Matches 101 - 150 out of 396 < 1 2 3 4 5 6 7 8 >
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6177454 Amide derivatives and medicinal compositions thereof  
An amide derivative represented by the following general formula (I) or a salt thereof and a pharmaceutical composition containing the amide derivative and a pharmaceutically acceptable vehicle....
6174883 3-substituted-2-oxindoles derivatives  
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H 2 synthase,...
6159938 Serine protease inhibitors comprising α-keto heterocycles  
Provided are methods of inhibiting the activity of a serine protease using protease inhibitors that include an alpha-keto heterocycle in their structure. The methods are useful in the treatment of...
6150385 1,3,4-thiadiazoles useful for the treatment of CMV infections  
The present invention presents novel 1,3,4-thiadiazole derivatives of formula I ##STR1## which have useful antiviral activity against herpes virus, cytomegalovirus (CMV).
6114327 Anti-viral compounds  
The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such...
6096769 Fungicidal co-formulation  
The invention relates a concentrated liquid fungicidal composition comprising a fungicidally acceptable carrier and/or surface active agent and (a) at least one compound of formula I, ##STR1## (b)...
6057319 3,4-Diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to cox-2 inhibitors  
The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for...
6051236 Composition for optimizing muscle performance during exercise  
A nutritional composition in a dry powder form for optimizing muscle performance during exercise and for enhancing muscle cell repair and recovery following the cessation of exercise. The dry...
6051572 Azetidine, pyrrolidine and piperidine derivatives  
A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT 1 -like...
6022875 Use of substituted 2,4-imidazolidinedione compounds as analgesics  
Disclosed in this invention is a method of analgesic treatment comprising administering an effective analgesic amount of a substituted 2,4-imidazolidinedione compound.
6013644 Spiro-substituted azacycles as modulators of chemokine receptor activity  
The present invention is directed spiro-substituted azacycles of formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , k, l and m are defined herein) which are useful as modulators of chemokine...
6008219 Bicyclic amine derivatives and their use as anti-psychotic agents  
This invention relates to compounds of formula (I) ##STR1## which are useful as modulators of D 3 receptors, in particular as antipsychotic agents.
6004988 Carboxylic acid derivatives, their preparation and their use  
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
6004963 Substituted 2, 4-imidazolidinedione compounds as pharmaceutical active ingredients  
A substituted 2,4-imidazolidinedione compound corresponding to the formula I ##STR1## a process for production thereof and the use of these compounds in a pharmaceutical preparation are described....
5998379 Serine protease inhibitors-proline analogs  
The present invention relates to certain substituted oxadiazole, thiadiazole, and triazole peptoids that are useful as inhibitors of serine proteases, in particular human neutrophil elastase....
5998446 2-[2-(Hetaryl oxymethylene)phenyl] crotonates used as pesticides and fungicides  
There are described compounds of the general formula I ##STR1## where the index and the substituents have the following meanings: R is cyano, halogen, alkyl or alkoxy; n is 0, 1 or 2, it being...
5981556 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors  
1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
5977149 Dihydrotriazole compounds and their use for controlling fungal plant diseases  
Cyclic amides of Formula (I) which are useful as fungicides wherein: A is O; S; N; NR 5 ;or CR 14 --, G is C or N; W is O or S; X is OR 1 , S(O) m R 1 or halogen; R 1 , R 2 , and R 5 are...
5972937 Heterocyclic compounds possessing 5HT.sub.2C receptor antagonist activity  
The invention relates to heterocyclic families of compounds having pharmacological activity, in particular possessing 5HT 2C receptor antagonist activity processes for their preparation, to...
5965565 Piperidines promote release of growth hormone  
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R 1 , R 1a , R...
5958958 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors  
1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
5948801 Treatment of retinal edema with brinzolamide  
Methods for preventing and treating retinal edema with brinzolamide are disclosed.
5942535 a!-Annelated pyrrole derivatives and pharmaceutical use thereof  
The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
5919809 3-substituted-2-oxindole derivatives  
This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the pharmaceutically-acceptable salts thereof which are inhibitors of prostaglandin H 2 synthase,...
5914344 Substituted carboxanilide derivative and plant disease control agent comprising same as active ingredient  
A substituted carboxanilide derivative represented by the formula (1): ##STR1## wherein A is a hydrogen atom or methyl, B is a methyl or ethyl, and Het is 1-methyl-3-substituted-4-pyrazolyl or...
5914351 Anti-viral aromatic hydrazones  
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
5912258 Thiadiazoleamide derivative and anti-ulcer drug  
A thiadiazoleamide derivative or a salt thereof expressed by the following Formula 1: ##STR1## wherein each of R 1 and R 2 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a...
5891883 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds  
The present invention relates to 4,4(disubstituted)cyclohexan-1-ol monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and...
5889025 Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them  
Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates...
5888941 Carbozamides with antifungal activity  
Compounds of general formula I and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these...
5872117 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same  
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral...
5863926 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds  
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating...
5861380 Serine protease inhibitors-keto and di-keto containing ring systems  
The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of...
5830869 Thiadiazole amide MMP inhibitors  
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase...
5824677 Substituted amino alcohol compounds  
Disclosed are compounds having a straight or branched aliphatic hydrocarbon structure of formula I: ##STR1## In formula I, n is an integer from one to four and m is an integer from four to twenty....
5821257 Thiadiazoles and their uses as antipicornaviral agents  
Compounds of the formula; ##STR1## wherein: Thi is thiadiazolyl or substituted thiadiazolyl alkoxy, fluoromethyl, difluoromethyl, trifluoromethyl, 1,1-difluoroethyl, halo, alkyl, cycloalkyl,...
5814646 Inhibitors of amyloid beta-protein production  
A method of protecting a warm-blooded mammal from the progression of Alzheimer's disease, which comprises administering an effective amount of a compound of general formula. ##STR1## in which: R 1 ...
5792783 3-heteroaryl-2-indolinone compounds for the treatment of disease  
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
5731335 (1-Heteroazolyl-1-heterocycane derivatives and their use as neuroprotective agents  
This invention provides heterocyclic compounds of formula (I) that are potentially useful in the treatment of neuropsychiatric disorders associated with progressive processes leading to neuronal...
5726195 Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents  
Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1- 5- 4- (5-nitro-2-thienyl)ethynyl!ph...
5723476 4-hydroxycoumarin-3-carboxamides for the treatment of diabetes mellitus  
The present invention provides some novel 4-hydroxycoumarin-3-carboxamide derivatives and the use of a broad class of 4-hydroxycoumarin-3-carboxamide derivatives for the treatment of a patient...
5719170 Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations  
Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the given meaning. The compounds are pharmacologically active and may therefore be used as pharmaceuticals, in...
5719171 Diaryl derivatives and their use as crop protection agents  
Diaryl derivatives of the general formula I ##STR1## where A is CHOR 1 , CHSR 1 , CHR 1 , CHCl or NOR 1 , B is OR 2 , SR 2 or NR 2 R 3 and Het is a mono-, di- or trinuclear...
5703065 Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds  
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R 3 , Q and R 1 are as defined herein. The compounds of formula I, and...
5693661 Anti-viral compounds  
Certain vinyl acetylene benzimidazole compounds which inhibit the growth of picornaviruses, such as rhinoviruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups,...
5688809 5-heteroarylindole derivatives  
The present invention relates to compounds of the formula ##STR1## The present invention also relates to intermediates for the preparation of compounds of the formula I, pharmaceutical compositions...
5686486 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections  
The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected...
5686474 Acetylene derivatives and crop protection agents containing them  
Acetylene derivatives of the general formula I ##STR1## where U, V and W are hydrogen, halogen, nitro, cyano, alkyl or alkoxy, A is alkylidene, alkoxymethylidene, alkylthiomethylidene or...
5677282 Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase  
Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by...
5668159 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists  
Matches 101 - 150 out of 396 < 1 2 3 4 5 6 7 8 >