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9028878 Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses  
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or...
9023874 Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests  
The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or...
8993619 Cyclic bridgehead ether DGAT1 inhibitors  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
8980920 Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C  
The present invention relates to novel Linked Tricyclic Aryl Compounds, compositions comprising at least one Linked Tricyclic Compound, and methods of using Linked Tricyclic Aryl Compounds for...
8980892 Insecticidal compounds  
A compound of formula (I): wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5a, R5b and R6 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to...
8962663 Small molecule inhibitors of the pleckstrin homology domain and methods for using same  
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
8957060 Tumescent antibiotic solution  
Disclosed herein are solutions and kits for tumescent antibiotic delivery. Embodiments of the solution comprise an antibiotic component, an anesthetic component and a vasoconstrictor component. In...
8933107 Pesticide thiazolyloxy substituted phenylamidine derivatives  
The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as...
8895535 Pyrrolidinones as MetAP-2 inhibitors  
Compounds of the formula I in which R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
8865704 Wnt pathway antagonists  
The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the...
8865744 (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles  
Disclosed are (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the...
8859596 Compounds as cannabinoid receptor ligands  
Disclosed herein are cannabinoid receptor ligands of formula (I) wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating...
8846727 Haloalkyl heteroaryl benzamide compounds  
A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
8841335 Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration  
Provided is a pharmaceutical composition for inhibiting apoptosis of neurons or neurodegeneration. The pharmaceutical composition effectively prevents or treats diseases related to apoptosis of...
8835469 Substituted benzamide derivatives as glucokinase (GK) activators  
The present invention relates to substituted benzamide derivatives of the Formula I and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers,...
8828908 Herbicidally active bicyclic 1,3-dione compounds  
Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
8822508 2-oxo-1-pyrrolidinyl imidazothiadiazole derivatives  
The present invention relates to 2-oxo-1-pyrrolidine imidazothiadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
8815918 Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives  
There is provided compounds of formula (I): wherein R1, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds...
8785443 Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof  
Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions comprising prodrugs of methyl hydrogen fumarate, and methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical...
8765731 Benzimidazole analogues for the treatment or prevention of flavivirus infections  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are...
8759378 Methods for treating blood disorders  
Methods of treating blood disorders are described.
8754053 Isoxazoline derivatives as insecticides  
The present invention relates to compounds formula (I), wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, R1, R2, R3, R4, R5, R6, R17,...
8741937 Gamma glutamyl transpeptidase inhibitors and methods of use  
Compositions and methods for inhibiting human gamma-glutamyl transpeptidase (GGT) in vivo or in vitro and for inhibiting and killing neoplastic cancer cells, for example for the treatment,...
8735430 Compounds which selectively modulate the CB2 receptor  
Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
8686007 Certain heterocycles, compositions thereof, and methods for their use  
Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, Z1, Z2, Z3, Z4 and m are as defined herein. Also provided is a...
8685975 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8680090 Sulfonyl containing benzothiazole inhibitors of endothelial lipase  
The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors...
8673910 Proteasome inhibitors for selectively inducing apoptosis in cancer cells  
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical...
8637528 Use of PDE7 inhibitors for the treatment of movement disorders  
A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a...
8629157 Pyrrolidine compounds which modulate the CB2 receptor  
Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those...
8623895 Mitotic kinesin inhibitors and methods of use thereof  
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the...
8614236 Methods of treating pulmonary disease using acetazolamide and structurally related derivatives  
The present invention is directed to a method of treating a subject for a pulmonary disease by administering a therapeutically effective amount of a compound of the formula: wherein R1, R2 or R3...
8604016 Heterocyclic inhibitors of glutaminase  
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the...
8591885 Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems  
Biocompatible intraocular drug delivery systems include a carbonic anhydrase inhibitor therapeutic agent and a polymeric component in the form of an implant, a microparticle, a plurality of...
8580828 Mitotic kinesin inhibitors and methods of use thereof  
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the...
8569345 Compounds and compositions as LXR modulators  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
8563550 Imidazolothiadiazoles for use as protein kinase inhibitors  
There is provided compounds of formula (I), wherein Z, M, R1, X, R2, R3 and B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof,...
8546391 Thiadiazole and oxadiazole derivatives, preparation thereof and therapeutic use thereof  
The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method...
8541453 Modulators of ATP-binding cassette transporters  
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions...
8536226 Methods for the treatment of dermatological disorders  
The present invention is directed to the use of a compound of formula (I) or pharmaceutically acceptable salt thereof, for the treatment of disorders mediated by the melanocortin-5 receptor,...
8524750 (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds  
A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is...
8518979 Alpha-halo- and alpha-alkyl-cyclopropylcarboxy compounds and uses thereof  
Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly...
8518943 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses  
The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
8507538 Selective heterocyclic sphingosine 1 phosphate receptor modulators  
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such...
8492371 Compounds as cannabinoid receptor ligands  
Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions...
8492415 Azoles and related derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) in antiviral therapy (HIV)  
The present invention relates to novel heterocyclic compounds, including oxadiazole compounds, pharmaceutical compositions and their use in the inhibition of reverse transcriptase and the...
8492405 Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity  
The present invention aims to provide a glucokinase activator useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like. A...
8481572 Pharmaceutical compositions and methods for the treatment of cancer  
Provided is a pharmaceutical composition including as an active component a compound of formula (I): wherein X and (R1)n are as defined, and a physiological acceptable carrier. Also provided is a...
8476302 α-ketoamide derivatives useful endothelial lipase inhibitors  
The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial...
8466182 Small molecule inhibitors of kynurenine-3-monooxygenase  
The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.