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9040530 1,2,4-triazine-6-carboxamide kinase inhibitors  
Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for...
9040568 Pharmaceutical compositions for the treatment of pain  
This invention discloses a method of treatment of osteoarthritis pain by administration of a composition containing a nicotinic acetylcholine receptor ligand and a nicotinic acetylcholine receptor...
9029406 N-carboxyalkylauristatins and use thereof  
The present application relates to new derivatives, substituted on the N terminus by a carboxyalkyl group, of monomethylauristatin E and monomethylauristatin F, to processes for preparing these...
9029377 Platelet-activating factor receptor antagonists  
Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other...
9029405 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate(SIP)receptors  
The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.
9006273 N-hetero-ring-substituted amide derivative  
Compounds having an excellent hypoglycemic effect and β cell- or pancreas-preserving effects or pharmaceutically acceptable salts thereof, and a pharmaceutical composition having an excellent...
9006276 Substituted oxindole derivatives, medicaments containing said derivatives and use thereof  
The invention relates to novel oxindole derivatives of general formula (I), wherein the substituents R1, R2, A, B, and Y are defined as in claim 1. The invention further relates to medicaments...
9000016 1,3,4-Oxadiazoles-2-thio derivatives as sphingosine-1 phosphate receptors modulators  
The present invention relates to substituted 1,3,4-oxadiazoles-2-thio derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8993619 Cyclic bridgehead ether DGAT1 inhibitors  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
8993605 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase  
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and...
8987256 Oxo-heterocyclic substituted carboxylic acid derivatives and the use thereof  
The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment...
8980920 Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C  
The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for...
8980837 Inhibitors of IAP  
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′,...
8975287 Methods for using 1,2,4-Oxadiazole benzoic acid compounds  
Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of...
8969345 Dibenzooxepin derivative  
A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a...
8957096 Herbicidally active oxime-ether-substituted benzoylamides  
What is described are oxime ether-substituted benzoylamides of the general formula (I) as herbicides. In this formula (I), R, Y and Y are radicals such as hydrogen, organic radicals such as alkyl,...
8952041 Modulators of sperm hypermobility and uses thereof  
The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the...
8951536 N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase  
The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof...
8946231 P2X3, receptor antagonists for treatment of pain  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
8946271 Water soluble furoxan derivatives having antitumor activity  
Water soluble compounds having a furoxan structure which are capable of inhibiting metabolic pathways involved in the development of the tumours are provided. The use of such compounds as a...
8940776 2-acylaminopropoanol-type glucosylceramide synthase inhibitors  
A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a...
8937093 Heterocyclic aspartyl protease inhibitors  
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, X, U, R1, R2, R3, and R4, are as defined herein, and...
8921359 Inhibitors of beta-secretase  
The present invention is directed to a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Pharmaceutical composition comprising a compound...
8916592 Malononitrile compounds  
Compounds of formula I wherein X is O or S(═O)n; n is 0, 1 or 2; R1 is optionally substituted alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl,...
8916594 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity  
This invention provides new compounds having NPY Y5 antagonistic activity. The present inventors found that a compound of the formula (I): wherein R1 is substituted or unsubstituted alkyl or the...
8906899 Azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8906945 Inhibitors of bacterial type III secretion system  
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system...
8901119 Peptide deformylase inhibitors  
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods...
8901156 Compounds and methods  
Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.
8895535 Pyrrolidinones as MetAP-2 inhibitors  
Compounds of the formula I in which R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
8895306 Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex  
The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor...
8889668 Oxadiazole diaryl compounds  
The invention relates to compounds of formula (I): wherein R1, R2, Ra, Rb, Rc and W, have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders,...
8883827 Azole derivatives as WTN pathway inhibitors  
The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such...
8877751 Benzothiazolone derivatives  
Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be...
8871738 Fused bicyclic oxazolidinone CETP inhibitor  
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol,...
8859598 1, 2, 4-oxadiazoles azetidine derivatives as sphingosine-1 phosphate receptors modulators  
The present invention relates to 1,2,4-oxadiazoles azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators...
8859597 Compounds that enhance Atoh1 expression  
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a...
8853219 Compounds and compositions for cognition-enhancement, methods of making, and methods of treating  
Disclosed are muscarinic agonist compounds including oxadiazole derivatives, compositions and preparations thereof. Also disclosed are methods of synthesizing such oxadiazole compounds. Further...
8846674 Nitric oxide enhancing prostaglandin compounds, compositions and methods of use  
The invention provides methods for treating ophthalmic disorders comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt thereof, and,...
8846729 2-thio-1,3,4-oxadiazoles azetidine derivatives as sphingosine-1 phosphate receptors modulators  
The present invention relates to 2-thio-1,3,4-oxadiazoles azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8846655 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8846728 Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8846727 Haloalkyl heteroaryl benzamide compounds  
A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
8841335 Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration  
Provided is a pharmaceutical composition for inhibiting apoptosis of neurons or neurodegeneration. The pharmaceutical composition effectively prevents or treats diseases related to apoptosis of...
8835470 Mandelamide heterocyclic compounds  
Disclosed are compounds of Formula (I) or stereoisomers, salts, or prodrugs thereof, wherein: Q is, or R1 is phenyl substituted with zero to 3 substituents; and R1, R2, R3, R4, R5, and G are...
8828908 Herbicidally active bicyclic 1,3-dione compounds  
Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
8822510 Substituted 3-phenyl-1,2,4-Oxadiazole compounds  
Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C1-C4 alkyl, or (ii) R1 and R2 together with the carbon atom to...
8822509 Pain-relieving compositions and uses therefor  
This invention discloses compositions and methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention discloses the use of sub-normovasodilatory...
8822511 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase  
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and...
8822467 Biaryl oxyacetic acid compounds  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...