Matches 201 - 250 out of 396 < 1 2 3 4 5 6 7 8 >
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5332430 Use of thiadiazole compounds as an antifouling active ingredient  
The invention relates to thiadiazole compounds of the type ##STR1## wherein R 1 , R 2 , R 3 are hydrogen alkyl groups having 1-4 carbon atoms substituted alkyl groups having 1-4 carbon...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR 1 R 2 --CO--Y--NR 3 --CHR 4 --CR 5 --CH 2 --(CR 6 R 7 ) r --Z--Het I in which R 1 to R 7 , W, X, Y, Z, r and Het...
5326776 Angiotensin II receptor antagonists  
Compounds are disclosed having the formula: ##STR1## wherein the substituents are defined herein. The compounds of the invention are angiotensin II receptor antagonists.
5298515 N-hetaryl-2-nitroanilines  
Abstract of the Disclosure: N-Hetaryl-2-nitroanilines Ia and Ib ##STR1## (R 1 =H, halogen, C 1 -C 4 -alkoxy; R 2 =NO 2 , CN, halogen, C 1 -C 4 -haloalkyl; R 3 =NO 2 , halogen, C 1 -C 6 ...
5296499 Indole derivatives, their production and use  
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl...
5288735 Treatment of glaucoma  
Method of treating glaucoma in a mammal, comprising administering to the mammal an effective amount of an active water-soluble carbonic anhydrase inhibitor having the formula: ##STR1## or a...
5270338 Acetazolamide-related compounds, process for their preparation, and pharmaceutical composition containing the same  
Compounds related to acetazolamide and to its N-methyl derivatives, of the formula: ##STR1## wherein Y is one of the following groups: ##STR2## R 1 being a straight or branched alkylene or...
5268375 Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present  
This invention relates to compounds of formula ##STR1## in which: R 1 and R 2 are similar or different and are each independently hydrogen or a group selected from CO 2 NC(NH 2 ) 2 ,...
5244906 Insect control with substituted oxadiazole and thiadiazole compounds  
Insects, especially sucking insects, such as brown planthoppers, and phytophageous mites, such as two-spotted spider mites, are controlled by applying an oxadiazole or thiadiazole compound...
5242937 Topically active ocular thiadiazole sulfonamide carbonic anhydrase inhibitors  
The present invention is directed to a compound of the formula: ##STR1## or pharmaceutically acceptable salts thereof which are useful in the treatment of glaucoma and in the assessment of corneal...
5240950 Carbazate derivatives, their production and use  
There are provided carbazate derivatives of the formula: R 1 --NCH--NHNH--R 2 wherein R 1 is a heterocyclic group; and R 2 is an esterified carboxyl group, and their salts, which are useful...
5234946 Substituted alkylamine derivatives  
The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R 1 represents (a) substituted or unsubstituted C 2 -6 alkenyl group, (b) substituted or unsubstituted C 3 -6...
5231108 Chemoprevention of electrophilic damage by mercaptopurine analogs  
Analogs of 6-mercaptopurine have been found to enhance the detoxification of various electrophilic toxicants in vivo, while having minimal cytotoxicity themselves. This property allows such...
5227392 Alkoxycoumarins substituted by a heterocyclic radical, their preparation and therapeutic agents containing these compounds  
An alkoxycoumarin substituted by a heterocyclic radical, or the formula ##STR1## R 1 and R 2 independently of one another are each hydrogen, C 1 -C 5 -alkyl, trifluoromethyl, phenyl or halogen,...
5225424 Methazolamide-derived carbonic anhydrase inhibitors  
N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)ylidene] -2-acetyloxyacetamide, commonly referred to as acetylhydroxymethazolamide and is a water soluble pharmacologically active carbonic...
5212189 Thiadiazole or oxadiazole analogs of fenamic acids containing substituted hydroxamate side chains as antiinflammatory agents  
The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or...
5206253 Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds  
The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if...
5190955 Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids  
Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxlyi c acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR...
5190963 Cyclopropane(thio)carboxamides, the preparation thereof and intermediates therefor, and the use thereof for controlling pests  
Cyclopropane(thio)carboxamides of the general formula I ##STR1## where the index and the substituents have the following meanings: n is 0, 1 or 2, it being possible for the R 2 radicals to be...
5177090 Microbicidal agents  
The invention relates to the use of 2,5-substituted 1,3,4-thiadiazoles of the formula ##STR1## in which R 1 stands for straight-chain or branched halogenoalkyl, R 2 stands for straight-chain...
5166165 Fungicidal agents based on heterocyclically substituted sulphones  
Use of compounds of the formula (I) ##STR1## in which Ar, R and X have the meaning indicated in the description, for combating phytopathogenic fungi in agriculture. The compounds of the formula...
5162349 Nematocidal and fungicidal compositions  
Mercapto-bis-[1,3,4-oxa- and -thiadiazoles] ##STR1## in which X 1 and X 2 independently of one another are oxygen or sulfur, R 1 is hydrogen or C 1 -C 5 alkyl which is unsubstituted or...
5158950 1,3-dithiol-2-ylidene derivatives and process for the preparation thereof  
2-(1,3-Dithiol-2-ylidene)-2-[N-(substituted) carbamoly] acetate esters and salts thereof, having potent therapeutic or prophylactic effect for hepatic disorder, are provided. Processes for their...
5157044 Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors  
Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase...
5135938 Leukotriene antagonists  
Leukotriene antagonist thiadiazoles have been prepared.
5134146 Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma  
The use of compounds for formula (I): ##STR1## or a salt or prodrug thereof; wherein one of X, Y, or Z is an oxygen or sulphur atom and the other two are nitrogen atoms, and the dotted circle...
5132316 Heterocyclic azabicyclic compounds for enhancing acetylcholine function  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which X represents R 1 OOC-- in which R 1 is C 1 -4 alkyl, C 2 -4 alkenyl or C 2 -4 alkynyl; R 2 O-- in which...
5116853 Phenylene derivatives  
Novel phenylene derivatives shown by the general formula ##STR1## wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R 1 represents a...
5104887 Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors  
High potency carbonic anhydrase inhibitors derived from methazolamide.
5095026 Prodrugs of carbonic anhydrase inhibitors  
Prodrugs are prepared of the carbonic anhydrase inhibitors 2-benzothiazolesulfonamide, hydroxymethazolamide, and dichlorphenamide. The prodrugs link a water soluble compound to the...
5095024 Substituted 1,3,4-thiadizaolinones, processes for their preparation, and their use for combating endoparasites  
Substituted 1,3,4-thiadiazolinones of the formula (I), ##STR1## in which X represents O or S, R 1 represents hydrogen, alkyl, alkoxy, alkylthio, halogen, halogenoalkyl, halogenoalkoxy or...
5091397 1-aza-bicyclico(2.2.1)heptanes  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents --CH 2 --Z where Z is a group ##STR2## in...
5086053 Derivatives of 1,3,4-thiadiazole, a method of obtaining them and pharmaceutical compositions containing them  
The present invention relates to thiadiazole derivatives having the formula: ##STR1## in which: R 1 represents a phenyl group, non-substituted or substitued 1 to 3 times by a halogen atom,...
5071841 Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production  
The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon...
5055480 Topically active ocular gem-diacylthiadiazole sulfonamide carbonic anhydrase inhibitors  
This invention relates to compounds of the following formula useful as a carbonic anhydrase inhibitor: A compound of the formula: ##STR1## and pharmaceutically acceptable salts thereof wherein X is...
5051421 Benzo-[b]thiophene derivatives  
Benzo[b]thiophene derivatives of formula ##STR1## their tautomers and salts, in which the index n is 0, 1 or 2, alk is lower alkylene, Ar is phenyl, naphthyl or a monocyclic, five- or six-membered...
5032591 Pharmaceutical preparations  
A pharmaceutical product comprising a potassium channel activator antihypertensive agent and a β-blocker antihypertensive agent as a combined preparation for simultaneous, separate or sequential...
5023257 Intramuscular injection forms of gyrase inhibitors  
Ciprofloxacin and related gyrase inhibitors are tolerated well if administered intramuscularly in the form of an aqueous suspension of the betaine form having an approximate neutral pH value or in...
5013745 Nematicidal compositions  
2-Mercapto-1,3,4-oxadiazoles and 2-mercapto-1,3,4-thiadiazoles of the formula I ##STR1## in which X 1 and X 2 independently of one another are oxygen or sulfur, R 1 is difluoromethyl or...
4992456 Fungicidal 2,5-disubstituted 1,3,4-thiadiazoles  
Fungicidal 2,5-disubstituted 1,3,4-thiadiazoles of the formula ##STR1## in which R 1 represents alkyl or unsubstituted or substituted aralkyl and R 2 represents in each case unsubstituted or...
4990523 Treatment of chronic inflammatory joint disease with arylsulfonamides  
A method of treating chronic inflammatory joint disease with arylsulfonamides of the formula: Z--SO 2 NR 1 R 2 wherein R 1 and R 2 are selected from hydrogen, lower alkyl, lower alkenyl,...
4988718 Pesticidal substituted 4-heterocyclyloximino-pyrazolin-5-ones, compositions and use  
Fungicidal substituted 4-heterocyclyloximinopyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another in each case represent hydrogen, alkyl, alkenyl, alkinyl,...
4987146 N-hetaryl imidazole derivatives  
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
4981852 Chemical compounds triamterene and hydrochlorothiazide  
A diuretic pharmaceutically acceptable solution of triamterene and solutions of triamterene and hydrochlorothiazide to provide an antihypertensive and diuretic effect for those in need thereof....
4981864 Method for inhibition of erythrocyte aggregation using anellated tricyclic compounds  
The present invention is concerned with the use of compounds of the general formula: ##STR1## wherein R 1 is a phenyl radical of the general formula: ##STR2## or R 1 is a 5 or 6 membered...
4968691 Heterocyclo-substituted azabicyclo muscannic agonists  
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which X represents a group ##STR2## in which p represents an integer of 2 to 4; r represents an integer of 1 or...
4968494 Methods and compositions for thrombolytic therapy  
Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either...
4960798 Methods for the treatment of angina  
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
4954518 4H-1-benzopyran-4-one derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient  
This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the...
4952580 Pesticidal polyhaloalkene derivatives  
Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y 1 and Y 2 are fluorine, Z is hydrogen or the same as Y 1 and Y 2 , and n is 1-4; provided that: ...
Matches 201 - 250 out of 396 < 1 2 3 4 5 6 7 8 >