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4571406 |
Anti-hypertensive chromans and chromenes
Compounds of formula (I): ##STR1## wherein: either one of R 1 and R 2 is hydrogen and the other is selected from the class of C 1 -6 alkylcarbonyl, C 1 -6 alkoxycarbonyl, C 1 -6 alkylcarbonyloxy,...
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4569942 |
N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted...
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4570000 |
Nitrogen heterocycles
The invention relates to nitrogen heterocycles which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of...
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4563476 |
Substituted 5-hydroxy-2,3-dihydrobenzofurans and analogs thereof useful as anti-inflammatory agents
Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted...
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4556672 |
3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and...
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4491587 |
Tetrazole derivatives
6-(1H-Tetrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo- pyrimidines, thiones, and imines are...
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4454147 |
Nematicidal 2-chloro-5-aryl-1,3,4-thiadiazoles
2-Chloro-5-aryl-1,3,4-thiadiazoles of the formula ##STR1## wherein X and Y are independently hydrogen, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, isothiocyano, trifluoromethylthio,...
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4447440 |
Sulphenamides-containing lipoxygenase inhibiting agents and their use in pharmaceutical compositions
The invention relates to sulphenamide compounds of Formula (I) as defined herein and to methods for their preparation. Also included in the invention are compositions containing said sulphenamide...
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4446142 |
Substituted oxadiazoles and thiadiazoles, and methods of preparation and use thereof
Compounds of the formula ##STR1## wherein R 1 is hydrogen, halogen, or alkyl, R 2 is halogen or alkyl, R 3 is hydrogen, acyl, or saturated or unsaturated alkyl, R 4 and R 5 are individually...
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4444770 |
New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and...
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4440775 |
Azolyl alkylthioureas and guanidines alkylaminonitroethylene compounds
The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H 2 -antagonists.
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4438123 |
Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure
Although dibasic carbonic anhydrase inhibitors (C.A.I.) can be administered systemically by oral or intravenous routes, attempts to administer them topically were inadvisable because of their...
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4432847 |
Poly sulfoxides from 1,3,4-thiadiazole-2,5-dithiol
Poly sulfoxides of the general formula ##STR1## where each R is a monovalent aliphatic radical bound to a sulfoxy group. Each R is defined as being individually selected from the group consisting...
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4428953 |
Pleuromutilin derivatives, their production and use
Novel pleuromutilin derivatives of formula I, ##STR1## in which R 1 is ethyl or vinyl, m is 0 or 1, and R 2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated...
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4427688 |
N-Substituted 2-methylnaphthylamides, their preparation, and their use for controlling fungi
N-Substituted 2-methylnaphthylamides of the formula ##STR1## where R 1 and R 2 have the meanings given in the description, their preparation and their use for controlling fungi.
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4424227 |
Gastric cytoprotection with heterocyclic sulfonamides
The present invention provides a method for gastrointestinal cytoprotection using a class of heterocyclic sulfonamides.
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4423053 |
Derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazol as antiviral agents and a process for the preparation thereof
Compounds which are derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazol of formula ##STR1## wherein R is a hydrogen atom or a --CH 3 , --C 2 H 5 , iso--C 3 H 7 , n--C 4 H 9 or --CH 2...
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4406902 |
Dipeptidase inhibitors
Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical...
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4388319 |
N-Heterocyclic alkyl-N'-thiadiazolyl, thiazolyl and isothiazolyl alkylthioureas, ureas and guanidines
The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is...
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4375472 |
Amidinosulphonic acid derivatives
Amidinosulphonic acid derivatives carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'[2-(5-methyl-4-imidazolylmethylthio)- ethyl]...
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4372963 |
Oxazolyl, isoxazolyl, triazolyl and thiadiazolyl alkyl bisamidines
Bisamidines carrying one unsaturated nitrogen heterocyclo-containing substituent, representative of which i; 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-
8-[N'-methylgu...
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4369186 |
4,5-Dichloroimidazole-2-carboxylic acid derivatives
4,5-Dichloroimidazole-2-carboxylic acid derivatives of the formula ##STR1## in which the group ##STR2## represents a carbon atom which has three bonds to hetero-atoms, and their salts with bases,...
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4369185 |
Fungicidal 2-sulfinyl-5-sulfonyl-1,3,4-thiadiazole derivatives
A method for production of novel antifungal 1,3,4-thiadiazole derivatives having a composition of the general formula ##STR1## wherein R 1 and R 2 are independently alkyl with from 1 to 6 carbon...
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4369187 |
3-Substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
Disclosed are 3-substituted-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxyli
c acids (I): ##STR1## wherein R is, inter alia, acyl, alkyl, and aralkyl. Such compounds and their pharmaceutically...
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4353917 |
Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole, their preparation, and formulations containing these compounds
Novel aminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and...
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4338328 |
Sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines
The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
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4338329 |
Antiviral method employing 1-sulfonylbenzimidazoles
Certain carbonyl-substituted-1-sulfonylbenzimidazole compounds are useful as antiviral agents.
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4325959 |
Hypoglycemic 4-(((1,3,4, thiadiazolyl)thio)methyl)benzoic acids, ester and amides
4-(((Heterocyclo)thio)methyl)benzoic acids, esters, amides and pharmaceutically-acceptable salts thereof having hypoglycemic activity in mammals, including a method of use and...
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4314838 |
Biocidal thiadiazolylmercapto-substituted haloacrylonitrile compounds
Novel biocidal compounds having the general structural formula ##STR1## wherein R is selected from the group consisting of C 1 -C 4 alkyl, including ethyl, ethyl, propyl and butyl, ##STR2##...
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4305927 |
Method for the management of intraocular pressure
A method for the management of intraocular pressure and for lessening the incidence of side effects associated therewith is disclosed. The method comprises administering continuously controlled low...
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4305950 |
Pharmaceutical agent containing amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole
Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds,...
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4285959 |
3-(N-1,3,4-Thiadiazolyl-2)-aminoalkyl-alkyl-acrylates and use thereof as bactericides
Novel 2-amino-thiadiazole derivatives of the formula ##STR1## are described. In the formula, R 1 is hydrogen or C 1 -C 4 alkyl; R 2 is C 1 -C 4 alkyl; R 3 is hydrogen or the group --CO--R 4...
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4285972 |
Method of treating scours
Scours in animals, particularly new-born calves, lambs, piglets and foals are treated with a compound containing an effective amount of an antidiarrheal amidinourea.
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4284640 |
Ethylene derivatives
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is...
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4282234 |
Certain heterocyclic-methylthioalkyl guanidine derivatives
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or...
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4269846 |
Heterocyclic compounds useful as anti-allergy agents
New benzoheterocyclic oxadiazolones and triazolones are described. These compounds are useful as anti-allergic reagents.
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4269873 |
2-, 5-, and 6-Substituted-1-carbadethiapen-2-em-3-carboxylic acids
Disclosed are 2-, 5- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein R 6 , R 7 , R 8 and R 9 are, inter alia, independently selected from the...
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4265898 |
Imidazo[2,1-b]-[1,3,4]-thiadiazole compounds, composition and their medicinal use
The present invention relates to certain new imidazo [2,1-b]-[1,3,4]-thiadiazole compounds, to the provision of pharmaceutical compositions containing said compounds and to the use of said...
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4264616 |
2-Iodoacetylimino-3-methyl-5-trifluoromethyl-1,3,4-thiadiazol-4-ine and use as a fungicide
The novel compound having the structural formula, ##STR1## which may be conveniently synthesized from readily available chemical substances is disclosed to be useful as a fungicide, particularly in...
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4237130 |
2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids
The invention relates to 2,3-dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids and derivatives thereof having diuretic-saluretic, uricosuric and antihypertensive...
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4220652 |
Isothiazolyl alkylaminoethylene compounds
The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is...
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4218460 |
Nitroimidazoles
Nitroimidazolylvinylthiadiazoles, their production, and formulations containing same for use as chemotherapeutics in the treatment of microbial infections in humans and animals, especially of...
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4211764 |
Gastric secretion stimulation with 2-amino-5-(2-aminoethyl)-1,3,4-thiadiozole
The proposed gastric secretion stimulator comprises an active principle which is 2-amino-5-(2-aminoethyl)-1,3,4-thiadiazole, and a pharmaceutical carrier for said active principle. The stimulator...
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4209522 |
Antimicrobial bis(5-nitro-2-thiazolyl)thioisothiazoles and thiadiazoles
The novel compounds corresponding to the formula ##STR1## or of the formula ##STR2## wherein R is a thiadiazole radical. These compounds exhibit utility in the control and kill of bacteria and fungi.
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4191769 |
Isothiourea compounds and pharmacological use
The compounds are N-(heterocyclomethylthioalkyl) derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or...
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4174398 |
Combating fungi with 1-alkyl-1-(1,3,4-thiadiazol-2-yl)-3-phenyl-ureas
1-Alkyl-1-(1,3,4-thiadiazol-2-yl)-3-phenyl-ureas of the formula ##STR1## in which R 1 is alkyl, R 2 is phenyl or substituted phenyl, and X is hydrogen or halogen, which possess fungicidal...
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4163048 |
Acylamino-1,2,4-oxadiazole or thiadiazole derivatives as anti-hypersensitivity agents
Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,2,4-oxadiazole or 1,2,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the...
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4160030 |
N-oxy and N-amino guanidines
The compounds are N-oxy and N-amino guanidines which are histamine H 2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio
)ethyl]guanidi ne.
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4154844 |
Pharmacologically active guanidine compounds in compositions and methods of use
The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.
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4152442 |
Certain acylamino-oxa (or thia) diazoles in treatment of hypersensitivity conditions
Acylamino heteroaryl compounds in which the heteroaryl nucleus is a 1,3,4-oxadiazole or 1,3,4-thiadiazole nucleus, methods of making the compounds and pharmaceutical formulations containing the...
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