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7608632 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7608631 |
4-(3,3-dihalo-allyloxy) phenol derivatives having pesticidal properties
Compounds of formula (I) wherein A o is a bond or a C 1 -C 6 alkylene bridge; A 1 , A 2 and A 3 are a C 1 -C 6 alkylene bridge; D is CH or N; W is, for example, O, S, SO, S0 2 ,...
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7605171 |
(3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
The present invention encompasses compounds of Formula I:
as well as the pharmaceutically acceptable salts thereof. The compounds are S1P 1 /Edg1 receptor agonists and thus have...
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7595343 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7595333 |
Agent for improving acidosis
An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity.
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7589113 |
Substituted oxadiazole compounds and their use as opioid receptor ligands
Substituted oxadiazole compounds corresponding to formula I:
in which X denotes CH, CH 2 , CH═CH, CH 2 CH 2 , CH 2 CH═CH or CH 2 CH 2 CH 2 ; R 1 denotes aryl or heteroaryl, in each case...
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7585884 |
Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof...
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7582663 |
Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7582662 |
Body weight gain inhibitor
The invention provides a pharmaceutical agent containing a compound having an angiotensin II antagonistic activity, a prodrug thereof or a salt thereof, which shows superior effect for the...
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7576109 |
1,3,4-oxadiazol-2-ones as PPAR delta modulators and their use thereof
The present invention is directed to 1,3,4-oxadiazolones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include...
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7572920 |
Benzimidazole derivative and use as a II receptor antagonist
The present invention relates to a compound represented by the formula (I)
wherein R 1 is a group represented by the formula
wherein R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are each...
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7572820 |
Chemical compounds
This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
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7563774 |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.
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7557136 |
Pyrrolidine derivatives as oxytocin antagonists
The present invention relates to novel pyrrolidine derivatives of Formula (I), its geometrical isomers, its optically active forms as enantiomers, diastercomers, mixtures of these and its racemate...
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7541372 |
Aryl-isoxazolo-4-yl-oxadiazole derivatives
The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula
wherein
R 1 , R 2 , and R 3 , are as defined in the specification and pharmaceutically acceptable acid...
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7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I)
or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
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7514434 |
Heterocyclic compounds having an oxadiazole moiety and hydro isomers thereof
The present invention relates to substituted diphenyl heterocycle compounds having an oxadiazole moiety and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present...
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7511059 |
Thiazolidinones, their production and use as pharmaceutical agents
The invention relates to thiazolidinones of general formula (I)
their production and use as inhibitors of polo-like kinases (Plk) for treating various diseases.
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7504402 |
Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
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7465748 |
Amide derivative
There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
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7459473 |
N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including...
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7456210 |
Benzyloxy derivatives
The present invention relates to compounds of formula I
wherein R 1 and R 2 are as defined in the specification and to pharmaceutically acceptable salts thereof for the treatment of diseases,...
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7452899 |
Gamma-secretase inhibitors
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7452878 |
Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7435750 |
Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I:
wherein Ar 1 , Ar 3 , A, B and D are defined herein. The...
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7435748 |
Gamma-secretase inhibitors
Compounds of formula I:
inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.
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7435747 |
Guanidine and amidine derivatives as factor Xa inhibitors
The present invention relates to compounds of the formula I,
in which R 0 ; Q; X; Q′, D, R 10 and V have the meanings indicated in the claims. The compounds of the formula I are valuable...
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7432293 |
Heterocyclic compounds useful as Nurr-1 activators
The present invention relates to compounds of formula (I): wherein R 1 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkyl-amino, di C 1-4 alkylamino, benzyloxy or C 2 -C 7 alkanoyl, R 2 is C 1-4 ...
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7429606 |
Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof...
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7425555 |
Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
Compounds of formula (I):
are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the...
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7419991 |
3-[5-(2-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, compositions, and methods for the use thereof
Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of...
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7414056 |
Pyrazole-amide compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where G, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7414048 |
4,5-dihydro-isoxazole derivatives and their pharmaceutical use
The present invention is concerned with the compounds of formula
wherein m, n and p are each independently 0 or 1 and q is 0, 1, 2, 3, 4 or 5; -A 1 =A 2 -A 3 =A 4 - is a pyridinylidene,...
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7407976 |
Thiazoles and oxazoles useful as modulators of ATP-Binding Cassette transporters
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions...
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7402606 |
Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
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7399765 |
Substituted diazabicycloalkane derivatives
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
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7390804 |
N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient
An N-containing five-membered ring compound of formula (I)
wherein all symbols are the same as described in the specification, and a non-toxic salt thereof.
The compound of formula (I) has an...
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7384963 |
2′-Methyl-5-(1,3,4-oxadiazol-2-yl)1, 1′-biphenyl-4-carboxaide derivatives and their use as p38 kinase
Compounds of formula (I), wherein R 1 is a phenyl group which may be optionally substituted; R 2 is selected from hydrogen, C 1-6 alkyl and (CH 2 ) p —C 3-7 cycloalkyl; R 3 is the group:...
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7384929 |
N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds,...
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7358265 |
Oxa-and thiadiazoles and their use as metalloproteinase inhibitors
Compounds formula (IA) or (IB), wherein W represents HO(C═O)—, HONH(C═O)— or H(C═O)N(OH)—; X represents —O— or —S—; and R 1 , R 2 , and R 3 are as defined in the description...
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RE40245 |
Gyrase inhibitors and uses thereof
The present invention relates to compounds of the formula I:
or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase...
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7354945 |
2-oxadiazolechromone derivatives
Novel compounds of the formula I
in which
R, X and n are as defined herein,
are inhibitors of tyrosine kinase and can be employed for the treatment of tumours, for neuroprotection and for...
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7354941 |
Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes
Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive...
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7351726 |
Substituted oxadiazolidinediones
The present invention relates generally to substituted oxadiazolidinediones and methods of using them.
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7351725 |
N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and...
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7348345 |
Nonnucleoside reverse transcriptase inhibitors
This invention relates to methods of treating an HIV infection with novel heterocyclic compounds of formula I wherein R 1 —R 4 , X 1 and X 2 are as defined in the summary and pharmaceutically...
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7345095 |
Sulfonamide compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula I
wherein R 1 , R 2 , R 3 , m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The...
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7342039 |
Substituted indole oximes
The present invention relates to substituted indole oximes and methods of using them.
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