, and prodrugs thereof) which are...
8901156 Compounds and methods  
Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.
8895571 Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors  
The present invention provides isoindolinone and pyrrolopyridinone derivatives, as well as their compositions and methods of use, that inhibit the activity of the serine/threonine kinase, Akt, and...
8895563 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8895590 Epothilone compounds, preparation method and use thereof  
Epothilone compounds represented by formula (I), their preparation methods and their use for preparing medicines are disclosed. The epothilone compounds are prepared by bioconversion and...