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7045544 |
Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases
The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals
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7045532 |
ACE-2 modulating compounds and methods of use thereof
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
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7041690 |
Inhibitors of HCV NS5B polymerase
The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated...
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7037927 |
Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention relates to compounds of formula (I)
that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7030162 |
Treatment of migraine headache
The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs...
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7026307 |
Method for producing 1,3-disubstituted 2-nitroguanidines
The present invention relates to a process for the preparation of compounds of the formula (I)
by reacting compounds of the formula (II)
in which
R 1 , R 2 , R 4 and Het are as...
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7026342 |
Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds
Provided is a method of treating or ameliorating a number of indications in an animal, including a human, comprising administering an effective amount of a compound of the formula I or IA,
...
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7026316 |
Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in...
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7022719 |
Preventing and reversing the formation of advance glycosylation endproducts
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
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7022330 |
Parenteral formulation for epothilone analogs
A process for formulating certain epothilone analogs for parenteral administration is disclosed wherein the analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, the...
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7008545 |
Synergistic biocidal mixtures
Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective...
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7008936 |
Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative diseases.
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7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
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7001903 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures of spinosyns and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests.
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7001916 |
Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
Disclosed are epothilone compounds of formula I,
which are useful as pharmaceutical compounds for treating, for example, malignant tumors and chronic inflammatory diseases and are useful in...
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6989384 |
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds,...
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6987112 |
Organic compound having cyano group and insecticides/miticides
The present invention is directed to compounds represented by Formula (1);
wherein A, R, X, Y and n are as defined in the description, the salts thereof, and insecticide/acaricide compositions...
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6984652 |
Gyrase inhibitors
Compounds comprising an indazolyl group and a thiazolyl group, preferably 7-substituted 3-(thiazol-2-yl)-1H-indazole compounds in which the indazolyl group and a thiazolyl group are each...
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6982264 |
Substituted alcohols useful in treatment of Alzheimer's disease
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R 1 , R 2 , R 3 , R N , R 20 and R C are defined herein. The compounds are useful in the treatment or...
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6974823 |
Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating...
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6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
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6967212 |
Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N; R 2a , R 2b , R 2c , X 1 to X 7 , R 1 , R 2 , R 3 , R 3a , R 4 , A, Y, m, and n are as defined herein, which compounds are...
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6960591 |
Propane-1,3-dione derivative
Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione...
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6960605 |
Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
Provided are, among other things, compounds of formula I or IA,
Also provided are methods of treatment with such compounds.
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6956049 |
Methods of modulating processes mediated by excitatory amino acid receptors
In accordance with the present invention, there are provided methods of modulating the activity of excitatory amino acid receptors using a specifically defined class of heterocyclic compounds. In...
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6956050 |
Imidazole compounds as anti-inflammatory and analgesic agents
This invention provides a compound of the formula (I):
wherein:
R 1 represents a hydrogen atom, an alkyl group, etc.; R 2 represents a hydrogen atom, a halogen atom, etc.; R 3 represents a...
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6949556 |
Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents
The present invention relates to compounds of general formula (I),
wherein R 1 -R 4 have the meanings given in the specification, A is CH2, CHOH or CH—(C 1 -C 3 -alkyl), B and C are...
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6949566 |
Thiazole and oxazole derivatives
A compound of the formula (I):
wherein R 1 is hydroxy and the like; R 2 is optionally substituted lower alkyl and the like; R 3 is hydrogen atom and the like; R 4 is optionally...
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6949536 |
Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
This invention provides a compound of the formula:
or its pharmaceutically acceptable salt thereof, wherein A is partially unsaturated or unsaturated five membered heterocyclic, or partially...
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6946468 |
3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
The present invention relates to inhibitors of ras farnesylation of the Formula I
wherein:
R 1 is for example H and further values as defined in the specification; R 2 is for example...
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6946462 |
N-monoacylated derivatives of o-phenylenediamines, their analogs and their use as pharmaceutical agents
New compounds represented by the formula
or pharmaceutically acceptable salts or prodrugs thereof,
wherein
X 1 and X 2 are each independently selected from a CH group or a nitrogen atom;...
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6946480 |
Glutaminyl based DPIV inhibitors
The present invention provides compounds of the formula:
wherein X═CH 2 or S or pharmaceutical acceptable salts thereof useful for treating conditions mediated by DPIV or DPIV-like enzymes,...
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6943185 |
Use of 2-methyl-thiazolidine-2,4-dicarboxylic acid and/or physiologically compatible salts thereof for producing a medicament for treating cancers
Use of 2-methyl-thiazolidine-2,4-dicarboxylic acid (2-MTDC) and/or its physiologically tolerable salts for the treatment and/or prevention of cancer.
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6936602 |
Benzazepine derivatives, process for the preparation of the same and uses thereof
Compounds of the general formula (I):
or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R 1 is a 5- to 6-membered...
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6936628 |
Oral administration of epothilones
The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have...
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6933308 |
Aminoalkyl thiazole derivatives as KCNQ modulators
Novel aminoalkylthiazole derivatives of Formula I are described which are openers of KCNQ potassium channels and are useful in the treatment of disorders responsive to the opening of the KCNQ...
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6930119 |
Liquid pharmaceutical composition
This invention relates to new pharmaceutical compositions and methods for their preparation, and in particular it relates to taste-masked liquid compositions comprising a solution of a histamine H...
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6927217 |
HIV protease inhibitors
The present invention relates to novel dihydropyrones of Formula I
wherein X is NH or NR 8 , which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in...
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6927227 |
Heterocyclic containing biphenyl aP2 inhibitors and method
aP2 inhibiting compounds are provided having the formula
wherein R 1 , R 2 , R 3 , R 4 , X—Z and
are as described herein.
A method is also provided for treating diabetes and related...
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6927211 |
Method for reducing toxicity of combined chemotherapies
Compositions and methods are provided for use in the treatment of cancer.
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6924297 |
Naphathalene derivatives which bind to the EP4 receptor
Compounds of formula (I)
and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a...
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6924300 |
Oxyiminoalkanoic acid derivatives
To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia,...
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6921538 |
Therapeutic treatments for neuropsychiatric disorders
Methods for treating psychiatric disorders include intracranial administration of a therapeutically effective amount of a neurotoxin, such as a botulinum toxin type A, to a human patient.
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6916834 |
Preparations and use of an Ah receptor ligand, 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester
Preparation, use, and structure of endogenous Ah receptor ligand is disclosed.
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6916835 |
Nitrate esters and their use for neurological conditions
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated...
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6903119 |
Amino acid derivatives and drugs containing the same as the active ingredient
The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification).
The compounds of the formula (I)...
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6894068 |
Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase
The present invention provides compositions and methods for the treatment of HIV infection. In particular, the present invention provides non-nucleoside inhibitors of reverse transcriptase (RT), as...
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6894049 |
Platinum complexes as antitumor agents
The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib
or a pharmaceutically acceptable salt thereof wherein:...
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6890905 |
Methods for improving islet signaling in diabetes mellitus and for its prevention
The present invention discloses methods for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic...
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