Matches 251 - 300 out of 396 < 1 2 3 4 5 6 7 8 >
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4952599 Phenylthioureas, phenylisothioureas, phenylcarbodiimides, pesticidal compositions containing them and their use in pest control  
Novel substituted phenylthioureas, phenylisothioureas and phenylcarbodiimides of formula I ##STR1## wherein R 1 is C 1 -C 10 alkyl, unsubstituted or substituted by one or more halogen atoms...
4943584 (p-Phenoxyphenoxy)-methyl-five-membered hetaryls  
Novel (p-phenoxyphenoxy)-methyl-five-membered heeroaromatic radicals of the formula ##STR1## where the substituents have the following meanings: R 1 , R 2 , R 3 hydrogen, halogen, C 1 -C 8 ...
4933356 Diflunisal potentiation of acetazolamide in the control of intraocular pressure  
The invention relates to an improved therapy to control intraocular pressure (IOP). More specifically, the present invention relates to an improved treatment of glaucoma patients to control ocular...
4927822 1,3,4-thiadiazoles  
There are described compounds of formula I, ##STR1## in which Y is S, O or NR 9 , n is 0 or 1, R 9 is hydrogen or alkyl C 1 to 10, R 3 is hydrogen, alkyl C 1 to 10, cycloalkyl C3 to 10,...
4904660 Histidine derivatives as superior renin inhibitors  
Novel compounds of the following formula (I) and their salts: A compound of the formula (I) ##STR1## These compounds are expected to be useful for renin inhibitors. Thus, the compounds are useful...
4898889 Methods for the treatment of hypertension  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 , R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4888168 Stable ophthalmic preparations containing acetazolamide  
There is provided a stable, ophthalmic aqueous composition for topical administration, comprising (a) acetazolamide and either (b) a pre-formed, pharmaceutically acceptable, aqueous gel or (c) an...
4882342 5-alkylbenzimidazoles, method of use and pharmaceutical compositions  
The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R 1 is a phenyl ring of the formula: ##STR2## or R 1 is naphthyl, heterocycle or a bicyclic heterocycle...
4880824 Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers  
Heterocyclic compounds of formulae (I) and (II): ##STR1## where R 1 and R 2 are alkyl, R 3 is H or alkyl, m is 2-5 and Het is a hetercycle such as thiazole, benzothiazole, substituted...
4863945 Pyrrolobenzimidazoles and pharmaceutical compositions containing them  
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
4861788 Antibacterial 1-normon-2-yl-heterocyclic compounds  
Compounds of formula (I): ##STR1## wherein ##STR2## is a 5-membered heterocyclic group having a 6-πelectron system, the five ring atoms being either (a) one carbon atom and four atoms selected...
4855310 Thiadiazole compounds as antagonists of SRS-A  
Novel heterocyclic compounds shown by the general formula ##STR1## or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of...
4855289 Combination of two active substances  
The invention concerns the use of a compound with diuretic properties and of a magnesium supplementation in the form of magnesium monoaspartate hydrochloride, magnesium oxide, magnesium hydroxide...
4851406 Heterocyclic-substituted indoles and pharmaceutical compositions containing them  
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
4835168 Thiadiazole antiviral agents  
Compounds of formula (I) ##STR1## wherein R 1 is hydrogen, and R 2 is cyano or --C(S)--NH--R 3 ; or R 1 and R 2 taken together are C(NH 2 ) 2 or C(R 5 )(NHR 3 '); R 3 and R 3...
4833152 Anti-hypertensive agents  
Novel inhibitors of angiotensin coverting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
4831032 Cardiotonic benzimidazoles  
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
4803211 Thiadizazole compounds as antagonists of SRS-A  
This invention relates to novel heterocyclic compounds structurally characterized by containing a specific heterocyclic group and by the presence of --CH 2 --S-- directly bound to the specific...
4786627 Thiadiazole guanidines  
Thiadiazole guanidines of formula 1 ##STR1## wherein R is hydrogen or C 1 -4 alkyl and their non-toxic salts. Processes for their preparation and pharmaceutical compositions thereof. The compounds...
4786639 Method for the treatment of reversible airways obstruction and asthma  
A method for the treatment and/or prophylaxis of reversible airways obstruction and asthma in mammals, which method comprises administering to the mammal in need of said treatment an effective...
4782072 Thiadiazole derivative  
2-Aminomethyl-5-(2-biphenylyl)-1,3,4-thiadiazole and is non-toxic salts. Processes for the preparation and pharmaceutical compositions thereof. The compound exhibits anticonvulsant activity and is...
4777179 Heterocyclic derivatives, processes for the use thereof and pharmaceutical compositions containing them  
The invention provides compounds of the general formula ##STR1## and physiologically acceptable salts and hydrates thereof, in which one of R 1 and R 2 represents hydrogen, halogen or a C 1 -4...
4774240 N-indolylethyl-sulphonic acid amides and their use  
The invention relates to N-indolylethyl-sulphonic acid amides of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined in the specification and X is carboxyl, alkoxycarbonyl,...
4772622 3,5-diamino-1,2,4-oxidiazoles as gastric secretion inhibitors  
Novel diamino oxadiazoles, wherein one of the amine functions is connected to a basicly-substituted heterocyclic group through a linear or cyclic connecting group, which are useful for the...
4772603 Method for treating congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals  
A method for the treatment and/or prophylaxis of congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals, such as humans, which method...
4767775 Substituted pyrazolin-5-ones, composition containing them, and method of combating fungi or bacteria  
Microbicidal substituted pyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another each represent hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl,...
4746669 Substituted thiazoles as immunoregulants  
Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with...
4745124 Orally effective anti-hypertensive agents  
Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, R 1 -A 1 ...
4738963 Method for the treatment of incontinence in mammals  
A method for the treatment and/or prophylaxis of incontinence in mammals, which method comprises administering to the mammal in need of said treatment an effective amount of a compound of formula...
4738960 1,3,4-Thiadiazole derivatives and pharmaceutical preparations useful as inhibitors for histamine-H.sub.2 receptors  
1,3,4-Thiadiazole derivatives corresponding to the general formula I ##STR1## which constitute highly effective inhibitors for histamine-H 2 receptors are described. These compounds in addition...
4735955 2-substituted cycloheptoimidazole derivatives and anti-ulcerative agents containing the same  
Derivatives of 2-substituted-cycloheptoimidazole are disclosed, which are represented by the following formula: ##STR1## wherein R is a hydrogen atom, a lower-alkyl, acetyl, lower-alkylaminoalkyl...
4728655 Sulfonamidines, process for the production thereof and pharmaceutical compositions containing the same  
Sulfonamidine is disclosed of the general formula (I): R--NH--CHN--SO 2 --R 1 (I) wherein R is a group selected from...
4727081 3,4-Diazole derivatives and pharmaceutical preparations containing these compounds  
3,4-Diazole derivatives corresponding to the general formula I ##STR1## which exert a highly selective action on histamine-H 2 receptors are described. Processes for the preparation of these...
4714707 Aryl substituted heterocycles for treating gastrointestinal motility dysfunction  
Aryl substituted diazaheterocyclic amines and their use in the treatment of gastrointestinal motility dysfunctions.
4713393 Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents  
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a...
4711915 Surface coating compositions containing substituted 1,3,4-thiadiazoles  
Surface coating compositions having improved resistance to attack by fungi and other microorganisms contain a biocidally effective amount of an antimicrobially active compound having the structural...
4696937 Thiosulfonate derivatives for inhibiting malformation or destruction of red blood corpuscules  
The invention relates to novel thiosulfonate derivatives of general formu a: R--S--SO 2 --R 1 in which R represents a 1H-imidazol-2-yl, quinolin-2-yl, 5-amino-1,3,4-thiadizol-2-yl or...
4695571 Tricyclic oxindole antiinflammatory agents  
Tricyclic oxindole carboxamides, prepared by (a) reaction of an isocyanate with the basic ring system or (b) ammonolysis of a corresponding alkyl ester, are non-steroidal antiinflammatory agents...
4695567 Pyrrolobenzimidazoles, pharmaceutical compositions containing them and method of using them to treat certain heart and circulatory diseases  
The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R 1 is hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 3 -C 7 cycloalkyl; ...
4686224 Oxindole antiinflammatory agents  
Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl...
4683228 Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion  
A guanidine derivative of the formula I: ##STR1## in which R 1 , R 2 , R 3 , R 4 , ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is...
4678789 Triazole antifungal agents  
Compounds of the general formula: ##STR1## wherein Ar is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and Het is a heterocyclic group which may optionally be substituted or...
4657905 Novel hypotensive imidazothiadiazolealkanecarboxamides  
Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R 1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S,...
4656176 2-thiazolyl, oxazolyl, triazolyl and thiadiazolyl alkylamino-3-nitro-heterocyclic compounds  
2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur...
4636515 Non-classical topical treatment for glaucoma  
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of a non-classical carbonic anhydrase inhibitor. The most preferred compound is methyl...
4636505 Amide derivatives  
Acylanilides of the formula ##STR1## wherein R 1 and R 2 , the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R 3 is hydrogen or...
4619939 Process for reducing intraocular pressure  
Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase...
4607043 Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acids and derivatives as cognition activators  
Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-alkanoic acids, base addition salts, esters, and amides are useful as agents for the reversal of amnesia. Pharmaceutical compositions containing said...
4588723 Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, intermediates for their preparation and their use in medicaments  
The invention relates to aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, processes for their preparation, intermediates which are used in their preparation, medicaments containing said...
4578388 Unsymmetrical guanidino, thioureido, isothioureido and nitromethyleneamino derivatives  
The compounds are C 2 -C 8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino). N-(N'-substituted...
Matches 251 - 300 out of 396 < 1 2 3 4 5 6 7 8 >